JosephDKhouryMD

PubMed

• Myeloid neoplasm with <10% blasts and t(3;5)(q25.1;q34)/NPM::MLF1: A classification dilemma.
  Fnu Sameeta, Hong Fang, Wei Wang, Zhenya Tang, Sa A Wang, Gokce A Toruner, Xenia Parisi, Joseph D Khoury, Ghayas Issa, Guillermo Garcia-Manero, L Jeffrey Medeiros, Gui...> ;American Journal of Hematology. 2024 Mar 5
• The Journey to Improve the College of American Pathologists Cancer Biomarker Reporting Protocols.
  Baskovich, B., Baras, A., Seethala, R., Fitzgibbons, P., Schneider, F., Harris, B., Khoury, J.> ;Archives of Pathology &amp; Laboratory Medicine. 2024 Feb 20
• Aleukemic Chronic Myeloid Leukemia Without Neutrophilia and Thrombocytosis: A Report From the BCR::ABL1 Pathology Group.
  Rivera, D., Cui, W., Gao, J., Peker, D., Zhang, Q., Dewar, R., Qiu, L., Konoplev, S., Hu, Z., Sasaki, K., Hu, A., E, S., Liu, M., Fang, H., Wang, W., Tang, G., Apperle...> ;Modern Pathology. 2024 Feb 1
• Genetics and pathologic landscape of lineage switch of acute leukemia during therapy.
  Zhou, T., Curry, C., Khanlari, M., Shi, M., Cui, W., Peker, D., Chen, W., Wang, E., Gao, J., Shen, Q., Xie, W., Jelloul, F., King, R., Yuan, J., Wang, X., Zhao, C., Ob...> ;Blood Cancer Journal. 2024 Jan 25
• Myelodysplastic neoplasms evolving from inherited bone marrow failure syndromes / germline predisposition syndromes: Back under the microscope.
  M Tarek Elghetany, Mrinal M Patnaik, Joseph D Khoury> ;Leukemia Research. 2024 Feb 1
• 1 citations
  The fifth edition of the WHO classification of mature B-cell neoplasms: open questions for research.
  Sarah E Coupland, Ming-Qing Du, Judith A Ferry, Daphne de Jong, Joseph D Khoury, Lorenzo Leoncini, Kikkeri N Naresh, German Ott, Reiner Siebert, Luc Xerri> ;The Journal of Pathology. 2024 Mar 1
• Optical Genome Mapping Helps to IdentifyRearrangement Arising from Cryptic Complex Chromosomal Aberrations: A Case Report and Literature Review.
  Vanjari, N., Zhao, M., Dave, B., Medeiros, L., Tang, G., Toruner, G., Wang, W., Thakral, B., Khoury, J., Tang, Z.> ;Genes. 2023 Dec 8
• 1 citations
  Fifth Edition of the World Health Classification of Tumors of the Hematopoietic and Lymphoid Tissue: Myeloid Neoplasms.
  Kanagal-Shamanna, R., Medeiros, L., , Loghavi, S., Nejati, R., Patnaik, M., Khoury, J., Naresh, K.> ;Modern Pathology. 2024 Feb 1
• Phase I Results of Bromodomain and Extra-Terminal Inhibitor PLX51107 in Combination with Azacitidine in Patients with Relapsed/Refractory Myeloid Malignancies.
  Jayastu Senapati, Warren C Fiskus, Naval Daver, Nathaniel R Wilson, Farhad Ravandi, Guillermo Garcia-Manero, Tapan Kadia, Courtney D DiNardo, Elias Jabbour, Jan Burger...> ;Clinical Cancer Research. 2023 Nov 1
• 3 citations
  ZNF683 marks a CD8T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome.
  Parry, E., Lemvigh, C., Deng, S., Dangle, N., Ruthen, N., Knisbacher, B., Broséus, J., Hergalant, S., Guièze, R., Li, S., Zhang, W., Johnson, C., Long, J., Yin, S., We...> ;Cancer Cell. 2023 Oct 9
• 1 citations
  Pathomic Features Reveal Immune and Molecular Evolution From Lung Preneoplasia to Invasive Adenocarcinoma.
  Chen, P., Rojas, F., Hu, X., Serrano, A., Zhu, B., Chen, H., Hong, L., Bandyoyadhyay, R., Aminu, M., Kalhor, N., Lee, J., El Hussein, S., Khoury, J., Pass, H., Moreira...> ;Modern Pathology. 2023 Dec 1
• 2 citations
  Correction: "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748.
  Rita Alaggio, Catalina Amador, Ioannis Anagnostopoulos, Ayoma D Attygalle, Iguaracyra Barreto de Oliveira Araujo, Emilio Berti, Govind Bhagat, Anita Maria Borges, Dani...> ;Leukemia. 2023 Sep 1
• Adjunct Therapy with T Regulatory Cells Decreases Inflammation and Preserves the Anti-Tumor Activity of CAR T Cells.
  Ke Zeng, Meixian Huang, Mi-Ae Lyu, Sairah Ahmed, Krina K Patel, Boro Dropulić, Jane Reese-Koc, Paolo F Caimi, Tara Sadeghi, Marcos de Lima, Christopher R Flowers, Simr...> ;Cells. 2023 Jul 18
• 3 citations
  A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and c...
  Jayastu Senapati, Muharrem Muftuoglu, Jo Ishizawa, Hussein A Abbas, Sanam Loghavi, Gautam Borthakur, Musa Yilmaz, Ghayas C Issa, Samuel I Dara, Mahesh Basyal, Li Li, K...> ;Blood Cancer Journal. 2023 Jun 29
• 1 citations
  TET2 truncating mutations predict a worse outcome in blastic plasmacytoid dendritic cell neoplasm.
  Hannah Beird, C Cameron Yin, Joseph D Khoury, Sherry Pierce, Hussein A Abbas, Li Zhao, Anna Skwarska, Muzaffar Qazilbash, Marina Konopleva, P Andrew Futreal, Naveen Pe...> ;Blood Advances. 2023 May 23
• 23 citations
  A phase 2 study of nivolumab combined with ibrutinib in patients with diffuse large B-cell Richter transformation of CLL.
  Nitin Jain, Jayastu Senapati, Beenu Thakral, Alessandra Ferrajoli, Philip Thompson, Jan Burger, Sreyashi Basu, Tapan Kadia, Naval Daver, Gautam Borthakur, Marina Konop...> ;Blood Advances. 2023 May 23
• 16 citations
  Mini-hyper-CVD plus inotuzumab ozogamicin, with or without blinatumomab, in the subgroup of older patients with newly diagnosed Philadelphia chromosome-negative B-cell...
  Elias Jabbour, Nicholas J Short, Jayastu Senapati, Nitin Jain, Xuelin Huang, Naval Daver, Courtney D DiNardo, Naveen Pemmaraju, William Wierda, Guillermo Garcia-Manero...> ;The Lancet. Haematology. 2023 Jun 1
• 2 citations
  Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma.
  Hoppe, M., Jaynes, P., Shuangyi, F., Peng, Y., Sridhar, S., Hoang, P., Liu, C., De Mel, S., Poon, L., Chan, E., Lee, J., Ong, C., Tang, T., Lim, S., Nagarajan, C., Gri...> ;Cancer Discovery. 2023 May 4
• 5 citations
  Response to the Comments from the Groupe Francophone de Cytogénétique Hématologique (GFCH) on the 5th edition of the World Health Organization classification of haemat...
  Reiner Siebert, Anna Schuh, German Ott, Ian A Cree, Ming-Qing Du, Judith Ferry, Andreas Hochhaus, Eric Solary, Kikkeri N Naresh, Joseph D Khoury> ;Leukemia. 2023 May 1
• Clinicopathologic Features of Therapy-Related Myeloid Neoplasms in Patients with Myeloma in the Era of Novel Therapies.
  Fatima Zahra Jelloul, Andres E Quesada, Richard K Yang, Shaoying Li, Wei Wang, Jie Xu, Guilin Tang, C Cameron Yin, Hong Fang, Siba El Hussein, Joseph Khoury, Roland L ...> ;Modern Pathology. 2023 Jun 1
• 1 citations
  Immune evasion phenotype is common in Richter transformation diffuse large B-cell lymphoma variant.
  Siba El Hussein, L Jeffrey Medeiros, Stephen K Gruschkus, Peng Wei, Ellen Schlette, Hong Fang, Fatima Zahra Jelloul, Wei Wang, Warren Fiskus, Rashmi Kanagal-Shamanna, ...> ;Virchows Archiv. 2023 Jun 1
• 3 citations
  Juvenile myelomonocytic leukemia; moving forward.
  M Tarek Elghetany, Hélène Cavé, Rita De Vito, Mrinal M Patnaik, Eric Solary, Khoury, J.> ;Leukemia. 2023 Mar 1
• 1 citations
  Immunophenotypic and genomic landscape of Richter transformation diffuse large B-cell lymphoma.
  Siba El Hussein, L Jeffrey Medeiros, Kirill A Lyapichev, Hong Fang, Fatima Zahra Jelloul, Warren Fiskus, Jiansong Chen, Peng Wei, Ellen Schlette, Jie Xu, Shaoying Li, ...> ;Pathology. 2023 Jun 1
• 12 citations
  North American Blastic Plasmacytoid Dendritic Cell Neoplasm Consortium: position on standards of care and areas of need.
  Naveen Pemmaraju, Hagop Kantarjian, Kendra Sweet, Eunice Wang, Jayastu Senapati, Nathaniel R Wilson, Marina Konopleva, Arthur E Frankel, Vikas Gupta, Ruben Mesa, Matth...> ;Blood. 2023 Feb 9
• 2 citations
  3q26.2/Rearrangements by Pericentric Inv(3): Diagnostic Challenges and Clinicopathologic Features.
  Zhenya Tang, Wei Wang, Su Yang, Hanadi El Achi, Hong Fang, Karen Amelia Nahmod, Gokce A Toruner, Jie Xu, Beenu Thakral, Edward Ayoub, Ghayas C Issa, C Cameron Yin, M J...> ;Cancers. 2023 Jan 11
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Journal Articles

• CD123 Expression Patterns and Selective Targeting with a CD123-Specific Antibody-Drug Conjugate (IMGN632) in Acute Lymphoblastic Leukemia  
  L Jeffrey Medeiros, Hagop M Kantarjian, Jeffrey L Jorgensen, Marina Konopleva, Elias J Jabbour, Joseph D Khoury, Sa A Wang, Sergej N Konoplev, Haematologica
• Focal Rosai–Dorfman Disease Coexisting with Lymphoma in the Same Anatomic Site: A Localized Histiocytic Proliferation Associated with MAPK/ERK Pathway Activation  
  Shaoying Li, L Jeffrey Medeiros, Joseph D Khoury, Nature
• Clinicopathologic and Molecular Features in Hairy Cell Leukemia-Variant: Single Institutional Experience  
  Tariq Muzzafar, L Jeffrey Medeiros, Xinyan Lu, Joseph D Khoury, Nature

Abstracts/Posters

• Outcome of Patients (Pts) with Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) without 3-Month Complete Molecular Response (CMR)
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• The Early Achievement of Measurable Residual Disease Negativity in the Treatment of Adults with Philadelphia-Negative B-Cell Acute Lymphoblastic Leukemia Is a Strong P...
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• p53 Mediated Bone Marrow Mesenchymal Stem Cell Expansion Supports Acute Myeloid Leukemia Development
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Prognostic Factors for Progression in Patients (pts) with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) in Complete Molecular Response (CMR) w...
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Efficacy of Targeted Therapy in Novel Pre-Clinical in Vitro and In Vivo Models of Richter Transformation-Diffuse Large B-Cell Lymphoma (RT-DLBCL)
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Updated Results of a Phase II Study of Reduced-Intensity Chemotherapy with Mini-Hyper-CVD in Combination with Inotuzumab Ozogamicin, with or without Blinatumomab, in O...
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Long-Term Safety and Efficacy of Hyper-CVAD Plus Ponatinib As Frontline Therapy for Adults with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Commonly Presents in the Setting of Prior or Concomitant Hematologic Malignancies (PCHM): Patient Characteristics ...
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Phase II Study of Blinatumomab in Patients with B-Cell Acute Lymphoblastic Leukemia (B-ALL) with Positive Measurable Residual Disease (MRD)
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Characteristics and Clinical Outcomes of Patients with Acute Lymphoblastic Leukemia with KMT2A (MLL) Rearrangement
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Results from a Phase 1/2 Clinical Trial of Tagraxofusp (SL-401) in Patients with Intermediate, or High Risk, Relapsed/Refractory Myelofibrosis
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Loss of EZH2 Protein Expression in Myelodysplastic Syndrome Correlates with EZH2 Mutation and Portends a Worse Outcome
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Pre-Clinical Efficacy of Co-Treatment with KDM1A (LSD1) Inhibitor and Ruxolitinib or BET Inhibitor Against Post-MPN-sAML Blast Progenitor Cells
  Joseph D. Khoury, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Myelodysplastic Syndromes: Laboratory Workup in the Context of New Concepts and Classification Criteria
  Joseph Khoury, MD, Current Hematologic Malignancy Reports, Orlando, FL, 12/9/2019
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Lectures

• Chemoimmunotherapy with Inotuzumab Ozogamicin Combined with Mini-Hyper-CVD, with or without Blinatumomab, for Newly Diagnosed Older Patients with Philadelphia Chromoso... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Results from Ongoing Phase 1/2 Clinical Trial of Tagraxofusp (SL-401) in Patients with Intermediate or High Risk Relapsed/Refractory Myelofibrosis 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Mechanisms Underlying Superior Efficacy of Co-Targeting BET Proteins and Anti-Apoptotic BCL2 or MCL1 Protein Against AML Blast Progenitor Cells 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Results from Ongoing Phase 1/2 Clinical Trial of Tagraxofusp (SL-401) in Patients with Relapsed/Refractory Chronic Myelomonocytic Leukemia (CMML) 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Novel BET Protein Degrader-Based Combinations Exert Lethality Against Human AML Resistant to BET Inhibitors Due to Increased Activity of β-Catenin-TCF7L2- MYC Axis 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
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