KapilBhallaMD

PubMed

• Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.
  Leandro C Cerchietti, Eloisi C Lopes, Shao Ning Yang, Katerina Hatzi, Karen L Bunting, Lucas A Tsikitas, Ana I Robles, Jennifer Walling, Gabriela Chiosis, Ari Melnick,...> ;Nature Medicine. 2024 Apr 3
• BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor.
  Warren Fiskus, Jessica Piel, Michael P Collins, Murphy Hentemann, Branko Cuglievan, Christopher P Mill, Christine Birdwell, Kaberi Das, John A Davis, Hanxi Hou, Antrix...> ;Blood. 2024 Feb 16
• Efficacy of novel agents against cellular models of familial platelet disorder with myeloid malignancy (FPD-MM).
  Mill, C., Fiskus, W., DiNardo, C., Reville, P., Davis, J., Birdwell, C., Das, K., Hou, H., Takahashi, K., Flores, L., Ruan, X., Su, X., Loghavi, S., Khoury, J., Bhalla...> ;Blood Cancer Journal. 2024 Feb 5
• Preclinical efficacy of targeting epigenetic mechanisms in AML with 3q26 lesions and EVI1 overexpression.
  Birdwell, C., Fiskus, W., Kadia, T., Mill, C., Sasaki, K., Daver, N., DiNardo, C., Pemmaraju, N., Borthakur, G., Davis, J., Das, K., Sharma, S., Horrigan, S., Ruan, X....> ;Leukemia. 2024 Mar 1
• 7 citations
  Characteristics and clinical outcomes of patients with myeloid malignancies and DDX41 variants.
  Alex Bataller, Sanam Loghavi, Yoheved Gerstein, Alexandre Bazinet, Koji Sasaki, Kelly S Chien, Danielle Hammond, Guillermo Montalban-Bravo, Gautam Borthakur, Nicholas ...> ;American Journal of Hematology. 2023 Nov 1
• Phase I Results of Bromodomain and Extra-Terminal Inhibitor PLX51107 in Combination with Azacitidine in Patients with Relapsed/Refractory Myeloid Malignancies.
  Jayastu Senapati, Warren C Fiskus, Naval Daver, Nathaniel R Wilson, Farhad Ravandi, Guillermo Garcia-Manero, Tapan Kadia, Courtney D DiNardo, Elias Jabbour, Jan Burger...> ;Clinical Cancer Research. 2023 Nov 1
• 4 citations
  Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells.
  Yannan Jia, Lina Han, Cassandra L Ramage, Zhe Wang, Connie C Weng, Lei Yang, Simona Colla, Helen Ma, Weiguo Zhang, Michael Andreeff, Naval Daver, Nitin Jain, Naveen Pe...> ;Haematologica. 2023 Oct 1
• 7 citations
  Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1.
  Warren Fiskus, Christopher P Mill, Christine Birdwell, John A Davis, Kaberi Das, Steffen Boettcher, Tapan M Kadia, Courtney D DiNardo, Koichi Takahashi, Sanam Loghavi,...> ;Blood Cancer Journal. 2023 Apr 13
• 1 citations
  Causal linkage of presence of mutant NPM1 to efficacy of novel therapeutic agents against AML cells with mutant NPM1.
  Christopher P Mill, Warren Fiskus, Kaberi Das, John A Davis, Christine E Birdwell, Tapan M Kadia, Courtney D DiNardo, Naval Daver, Koichi Takahashi, Koji Sasaki, Gerar...> ;Leukemia. 2023 Jun 1
• 2 citations
  Characteristics and clinical outcomes of patients with acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2).
  Guillaume Richard-Carpentier, Caitlin R Rausch, Koji Sasaki, Danielle Hammond, Kiyomi Morita, Koichi Takahashi, Guilin Tang, Rashmi Kanagal-Shamanna, Kapil Bhalla, Cou...> ;Haematologica. 2023 Sep 1
• 1 citations
  Immune evasion phenotype is common in Richter transformation diffuse large B-cell lymphoma variant.
  Siba El Hussein, L Jeffrey Medeiros, Stephen K Gruschkus, Peng Wei, Ellen Schlette, Hong Fang, Fatima Zahra Jelloul, Wei Wang, Warren Fiskus, Rashmi Kanagal-Shamanna, ...> ;Virchows Archiv. 2023 Jun 1
• 1 citations
  Immunophenotypic and genomic landscape of Richter transformation diffuse large B-cell lymphoma.
  Siba El Hussein, L Jeffrey Medeiros, Kirill A Lyapichev, Hong Fang, Fatima Zahra Jelloul, Warren Fiskus, Jiansong Chen, Peng Wei, Ellen Schlette, Jie Xu, Shaoying Li, ...> ;Pathology. 2023 Jun 1
• 11 citations
  Clinical outcomes associated with NPM1 mutations in patients with relapsed or refractory AML.
  Ghayas C Issa, Aram Bidikian, Sangeetha Venugopal, Marina Konopleva, Courtney D DiNardo, Tapan M Kadia, Gautam Borthakur, Elias Jabbour, Naveen Pemmaraju, Musa Yilmaz,...> ;Blood Advances. 2023 Mar 28
• 17 citations
  Activity of menin inhibitor ziftomenib (KO-539) as monotherapy or in combinations against AML cells with MLL1 rearrangement or mutant NPM1.
  Warren Fiskus, Naval Daver, Steffen Boettcher, Christopher P Mill, Koji Sasaki, Christine E Birdwell, John A Davis, Kaberi Das, Koichi Takahashi, Tapan M Kadia, Courtn...> ;Leukemia. 2022 Nov 1
• 8 citations
  Implications of RAS mutational status in subsets of patients with newly diagnosed acute myeloid leukemia across therapy subtypes.
  Daniel Rivera, Kunhwa Kim, Rashmi Kanagal-Shamanna, Gautam Borthakur, Guillermo Montalban-Bravo, Naval Daver, Courtney Dinardo, Nicholas J Short, Musa Yilmaz, Naveen P...> ;American Journal of Hematology. 2022 Dec 1
• 7 citations
  Differential prognostic impact of RUNX1 mutations according to frontline therapy in patients with acute myeloid leukemia.
  Sangeetha Venugopal, Courtney D DiNardo, Sanam Loghavi, Wei Qiao, Farhad Ravandi, Marina Konopleva, Tapan Kadia, Kapil Bhalla, Elias Jabbour, Ghayas C Issa, Walid Maca...> ;American Journal of Hematology. 2022 Dec 1
• 41 citations
  TP53 copy number and protein expression inform mutation status across risk categories in acute myeloid leukemia.
  Mehrnoosh Tashakori, Tapan Kadia, Sanam Loghavi, Naval Daver, Rashmi Kanagal-Shamanna, Sherry Pierce, Dawen Sui, Peng Wei, Farnoosh Khodakarami, Zhenya Tang, Mark Rout...> ;Blood. 2022 Jul 7
• 29 citations
  Phase II Study of Venetoclax Added to Cladribine Plus Low-Dose Cytarabine Alternating With 5-Azacitidine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia.
  Tapan M Kadia, Patrick K Reville, Xuemei Wang, Caitlin R Rausch, Gautam Borthakur, Naveen Pemmaraju, Naval G Daver, Courtney D DiNardo, Koji Sasaki, Ghayas C Issa, Mar...> ;Journal of Clinical Oncology. 2022 Nov 20
• Major clinical response in a patient with leukemia cutis treated with the bromodomain inhibitor PLX51107 and azacitidine.
  Kunhwa Kim, Alexandre Bazinet, Sanam Loghavi, Marina Konopleva, Kapil Bhalla, Naval Daver, Joseph D Khoury, Tapan Kadia, Nathaniel R Wilson, Jonathan L Curry, Meghan H...> ;Leukemia Research. 2022 Aug 1
• 15 citations
  Targeting the NRF2/HO-1 Antioxidant Pathway in FLT3-ITD-Positive AML Enhances Therapy Efficacy.
  Sankaranarayan Kannan, Mary E Irwin, Shelley M Herbrich, Tiewei Cheng, LaNisha L Patterson, Marisa J L Aitken, Kapil Bhalla, M James You, Marina Konopleva, Patrick A Z...> ;Antioxidants. 2022 Apr 5
• 6 citations
  Comparative effectiveness of oral dexamethasone vs. oral prednisolone for acute exacerbation of asthma: A randomized control trial.
  Bhaskar Banoth, Anjali Verma, Kapil Bhalla, Alok Khanna, Saraswathi Holla, Swati Yadav> ;Journal of Family Medicine and Primary Care. 2022 Apr 1
• 4 citations
  Efficacy of CDK9 inhibition in therapy of post-myeloproliferative neoplasm (MPN) secondary (s) AML cells.
  Warren Fiskus, Taghi Manshouri, Christine Birdwell, Christopher P Mill, Lucia Masarova, Prithviraj Bose, Tapan M Kadia, Naval Daver, Courtney D DiNardo, Gautam Borthak...> ;Blood Cancer Journal. 2022 Jan 31
• 47 citations
  Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c).
  Warren Fiskus, Steffen Boettcher, Naval Daver, Christopher P Mill, Koji Sasaki, Christine E Birdwell, John A Davis, Koichi Takahashi, Tapan M Kadia, Courtney D DiNardo...> ;Blood Cancer Journal. 2022 Jan 11
• 10 citations
  Integrated Clinical Genotype-Phenotype Characteristics of Blastic Plasmacytoid Dendritic Cell Neoplasm
  C. Cameron Yin, Naveen Pemmaraju, M. James You, Shaoying Li, Jie Xu, Wei Wang, Zhenya Tang, Omar Alswailmi, Kapil N. Bhalla, Muzaffar H. Qazilbash, Marina Konopleva, J...> ;Cancers. 2021 Nov 23
• 27 citations
  Effective therapy of AML with RUNX1 mutation by co-treatment with inhibitors of protein translation and BCL2.
  Christopher P. Mill, Warren Fiskus, Courtney D. DiNardo, Christine Birdwell, John A. Davis, Tapan M. Kadia, Koichi Takahashi, Nicholas J. Short, Naval Daver, Maro Ohan...> ;Blood. 2021 Oct 3
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