JoshuaPaulKlopperMD

Endocrinology • South San Francisco, CA

Diabetes, Lipid Metabolism, Thyroid

Medical Director, Endocrinology - Veracyte, Inc.

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Office
6000 Shoreline Court
Suite 300
South San Francisco, CA 94080
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Education & Training

University of ColoradoFellowship, Endocrinology, Diabetes, and Metabolism, 2002 - 2006
University of ColoradoResidency, Internal Medicine, 1999 - 2002
Emory University School of MedicineClass of 1999

Certifications & Licensure

CO State Medical License 2002 - 2025

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

A Pilot Clinical Trial for Poorly Differentiated Thyroid Cancer - Correlation to Retinoid and Peroxisome-proliferator-activated Receptor (PPARy) Expression Start of enrollment: 2008 Nov 01
Completed
Early Phase 1

Publications & Presentations

PubMed

1 citations
Thyroglobulin Cutoff Values for Detecting Excellent Response to Therapy in Patients With Differentiated Thyroid Cancer.
Jennifer A Sipos, Joseph Aloi, Andrew Gianoukakis, Stephanie L Lee, Joshua P Klopper, Jacqueline T Kung, Mark A Lupo, David Morgenstern, Cristina Prat-Knoll, Andre Sch...> ;Journal of the Endocrine Society. 2023 Aug 1
6 citations
Real-World Performance of the Afirma Genomic Sequencing Classifier (GSC)-A Meta-analysis.
Christian E Nasr, Massimiliano Andrioli, Mayumi Endo, R Mack Harrell, Masha J Livhits, Ibitoro Osakwe, Preethi Polavarapu, Allan Siperstein, Shuanzeng Wei, Xingyu Zhen...> ;The Journal of Clinical Endocrinology and Metabolism. 2023 May 17
2 citations
Risk of malignancy in cytologically indeterminate thyroid nodules harboring thyroid stimulating hormone receptor mutations.
Dorota Whitmer, John E Phay, Shelby Holt, Benjamin O'Donnell, Jay Nguyen, Dennis Joseph, Anthony Chi, Shuyang Wu, Yangyang Hao, Jing Huang, Joshua P Klopper, Richard T...> ;Frontiers in Endocrinology. 2022 Jan 1
11 citations
Improving the adoption of thyroid cancer clinical practice guidelines
Ilya Likhterov, R. Michael Tuttle, Grace C. Haser, Henry K. Su, Donald A. Bergman, Eran E. Alon, Victor Bernet, Elise M. Brett, Rhoda H. Cobin, Eliza H. Dewey, Gerard ...> ;The Laryngoscope. 2016 Nov 1
12 citations
Ultrasound‐based clinical prediction rule model for detecting papillary thyroid cancer in cervical lymph nodes: A pilot study
Nayana U. Patel, Kristin McKinney, Sarah M. Kreidler, Teresa M. Bieker, Paul Russ, Katherine M. Roberts, Deborah H. Glueck, Maria Albuja-Cruz, Joshua P. Klopper, Bryan...> ;Journal of Clinical Ultrasound. 2016 Mar 4
55 citations
ACTIVE SURVEILLANCE FOR PAPILLARY THYROID MICROCARCINOMA: NEW CHALLENGES AND OPPORTUNITIES FOR THE HEALTH CARE SYSTEM.
Grace C. Haser, R. Michael Tuttle, Henry K. Su, Eran E. Alon, Donald A. Bergman, Victor Bernet, Elise M. Brett, Rhoda H. Cobin, Eliza H. Dewey, Gerard M. Doherty, Laur...> ;Endocrine Practice. 2016 Jan 22
9 citations
A “safe and effective” protocol for management of post-thyroidectomy hypocalcemia
Maria Albuja-Cruz, Nikita Pozdeyev, Steven Robbins, Radhika Chandramouli, Christopher D. Raeburn, Joshua P. Klopper, Bryan R. Haugen, Robert C. McIntyre> ;American Journal of Surgery. 2015 Dec 1
54 citations
Management of recurrent and persistent metastatic lymph nodes in well-differentiated thyroid cancer: a multifactorial decision-making guide for the Thyroid Cancer Care...
Mark L. Urken, Mira Milas, Gregory W. Randolph, Ralph P. Tufano, Donald A. Bergman, Victor Bernet, Elise M. Brett, James D. Brierley, Rhoda H. Cobin, Gerard M. Doherty...> ;Head & Neck. 2015 Apr 1
3 citations
A Phase II Trial of Bexarotene for Advanced Differentiated Thyroid Cancer
KlopperJoshua, KaneMadeleine, JimenoAntonio, SamsSharon, FrenchJena, PikeLaura, TompkinsKenneth, HaugenBryan> ;Thyroid. 2015 May 4
20 citations
Database and registry research in thyroid cancer: striving for a new and improved national thyroid cancer database.
Saral Mehra, R. Michael Tuttle, Mira Milas, Lisa A. Orloff, Donald A. Bergman, Victor Bernet, Elise M. Brett, Rhoda H. Cobin, Gerard M. Doherty, Benjamin L. Judson, Jo...> ;Thyroid. 2015 Feb 4
7 citations
What Is the Gold Standard for Comprehensive Interinstitutional Communication of Perioperative Information for Thyroid Cancer Patients? A Comparison of Existing Electro...
Laura L. Dos Reis, R. Michael Tuttle, Eran E. Alon, Donald A. Bergman, Victor Bernet, Elise M. Brett, Rhoda H. Cobin, Gerard M. Doherty, Jeffrey R. Harris, Joshua P. K...> ;Thyroid. 2014 Oct 10
10 citations
Improving the Quality of Thyroid Cancer Care: How Does the Thyroid Cancer Care Collaborative Cross the Institute of Medicine's Quality Chasm?
Saral Mehra, R. Michael Tuttle, Donald A. Bergman, Victor Bernet, Elise M. Brett, Rhoda H. Cobin, Gerard M. Doherty, Joshua P. Klopper, Stephanie L. Lee, Josef Machac,...> ;Thyroid. 2014 Apr 9
153 citations
Multicenter Clinical Experience With the Afirma Gene Expression Classifier
Erik K. Alexander, Melanie Schorr, Joshua P. Klopper, Caroline S Kim, Jennifer A. Sipos, Fadi Nabhan, Charles Parker, David L. Steward, Susan J. Mandel, Bryan R. Haugen> ;The Journal of Clinical Endocrinology and Metabolism. 2014 Jan 1
79 citations
Efatutazone, an Oral PPAR-γ Agonist, in Combination With Paclitaxel in Anaplastic Thyroid Cancer: Results of a Multicenter Phase 1 Trial
Robert C. Smallridge, John A. Copland, Marcia S. Brose, J. T. Wadsworth, Yariv Houvras, Michael E. Menefee, Keith C. Bible, Manisha H. Shah, Ann Wild Gramza, Joshua P....> ;The Journal of Clinical Endocrinology and Metabolism. 2013 Apr 15
118 citations
The Impact of Benign Gene Expression Classifier Test Results on the Endocrinologist–Patient Decision to Operate on Patients with Thyroid Nodules with Indeterminate Fin...
Daniel Stephen Duick, Joshua P. Klopper, James C. Diggans, Lyssa Friedman, Giulia C. Kennedy, Richard B. Lanman, Bryan McIver> ;Thyroid. 2012 Oct 1
97 citations
Programmed Death-1+ T Cells and Regulatory T Cells Are Enriched in Tumor-Involved Lymph Nodes and Associated with Aggressive Features in Papillary Thyroid Cancer
Jena D. French, Gregory Kotnis, Sherif Said, Christopher D. Raeburn, Robert C. McIntyre, Joshua P. Klopper, Bryan R. Haugen> ;The Journal of Clinical Endocrinology and Metabolism. 2012 Mar 30
20 citations
Consumptive hypothyroidism resulting from hepatic vascular tumors in an athyreotic adult.
David J. Howard, Francisco G. La Rosa, Stephen A. Huang, Domenico Salvatore, Michelle A. Mulcahey, Jennifer Sang-Lee, Michael Wachs, Joshua P. Klopper> ;The Journal of Clinical Endocrinology and Metabolism. 2011 Apr 20
26 citations
Thyroid Cancer Resistance to Vitamin D Receptor Activation Is Associated with 24-Hydroxylase Levels But Not the ff FokI Polymorphism
Vibha Sharma, Deborah L. Fretwell, Zachary Crees, Anna Kerege, Joshua P. Klopper> ;Thyroid. 2010 Oct 1
116 citations
Tumor-associated lymphocytes and increased FoxP3+ regulatory T cell frequency correlate with more aggressive papillary thyroid cancer.
Jena D. French, Zachary Weber, Deborah L. Fretwell, Sherif Said, Joshua P. Klopper, Bryan R. Haugen> ;The Journal of Clinical Endocrinology and Metabolism. 2010 May 1
11 citations
Combination PPARgamma and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2.
Joshua P. Klopper, Vibha Sharma, Reid P. Bissonnette, Bryan R. Haugen> ;PPAR Research. 2010 Jan 1
500 citations
Molecular Testing for Mutations in Improving the Fine-Needle Aspiration Diagnosis of Thyroid Nodules
Yuri E. Nikiforov, David L. Steward, Toni M. Robinson-Smith, Bryan R. Haugen, Joshua P. Klopper, Zhaowen Zhu, James A. Fagin, Mercedes Falciglia, Katherine Weber, Mari...> ;The Journal of Clinical Endocrinology and Metabolism. 2009 Jun 1
16 citations
Retinoid and thiazolidinedione therapies in melanoma: an analysis of differential response based on nuclear hormone receptor expression
Joshua P. Klopper, Vibha Sharma, Andrew Berenz, William R. Hays, Michele M Loi, Umarani Pugazhenthi, Sherif Said, Bryan R. Haugen> ;Molecular Cancer. 2009 Mar 6
490 citations
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
Rebecca E. Schweppe, Joshua P. Klopper, Christopher Korch, Umarani Pugazhenthi, Miriam Benezra, Jeffrey A. Knauf, James A. Fagin, Laura A. Marlow, John A. Copland, Rob...> ;The Journal of Clinical Endocrinology and Metabolism. 2008 Nov 1
Can calcitonin and carcinoembryonic antigen doubling times predict progression of thyroid carcinoma
Joshua P. Klopper, Bryan R. Haugen> ;Nature Clinical Practice. Endocrinology & Metabolism. 2008 Jun 10
16 citations
In vivo and microarray analysis of rexinoid-responsive anaplastic thyroid carcinoma.
Joshua P. Klopper, Andrew Berenz, William R. Hays, Vibha Sharma, Umarani Pugazhenthi, Jennifer S. Janssen, Meenakshi Singh, Reid P. Bissonnette, Bryan R. Haugen> ;Clinical Cancer Research. 2008 Jan 15
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Lectures

Introductory Hands-on Thyroid Ultrasound Workshop
ENDO 2019 - New Orleans, LA - 3/22/2019
Clinical Diabetes and Endocrinology in 2013
National Jewish Health, Snowmass, Colorado - 1/19/2013

Press Mentions

Veracyte Announces New Data Suggesting Afirma Testing Can Help Personalize Care for Patients with Thyroid NodulesFebruary 1st, 2023
Veracyte Further Strengthens Medical Team with Appointment of Joshua Klopper, M.D., as Medical Director of EndocrinologySeptember 1st, 2021
New Data Presented at the 2023 ATA Annual Meeting Demonstrate That Veracyte’s Afirma-Based Testing Can Uncover Key Molecular Hallmarks of Thyroid CancerOctober 10th, 2023
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