KarenSharrockMcCoyMD

Pediatric Pulmonology • Columbus, OH

Professor of Pediatrics, Ohio State University

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Office
700 Children's Drive
Department Of Pulmonary Medicine
Columbus, OH 43205
Phone+1 614-722-4766

Fax+1 614-722-4755
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Education & Training

University of Arizona College of Medicine-TucsonFellowship, Pulmonary Disease and Critical Care Medicine, 1979 - 1982
University of North Carolina HospitalsResidency, Pediatrics, 1976 - 1979
University of North Carolina at Chapel Hill School of MedicineClass of 1975

Certifications & Licensure

OH State Medical License 1982 - 2024
NC State Medical License 1976 - 2018
FL State Medical License 1985 - 1987
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Pulmonology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2012-2014
Fellow (FAAP) American Academy of Pediatrics

Clinical Trials

Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis Patients With P. Aeruginosa Start of enrollment: 2005 Feb 01
Completed
Phase 3
Prevention of Cystic Fibrosis Diabetes Start of enrollment: 2010 May 01
Terminated
Phase 3
Baby Observational and Nutritional Study Start of enrollment: 2011 Dec 01
Completed
G551D Observational Study- Expanded to Additional Genotypes and Extended for Long Therm Follow up (GOAL-e2) Start of enrollment: 2014 Jan 01
Completed
Effects of an Antioxidant-Enriched Multivitamin Supplement on Inflammation and Oxidative Stress in Cystic Fibrosis Start of enrollment: 2013 Jun 01
Completed
Phase 2
OPTIMIZing Treatment for Early Pseudomonas Aeruginosa Infection in Cystic Fibrosis Start of enrollment: 2014 Jun 01
Completed
Phase 3
A Phase 2 Study to Evaluate the Safety, Tolerability, PK and PD of ELX-02 in Cystic Fibrosis Patients With G542X Allele Start of enrollment: 2019 Nov 25
Completed
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

3 citations
Impact of chronic medication de-escalation in patients with cystic fibrosis taking elexacaftor, tezacaftor, ivacaftor: A retrospective review.
Emma L Guenther, Karen S McCoy, Mariah Eisner, Shasha Bai, Christopher J Nemastil, Kimberly J Novak, Terri Johnson, Emily M Stephan> ;Journal of Cystic Fibrosis. 2024 Jan 1
Airway transcriptome networks identify susceptibility to frequent asthma exacerbations in children.
Kieran J Phelan, Kimberly A Dill-McFarland, Arjun Kothari, R Max Segnitz, Jeff Burkle, Brittany Grashel, Seth Jenkins, Daniel Spagna, Lisa J Martin, David B Haslam, Jo...> ;The Journal of Allergy and Clinical Immunology. 2023 Jul 1
9 citations
Clinical change 2 years from start of elexacaftor-tezacaftor-ivacaftor in severe cystic fibrosis.
Karen S McCoy, Jill Blind, Terri Johnson, Patti Olson, Laura Raterman, Shasha Bai, Mariah Eisner, Shahid I Sheikh, Stephan Druhan, Cody Young, Kimberly Pasley> ;Pediatric Pulmonology. 2023 Apr 1
Clinical management of pediatric patients with cystic fibrosis and autism spectrum disorder.
Kimberly Pasley, Katelyn Krivchenia, Mary Lynn Dell, Karen S McCoy, Grace R Paul> ;Pediatric Pulmonology. 2023 Apr 1
21 citations
Impact of elexacaftor-tezacaftor-ivacaftor on bacterial colonization and inflammatory responses in cystic fibrosis.
Shahid Sheikh, Rodney D Britt Jr, Nancy A Ryan-Wenger, Aiman Q Khan, Brandon W Lewis, Courtney Gushue, Hazel Ozuna, Devi Jaganathan, Karen McCoy, Benjamin T Kopp> ;Pediatric Pulmonology. 2023 Mar 1
16 citations
Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor.
Shuzhong Zhang, Chandra L Shrestha, Frank Robledo-Avila, Devi Jaganathan, Benjamin L Wisniewski, Nevian Brown, Hanh Pham, Katherine Carey, Amal O Amer, Luanne Hall-Sto...> ;The European Respiratory Journal. 2023 Apr 1
4 citations
Cystic fibrosis transmembrane conductance regulator modulators and the exocrine pancreas: A scoping review.
Mitchell L Ramsey, Susan S Li, Luis F Lara, Yevgeniya Gokun, Venkata S Akshintala, Darwin L Conwell, John Heintz, Stephen E Kirkby, Karen S McCoy, Georgios I Papachris...> ;Journal of Cystic Fibrosis. 2023 Mar 1
12 citations
Biofilm aggregates and the host airway-microbial interface.
Luanne Hall-Stoodley, Karen S McCoy> ;Frontiers in Cellular and Infection Microbiology. 2022 Jan 1
14 citations
Elexacaftor/Tezacaftor/Ivacaftor Improved Clinical Outcomes in a Patient with N1303K-CFTR Based on In Vitro Experimental Evidence.
Yunjie Huang, Grace R. Paul, Jesun Lee, Sunitha Yarlagadda, Karen McCoy, Anjaparavanda P. Naren> ;American Journal of Respiratory and Critical Care Medicine. 2021 Nov 15
4 citations
Aquagenic wrinkling in children under two years of age: Could this be a potential clinical referral tool for cystic fibrosis among non-screened populations?
Grace R. Paul, Shasha Bai, Kenneth Jackson, Karen McCoy> ;Journal of Cystic Fibrosis. 2021 May 17
23 citations
Long-term safety and efficacy of tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR ...
Patrick A. Flume, Reta Fischer Biner, Damian G Downey, Cynthia A. Brown, Manu Jain, Rainald Fischer, Kris De Boeck, Gregory S Sawicki, Philip Chang, Hildegarde Paz-Dia...> ;The Lancet. Respiratory Medicine. 2021 Feb 10
2 citations
Weighing in on asthma: Insights on BMI, magnesium, and hospitalizations from the Ohio Pediatric Asthma Repository.
Christine L. Schuler, Jocelyn M. Biagini Myers, Carolyn M. Kercsmar, Valentina Pilipenko, John Kroner, Jeffrey M. Simmons, Stephen R. Austin, Samantha M. Gunkelman, Kr...> ;The Journal of Asthma. 2020 Dec 1
Transparency and diversity in cystic fibrosis research - Authors' reply.
Karen McCoy, Harry G.M. Heijerman, Jennifer L. Taylor-Cousar, David Waltz, Patrick R Sosnay, Bonnie W. Ramsey, Steven M. Rowe, John Welter> ;Lancet. 2020 Aug 29
2 citations
Practitioner Due Diligence: Real-World Lumacaftor/Ivacaftor Use.
Emily M Stephan, Christopher J. Nemastil, Ann Salvator, Susan Gemma, Clarissa J Dilaveris, Anne Rice, Kelly T Sakellaris, Kimberly J. Novak, Karen McCoy> ;The Journal of Pediatric Pharmacology and Therapeutics. 2020 Jun 1
16 citations
Mucus plugging, air trapping, and bronchiectasis are important outcome measures in assessing progressive childhood cystic fibrosis lung disease.
Terry E. Robinson, Michael L. Goris, Richard B. Moss, Lu Tian, Peiyi Kan, Mignote Yilma, Karen McCoy, Beverley Newman, Pim A. de Jong, Frederick R. Long, Alan S. Brody...> ;Pediatric Pulmonology. 2020 Jan 21
622 citations
Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation : a double...
Harry G.M. Heijerman, Edward F. McKone, Damian G. Downey, Eva Van Braeckel, Steven M. Rowe, Elizabeth Tullis, Marcus A. Mall, John Welter, Bonnie W. Ramsey, Charlotte ...> ;Lancet. 2019 Nov 23
74 citations
Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial
Felix Ratjen, Stephanie D. Davis, Sanja Stanojevic, Richard A. Kronmal, Karen Hinckley Stukovsky, Neal W. Jorgensen, Margaret Rosenfeld, Gwen Kerby, Carol Kopecky, Meg...> ;The Lancet. Respiratory Medicine. 2019 Sep 1
9 citations
Pulmonary findings in infants with cystic fibrosis during the first year of life: Results from the Baby Observational and Nutrition Study (BONUS) cohort study
Danielle Goetz, Benjamin T. Kopp, Ann Salvator, Melissa Moore-Clingenpeel, Karen McCoy, Daniel H. Leung, Margaret Kloster, Bonnie R. Ramsey, Sonya H. Heltshe, Drucy Bo...> ;Pediatric Pulmonology. 2019 Jan 22
12 citations
Urinary metabolomics reveals unique metabolic signatures in infants with cystic fibrosis
Benjamin T. Kopp, Elizabeth Joseloff, Danielle Goetz, B. Ingram, Sonya L. Heltshe, Daniel H. Leung, Bonnie W. Ramsey, Karen McCoy, Drucy Borowitz> ;Journal of Cystic Fibrosis. 2019 Jul 1
34 citations
Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses.
Frank Robledo-Avila, Juan de Dios Ruiz-Rosado, Kenneth L. Brockman, Benjamin T. Kopp, Amal O. Amer, Karen McCoy, Lauren O. Bakaletz, Santiago Partida-Sanchez> ;Journal of Immunology. 2018 Oct 1
164 citations
Ivacaftor treatment of cystic fibrosis in children aged 12 to <24 months and with a CFTR gating mutation (ARRIVAL): a phase 3 single-arm study
Margaret Rosenfeld, Claire E. Wainwright, Mark Higgins, Linda T Wang, Charlotte M. McKee, Daniel Campbell, S. Tian, Jennifer Schneider, Steve Cunningham, Jane C. Davie...> ;The Lancet. Respiratory Medicine. 2018 Jul 1
5 citations
Ohio Pediatric Asthma Repository: Opportunities to Revise Care Practices to Decrease Time to Physiologic Readiness for Discharge.
Jeffrey M. Simmons, Jocelyn M. Biagini Myers, Lisa J Martin, Carolyn M. Kercsmar, Christine L. Schuler, Valentina Pilipenko, John Kroner, Hua He, Stephen R. Austin, Hu...> ;Hospital Pediatrics. 2018 Jun 1
26 citations
Effects of an antioxidant-enriched multivitamin in cystic fibrosis
Scott D. Sagel, Umer Khan, Raksha Jain, Gavin R. Graff, Cori L. Daines, Jordan M. Dunitz, Drucy Borowitz, David M. Orenstein, Ibrahim Abdulhamid, Julie E Noe, John P. ...> ;American Journal of Respiratory and Critical Care Medicine. 2018 Sep 1
8 citations
Adjunctive Pharmacotherapies in Children With Asthma Exacerbations Requiring Continuous Albuterol Therapy: Findings From The Ohio Pediatric Asthma Repository.
Steven L. Shein, Obada Farhan, Nathan Morris, Nabihah Mahmood, Sherman J. Alter, Jocelyn M. Biagini Myers, Samantha M. Gunkelman, Carolyn M. Kercsmar, Gurjit K. Khuran...> ;Hospital Pediatrics. 2018 Feb 1
60 citations
Mycobacterium abscessus Smooth and Rough Morphotypes Form Antimicrobial-Tolerant Biofilm Phenotypes but Are Killed by Acetic Acid.
Gillian Clary, Smitha J. Sasindran, Laurel Mason, Sara L. Cole, Abul K. Azad, Karen McCoy, Larry S. Schlesinger, Luanne Hall-Stoodley> ;Antimicrobial Agents and Chemotherapy. 2018 Feb 23
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Journal Articles

Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses
Karen McCoy, Benjamin T Kopp, The Journal of Immunology
Ohio Pediatric Asthma Repository: Opportunities to Revise Care Practices to Decrease Time to Physiologic Readiness for Discharge
Kristie R Ross, Carolyn M Kercsmar, Samantha M Gunkelman, Pierre A Vauthy, Karen S McCoy, Sherman J Alter, AAP News

Press Mentions

Nationwide Children's: New Cystic Fibrosis Treatment Could Treat 90% of PatientsDecember 13th, 2019
Lansoprazole for Children with Poorly Controlled AsthmaA Randomized Controlled TrialJanuary 25th, 2012