KarenRuthRabinMDPhD

Pediatric Hematology & Oncology • Houston, TX

Associate Professor, Pediatrics, Baylor College of Medicine

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Office
1102 Bates St., Suite 750.00
Texas Children's Cancer Center
Houston, TX 77030
Phone+1 832-822-4242

Fax+1 832-825-1206
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Education & Training

Stanford Health Care-Sponsored Stanford UniversityFellowship, Pediatric Hematology/Oncology, 2001 - 2004
University of California (San Francisco)Residency, Pediatrics, 1998 - 2001
University of California San Francisco School of MedicineClass of 1998

Certifications & Licensure

CA State Medical License 2000 - Present
TX State Medical License 2006 - 2025
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2001 Oct 18
Active, not recruiting
Phase 3
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Start of enrollment: 2004 Mar 25
Recruiting
Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET Start of enrollment: 2007 Mar 26
Active, not recruiting
Phase 3
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Jun 20
Active, not recruiting
Phase 3
Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma Start of enrollment: 2011 Sep 01
Completed
Phase 1
Cabozantinib S-Malate in Treating Younger Patients With Recurrent or Refractory Solid Tumors Start of enrollment: 2012 Nov 14
Completed
Phase 1
Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas Start of enrollment: 2013 Sep 03
Completed
Phase 1
Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors Start of enrollment: 2014 Mar 28
Completed
Phase 1, Phase 2
Talazoparib and Temozolomide in Treating Younger Patients With Refractory or Recurrent Malignancies Start of enrollment: 2014 May 16
Completed
Phase 1, Phase 2
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Publications & Presentations

PubMed

3 citations
Prognostic significance of ETP phenotype and minimal residual disease in T-ALL: a Children's Oncology Group study.
Meenakshi Devidas, Ryan J Summers, Zhiguo Chen, Patrick A Zweidler-McKay, Naomi J Winick, William L Carroll, Mignon L Loh, Stephen P Hunger, Kimberly P Dunsmore, Stuar...> ;Blood. 2023 Dec 14
Racial and ethnic disparities in acuity of presentation among children with newly diagnosed acute leukemia.
Lena E Winestone, Kelly D Getz, Yimei Li, Evanette Burrows, Michael E Scheurer, Vicky Tam, Jennifer J Wilkes, Tamara P Miller, Alix E Seif, Karen R Rabin, Brian T Fish...> ;Pediatric Blood & Cancer. 2024 Jan 1
Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN).
Wendy Hsiao, Yimei Li, Kelly Getz, Lusha Cao, Edward Krause, Mark Ramos, Judy Lee, Maria Monica Gramatges, Karen R Rabin, Michael E Scheurer, Richard Aplenc, Michelle ...> ;Pediatric Blood & Cancer. 2023 Dec 1
Flow cytometric assessment of leukemia-associated monocytes in childhood B-cell acute lymphoblastic leukemia outcome.
Gloria P Contreras Yametti, Nikki A Evensen, Jennifer M Schloss, Clemence Aldebert, Emily Duan, Yan Zhang, Jiyuan Hu, Tiffany M Chambers, Michael E Scheurer, David T T...> ;Blood Advances. 2023 Aug 8
1 citations
SARS-CoV-2 infections in patients enrolled on the Children's Oncology Group standard-risk B-cell acute lymphoblastic leukemia trial, AALL1731.
Caitlin W Elgarten, John A Kairalla, Joel C Thompson, Tamara P Miller, Cindy Wang, Susan Conway, Mignon L Loh, Elizabeth A Raetz, Sumit Gupta, Rachel E Rau, Anne Angio...> ;Ejhaem. 2023 Aug 1
2 citations
Children's Oncology Group blueprint for research: Acute lymphoblastic leukemia.
Elizabeth A Raetz, Deepa Bhojwani, Meenakshi Devidas, Lia Gore, Karen R Rabin, Sarah K Tasian, David T Teachey, Mignon L Loh> ;Pediatric Blood & Cancer. 2023 Sep 1
1 citations
Management of Down Syndrome-Associated Leukemias: A Review.
Philip J Lupo, Nirali N Shah, Johann Hitzler, Karen R Rabin, Verma, A.> ;JAMA Oncology. 2023 Sep 1
8 citations
Central nervous system status is prognostic in T-cell acute lymphoblastic leukemia: a Children's Oncology Group report.
Nathan P Gossai, Meenakshi Devidas, Zhiguo Chen, Brent L Wood, Patrick A Zweidler-McKay, Karen R Rabin, Mignon L Loh, Elizabeth A Raetz, Naomi J Winick, Michael J Burk...> ;Blood. 2023 Apr 13
1 citations
Prognostic impact of pretreatment immunoglobulin clonal composition in pediatric B-lymphoblastic leukemia.
Lik Wee Lee, Meenakshi Devidas, Yunfeng Dai, Karen R Rabin, Sumit Gupta, Mignon L Loh, Ilan R Kirsch, Brent Wood, Rachel E Rau, Fries, C.> ;Haematologica. 2023 Mar 1
2 citations
Novel and replicated clinical and genetic risk factors for toxicity from high-dose methotrexate in pediatric acute lymphoblastic leukemia.
Mark Zobeck, M Brooke Bernhardt, Kala Y Kamdar, Karen R Rabin, Philip J Lupo, Michael E Scheurer> ;Pharmacotherapy. 2023 Mar 1
18 citations
Racial and ethnic disparities in childhood and young adult acute lymphocytic leukaemia: secondary analyses of eight Children's Oncology Group cohort trials.
Sumit Gupta, Yunfeng Dai, Zhiguo Chen, Lena E Winestone, David T Teachey, Kira Bona, Richard Aplenc, Karen R Rabin, Patrick Zweidler-McKay, Andrew J Carroll, Nyla A He...> ;The Lancet. Haematology. 2023 Feb 1
1 citations
Ethnic-specific predictors of neurotoxicity among patients with pediatric acute lymphoblastic leukemia after high-dose methotrexate.
Rachel D Harris, Melanie Brooke Bernhardt, Mark C Zobeck, Olga A Taylor, Maria Monica Gramatges, Eric S Schafer, Philip J Lupo, Karen R Rabin, Michael E Scheurer, Aust...> ;Cancer. 2023 Apr 15
Absolute lymphocyte count recovery following initial acute myelogenous leukemia therapy: Implications for adoptive cell therapy.
John C Molina, Yimei Li, William R Otto, Tamara P Miller, Kelly D Getz, Carly Mccoubrey, Mark Ramos, Edward Krause, Lusha Cao, M Monica Gramatges, Karen Rabin, Michael...> ;Pediatric Blood & Cancer. 2023 Jan 1
2 citations
Improving infectious adverse event reporting for children and adolescents enrolled in clinical trials for acute lymphoblastic leukemia: A report from the Children's On...
Caitlin W Elgarten, Joel C Thompson, Anne Angiolillo, Zhiguo Chen, Susan Conway, Meenakshi Devidas, Sumit Gupta, John A Kairalla, Jennifer L McNeer, Maureen M O'Brien,...> ;Pediatric Blood & Cancer. 2022 Nov 1
13 citations
Rates of laboratory adverse events by course in paediatric leukaemia ascertained with automated electronic health record extraction: a retrospective cohort study from ...
Tamara P Miller, Kelly D Getz, Yimei Li, Biniyam G Demissei, Peter C Adamson, Todd A Alonzo, Evanette Burrows, Lusha Cao, Sharon M Castellino, Marla H Daves, Brian T F...> ;The Lancet. Haematology. 2022 Sep 1
1 citations
Epigenome-wide association study of acute lymphoblastic leukemia in children with Down syndrome.
Shaobo Li, Pagna Sok, Keren Xu, Ivo S Muskens, Natalina Elliott, Swe Swe Myint, Priyatama Pandey, Helen M Hansen, Libby M Morimoto, Alice Y Kang, Catherine Metayer, Xi...> ;Blood Advances. 2022 Jul 26
21 citations
An updated assessment of 43,110 patients enrolled in the Childhood Cancer Research Network: A Children's Oncology Group report.
Austin L Brown, Pagna Sok, Michael E Scheurer, Karen R Rabin, Erin L Marcotte, Douglas S Hawkins, Logan G Spector, Philip J Lupo> ;Cancer. 2022 Jul 15
9 citations
Sex-based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children's Oncology Group report.
Sumit Gupta, David T Teachey, Zhiguo Chen, Karen R Rabin, Kimberly P Dunsmore, Eric C Larsen, Kelly W Maloney, Leonard A Mattano Jr, Stuart S Winter, Andrew J Carroll,...> ;Cancer. 2022 May 1
Residence in a Latinx enclave and end-induction minimal residual disease positivity among children with acute lymphoblastic leukemia.
Joshua P Muñiz, John P Woodhouse, Amy E Hughes, Sandi L Pruitt, Karen R Rabin, Michael E Scheurer, Philip J Lupo, Jeremy M Schraw> ;Pediatric Hematology and Oncology. 2022 Oct 1
1 citations
Genetic Ancestry and Childhood Acute Lymphoblastic Leukemia Subtypes and Outcomes in the Genomic Era.
Karen R Rabin> ;JAMA Oncology. 2022 Mar 1
19 citations
Outcomes in adolescent and young adult patients (16 to 30 years) compared to younger patients treated for high-risk B-lymphoblastic leukemia: report from Children's On...
Michael J. Burke, Meenakshi Devidas, Zhiguo Chen, Wanda L. Salzer, Elizabeth A. Raetz, Karen R. Rabin, Nyla A. Heerema, Andrew J. Carroll, Julie M. Gastier-Foster, Mic...> ;Leukemia. 2021 Nov 1
6 citations
Comparison of the blood, bone marrow, and cerebrospinal fluid metabolomes in children with b-cell acute lymphoblastic leukemia.
Jeremy M. Schraw, John P. Woodhouse, Melanie Brooke Bernhardt, Olga A. Taylor, Terzah M. Horton, Michael E. Scheurer, M. Fatih Okcu, Karen R. Rabin, Philip J. Lupo, Au...> ;Scientific Reports. 2021 Oct 4
Risk stratification for Down syndrome and acute lymphocytic leukaemia: one size does not fit all.
Karen R. Rabin> ;The Lancet. Haematology. 2021 Oct 1
3 citations
Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia.
Taylor J Chen, Wa Du, Jacob J. Junco, Cory Seth Bridges, Ye Shen, Monica Puppi, Karen R. Rabin, H. Daniel Lacorazza> ;Oncotarget. 2021 Aug 31
4 citations
Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia.
David Spencer Mangum, Julia Meyer, Clinton C. Mason, Soheil Shams, Luke Maese, Jamie D. Gardiner, Jonathan M. Downie, Deqing Pei, Cheng Cheng, Adam Gleason, Minjie Luo...> ;JAMA Oncology. 2021 Oct 1
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Abstracts/Posters

The Genomic Landscape of Childhood Acute Lymphoblastic Leukemia
Karen R. Rabin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Germline RUNX1 Variation and Predisposition to T-Cell Acute Lymphoblastic Leukemia in Children
Karen R. Rabin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Pharmacological Inhibition of MAP2K7 Induces Apoptosis and Cell Cycle Arrest in T-Cell Acute Lymphoblastic Leukemia
Karen R. Rabin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Excellent Outcomes with Reduced Frequency of Vincristine and Dexamethasone Pulses in Children with National Cancer Institute (NCI) Standard-Risk B Acute Lymphoblastic ...
Karen R. Rabin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Transient Elevations in Markers of Hepatic Function during Pediatric Acute Lymphoblastic Leukemia Treatment Are Common but Do Not Influence Outcomes: A Study of 805 Pa...
Karen R. Rabin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
A Novel Short Latency, High Penetrance Model of KRAS Mutation-Driven T-Cell Acute Lymphoblastic Leukemia
Karen R. Rabin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Rates of Laboratory Adverse Events By Chemotherapy Course for Pediatric Acute Leukemia Patients within the Leukemia Electronic Abstraction of Records Network (LEARN)
Karen R. Rabin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Delays in Therapy Do Not Impact Survival in Childhood Acute Lymphoblastic Leukemia: A Report from the Learn Consortium
Karen R. Rabin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Outcome in Adolescent and Young Adult (AYA) Patients Compared to Younger Patients Treated for High-Risk B-Lymphoblastic Leukemia (HR B-ALL): Report from the ChildrenÍs...
Karen R. Rabin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Press Mentions

Dasatinib Superior to Imatinib in Pediatric ALLJanuary 16th, 2020
Novel Approach Identifies Factors Linked to Poor Treatment Outcomes in Acute Lymphoblastic LeukemiaOctober 24th, 2019
Improving B-ALL Outcomes in Children With Down SyndromeFebruary 14th, 2024
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