JosephHiattMDPhD

PubMed

• Author Correction: A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA.
  Anna-Lisa Doebley, Minjeong Ko, Hanna Liao, A Eden Cruikshank, Katheryn Santos, Caroline Kikawa, Joseph B Hiatt, Robert D Patton, Navonil De Sarkar, Katharine A Collie...> ;Nature Communications. 2023 Jan 25
• 20 citations
  A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA.
  Anna-Lisa Doebley, Minjeong Ko, Hanna Liao, A Eden Cruikshank, Katheryn Santos, Caroline Kikawa, Joseph B Hiatt, Robert D Patton, Navonil De Sarkar, Katharine A Collie...> ;Nature Communications. 2022 Dec 3
• 37 citations
  MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity.
  Eli Grunblatt, Nan Wu, Huajia Zhang, Xiaoli Liu, Justin P. Norton, Yamini M. Ohol, Paul Leger, Joseph B. Hiatt, Emily Eastwood, Rhiana Thomas, Ali H. Ibrahim, Deshui J...> ;Genes & Development. 2020 Sep 1
• 38 citations
  MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer.
  Arnaud Augert, Haritha Mathsyaraja, Ali H. Ibrahim, Brian Freie, Michael Geuenich, Pei-Feng Cheng, Sydney P. Alibeckoff, Nan Wu, Joseph B. Hiatt, Ryan Basom, Adi F. Ga...> ;Cancer Cell. 2020 Jul 13
• 237 citations
  The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line
  Andrew Adey, Joshua N. Burton, Joseph B. Hiatt, Alexandra P. Lewis, Beth Martin, Ruolan Qiu, Choli Lee, Jay Shendure> ;Nature. 2013 Aug 8
• 4 citations
  Delivering a STINGing Blow to Small Cell Lung Cancer via Synergistic Inhibition of DNA-Damage Response and Immune-Checkpoint Pathways.
  Joseph B. Hiatt, David MacPherson> ;Cancer Discovery. 2019 May 1
• 27 citations
  Fatal enteric plexus neuropathy after one dose of ipilimumab plus nivolumab: a case report.
  Jacob S. Appelbaum, Joseph B. Hiatt, Gideon Steinbach, F. Marc Stewart, Hannah Thomas, Paul Nghiem, Raj P. Kapur, John A. Thompson, Shailender Bhatia> ;Journal for Immunotherapy of Cancer. 2018 Aug 31
• 19 citations
  MAdCAM costimulation through Integrin-α4β7 promotes HIV replication.
  Fatima Nawaz, Livia R. Goes, Jocelyn C Ray, Ronke Olowojesiku, Alia Sajani, Aftab A. Ansari, Ian Perrone, Joseph Hiatt, Donald Van Ryk, Danlan Wei, Mia Waliszewski, Ma...> ;Mucosal Immunology. 2018 Jun 6
• 226 citations
  PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia
  Laura A. Jansen, Ghayda Mirzaa, Gisele E. Ishak, Joseph B. Hiatt, William H. Roden, Sonya A. Gunter, Susan L. Christian, Sarah Collins, Carissa Adams, Jean Baptiste Ri...> ;Brain. 2015 Jun 1
• Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes.
  Kumar A, Boyle EA, Tokita M, Mikheev AM, Sanger MC, Girard E, Silber JR, Gonzalez-Cuyar LF, Hiatt JB, Adey A, Lee C, Kitzman JO, Born DE, Silbergeld DL, Olson JM, Rost...> ;Genome biology. 2014-12-03
• Recurrent de novo mutations implicate novel genes underlying simplex autism risk.
  O'Roak BJ, Stessman HA, Boyle EA, Witherspoon KT, Martin B, Lee C, Vives L, Baker C, Hiatt JB, Nickerson DA, Bernier R, Shendure J, Eichler EE> ;Nature communications. 2014-11-24
• 64 citations
  Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species.
  Keith R Bradnam, Joseph N Fass, Anton Alexandrov, Paul Baranay, Michael Bechner, Inanç Birol, Sébastien Boisvert, Jarrod A Chapman, Guillaume Chapuis, Rayan Chikhi, Ha...> ;Gigascience. 2013 Jul 22
• 72 citations
  Mammalian X Upregulation Is Associated with Enhanced Transcription Initiation, RNA Half-Life, and MOF-Mediated H4K16 Acetylation
  Xinxian Deng, Joel B. Berletch, Wenxiu Ma, Joseph B. Hiatt, William Stafford Noble, Jay Shendure, Christine M. Disteche> ;Developmental Cell. 2013 Apr 15
• 110 citations
  Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
  Lea M. Starita, Jonathan N. Pruneda, Russell S. Lo, Douglas M. Fowler, Joseph B. Hiatt, Jay Shendure, Peter S. Brzovic, Stanley Fields, Rachel E. Klevit> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Apr 2
• Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variation.
  Hiatt JB, Pritchard CC, Salipante SJ, O'Roak BJ, Shendure J> ;Genome research. 2013-02-04
• 931 citations
  Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.
  , , , , , , , , , , , , , , , , , , , , , , , , > ;Science. 2012 Dec 21
• 262 citations
  Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting
  Gabriel B. Loeb, Aly A. Khan, Joseph B. Hiatt, Jay Shendure, Robert B. Darnell, Christina S. Leslie, Alexander Y. Rudensky> ;Molecular Cell. 2012 Dec 14
• 8 citations
  Capturing native long-range contiguity by in situ library construction and optical sequencing
  Jerrod J. Schwartz, Joseph B. Hiatt, Andrew Adey, Jay Shendure> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov 13
• Detection of ultra-rare mutations by next-generation sequencing.
  Schmitt MW, Kennedy SR, Salk JJ, Fox EJ, Hiatt JB, Loeb LA> ;Proceedings of the National Academy of Sciences of the United States of America. 2012-08-01
• 362 citations
  Massively parallel functional dissection of mammalian enhancers in vivo
  Joseph B. Hiatt, Daniela Witten, Mee J. Kim, Robin P. Smith, Dalit May, Choli Lee, Jennifer M. Andrie, Su-In Lee, Gregory M. Cooper, Nadav Ahituv, Len A. Pennacchio, J...> ;Nature Biotechnology. 2012 Mar 1
• 230 citations
  Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster
  Joseph B. Hiatt, Di Kim Nguyen, Sevinc Ercan, David Sturgill, LaDeana W. Hillier, Felix Schlesinger, Carrie A. Davis, Valerie Reinke, Thomas R. Gingeras, Jay Shendure,...> ;Nature Genetics. 2011 Dec 1
• 173 citations
  Haplotype-resolved genome sequencing of a Gujarati Indian individual
  Jacob O. Kitzman, Alexandra P. MacKenzie, Joseph B. Hiatt, Rupali P Patwardhan, Peter H. Sudmant, Sarah B. Ng, Can Alkan, Ruolan Qiu, Evan E. Eichler, Jay Shendure> ;Nature Biotechnology. 2011 Jan 1
• Parallel, tag-directed assembly of locally derived short sequence reads.
  Hiatt JB, Patwardhan RP, Turner EH, Lee C, Shendure J> ;Nature methods. 2010-01-17
• 224 citations
  The integrin α4β7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
  Claudia Cicala, Elena Martinelli, Jonathan P. McNally, Diana J. Goode, Ravindra Gopaul, Joseph Hiatt, Katija Jelicic, Shyamasundaran Kottilil, Katilyn Macleod, Angelin...> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Dec 8
• 45 citations
  Automated microfluidic chromatin immunoprecipitation from 2,000 cells
  Joseph B. Hiatt, Rung Lu, Joanne L. Attema, Neethan A. Lobo, Irving L. Weissman, Michael F. Clarke, Stephen R. Quake> ;Lab on a Chip. 2009 May 21
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Lectures

• Identifying small cell lung cancer resistance mechanisms to cytotoxic T cells in vitro using whole genome CRISPR screening. 
  2019 ASCO Annual Meeting - 6/1/2019