Jonathan Sylvan Williams MD MMSc

Endocrinology•Boston, MA

Adrenal Disease, Diabetes, Obesity

Associate Professor of Medicine, Harvard Medical School

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221 Longwood Ave# BrighamBoston, MA 02115
Phone+1 617-732-5661

Education & Training

Harvard Medical SchoolMMSc, ., ., 2002 - 2004
Mass General Brigham/Brigham and Women's HospitalFellowship, Endocrinology, Diabetes, and Metabolism, 2001 - 2004
Mass General Brigham/Brigham and Women's HospitalResidency, Internal Medicine, 1998 - 2001
Drexel University College of MedicineClass of 1998
Brigham Young UniversityBS, Microbiology, 1986 - 1992

Certifications & Licensure

FL State Medical License 2011 - 2025
MA State Medical License 2000 - 2025
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

Early Career Mentoring Award Brigham and Women's Hospital, 2012
Member Alpha Omega Alpha, 1996

Clinical Trials

Vitamin D Supplementation Reduces Renin-Angiotensin System Activity in Obesity Start of enrollment: 2010 Feb 01
Completed
Not Applicable
Assessment of Renin Inhibition on Insulin Sensitivity, Diastolic Function and Aortic Compliance Start of enrollment: 2010 Jun 01
Terminated
Not Applicable
Caveolin-1 and Vascular Dysfunction Start of enrollment: 2010 Oct 01
Active, not recruiting
Phase 1
Impact of Chronic Circadian Disruption vs. Chronic Sleep Restriction on Metabolism Start of enrollment: 2014 Mar 31
Completed
Not Applicable
The Role of Minerelocorticoid Receptor on Modulating Aldosterone Production Start of enrollment: 2016 Jan 01
Completed
Phase 1
Effect of Statin Use on Aldosterone Secretion Start of enrollment: 2016 Apr 01
Completed
Phase 1
Lysine-specific Demethylase 1 and Salt-sensitivity in Humans Start of enrollment: 2017 Jan 02
ACTIVE_NOT_RECRUITING
NA
Mineralocorticoid Receptor (MR) Antagonist (Eplerenone) vs Amlodipine and STRIATIN Start of enrollment: 2019 Jan 15
COMPLETED
PHASE4
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Publications & Presentations

PubMed

Increased Salt-Sensitive Blood Pressure in Women vs Men: Is Relative Hyperaldosteronism the Mechanism?
Ezgi Caliskan Guzelce, Kelly Yin Han Wong, Mahyar Heydarpour, Luminita H Pojoga, Jose Romero
The Journal of Clinical Endocrinology and Metabolism. 2025-08-07
Ser107Pro links difficulty awakening in the morning to adiposity through circadian regulation of adipose thermogenesis.
Cynthia Tchio, Matthew Maher, Christopher Moth, Jens Meiler, Jacqueline Lane
Biorxiv. 2025-07-30
An integrative approach prioritizes the orphan GPR61 genomic region in tissue-specific regulation of chronotype.
Cynthia Tchio, Jonathan S Williams, Herman Taylor, Hanna M Ollila, Richa Saxena
Sleep Advances. 2025-04-01

Grant Support

Dietary BiomarkersNational Institutes of Health/Food and Drug Administration2022–2026
Striatin and HypertensionNIH/NHLBI2019–2023
Metabolic effects of sleep and circadian disruptionNIH/NIA2013–2019

Committees

Chair, Mass General Brigham, IRB 2022 - Present
Lead Medical Research Officer, Brigham and Women's Hospital 2020 - Present
Board of Directors, Association for Patient-Oriented Research
Associate Editor, Metabolism: Clinical and Experimental

Other Languages

Spanish