JonathanZagerMD

Melanoma, Surgical Oncology (Other than Breast)

Chief Academic Officer Designated Institutional Official Director of Regional Therapies Senior Member, Department of Cutaneous Oncology, Moffitt Cancer Center Professor of Surgery and Chair of the Department of Oncologic Sciences, USF-Morsani College of Medicine.

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Overview of Dr. Zager

Dr. Jonathan Zager is a surgical oncologist, Director of Regional Therapies and Senior Member in the Cutaneous Oncology Department at the H. Lee Moffitt Cancer Center and Research Institute in Tampa FL. He is the Chief Academic Officer at Moffitt Cancer Center as well as the Designated Institutional Official (ACGME). He is a professor of surgery and Chair of the Department of Oncologic Sciences at the University of South Florida Morsani College of Medicine. He received his medical degree from Tel Aviv University Sackler and has been in practice 20 years. He specializes in melanoma and surgical oncology (other than breast) and is experienced in the multidisciplinary management of melanoma, Merkel cell carcinoma and other complicated soft tissue and cutaneous malignancies. Dr. Zager has published nearly 300 peer reviewed articles edited textbooks and textbook chapters. He has given over 350 talks national and internationally on melanoma, Merkel cell carcinoma, basal and squamous cell carcinomas including topics such as regional therapies and the management of complex advanced and recurrent disease.

Office
10920 North McKinley Drive
4123
Tampa, FL 33612
Book by Phone+1(813) 993-0509

Fax+1 813-745-5725
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Education & Training

University of Texas M D Anderson Cancer CenterFellowship, Complex General Surgical Oncology, 2004 - 2006
Montefiore Medical Center/Albert Einstein College of MedicineResidency, Surgery, 2001 - 2004
Memorial Sloan Kettering Cancer CenterFellowship, Hepatobiliary Surgery, 1999 - 2001
Zucker School of Medicine at Hofstra/NorthwellResidency, Surgery, 1997 - 1999
Tel Aviv University SacklerClass of 1997

Certifications & Licensure

FL State Medical License 2006 - 2025
GA State Medical License 2014 - 2024
TX State Medical License 2004 - 2024
NY State Medical License 1998 - 2005
American Board of Surgery Surgery

Awards, Honors, & Recognition

Best Doctors in America Best Doctors
Americas Top Surgeons
Patients Choice Award Patients Choice
Whos Who in Medicine and Healthcare Marquis Whos Who
Most Compassionate Doctor American Registry
Fellow (FACS) American College of Surgeons
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Clinical Trials

Study of RAD001 in Soft Tissue Extremity and/or Retroperitoneal Sarcomas Start of enrollment: 2010 Jan 01
Terminated
Phase 2
Vaccine Combining Multiple Class I Peptides and Montanide ISA 51VG With Escalating Doses of Anti-PD-1 Antibody Nivolumab or Ipilimumab With Nivolumab For Patients With Resected Stages IIIC/ IV Melanoma Start of enrollment: 2010 Aug 13
Completed
Phase 1
Study of XL888 With Vemurafenib for Patients With Unresectable BRAF Mutated Stage III/IV Melanoma Start of enrollment: 2012 Jul 27
Completed
Phase 1
Vemurafenib With Lymphodepletion Plus Adoptive Cell Transfer & High Dose IL-2 Metastatic Melanoma Start of enrollment: 2012 Aug 03
Active, not recruiting
Phase 2
Ipilimumab With Lymphodepletion Plus Adoptive Cell Transfer and High Dose IL-2 in Melanoma Mets Pts Start of enrollment: 2012 Oct 09
Active, not recruiting
Not Applicable
Expanded Access Study of Melphalan With Delcath CS-PHP System in Patients With Ocular/Cutaneous Melanoma Mets to Liver
No longer available
Detection of Immune Cell Infiltration Into Melanomas Treated by PV-10, a Feasibility Study Start of enrollment: 2013 Jan 24
Completed
Phase 1
Phase I of Histone Deacetylase (HDAC) Inhibitor Panobinostat With Ipilimumab With Unresectable III/IV Melanoma Start of enrollment: 2014 Jan 07
Completed
Phase 1
Biomarker Correlates of Hypoxia in Metastatic Melanoma Start of enrollment: 2014 Oct 01
Withdrawn
Phase 2
PV-10 in Combination With Pembrolizumab for Treatment of Metastatic Melanoma Start of enrollment: 2015 Oct 01
Active, not recruiting
Phase 1, Phase 2
Percutaneous Hepatic Perfusion in Patients With Hepatic-dominant Ocular Melanoma Start of enrollment: 2016 Feb 01
Completed
Phase 3
Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C Melanoma Patients Start of enrollment: 2018 Sep 20
Recruiting
Phase 3
Neoadjuvant Immunotherapy With Tavo + Electroporation in Combination With Nivo. in Melanoma Patients Start of enrollment: 2020 Dec 22
Active, not recruiting
Phase 2
Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell Carcinoma Start of enrollment: 2021 Oct 22
Recruiting
Phase 1
An Open-Label Expanded Access Study of the Melphalan/Hepatic Delivery System (HDS) in Patients With Hepatic Dominant Ocular Melanoma Start of enrollment: 2022 Jun 10
Active, not recruiting
Phase 3
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma Start of enrollment: 2019 Dec 17
Recruiting
Phase 3
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Management of melanoma: can we use gene expression profiling to help guide treatment and surveillance?
Zager, J., Hyams, D.> ;Clinical & Experimental Metastasis. 2023 Dec 8
ASO Visual Abstract: Timing of Adjuvant Immunotherapy in Stage III Melanoma, Does It Matter?
Kristen E Rhodin, Sin-Ho Jung, Kelly Elleson, Danielle DePalo, Richard Straker, Sophia McKinley, Kate Beekman, Lily Parker, Suephy Chen, Matthew K Iyer, April K S Sala...> ;Annals of Surgical Oncology. 2023 Oct 1
Oncolytic intralesional therapy for metastatic melanoma.
Danielle K DePalo, Matthew C Perez, Anne Huibers, Roger Olofsson Bagge, Jonathan S Zager> ;Clinical & Experimental Metastasis. 2023 Aug 9
2 citations
Timing of Adjuvant Immunotherapy in Stage III Melanoma, Does it Matter?
Kristen E Rhodin, Sin-Ho Jung, Kelly Elleson, Danielle DePalo, Richard Straker, Sophia McKinley, Kate Beekman, Lily Parker, Suephy Chen, Matthew K Iyer, April K S Sala...> ;Annals of Surgical Oncology. 2023 Oct 1
ASO Visual Abstract: Recurrence Patterns for Regionally Metastatic Melanoma Treated in the Era of Adjuvant Therapy: A Systematic Review and Meta-Analysis.
Jaileene Pérez-Morales, Kristy K Broman, Deepti Bettampadi, Mary Katherine Haver, Jonathan S Zager, Matthew B Schabath> ;Annals of Surgical Oncology. 2023 Apr 1
2 citations
Talimogene Laherparepvec in Combination with Immunotherapy, A Viable Option?
Jonathan S Zager, Alexander C J van Akkooi> ;Annals of Surgical Oncology. 2023 Mar 1
Recurrence Patterns for Regionally Metastatic Melanoma Treated in the Era of Adjuvant Therapy: A Systematic Review and Meta-Analysis.
Jaileene Pérez-Morales, Kristy K Broman, Deepti Bettampadi, Mary Katherine Haver, Jonathan S Zager, Matthew B Schabath> ;Annals of Surgical Oncology. 2023 Apr 1
An Internally Validated Prognostic Risk-Score Model for Disease-Specific Survival in Clinical Stage I and II Merkel Cell Carcinoma.
Shannon, A., Straker, R., Carr, M., Sun, J., Landa, K., Baecher, K., Lynch, K., Bartels, H., Panchaud, R., Keele, L., Lowe, M., Slingluff, C., Jameson, M., Tsai, K., F...> ;Annals of Surgical Oncology. 2022 Oct 1
ASO Visual Abstract: An Internally Validated Prognostic Risk Score Model for Disease-Specific Survival in Clinical Stage I and II Merkel Cell Carcinoma.
Shannon, A., Straker, R., Carr, M., Sun, J., Landa, K., Baecher, K., Lynch, K., Bartels, H., Panchaud, R., Keele, L., Lowe, M., Slingluff, C., Jameson, M., Tsai, K., F...> ;Annals of Surgical Oncology. 2022 Oct 1
5 citations
Outcomes with adjuvant anti-PD-1 therapy in patients with sentinel lymph node-positive melanoma without completion lymph node dissection.
Eroglu, Z., Broman, K., Thompson, J., Nijhuis, A., Hieken, T., Kottschade, L., Farma, J., Hotz, M., Deneve, J., Fleming, M., Bartlett, E., Sharma, A., Dossett, L., Hug...> ;Journal for Immunotherapy of Cancer. 2022 Aug 1
11 citations
The efficacy of immune checkpoint blockade for melanoma in-transit with or without nodal metastases - A multicenter cohort study.
Carl-Jacob Holmberg, Lars Ny, Tina J Hieken, Matthew S Block, Michael J Carr, Vernon K Sondak, Christoffer Örtenwall, Dimitrios Katsarelias, Florentia Dimitriou, Alexa...> ;European Journal of Cancer. 2022 Jul 1
4 citations
Efficacy of Neoadjuvant Intratumoral Darleukin/Fibromun (L19IL2 + L19TNF) in Patients with Clinical Stage IIIB/C Melanoma (Neo-DREAM).
Areeba Saif, Alexander J Rossi, Amod Sarnaik, Jonathan M Hernandez, Jonathan S Zager> ;Annals of Surgical Oncology. 2022 Jun 1
20 citations
Neoadjuvant Systemic Therapy (NAST) in Patients with Melanoma: Surgical Considerations by the International Neoadjuvant Melanoma Consortium (INMC).
van Akkooi, A., Hieken, T., Burton, E., Ariyan, C., Ascierto, P., Asero, S., Blank, C., Block, M., Boland, G., Caraco, C., Chng, S., Davidson, B., Duprat Neto, J., Far...> ;Annals of Surgical Oncology. 2022 Jun 1
ASO Visual Abstract: Evaluation of Indications for Sentinel Node Biopsy in Early-Stage Melanoma with the Advent of Adjuvant Systemic Therapy: An International Multicen...
Marc D Moncrieff, Serigne N Lo, Richard A Scolyer, Martin J Heaton, Jenny P Nobes, Andrew P Snelling, Michael J Carr, Carolyn Nessim, Ryckie Wade, A Howard Peach, Rumi...> ;Annals of surgical oncology. 2022 May 25
Patterns of recurrence and prognosis in pathologic stage I and II Merkel cell carcinoma: A multicenter, retrospective cohort analysis.
Andrew D Tieniber, Adrienne B Shannon, Michael J Carr, James Sun, Karenia Landa, Kirsten M Baecher, Kevin Lynch, Harrison G Bartels, Robyn Panchaud, Michael C Lowe, Cr...> ;Journal of the American Academy of Dermatology. 2023 Jan 1
28 citations
Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy.
Jiannong Li, Inna Smalley, Zhihua Chen, Jheng-Yu Wu, Manali S Phadke, Jamie K Teer, Thanh Nguyen, Florian A Karreth, John M Koomen, Amod A Sarnaik, Jonathan S Zager, N...> ;Clinical Cancer Research. 2022 May 13
7 citations
Evaluation of the Indications for Sentinel Node Biopsy in Early-Stage Melanoma with the Advent of Adjuvant Systemic Therapy: An International, Multicenter Study.
Marc D Moncrieff, Serigne N Lo, Richard A Scolyer, Martin J Heaton, Jenny P Nobes, Andrew P Snelling, Michael J Carr, Carolyn Nessim, Ryckie Wade, A Howard Peach, Rumi...> ;Annals of Surgical Oncology. 2022 Sep 1
ASO Visual Abstract: Is There a Relationship Between Tumor-Infiltrating Lymphocytes (TILs) and Regression in Melanoma?
Steven Morrison, Gang Han, Faith Elenwa, John Vetto, Graham Fowler, Stanley P Leong, Mohammed Kashani-Sabet, Barbara Pockaj, Heidi E Kosiorek, Jonathan S Zager, Jane L...> ;Annals of surgical oncology. 2022 May 1
2 citations
An update on local and systemic therapies for nonmelanoma skin cancer.
Danielle K DePalo, Jonathan S Zager, Elleson, K., Kelly M Elleson> ;Expert Review of Anticancer Therapy. 2022 May 1
Prognostic Biomarkers in Melanoma: The Legacy of a Surgeon Scientist Who Followed the Data.
Giorgos Karakousis, Jonathan Zager> ;Annals of Surgical Oncology. 2022 May 1
6 citations
Is There a Relationship Between TILs and Regression in Melanoma?
Gang Han, Faith Elenwa, John T Vetto, Graham Fowler, Stanley P Leong, Mohammed Kashani-Sabet, Barbara Pockaj, Heidi E Kosiorek, Jonathan S Zager, Jane L Messina, Nicol...> ;Annals of Surgical Oncology. 2022 May 1
ASO Author Reflections: Is There a Relationship Between TIL and Regression in Melanoma?
Jonathan S Zager, John Vetto, Morrison, S.> ;Annals of Surgical Oncology. 2022 May 1
2 citations
Is the presence of tumor-infiltrating lymphocytes predictive of outcomes in patients with melanoma?
Gang Han, Faith Elenwa, John T Vetto, Graham Fowler, Stanley P Leong, Mohammed Kashani-Sabet, Barbara A Pockaj, Heidi E Kosiorek, Jonathan S Zager, Vernon K Sondak, Ja...> ;Cancer. 2022 Apr 1
Dedication to late Dale Han, MD.
Giorgos C Karakousis, Stanley P Leong, Jonathan S Zager> ;Clinical & Experimental Metastasis. 2022 Feb 1
1 citations
Introduction: Novel Frontiers in Cancer Metastasis.
Stanley P Leong, Jonathan S Zager> ;Clinical & Experimental Metastasis. 2022 Feb 1
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Journal Articles

Microsatellitosis in Patients with Melanoma
Richard L White, Mark B Faries, Stanley P Leong, Andrew J Sinnamon, Dale Han, Jane L Messina, Barbara A Pockaj, Giorgos C Karakousis, Edmund K Bartlett, John T Vetto, ..., Annals of Surgical Oncology
Management of Sentinel Lymph Node Metastasis in Merkel Cell Carcinoma: Completion Lymphadenectomy, Radiation, or Both?
C Wayne Cruse, Vernon K Sondak, Ricardo J Gonzalez, Daniel E Oliver, Jane L Messina, Louis B Harrison, Jonathan S Zager, Amod A Sarnaik, Annals of Surgical Oncology
Talimogene Laherparepvec (TVEC) for the Treatment of Advanced Melanoma: A Single-Institution Experience
Jonathan S Zager, Amod A Sarnaik, Annals of Surgical Oncology
Resection Margins in Merkel Cell Carcinoma: Is a 1-Cm Margin Wide Enough?
Daniel E Oliver, Vernon K Sondak, C Wayne Cruse, Louis B Harrison, Ricardo J Gonzalez, Amod A Sarnaik, Jonathan S Zager, Jane L Messina, Annals of Surgical Oncology
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Press Mentions

Study: Melanoma Referral Centers Worldwide Adopt Systemic Therapies, Reduce Lymph Node Removal SurgeriesMarch 2nd, 2022
Positive Preliminary Results from Delcath Systems’ FOCUS Trial Presented at the 2021 ASCO Annual MeetingJune 7th, 2021
Moffitt Cancer Center Presents New Data from Dozens of Clinical Research Studies at ASCOJune 1st, 2021
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Committees

Chair, Disease Site Working Group - Melanoma/ Sarcoma. SSO

Professional Memberships

Society of Surgical Oncology - SSO
Member
American College of Surgeons - ACS
Member

Hospital Affiliations

H. Lee Moffitt Cancer Center and Research InstituteTampa, Florida

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CIGNA PPO
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Multiplan PPO
Pacificare HMO
United Healthcare - Direct Choice Plus POS
United Healthcare - Direct Options PPO
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