KaikobadIraniMD

PubMed

• 1 citations
  Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting.
  Jun Sun, M Nedim Ince, Clara Abraham, Terrence Barrett, Lisa A Brenner, Yingzi Cong, Reza Dashti, Pradeep K Dudeja, David Elliott, Thomas S Griffith, Peter S Heeger, A...> ;Gut Microbes. 2023 Dec 1
• Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome.
  Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J...> ;Nature Communications. 2023 Sep 11
• SUMOylation of the cardiac sodium channel Na1.5 modifies inward current and cardiac excitability.
  Jin-Young Yoon, Alexander M Greiner, Julia S Jacobs, Young-Rae Kim, Tyler P Rasmussen, William J Kutschke, Daniel S Matasic, Ajit Vikram, Ravinder R Gaddam, Haider Meh...> ;Heart Rhythm. 2023 Nov 1
• Role of miR-204 in segmental cardiac effects of phenylephrine and pressure overload.
  Ravinder Reddy Gaddam, Veda Sudhir Amalkar, Veeresh Kumar Sali, Krishnamurthy Nakuluri, Julie S Jacobs, Young-Rae Kim, Quixia Li, Raman Bahal, Kaikobad Irani, Ajit Vikram> ;Biochemical and Biophysical Research Communications. 2023 Oct 1
• 1 citations
  miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes.
  Seonhee Kim, Ikjun Lee, Shuyu Piao, Harsha Nagar, Su-Jeong Choi, Young-Rae Kim, Kaikobad Irani, Byeong Hwa Jeon, Cuk-Seong Kim> ;Communications Biology. 2022 Sep 21
• 8 citations
  Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome.
  Jin-Young Yoon, Nastaran Daneshgar, Yi Chu, Biyi Chen, Marco Hefti, Ajit Vikram, Kaikobad Irani, Long-Sheng Song, Charles Brenner, E Dale Abel, Barry London, Dao-Fu Dai> ;Clinical and Translational Medicine. 2022 Jul 1
• 5 citations
  γ Peptide Nucleic Acid-Based miR-122 Inhibition Rescues Vascular Endothelial Dysfunction in Mice Fed a High-Fat Diet.
  Ravinder Reddy Gaddam, Karishma Dhuri, Young-Rae Kim, Julia S Jacobs, Vikas Kumar, Qiuxia Li, Kaikobad Irani, Raman Bahal, Ajit Vikram> ;Journal of Medicinal Chemistry. 2022 Feb 24
• 4 citations
  The microRNA-204-5p inhibits APJ signalling and confers resistance to cardiac hypertrophy and dysfunction.
  Ravinder Reddy Gaddam, Young-Rae Kim, Julia S Jacobs, Jin-Young Yoon, Qiuxia Li, Angela Cai, Hamsitha Shankaiahgari, Barry London, Kaikobad Irani, Ajit Vikram> ;Clinical and Translational Medicine. 2022 Jan 1
• Atrial-paced, exercise-similar heart rate envelope induces myocardial protection from ischaemic injury.
  Zhiyong Zhu, Zhan Gao, Biyi Chen, Duane D. Hall, Rachel A Minerath, Olha M. Koval, Ana Sierra, Ekaterina Subbotina, Xiaoyi Zhu, Young-Rae Kim, Jun Yang, Isabella M. Gr...> ;Europace. 2021 Nov 18
• 2 citations
  CRIF1 Deficiency Increased Homocysteine Production by Disrupting Dihydrofolate Reductase Expression in Vascular Endothelial Cells.
  Ikjun Lee, Shuyu Piao, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Byeong Hwa Jeon, Sang-Ha Oh, Kaikobad Irani, Cuk-Seong Kim> ;Antioxidants. 2021 Oct 20
• 5 citations
  Genetic deletion of miR-204 improves glycemic control despite obesity in db/db mice
  Ravinder Reddy Gaddam, Young-Rae Kim, Quixia Li, Julia S. Jacobs, Mohanad Gabani, Akansha Mishra, Joseph A. Promes, Yumi Imai, Kaikobad Irani, Ajit Vikram> ;Biochemical and Biophysical Research Communications. 2020 Nov 5
• 10 citations
  Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice
  Ravinder Reddy Gaddam, Veronica Peotta Jacobsen, Young-Rae Kim, Mohanad Gabani, Julia S. Jacobs, Karishma Dhuri, Santosh Kumar, Modar Kassan, Qiuxia Li, Raman Bahal, R...> ;Scientific Reports. 2020 Jun 22
• 9 citations
  Modulation of the cardiac sodium channel NaV1.5 peak and late currents by NAD+ precursors.
  Daniel S. Matasic, Jin-Young Yoon, Jared M. McLendon, Haider Mehdi, Mark S. Schmidt, Pravda Quinones, Gina M. Morgan, Ryan L. Boudreau, Kaikobad Irani, Charles Brenner...> ;Journal of Molecular and Cellular Cardiology. 2020 Mar 21
• 14 citations
  SUMO2 regulates vascular endothelial function and oxidative stress in mice
  Young-Rae Kim, Julia S. Jacobs, Qiuxia Li, Ravinder Reddy Gaddam, Ajit Vikram, Jing Liu, Modar Kassan, Kaikobad Irani, Santosh Kumar> ;American Journal of Physiology. Heart and Circulatory Physiology. 2019 Oct 4
• 12 citations
  MiR-204 regulates type 1 IP3R to control vascular smooth muscle cell contractility and blood pressure.
  Mohanad Gabani, Jing Liu, Karima Ait-Aissa, Olha M. Koval, Young-Rae Kim, Diana Castañeda, Ajit Vikram, Julia S. Jacobs, Isabella M. Grumbach, Mohamed Trebak, Kaikobad...> ;Cell Calcium. 2019 Mar 23
• 15 citations
  Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress.
  Su-jeong Choi, Shuyu Piao, Harsha Nagar, Saet-Byel Jung, Seonhee Kim, Ikjun Lee, Sungmin Kim, Hee-Jung Song, Nara Shin, Dong Woon Kim, Kaikobad Irani, Byeong Hwa Jeon,...> ;Biochemical and Biophysical Research Communications. 2018 Sep 10
• 26 citations
  A common variant alters SCN5A–miR-24 interaction and associates with heart failure mortality
  Xiaoming Zhang, Jin-Young Yoon, Michael Morley, Jared M. McLendon, Kranti A. Mapuskar, Rebecca Gutmann, Haider Mehdi, Heather L. Bloom, Samuel C. Dudley, Patrick T. El...> ;The Journal of Clinical Investigation. 2018 Mar 1
• 12 citations
  CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation.
  Shuyu Piao, Jun Wan Lee, Harsha Nagar, Saet-Byel Jung, Su-jeong Choi, Seonhee Kim, Ikjun Lee, Sungmin Kim, Nara Shin, Yu Ran Lee, Sang Do Lee, Jin Bong Park, Kaikobad ...> ;Plos One. 2018 Feb 23
• 29 citations
  Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity.
  Shubha Murthy, Olha M. Koval, Juan M. Ramiro Diaz, Santosh Kumar, Daniel W. Nuno, Jason A. Scott, Chantal Allamargot, Linda J. Zhu, Kim Broadhurst, Velarchana Santhana...> ;Plos One. 2017 Oct 23
• 12 citations
  Abnormal CD161+ immune cells and retinoic acid receptor-related orphan receptor γt-mediate enhanced IL-17F expression in the setting of genetic hypertension.
  Madhu V. Singh, Michael Z. Cicha, Santosh Kumar, David K. Meyerholz, Kaikobad Irani, Mark W. Chapleau, Francois M. Abboud> ;The Journal of Allergy and Clinical Immunology. 2017 Sep 1
• 34 citations
  MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1
  Modar Kassan, Ajit Vikram, Qiuxia Li, Young-Rae Kim, Santosh Kumar, Mohanad Gabani, Jing Liu, Julia S. Jacobs, Kaikobad Irani> ;Scientific Reports. 2017 Aug 24
• 22 citations
  CR6-Interacting Factor 1 Deficiency Impairs Vascular Function by Inhibiting the Sirt1-Endothelial Nitric Oxide Synthase Pathway.
  Harsha Nagar, Saet-Byel Jung, Min Jeong Ryu, Su-jung Choi, Shuyu Piao, Hee-Jung Song, Shin Kwang Kang, Nara Shin, Dong Woon Kim, Seon-Ah Jin, Jin-Ok Jeong, Kaikobad Ir...> ;Antioxidants & Redox Signaling. 2017 Aug 1
• 2 citations
  Reversible lysine acetylation: Another layer of post-translational regulation of the cardiac sodium channel.
  Jin-Young Yoon, Ajit Vikram, Barry London, Kaikobad Irani> ;Channels. 2017 Jul 7
• 1 citations
  Corrigendum: Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress.
  Modar Kassan, Ajit Vikram, Young-Rae Kim, Qiuxia Li, Adam Kassan, Hemal H Patel, Santosh Kumar, Mohanad Gabani, Jing Liu, Julia S Jacobs, Kaikobad Irani> ;Scientific Reports. 2017 Apr 10
• 47 citations
  Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel
  Ajit Vikram, Christopher M. Lewarchik, Jin-Young Yoon, Asma Naqvi, Santosh Kumar, Gina M. Morgan, Julia S. Jacobs, Qiuxia Li, Young-Rae Kim, Modar Kassan, Jing Liu, Mo...> ;Nature Medicine. 2017 Mar 1
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