JuanMSaavedraMD

Psychiatry • North Bethesda, MD

Adjunct Professor, Department of Pharmacology and Physiology, Georgetown University Medical Center

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Office
11119 Rockville Pike
North Bethesda, MD 20852
Phone+1 301-910-5505

Fax+1 301-530-4731
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Education & Training

University of Buenos AiresClass of 1965

Certifications & Licensure

MD State Medical License 1978 - 2025

Publications & Presentations

PubMed

5 citations
Introduction to the Special Issue “The Brain-Gut Axis”
Yvette Taché, Juan M. Saavedra> ;Cellular and Molecular Neurobiology. 2021 Oct 15
In Memoriam: Horst Grobecker (1934-2019).
Saavedra, J. M.> ;Cell. Mol. Neurobiol.. 2019 May 28
19 citations
Telmisartan Protects a Microglia Cell Line from LPS Injury Beyond AT1 Receptor Blockade or PPARγ Activation.
Abdel G. Elkahloun, Yara Rodriguez, Seham Alaiyed, Erin D. Wenzel, Juan M. Saavedra> ;Molecular Neurobiology. 2019 May 1
56 citations
MALAT1 Up-Regulator Polydatin Protects Brain Microvascular Integrity and Ameliorates Stroke Through C/EBPβ/MALAT1/CREB/PGC-1α/PPARγ Pathway
Wenchen Ruan, Jingwei Li, Yazhou Xu, Yunjie Wang, Feng Zhao, Xu Yang, Hulin Jiang, Luyong Zhang, Juan M. Saavedra, Lei Shi, Tao Pang> ;Cellular and Molecular Neurobiology. 2019 Jan 3
155 citations
A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization.
Yunjie Wang, Yun Huang, Yazhou Xu, Wenchen Ruan, Haojie Wang, Yihua Zhang, Juan M. Saavedra, Luyong Zhang, Zhangjian Huang, Tao Pang> ;Antioxidants & Redox Signaling. 2018 Jan 10
9 citations
Angiotensin II AT2 Receptors Contribute to Regulate the Sympathoadrenal and Hormonal Reaction to Stress Stimuli.
Juan M. Saavedra, Ines Armando> ;Cellular and Molecular Neurobiology. 2018 Jan 1
34 citations
Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions.
Yunjie Wang, Wenchen Ruan, Junru Mi, Jingzi Xu, Haojie Wang, Zhengyu Cao, Juan M. Saavedra, Zhang Luyong, Hansen Lin, Tao Pang> ;Brain, Behavior, and Immunity. 2018 Jan 1
Significance of the Stress Research: "In Memoriam, Richard Kvetnansky".
Zorad, S.,Jezova, D.,Strbak, V.,Macho, L.,Saavedra, J. M.> ;Cell. Mol. Neurobiol.. 2017 Dec 01
In Memoriam: Adil J. Nazarali.
Baker, G. B., Saavedra, J. M.> ;Cellular and molecular neurobiology. 2017 Sep 17
58 citations
Beneficial effects of Angiotensin II receptor blockers in brain disorders.
Juan M. Saavedra> ;Pharmacological Research. 2017 Nov 1
61 citations
Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer's Disease.
Juan M. Saavedra> ;Cellular and Molecular Neurobiology. 2016 Mar 18
35 citations
An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer's disease
Abdel G. Elkahloun, Roman Hafko, Juan M. Saavedra> ;Alzheimer's Research & Therapy. 2016 Jan 28
55 citations
Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction.
Yuanxue Gao, Xiaojun Xu, Sai Chang, Yunjie Wang, Yazhou Xu, Siqi Ran, Zhangjian Huang, Ping Li, Jia Li, Luyong Zhang, Juan M. Saavedra, Hong Liao, Tao Pang> ;Toxicology and Applied Pharmacology. 2015 Dec 1
104 citations
Neurorestoration after traumatic brain injury through angiotensin II receptor blockage
Sonia Villapol, Maria G. Balarezo, Kwame Ofori Affram, Juan M. Saavedra, Aviva J. Symes> ;Brain. 2015 Nov 1
108 citations
Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation
Yuan Xu, Yazhou Xu, Yurong Wang, Yunjie Wang, Ling He, Zhenzhou Jiang, Zhangjian Huang, Hong Liao, Jia Li, Juan M. Saavedra, Luyong Zhang, Tao Pang> ;Brain, Behavior, and Immunity. 2015 Nov 1
29 citations
Hepatic Expression of Serum Amyloid A1 Is Induced by Traumatic Brain Injury and Modulated by Telmisartan
Sonia Villapol, Dmitry Kryndushkin, Maria G. Balarezo, Ashley M. Campbell, Juan M. Saavedra, Frank Shewmaker, Aviva J. Symes> ;The American Journal of Pathology. 2015 Oct 1
131 citations
Neuroprotective effects of angiotensin receptor blockers.
Sonia Villapol, Juan M. Saavedra> ;American Journal of Hypertension. 2015 Mar 1
75 citations
Telmisartan ameliorates glutamate-induced neurotoxicity: Roles of AT1 receptor blockade and PPARγ activation
Juan Wang, Tao Pang, Roman Hafko, Julius Benicky, Enrique Sanchez-Lemus, Juan M. Saavedra> ;Neuropharmacology. 2014 Apr 1
13 citations
Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking
Young In Sohn, Nathanael J. Lee, Andrew Chung, Juan M. Saavedra, R. Scott Turner, Daniel T.S. Pak, Hyang-Sook Hoe> ;Biochemical and Biophysical Research Communications. 2013 Oct 4
59 citations
Commercially Available Angiotensin II At2 Receptor Antibodies Are Nonspecific
Roman Hafko, Sonia Villapol, Regina Nostramo, Aviva J. Symes, Esther L. Sabban, Tadashi Inagami, Juan M. Saavedra> ;Plos One. 2013 Jul 1
88 citations
Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice
Sonia Villapol, Alexandra K. Yaszemski, Trevor T. Logan, Enrique Sanchez-Lemus, Juan M. Saavedra, Aviva J. Symes> ;Neuropsychopharmacology. 2012 Aug 15
8 citations
Regulation of Angiotensin II Type 2 Receptor Gene Expression in the Adrenal Medulla by Acute and Repeated Immobilization Stress
Regina Nostramo, Andrej Tillinger, Juan M. Saavedra, Ashok Kumar, Varunkumar Pandey, Lidia I. Serova, Richard Kvetnansky, Esther L. Sabban> ;The Journal of Endocrinology. 2012 Nov 1
146 citations
Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders.
Juan M. Saavedra> ;Clinical Science. 2012 Nov 1
91 citations
Six Commercially Available Angiotensin II AT1 Receptor Antibodies are Non-specific
Julius Benicky, Roman Hafko, Enrique Sanchez-Lemus, Greti Aguilera, Juan M. Saavedra> ;Cellular and Molecular Neurobiology. 2012 Jul 28
69 citations
Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders.
Juan M. Saavedra> ;Cellular and Molecular Neurobiology. 2012 Jul 1
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Press Mentions

Introduction to the Special Issue “Neuroactive Steroids”April 2nd, 2019

Grant Support

Mechanistic Studies On Stress, Brain Inflammation And NeuroprotectionNational Institute Of Mental Health2011
Mechanistic Studies On Stress, Inflammation And NeuroprotectionNational Institute Of Mental Health2010
Role Of Neuropeptides And Biogenic Amines In Stress And Brain InflammationNational Institute Of Mental Health2009
Role Of Neuropeptides And Biogenic Amines In Stress And Brain InflammationNational Institute Of Mental Health2007–2008
Role Of Neuropeptides And Biogenic Amines In Stress AndNational Institute Of Mental Health2001–2006
Neuropeptides/Biogenic Amines In Stress &Brain IschemiaNational Institute Of Mental Health2005
Neuropeptides/Biogenic Amines: Stress And Brain IschemiaNational Institute Of Mental Health2004
Role Of Neuropeptides And Biogenic Amines In Stress And Brain IschemiaNational Institute Of Mental Health1998–2000
Noval Human Macrophage ReceptorNational Institute Of Mental Health1998–1999
Role Of Neuropeptides And Biogenic Amines In Brain FunctionNational Institute Of Mental Health1997