JosephP.CasazzaMDPh.D.

PubMed

• 29 citations
  Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial.
  Joseph P Casazza, Evan M Cale, Sandeep Narpala, Galina V Yamshchikov, Emily E Coates, Cynthia S Hendel, Laura Novik, LaSonji A Holman, Alicia T Widge, Preeti Apte, Ing...> ;Nature Medicine. 2022 May 1
• 14 citations
  Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys.
  Amarendra Pegu, Ling Xu, Megan E DeMouth, Giulia Fabozzi, Kylie March, Cassandra G Almasri, Michelle D Cully, Keyun Wang, Eun Sung Yang, Joana Dias, Christine M Fennes...> ;Cell Reports. 2022 Jan 4
• 2 citations
  Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings.
  Kristin L Boswell, Timothy A Watkins, Evan M Cale, Jakob Samsel, Sarah F Andrews, David R Ambrozak, Jefferson I Driscoll, Michael A Messina, Sandeep Narpala, Christine...> ;Frontiers in Immunology. 2022 Jan 1
• 25 citations
  Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread.
  Jason M. Hataye, Joseph P. Casazza, Katharine Best, C. Jason Liang, Taina T. Immonen, David R. Ambrozak, Samuel Darko, Amy R. Henry, Farida Laboune, Frank Maldarelli, ...> ;Cell Host & Microbe. 2019 Nov 21
• 54 citations
  Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial
  Martin R. Gaudinski, Katherine V. Houser, Nicole A. Doria-Rose, Grace L. Chen, Ro Shauna S Rothwell, Nina M. Berkowitz, Pamela Costner, LaSonji A. Holman, Ingelise J. ...> ;The Lancet. HIV. 2019 Oct 1
• 73 citations
  Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label ph...
  Martin R. Gaudinski, Emily E. Coates, Laura Novik, Alicia T. Widge, Katherine V. Houser, Eugeania Burch, LaSonji A. Holman, Ingelise J. Gordon, Grace L. Chen, Cristina...> ;Lancet. 2019 Mar 2
• 115 citations
  Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies.
  Constantinos Petrovas, Sara Ferrando-Martinez, Michael Y. Gerner, Joseph P. Casazza, Amarendra Pegu, Claire Deleage, Arik Cooper, Jason Hataye, Sarah Andrews, David R....> ;Science Translational Medicine. 2017 Jan 18
• 141 citations
  Multiple Origins of Virus Persistence during Natural Control of HIV Infection
  Eli A. Boritz, Samuel Darko, Luke Swaszek, Gideon Wolf, David Wells, Xiaolin Wu, Amy R. Henry, Farida Laboune, Jianfei Hu, David R. Ambrozak, Marybeth S. Hughes, Re...> ;Cell. 2016 Aug 11
• 7 citations
  HIV-1-Specific Antibody Response and Function after DNA Prime and Recombinant Adenovirus 5 Boost HIV Vaccine in HIV-Infected Subjects.
  Johannes S. Gach, Andrea Gorlani, Emmanuel Y. Dotsey, Juan C. Becerra, Chase T. M. Anderson, Baiba Berzins, Philip L. Felgner, Donald N. Forthal, Steven G. Deeks, Timo...> ;Plos One. 2016 Aug 8
• 349 citations
  Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
  Rebecca M. Lynch, Eli Boritz, Emily E. Coates, Adam DeZure, Patrick J Madden, Pamela Costner, Mary E. Enama, Sarah H. Plummer, LaSonji A. Holman, Cynthia S. Hendel, In...> ;Science Translational Medicine. 2015 Dec 23
• 13 citations
  Selective Loss of Early Differentiated, Highly Functional PD1high CD4 T Cells with HIV Progression.
  Robert Paris, Constantinos Petrovas, Sara Ferrando-Martinez, Eirini Moysi, Kristin L. Boswell, Eva Archer, Takuya Yamamoto, David R. Ambrozak, Joseph P. Casazza, Richa...> ;Plos One. 2015 Dec 17
• 80 citations
  Activation and lysis of human CD4 cells latently infected with HIV-1.
  Amarendra Pegu, Mangaiarkarasi Asokan, Lan Wu, Keyun Wang, Jason Hataye, Joseph P. Casazza, Xiaoti Guo, Wei Shi, Ivelin S. Georgiev, Tongqing Zhou, Xuejun Chen, Sijy O...> ;Nature Communications. 2015 Oct 20
• 10 citations
  IFNγ − TNFα − IL2 − MIP1α − CD107a + PRF1 + CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans
  Sara Ferrando-Martinez, Ezequiel Ruiz-Mateos, Joseph P. Casazza, Rebeca S. de Pablo-Bernal, Beatriz Dominguez-Molina, M. Ángeles Muñoz-Fernández, Juan Delgado, Rafael ...> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2015 Oct 1
• 12 citations
  Phase I clinical evaluation of seasonal influenza hemagglutinin (HA) DNA vaccine prime followed by trivalent influenza inactivated vaccine (IIV3) boost.
  Julie E. Ledgerwood, Zonghui Hu, Pamela Costner, Galina Yamshchikov, Mary E. Enama, Sarah H. Plummer, Cynthia S. Hendel, LaSonji A. Holman, Brenda Larkin, Ingelise J. ...> ;Contemporary Clinical Trials. 2015 Sep 1
• 249 citations
  Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors
  Tongqing Zhou, Rebecca M. Lynch, Lei Chen, Priyamvada Acharya, Xueling Wu, Nicole A. Doria-Rose, M. Gordon Joyce, Daniel Lingwood, Cinque Soto, Robert T. Bailer, Micha...> ;Cell. 2015 Jun 4
• 31 citations
  Effect of therapeutic intensification followed by HIV DNA prime and rAd5 boost vaccination on HIV-specific immunity and HIV reservoir (EraMune 02): a multicentre rando...
  Chad J. Achenbach, Lambert Assoumou, Steven G. Deeks, Timothy J. Wilkin, Baiba Berzins, Joseph P. Casazza, Sidonie Lambert-Niclot, Richard A. Koup, Dominique Costaglio...> ;The Lancet. HIV. 2015 Mar 1
• 50 citations
  Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers
  Tae-Wook Chun, J. Shawn Justement, Danielle Murray, Connie J. Kim, Jana Blazkova, Claire W. Hallahan, Erika Benko, Cecilia T. Costiniuk, Gabor Kandel, Mario A. Ostrows...> ;The Journal of Infectious Diseases. 2013 Nov 1
• 75 citations
  De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts.
  Jiang Zhu, Xueling Wu, Baoshan Zhang, Krisha McKee, Sijy O'Dell, Cinque Soto, Tongqing Zhou, Joseph P. Casazza, Nisc Comparative Sequencing Program, James C. Mullikin,...> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Oct 22
• 95 citations
  Single cell analysis of lymph node tissue from HIV-1 infected patients reveals that the majority of CD4+ T-cells contain one HIV-1 DNA molecule.
  Lina Josefsson, Sarah Palmer, Nuno R. Faria, Philippe Lemey, Joseph P. Casazza, David R. Ambrozak, Mary F. Kearney, Wei Shao, Shyamasundaran Kottilil, Michael C. Snell...> ;Plos Pathogens. 2013 Jun 20
• 102 citations
  The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis.
  Joseph N Jarvis, Joseph P. Casazza, Hunter H. Stone, Graeme Meintjes, Stephen D. Lawn, Stuart M. Levitz, Thomas S. Harrison, Richard A. Koup> ;The Journal of Infectious Diseases. 2013 Jun 15
• 44 citations
  Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire
  Joseph P. Casazza, Kathryn Bowman, Selorm Adzaku, Emily C. Smith, Mary E. Enama, Robert T. Bailer, David Price, Emma Gostick, Ingelise J. Gordon, David R. Ambrozak, Ma...> ;The Journal of Infectious Diseases. 2013 Jun 15
• 41 citations
  Differential Gag-Specific Polyfunctional T Cell Maturation Patterns in HIV-1 Elite Controllers
  Sara Ferrando-Martinez, Joseph P. Casazza, Manuel Leal, Kawthar Machmach, Ma Ángeles Muñoz-Fernández, Pompeyo Viciana, Richard A. Koup, Ezequiel Ruiz-Mateos> ;Journal of Virology. 2012 Jan 25
• 151 citations
  Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection
  Takuya Yamamoto, David Price, Joseph P. Casazza, Guido Ferrari, Martha Nason, Pratip K. Chattopadhyay, Mario Roederer, Emma Gostick, Peter D. Katsikis, Daniel C. Douek...> ;Blood. 2011 May 5
• 36 citations
  A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults
  Angela M. Minassian, Rosalind Rowland, Natalie E. R. Beveridge, Ian D. Poulton, Iman Satti, Stephanie A. Harris, Hazel C. Poyntz, Matthew Hamill, Kristin L. Griffiths,...> ;BMJ Open. 2011 Jan 1
• 180 citations
  Preferential infection and depletion of Mycobacterium tuberculosis–specific CD4 T cells after HIV-1 infection
  Christof Geldmacher, Njabulo Ngwenyama, Alexandra Schuetz, Constantinos Petrovas, Klaus Reither, Edwin J. Heeregrave, Joseph P. Casazza, David R. Ambrozak, Mark K. Lou...> ;The Journal of Experimental Medicine. 2010 Dec 20
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