JonathanWilsonYewdellMDPhD

PubMed

• 48 citations
  Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells.
  Nimitha R. Mathew, Jayalal K. Jayanthan, Ilya V. Smirnov, Jonathan L. Robinson, Hannes Axelsson, Sravya Sowdamini Nakka, Aikaterini Emmanouilidi, Paulo Czarnewski, Wil...> ;Cell Reports. 2021 Jun 22
• 8 citations
  Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1 157-165 tumor-specific peptide.
  Eugene Shenderov, Matheswaran Kandasamy, Uzi Gileadi, Ji-Li Chen, Dawn Shepherd, James S. Gibbs, Gennaro Prota, Jonathan D. Silk, Jonathan W. Yewdell, Vincenzo Cerundolo> ;Journal for Immunotherapy of Cancer. 2021 Jun 1
• 4 citations
  Cutting Edge: Myosin 18A Is a Novel Checkpoint Regulator in B Cell Differentiation and Antibody-Mediated Immunity.
  Michael B. Cheung, Gospel Enyindah-Asonye, Ken Matsui, Ivan Kosik, Nina Dvorina, William M. Baldwin, Jonathan W. Yewdell, Neetu Gupta> ;Journal of Immunology. 2021 May 17
• 9 citations
  Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents
  Zarkoob H, Anna Allué-Guardia, Chen Y, Jung O, Andreu Garcia-Vilanova, Min Jae Song, Jun-Gyu Park, Fatai S. Oladunni, Judith Miller, Tung Y, Ivan Kosik, David C. Schul...> ;Biorxiv. 2021 May 12
• 33 citations
  Individuals cannot rely on COVID-19 herd immunity: Durable immunity to viral disease is limited to viruses with obligate viremic spread.
  Jonathan W. Yewdell> ;Plos Pathogens. 2021 Apr 26
• 15 citations
  SARS-CoV-2 seroassay optimization and performance in a population with high background reactivity in Mali
  Issaka Sagara, John Woodford, Alassane Dicko, Amatigue Zeguime, M'Bouye Doucoure, Jennifer Kwan, Irfan Zaidi, Justin Doritchamou, Maryonne Snow-Smith, Nada Alani, Jona...> ;Medrxiv. 2021 Mar 12
• 96 citations
  Most non-canonical proteins uniquely populate the proteome or immunopeptidome.
  Maria Virginia Ruiz Cuevas, Marie-Pierre Hardy, Jaroslav Hollý, Eric Bonneil, Chantal Durette, Mathieu Courcelles, Joel Lanoix, Caroline Côté, Louis M. Staudt, Sébasti...> ;Cell Reports. 2021 Mar 9
• 4 citations
  Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses.
  Peter Radvak, Martina Kosikova, Yuan-Chia Kuo, Xing Li, Richard Garner, Falko Schmeisser, Ivan Kosik, Zhiping Ye, Jerry P. Weir, Jonathan W. Yewdell, Hang Xie> ;NPJ Vaccines. 2021 Feb 26
• 58 citations
  Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas
  Devin Dersh, James D. Phelan, Megan E. Gumina, Boya Wang, Jesse H. Arbuckle, Jaroslav Holly, Rigel J. Kishton, Tovah E. Markowitz, Mina O. Seedhom, Nathan Fridlyand, G...> ;Immunity. 2021 Jan 12
• 9 citations
  Immune MAL2-practice: breast cancer immunoevasion via MHC class I degradation
  Devin Dersh, Jonathan W. Yewdell> ;The Journal of Clinical Investigation. 2021 Jan 4
• 9 citations
  An R848-Conjugated Influenza Virus Vaccine Elicits Robust Immunoglobulin G to Hemagglutinin Stem in a Newborn Nonhuman Primate Model.
  Elene A Clemens, Beth C. Holbrook, Masaru Kanekiyo, Jonathan W. Yewdell, Barney S. Graham, Martha A. Alexander-Miller> ;The Journal of Infectious Diseases. 2021 Jul 15
• 14 citations
  A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization
  William T. Yewdell, Young Jun Kim, Priyanka Chowdhury, Colleen M. Lau, Ryan M. Smolkin, Kalina T. Belcheva, Keith C. Fernandez, Montserrat Cols, Wei-Feng Yen, Bharat V...> ;Immunity. 2020 Nov 17
• 9 citations
  Author Correction: A few good peptides: MHC class I-based cancer immunosurveillance and immunoevasion.
  Devin Dersh, Jaroslav Hollý, Jonathan W. Yewdell> ;Nature Reviews. Immunology. 2020 Sep 1
• 116 citations
  A few good peptides: MHC class I-based cancer immunosurveillance and immunoevasion.
  Devin Dersh, Jaroslav Hollý, Jonathan W. Yewdell> ;Nature Reviews. Immunology. 2021 Feb 1
• 59 citations
  Decoding mRNA translatability and stability from the 5' UTR.
  Longfei Jia, Yuanhui Mao, Quanquan Ji, Devin Dersh, Jonathan W. Yewdell, Shu-Bing Qian> ;Nature Structural & Molecular Biology. 2020 Jul 27
• 20 citations
  DRiPs get molecular.
  Jonathan W. Yewdell, Jaroslav Hollý> ;Current Opinion in Immunology. 2020 Jun 1
• 30 citations
  Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection
  Jessica Sook Yuin Ho, Matthew Angel, Yixuan Ma, Elizabeth Sloan, Guojun Wang, Carles Martínez-Romero, Marta Alenquer, Vladimir Roudko, Liliane Chung, Simin Zheng, Max ...> ;Cell. 2020 Jun 25
• 118 citations
  The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans.
  John L. Johnson, Rebecca L. Rosenthal, James J. Knox, Arpita Myles, Martin S. Naradikian, Joanna Madej, Mariya Kostiv, Aaron M. Rosenfeld, Wenzhao Meng, Shannon R. Chr...> ;Immunity. 2020 May 19
• 8 citations
  Host CD8α+ and CD103+ dendritic cells prime transplant antigen-specific CD8+ T cells via cross-dressing.
  Bin Li, Chunni Lu, Sara Oveissi, Jing Song, Kun Xiao, Damien Zanker, Mubin Duan, Jianxin Chen, Huji Xu, Quanming Zou, Chao Wu, Jonathan W. Yewdell, Weisan Chen> ;Immunology and Cell Biology. 2020 Aug 1
• 11 citations
  Influenza-infected newborn and adult monkeys exhibit a strong primary antibody response to hemagglutinin stem.
  Elene A Clemens, Davide Angeletti, Beth C. Holbrook, Masaru Kanekiyo, Matthew J. Jorgensen, Barney S. Graham, Jonathan W. Yewdell, Martha A. Alexander-Miller> ;JCI Insight. 2020 Mar 12
• 45 citations
  Original Antigenic Sin: How Original? How Sinful?
  Jonathan W. Yewdell, Jefferson J.S. Santos> ;Cold Spring Harbor Perspectives in Medicine. 2021 May 1
• 80 citations
  UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis
  Lihui Wang, Yue Xu, Heather Rogers, Layla F. Saidi, Constance Tom Noguchi, Honglin Li, Jonathan W. Yewdell, Nicholas R. Guydosh, Yihong Ye> ;Cell Research. 2020 Jan 1
• 3 citations
  Universal Principled Review: A Community-Driven Method to Improve Peer Review
  Matthew F. Krummel, Catherine A. Blish, Michael S. Kuhns, Ken Cadwell, Andrew Oberst, Ananda W. Goldrath, K. Mark Ansel, Hongbo Chi, Ryan M. O'Connell, E. John Wherry,...> ;Cell. 2019 Dec 12
• 34 citations
  Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
  Jennifer E. Cowan, Justin Malin, Yongge Zhao, Mina O. Seedhom, Christelle Harly, Izumi Ohigashi, Michael C. Kelly, Yousuke Takahama, Jonathan W. Yewdell, Maggie Cam, A...> ;Nature Communications. 2019 Dec 2
• 11 citations
  Hemagglutinin head-specific responses dominate over stem-specific responses following prime boost with mismatched vaccines.
  Sinthujan Jegaskanda, Sarah Andrews, Adam K. Wheatley, Jonathan W. Yewdell, Adrian B. McDermott, Kanta Subbarao> ;JCI Insight. 2019 Nov 14
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Journal Articles

• Casting a Wider Net: Immunosurveillance by Nonclassical MHC Molecules  
  Jonathan Yewdell, MD, PLoS One
• Influenza A Virus Negative Strand RNA Is Translated for CD8+ T Cell Immunosurveillance  
  Jonathan W Yewdell, Jacqueline W Mays, The Journal of Immunology
• Serious Adverse Events of Older Adults in Nursing Home and Community Intervention Trials  
  Datta R, Trentalange M, Van Ness PH, McGloin JM, Guralnik JM, Miller ME, Walkup MP, Nadkarni N, Pahor M, Gill TM, Quagliarello V, Juthani-Mehta M for the Life Study Group, Contemp Clin Trials Commun, 1/1/2018
• Distressing Symptoms, Disability and Hospice Services at the End of Life: Prospective Cohort Study (with editorial)  
  Gill TM, Han L, Leo-Summers LS, Gahbauer EA, Allore HG, J Am Geriatr Soc, 1/1/2018
• The Effect of Testosterone on Cardiovascular Biomarkers in the Testosterone Trials  
  Mohler ER 3rd, Ellenberg SS, Lewis CE, Wenger NK, Budoff MJ, Lewis MR, Barrett-Connor E, Swerdloff RS, Stephens-Shields AJ, Bhasin S, Cauley JA, Crandall JP, Cunningha..., J Clin Endocrinol Metab, 1/1/2018
• Risk association of congenital anomalies in patients with ambiguous genitalia: A 22-year single-center experience  
  Heeley JM, Hollander AS, Austin PF, Merritt DF, Wesevich VG; Washington University School of Medicine in St Louis DSD Team, Amarillo IE, J Pediatr Urol, 1/17/2017
• Evaluation and management of tethered cord syndrome in occult spinal dysraphism: Recommendations from the international children's continence society  
  Tuite GF, Thompson DNP, Austin PF, Bauer SB, Neurourol Urodyn, 1/9/2017
• Diagnosis and management of bladder bowel dysfunction in children with urinary tract infections: a position statement from the International Children's Continence Society  
  Yang S, Chua ME, Bauer S, Wright A, Brandström P, Hoebeke P, Rittig S, De Gennaro M, Jackson E, Fonseca E, Nieuwhof-Leppink A, Austin P, Pediatr Nephrol, 1/3/2017
• Immunity to Viruses, Editorial Overview  
  Yewdell, J.W., Rimmezwaan, G., Curr Opin Virol, 1/1/2017
• Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006 to 2013  
  Lipska KJ, Yao X, Herrin J, McCoy RG, Ross JS, Steinman MA, Inzucchi SE, Gill TM, Krumholz HK, Shah ND, Diabetes Care, 1/1/2017
• The Subsequent Course of Disability in Older Persons Discharged to a Skilled Nursing Facility after Hospitalization  
  Liu Z, Han L, Leo-Summers LS, Gahbauer EA, Allore HA, Gill TM, Exp Gerontol, 1/1/2017
• Effect of Metabolic Syndrome on the Mobility Benefit of a Structured Physical Activity Intervention – The Lifestyle Interventions and Independence for Elders Randomize...  
  Botoseneanu A, Chen H, Ambrosius WT, Allore HG, Anton S, Folta SC, King AC, Nicklas BJ, Spring BJ, Strotmeyer ES, Gill TM for the LIFE Study Group, J Am Geriatr Soc, 1/1/2017
• Effect of Physical Activity on Self-reported Disability in Older Adults: Results from The LIFE Study  
  Manini TM, Beavers DP, Pahor M, Guralnik JM, Spring B, Church TS, King AC, Folta SC, Glynn NW, Marsh AP, Gill TM for the LIFE Study Group, J Am Geriatr Soc, 1/1/2017
• Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility  
  Santanasto AJ, Glynn NW, Lovato LC, Blair SN, Fielding RA, Gill TM, Guralnik JM, Fang-Chi H, King AC, Strotmeyer ES, Manini TM, Marsh AP, McDermott MM, Goodpaster BH, ..., J Am Geriatr Soc, 1/1/2017
• Research Priorities to Advance the Health and Health Care of Older Adults with Multiple Chronic Conditions  
  Tisminetzky M, Bayliss EA, Magaziner JA, Allore HG, Anzuoni K, Boyd CM, Gill TM, Go AS, Greenspan SL, Hanson LR, Hornbrook MC, Kitzman DW, Larson EB, Naylor MD, Shirle..., J Am Geriatr Soc, 1/1/2017
• Evaluating Distinctions in the Assessment of Late-Life Disability  
  Gill TM, Williams CS, J Gerontol Med Sci, 1/1/2017
• Varied role of ubiquitylation in generating MHC class I peptide ligands  
  Wei, J.J., Zanker, D., Di Carluccio, A.R., Smelkinson, M.G., Takeda, K., Seedhom, M., Dersh, D., Gibbs, J.S., Yang, N., Jadhav, A., Chen, W., Yewdell, J.W., J Immunol, 1/1/2017
• Testosterone Treatment and Coronary Artery Plaque Volume in Older Men with Low Testosterone  
  Budoff MJ, Ellenberg SS, Lewis CE, Mohler ER, Wenger NK, Bhasin S, Barrett-Connor E, Swerdloff RS, Stephens-Shields AJ, Cauley JA, Crandall JP, Cunningham GR, Ensrud K..., JAMA, 1/1/2017
• Testosterone Treatment and Cognitive Function in Older Men with Low Testosterone and Age-Associated Memory Impairment  
  Resnick SM, Matsumoto AM, Stephens-Shields AJ, Ellenberg SS, Gill TM, Shumaker SA, Pleasants DD, Barrett-Connor E, Bhasin S, Cauley JA, Cella D, Crandall JP, Cunningha..., JAMA, 1/1/2017
• Association between Structured Physical Activity and Sedentary Time in Older Adults  
  Wanigatunga AA, Ambrosius WT, Rejeski WJ, Gill TM, Glynn NW, Tudor-Locke CE, Manini TM, JAMA, 1/1/2017
• Association of Testosterone Levels with Anemia in Older Men: A Controlled Clinical Trial  
  Roy CN, Snyder PJ, Stephens-Shields AJ, Artz AS, Bhasin S, Cohen HJ, Farrar JT, Gill TM, Zeldow B, Cella D, Barrett-Connor E, Cauley JA, Crandall JP, Cunningham GR, En..., JAMA Intern Med, 1/1/2017
• The Current Status of Clinical Drug Trials in Pediatric Urology  
  Austin PF, J Urol, 1/1/2017
• Review of Incidence of Pseudophakic Cystoid Macular Edema and OCT-Detectable Changes in central macular thickness in patients receiving prostaglandin analogues in the ...  
  SH, J Allen, K Petro, J Wilgucki, Z Balest, N Anand, J Lockwood, J Katz, J Micheletti, H Park, S Reddy, and S Walia, EyeWorld, 1/1/2017
• Prospective assessment of cosmesis before and after genital surgery  
  Nokoff NJ, Palmer B, Mullins AJ, Aston CE, Austin P, Baskin L, Bernabe K, Chan YM, Cheng EY, Diamond DA, Fried A, Frimberger D, Galan D, Gonzalez L, Greenfield S, Kolo..., J Pediatr Urol, 1/1/2017
• CEVL interactive - Best surgical practices to repair high common urogenital sinus by anterior sagittal transrectal approach (ASTRA) and genitoplasty  
  Salle JL, Maizels M, Yerkes EB, Austin P, J Pediatr Urol, 1/1/2017
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Books/Book Chapters

• Immunology of Infectious Diseases 
  Chapter: Overview of the viral antigens. 
  Yewdell, J.W. , Bennink, J.R.Editors: S. H. E. Kaufmann, S.H.E., Sacks, D., Rouse, B..ASM Press, Washington, DCEdition 2nd,2009
• Immunobiology of Influenza Infection: Approaches for an Emerging Zoonotic Disease 
  Chapter: Frontiers in viral immunology: Sympathetic nervous system control of anti-influenza immunity. 
  Page 73 - 84Grebe, K.M., Irvine, K.R., Hickman, H.D., Yewdell, J.W., Bennink, J.R.Editors: R.A. Tripp.Research Signpost, Kerala, India2008
• Immunodominance: the choice of the immune system 
  Chapter: Endogenous antigen processing. 
  Page 75 - 90Yewdell, J.W.Editors: J. Frelinger.Wiley, Hoboken, NJ2006
• Topley and Wilson’s Microbiology and Microbial Infections, Immunology Volume 
  Chapter: MHC class I antigen processing system. 
  Page 403 - 418Yewdell, J.W.Editors: S.H.E. Kauffman, M.W. Steward.Hodder Arnold, London, United KingdomEdition 10th,2005
• Clinical Virology 
  Chapter: Immune response to viruses. 
  Page 273 - 310Yewdell, J.W., Bennink, J.R.Editors: D.D. Richman, R.J. Whitely, F.G. Hayden.ASM press, Washington, DCEdition 2nd,2002
• Textbook of Influenza 
  Chapter: Cell-mediated immunity to influenza. 
  Epstein, S.L., Yewdell, J.W., Bennink, J.R.Editors: K. Nicholson, R. Webster, A. Hay, N. Cox.Blackwell, Oxford, United KingdomEdition 2nd,2002
• DNA Vaccines 
  Chapter: Minigene-based vaccines for eliciting CD8+ T cell responses. 
  Yewdell, J.W.Editors: H.C.J. Ertl.Landes Bioscience, Austin, TX2002
• Immunology of Infectious Diseases 
  Chapter: Overview of the viral antigens 
  Yewdell, J.W. , Bennink, J.R.Editors: S. H. E. Kaufmann, S.H.E., Sher, A., Ahmed. R..ASM Press, Washington, DC2002
• Options for the control of influenza III 
  Chapter: Why are so few viral peptides recognized by MHC class I restricted T lymphocytes? 
  Page 195 - 202Deng, Y, Bennink, J.R., Yewdell, J.W.Editors: L.E. Brown, A.W. Hampson, R.G. Webster.Elsevier, New York, NY1996
• Options for the control of influenza III 
  Chapter: Using N-linked glycosylation to study the generation of MHC class I associated peptides from exported proteins. 
  Page 203 - 208Bacik, I., Snyder, H.-L., Anton, Russ, G., Otvos, L., Yewdell, J.W., Bennink, J.R.Editors: L.E. Brown, A.W. Hampson, R.G. Webster.Elsevier, New York, NY1996
• Antigen Processing and Presentation 
  Chapter: Where do MHC class I-associated peptides come from? 
  Page 17 - 31Yewdell, J.W., Cox, J.H., Link, H., Bacik, I., and Bennink, J.R.Editors: R.E. Humphries, S. Pierce.Academic Press, New York, NY1994
• Encyclopedia of Virology 
  Chapter: Structure of influenza virus antigens. 
  Page 722 - 727Yewdell, J.W., Bennink, J.R., and Laver, W.G.Editors: A. Granoff, R. Webster.1994
• Viruses and the cellular immune response 
  Chapter: Processing and presentation of viral proteins to MHC Class I-restricted T lymphocytes. 
  Page 31 - 48Yewdell, J.W., Eisenlohr, L., Cox, J., Esquivel, F., Anderson, R., Lapham, C., Ffrench, R., Bennink, J.R.Editors: D. B. Thomas.Plenum, New York, NY1993
• Immunogenicity: UCLA Symposium on Molecular and Cellular Biology Vol. 113 
  Chapter: Where do class I molecules associate with foreign antigens? 
  Page 1 - 6Yewdell, J.W., Eisenlohr, L.C., and Bennink, J.R.Editors: C.A. Janeway, Jr., J. Sprent and E. Sercarz.Wiley-Liss, New York, NY1990
• Influenza Viruses 
  Chapter: The specificity and function of T lymphocytes induced by influenza A viruses. 
  Page 361 - 429Yewdell, J.W., and Hackett, C.J.Editors: R. Krug.Plenum Press, New York, NY1989
• Progress in Immunology: 7th International Congress of Immunology 
  Chapter: Blockade of MHC class I molecule transport from the endoplasmic reticulum inhibits presentation of protein antigens to cytotoxic T lymphocytes. 
  Page 922 - 930Cox, J.H., Bennink, J.R., Eisenlohr, L.C., and Yewdell, J.W.Editors: F. Melchers et al.Springer-Verlag, New York, NY1989
• Cell Biology of Virus Entry, Replication, and Pathogenesis 
  Chapter: B-cell lysis of mouse hepatitis virus-infected cells: fusion of target and effector cells. 
  Page 417 - 423Wysocka, M., Korngold, R., Yewdell, J.W., and Bennink, J.R.Editors: R. Compans, A. Helenius, M.B.A. Oldstone.A.R. Liss, New York, NY1988
• Virus Attachment and Entry into Cells 
  Chapter: Monoclonal antibodies as probes for influenza virus hemagglutinin structure and function during the infectious cycle. 
  Page 60 - 65Yewdell, J.W., Taylor, A., Caton, A., Gerhard, W., and Bachi, T.Editors: R. Crowell and K. Lonborg-Holmes.ASM, Washington, DC1986
• Vaccines: New Concepts and Developments 
  Chapter: Recognition of individual viral antigens by cytotoxic T lymphocytes. 
  Page 202 - 210Yewdell J.W., Bennink, J.R.; Smith, G., and Moss, B.Editors: H. Kohler and P.T. LoVerde.Longman Scientific and Technical, Essex, United Kingdom1986
• Options for the Control of Influenza 
  Chapter: Vaccinia virus recombinants expressing influenza virus genes. 
  Page 375 - 391Smith, G.L., Bennink, J.R., Yewdell, J.W., Small, P.A., Murphy, B.R., and Moss, B.Editors: A.P. Kendal and P.A. Patriaca.Alan R. Liss, New York, NY1986
• Current communications in molecular biology. Immune recognition of protein antigens 
  Chapter: B cell recognition sites of the hemagglutinin molecule of A/PR/8/34 influenza virus analyzed by means of a series of sequentially selected virus mutants. 
  Page 24 - 29Yewdell J.W., Taylor, A., McCreedy, D., Caton, A., Gerhard, W.Editors: W.G. Laver and GM Air.Cold Spring Harbor Laboratory, Cold Spring Harbor, NY1985
• Current communications in molecular biology. Immune recognition of protein antigens 
  Chapter: Recognition of cloned influenza A virus gene products by cytotoxic T lymphocytes. 
  Page 124 - 128Yewdell J.W., Bennink, J.R., Smith G.L. and Moss, B.Editors: W.G. Laver and GM Air.Cold Spring Harbor Laboratory, Cold Spring Harbor, NY1985
• Vaccinia viruses as vectors for vaccine antigens 
  Chapter: Influenza virus specific cell-mediated immunity to vaccinia virus recombinants. 
  Page 169 - 174Bennink, J.R., Yewdell, J.W., Smith, G.L., Moss, B.Editors: G. Quinnan.Elsevier Press, New York, NY1985
• T Cell Clones 
  Chapter: The role of virus-specific CTL in vivo. 
  Page 237 - 242Bennink, J.R., Yewdell, J.W., Feldman, A., Gerhard W., and Doherty,, P.C.Editors: H Von Boehmer and W Haas.Elsevier Press, New York, NY1985
• Negative Strand Viruses 
  Chapter: Antigenic alteration of the influenza virus hemagglutinin during the infectious cycle. 
  Page 247 - 252Bachi, T., Yewdell, J.W., and Gerhard, W.Editors: D. Bishop, R. Compans.Elsevier, New York, NY1984
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