JosephJamesLynchMD

PubMed

• Practical and Cost-Effective Manufacturing Route for the Synthesis of a β-Lactamase Inhibitor.
  Miller, S. P.,Zhong, Y. L.,Liu, Z.,Simeone, M.,Yasuda, N.,Limanto, J.,Chen, Z.,Lynch, J.,Capodanno, V.> ;Org. Lett.. 2013 Dec 18
• Comparison of the intrinsic vasorelaxant and inotropic effects of the antiarrhythmic agents vernakalant and flecainide in human isolated vascular and cardiac tissues.
  Lynch, J. J.,Regan, C. P.,Beatch, G. N.,Gleim, G. W.,Morabito, C. J.> ;J. Cardiovasc. Pharmacol.. 2013 Mar
• Rate-Dependent Effects of Vernakalant in the Isolated Non-Remodeled Canine Left Atria Are Primarily Due to Block of the Sodium Channel Comparison with Ranolazine and d...
  Burashnikov, A., Pourrier, M., Gibson, J.K., Lynch, J.J., Antzelevitch, C.> ;Circ Arrhythm Electrophysiol. 2012 Apr
• Comparison of electrophysiological and antiarrhythmic effects of vernakalant, ranolazine, and sotalol in canine pulmonary vein sleeve preparations.
  Sicouri, S., Pourrier, M., Gibson, J.K., Lynch, J.J., Antzelevitch, C.> ;Heart Rhythm. 2012 Mar
• Effect of calcitonin gene-related peptide receptor antagonism on the systemic blood pressure responses to mechanistically diverse vasomodulators in conscious rats.
  Lynch, J.J., Detwiler, T.J., Kane, S.A., Regan, C.P.> ;J Cardiovasc Pharmacol. 2010 Nov
• Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary ...
  Lynch, J.J., Regan, C.P., Edvinsson, L., Hargreaves, R.J., Kane, S.A.> ;J Cardiovasc Pharmacol. 2010 May
• Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist.
  Salvatore, C.A., Moore, E.L., Calamari, A., Cook, J.J., Michener, M.S., O'Malley, S., Miller, P.J., Sur, C., Williams, D.L., Zeng, Z., Danziger, A., Lynch, J.J., Regan...> ;J Pharmacol Exp Ther. 2010 Apr
• The prototype serotonin 5-HT 1B/1D agonist sumatriptan increases the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.
  Lynch, J.J., Stump, G.L., Kane, S.A., Regan, C.P.> ;J Cardiovasc Pharmacol. 2009-06-01
• Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.
  Regan, C.P., Stump, G.L., Kane, S.A., Lynch, J.J.> ;J Pharmacol Exp Ther. 2009-02-01
• Long term assessment of blood pressure transducer drift in rhesus monkeys chronically instrumented with telemetry implants.
  Regan, H.K., Lynch, J.J., Regan, C.P.> ;J Pharmacol Toxicol Methods. 2009-01-01
• Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipy...
  Regan, C.P., Kiss, L., Stump, G.L., McIntyre, C.J., Beshore, D.C., Liverton, N.J., Dinsmore, C.J., Lynch, J.J.> ;J Pharmacol Exp Ther. 2008 Jan
• An improved automated method to quantitate infarct volume in triphenyltetrazolium stained rat brain sections.
  Regan, H.K., Detwiler, T.J., Huang, J.C., Lynch, J.J., Regan, C.P.> ;J Pharmacol Toxicol Methods. 2007-11-01
• In vivo cardiac electrophysiologic and antiarrhythmic effects of an isoquinoline IKur blocker, ISQ-1, in rat, dog, and nonhuman primate.
  Regan, C.P., Stump, G.L., Wallace, A.A., Anderson, K.D., McIntyre, C.J., Liverton, N.J., Lynch, J.J.> ;J Cardiovasc Pharmacol. 2007 Apr
• Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N...
  Liverton, N.J., Bednar, R.A., Bednar, B., Butcher, J.W., Claiborne, C.F., Claremon, D.A., Cunningham, M., DiLella, A.G., Gaul, S.L., Libby, B.E., Lyle, E.A., Lynch, J....> ;J Med Chem. 2007 Feb 22
• Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation.
  Trotter, B.W., Nanda, K.K., Kett, N.R., Regan, C.P., Lynch, J.J., Stump, G.L., Kiss, L., Wang, J., Spencer, R.H., Kane, S.A., White, R.B., Zhang, R., Anderson, K.D., L...> ;J Med Chem. 2006 Nov 30
• Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.
  Brochu, R.M., Dick, I.E., Tarpley, J.W., McGowan, E., Gunner, D., Herrington, J., Shao, P.P., Ok, D., Li, C., Parsons, W.H., Stump, G.L., Regan, C.P., Lynch, J.J., Lyo...> ;Mol Pharmacol. 2006 Mar
• In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhum...
  Regan, C.P., Wallace, A.A., Cresswell, H.K., Atkins, C.L., Lynch, J.J.> ;J Pharmacol Exp Ther. 2006 Feb
• In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide.
  Stump, G.L., Wallace, A.A., Regan, C.P., Lynch, J.J.> ;J Pharmacol Exp Ther. 2005 Dec
• Novel method to assess cardiac electrophysiology in the rat: characterization of standard ion channel blockers.
  Regan, C. P.,Cresswell, H. K.,Zhang, R.,Lynch, J. J.> ;J Cardiovasc Pharmacol. 2005 Jul
• 9-hydroxyazafluorenes and their use in thrombin inhibitors.
  Stauffer, K.J., Williams, P.D., Selnick, H.G., Nantermet, P.G., Newton, C.L., Homnick, C.F., Zrada, M.M., Lewis, S.D., Lucas, B.J., Krueger, J.A., Pietrak, B.L., Lyle,...> ;J Med Chem. 2005 Apr 7
• Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for ...
  Bilodeau, M.T., Balitza, A.E., Koester, T.J., Manley, P.J., Rodman, L.D., Buser-Doepner, C., Coll, K.E., Fernandes, C., Gibbs, J.B., Heimbrook, D.C., Huckle, W.R., Koh...> ;J Med Chem. 2004 Dec 2
• NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles.
  McCauley, J.A., Theberge, C.R., Romano, J.J., Billings, S.B., Anderson, K.D., Claremon, D.A., Freidinger, R.M., Bednar, R.A., Mosser, S.D., Gaul, S.L., Connolly, T.M.,...> ;J Med Chem. 2004 Apr 8
• Effects of inhibition of alpha-CGRP receptors on cardiac and peripheral vascular dynamics in conscious dogs with chronic heart failure.
  Shen, Y., Mallee, J.J., Handt, L.K., Gilberto, D.B., Lynch, J.J., Hargreaves, R.J., Koblan, K.S., Gould, R.J., Kane, S.A.> ;J Cardiovasc Pharmacol. 2003 Nov
• A growth hormone secretagogue prevents ischemic-induced mortality independently of the growth hormone pathway in dogs with chronic dilated cardiomyopathy.
  Shen, Y., Lynch, J.J., Hargreaves, R.J., Gould, R.J.> ;J Pharmacol Exp Ther. 2003 Aug
• In vivo canine cardiac electrophysiologic profile of 1,4-benzodiazepine IKs blockers.
  Stump, G.L., Smith, G.R., Tebben, A.J., Jahansouz, H., Salata, J.J., Selnick, H.G., Claremon, D.A., Lynch, J.J.> ;J Cardiovasc Pharmacol. 2003 Jul
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