JoshuaJamesGruberMD

PubMed

• 2 citations
  Serine starvation silences estrogen receptor signaling through histone hypoacetylation.
  Albert M Li, Bo He, Dimitris Karagiannis, Yang Li, Haowen Jiang, Preethi Srinivasan, Yaniel Ramirez, Meng-Ning Zhou, Christina Curtis, Joshua J Gruber, Chao Lu, Erinn ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Sep 19
• 1 citations
  Acetyl-Click Screening Platform Identifies Small-Molecule Inhibitors of Histone Acetyltransferase 1 (HAT1).
  Jitender D Gaddameedi, Tristan Chou, Benjamin S Geller, Amithvikram Rangarajan, Tarun A Swaminathan, Danielle Dixon, Katherine Long, Caiden J Golder, Van A Vuong, Sele...> ;Journal of Medicinal Chemistry. 2023 Apr 27
• 9 citations
  Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma.
  Haowen Jiang, Rachel L Greathouse, Sarah Jane Tiche, Man Zhao, Bo He, Yang Li, Albert M Li, Balint Forgo, Michaela Yip, Allison Li, Moriah Shih, Selene Banuelos, Meng-...> ;Cancer Research. 2023 Jan 18
• 38 citations
  A phase II study of talazoparib monotherapy in patients with wild-type BRCA1 and BRCA2 with a mutation in other homologous recombination genes.
  Joshua J Gruber, Anosheh Afghahi, Kirsten Timms, Alyssa DeWees, Wyatt Gross, Vasily N Aushev, Hsin-Ta Wu, Mustafa Balcioglu, Himanshu Sethi, Danika Scott, Jessica Fora...> ;Nature Cancer. 2022 Oct 1
• 11 citations
  Chromatin accessibility associates with protein-RNA correlation in human cancer
  Joshua J. Gruber, Ahmed A. Metwally, Lihua Jiang, Warren D. Reynolds, John B. Sunwoo, Lisa A. Orloff, Howard Y. Chang, Maya Kasowski, Michael Snyder, Akshay Sanghi> ;Nature Communications. 2021 Sep 30
• 8 citations
  Intracranial Pressure and Cerebral Perfusion Pressure in Large Spontaneous Intracranial Hemorrhage and Impact of Minimally Invasive Surgery.
  Mais Al-Kawaz, Yunke Li, Richard E. Thompson, Radhika Avadhani, Adam de Havenon, Joshua J. Gruber, Issam A. Awad, Daniel F. Hanley, Wendy C. Ziai> ;Frontiers in Neurology. 2021 Aug 26
• 11 citations
  Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage and Risk of Stroke: A MISTIE III and ATACH-2 Analysis.
  Santosh B. Murthy, Cenai Zhang, Ajay Gupta, Sung Min Cho, Lucia Rivera-Lara, Radhika Avadhani, Joshua J. Gruber, Costantino Iadecola, Guido J. Falcone, Kevin N. Sheth,...> ;Stroke. 2021 Jan 20
• 33 citations
  A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage
  Santosh B. Murthy, Sung Min Cho, Ajay Gupta, Ashkan Shoamanesh, Babak B. Navi, Radhika Avadhani, Joshua J. Gruber, Yunke Li, Tatiana Greige, Vasileios-Arsenios Lioutas...> ;JAMA Neurology. 2020 Nov 1
• 18 citations
  Association of Tumor-Infiltrating Lymphocytes with Homologous Recombination Deficiency and BRCA1/2 Status in Patients with Early Triple-Negative Breast Cancer: A Poole...
  Melinda L. Telli, Charles Chu, Sunil Badve, Shaveta Vinayak, Daniel P. Silver, Steven J. Isakoff, Virginia G. Kaklamani, William J. Gradishar, Vered Stearns, Roisin M....> ;Clinical Cancer Research. 2020 Jun 1
• 31 citations
  Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia.
  Yang Li, Joshua J. Gruber, Ulrike M. Litzenburger, Yiren Zhou, Yu Rebecca Miao, Edward L. LaGory, Albert M. Li, Zhen Hu, Michaela Yip, Lori S. Hart, John M. Maris, How...> ;Cell Death & Disease. 2020 Feb 6
• 7 citations
  High-Resolution Bisulfite-Sequencing of Peripheral Blood DNA Methylation in Early-Onset and Familial Risk Breast Cancer Patients
  Justin Chen, Maria K. Haanpää, Joshua J. Gruber, Natalie Jäger, James M. Ford, Michael Snyder> ;Clinical Cancer Research. 2019 Sep 1
• 41 citations
  HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding
  Joshua J. Gruber, Benjamin Geller, Andrew M. Lipchik, Justin Chen, Ameen A. Salahudeen, Ashwin N. Ram, James M. Ford, Calvin J. Kuo, Michael Snyder> ;Molecular Cell. 2019 Aug 22
• 6 citations
  Chromatin Remodeling in Response to BRCA2-Crisis.
  Joshua J. Gruber, Justin Chen, Benjamin Geller, Natalie Jäger, Andrew M. Lipchik, Guangwen Wang, Allison W. Kurian, James M. Ford, Michael Snyder> ;Cell Reports. 2019 Aug 20
• 106 citations
  Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility.
  Ryan S. Stowers, Anna Shcherbina, Johnny Israeli, Joshua J. Gruber, Julie Chang, Sungmin Nam, Atefeh Rabiee, Mary N. Teruel, Michael Snyder, Anshul Kundaje, Ovijit Cha...> ;Nature Biomedical Engineering. 2019 Jul 8
• 13 citations
  Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid
  Qing Liu, Kevin Van Bortle, Yue Zhang, Ming-Tao Zhao, Joe Z. Zhang, Benjamin Geller, Joshua J. Gruber, Chao Jiang, Joseph C. Wu, Michael Snyder> ;Scientific Reports. 2018 Aug 28
• Outstanding Questions in the Clinical Management of Triple-Negative Breast Cancer
  Joshua J. Gruber, Melinda L. Telli> ;Journal of Oncology Practice. 2017 May 10
• 14 citations
  Association of AHSG with alopecia and mental retardation (APMR) syndrome
  M. Reza Sailani, Fereshteh Jahanbani, Jafar Nasiri, Mahdiyeh Behnam, Mansoor Salehi, Maryam Sedghi, Majid Hoseinzadeh, Shinichi Takahashi, Amin Zia, Joshua J. Gruber, ...> ;Human Genetics. 2017 Jan 4
• 49 citations
  Differentiated thyroid cancer: focus on emerging treatments for radioactive iodine-refractory patients.
  Joshua J. Gruber, A. Dimitrios Colevas> ;The Oncologist. 2015 Feb 1
• 61 citations
  Long-lived microRNA–Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses
  Scott H. Olejniczak, Gaspare La Rocca, Joshua J. Gruber, Craig B. Thompson> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Jan 2
• 67 citations
  Ars2 Promotes Proper Replication-Dependent Histone mRNA 3′ End Formation
  Joshua J. Gruber, Scott H. Olejniczak, Jeongsik Yong, Gaspare La Rocca, Gideon Dreyfuss, Craig B. Thompson> ;Molecular Cell. 2012 Jan 13
• 744 citations
  Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
  David R. Wise, Patrick S. Ward, Jessica E.S. Shay, Justin R. Cross, Joshua J. Gruber, Uma M. Sachdeva, Jesse M. Platt, Raymond G. DeMatteo, M. Celeste Simon, Craig B. ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2011 Dec 6
• 47 citations
  Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription
  Timothy P Cash, Joshua J. Gruber, Tiffiney R. Hartman, Elizabeth P. Henske, M. C. Simon> ;Oncogene. 2011 Jun 2
• 138 citations
  Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming.
  Fangping Zhao, Anthony A. Mancuso, Thi Bui, Xuemei Tong, Joshua J. Gruber, Cezary R. Swider, Patricia V. Sanchez, Julian J. Lum, Nabil Sayed, Junia V. Melo, Alexander ...> ;Oncogene. 2010 May 20
• 109 citations
  The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation
  Xuemei Tong, Fangping Zhao, Anthony A. Mancuso, Joshua J. Gruber, Craig B. Thompson> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Dec 22
• 168 citations
  Ars2 Regulates Both miRNA- and siRNA- Dependent Silencing and Suppresses RNA Virus Infection in Drosophila
  Leah R. Sabin, Rui Zhou, Joshua J. Gruber, Nina Lukinova, Shelly Bambina, Allison Berman, Chi Kong Lau, Craig B. Thompson, Sara Cherry> ;Cell. 2009 Jul 23
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Lectures

• Talazoparib beyond BRCA: A phase II trial of talazoparib monotherapy in <em>BRCA1</em> and <em>BRCA2</em> wild-type patients with advanced HER2-negative breast cancer ... 
  ASCO Annual Meeting 2019 - Chicago, IL - 6/3/2019