Karl L Insogna MD member ACP
Diabetes, Lipid Metabolism, Osteoporosis & Bone Metabolism Medicine
Ensign Professor of Medicine, Yale School of Medicine
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789 Howard AveBldgNew Haven, CT 06519
Phone+1 203-737-1932
Fax+1 203-737-2812
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Summary
- Dr. Karl Insogna is a tenured Professor at Yale and an internationally recognized expert in the field of metabolic bone disease. He has published widely on the topic in the field's leading scientific journals, is quoted often in the lay press, and has frequently appeared on radio and television. He is a Fellow of the American Association for the Advancement of Science, and was a member of the National Institutes of Health Consensus Conference, which established new recommendations for the optimal level of calcium intake for all Americans - now adopted nationwide. He is a leading researcher in the causes of bone loss in such diseases as osteoporosis and primary hyperparathyroidism, and is currently conducting studies in, among other areas, the role of diet in the development of osteoporosis.
Education & Training
Yale-New Haven Medical CenterFellowship, Endocrinology, Diabetes, and Metabolism, 1980 - 1982
University of Rochester Medical CenterResidency, Internal Medicine, 1976 - 1980
Uconn School Of MedicineClass of 1976
Certifications & Licensure
CT State Medical License 1980 - 2027
American Board of Internal Medicine Internal Medicine- American Board of Internal Medicine Endocrinology, Diabetes and Metabolism
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2014, 2016-2017
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2014, 2016-2017
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2014
Clinical Trials
Publications & Presentations
PubMed
- Selective deletion of the membrane-bound isoform of CSF1 in vivo augments the anabolic response to PTH without impairing bone resorption.Gang-Qing Yao, Meiling Zhu, Karl Insogna
Bone Reports. 2026-03-01 - 3D-DXA reveals significant effects of burosumab on trabecular and cortical skeletal envelopes in symptomatic adults with X-linked hypophosphatemia.Rucha Patki, Thomas Carpenter, Keerti Murari, Stephen Parziale, Yanhong Deng
Journal of Bone and Mineral Research. 2025-11-29 - Protein Supplementation, Plasma Branched-Chain Amino Acids, and Insulin Resistance in Postmenopausal Women: An Ancillary Study from the Supplemental Protein to Outsmar...Jessica Dauz Bihuniak, Alessandra Byer, Christine A Simpson, Rebecca R Sullivan, Josephine M Dudzik
Nutrients. 2025-06-25
Journal Articles
- A Randomized, Double‐Blind, Placebo‐Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti‐FGF23 Antibody, in Adults with X‐Linked Hypophosphatemia: W...Thomas Weber, Mary D Ruppe, Anthony A Portale, Erik A Imel, Thomas O Carpenter, Karl L Insogna, Farzana Perwad, Pisit Pitukcheewanont, Journal of Bone and Mineral Research
Press Mentions
In Memoriam: Joseph Lewis Belsky, MDOctober 1st, 2025- Collaborative Program Aims to Improve Study of HIV and Rheumatic and Musculoskeletal Diseases in UgandaAugust 5th, 2025
- Listen to "Peter Tebben Selected as Director of Yale Bone Center"October 7th, 2024
Grant Support
- Different Roles for Colony Stimulating Factor 1 Isoforms in Anabolic Therapy for Low Bone MassYALE UNIVERSITY2023–2028
- The Role of Sphingosine Kinase in Bone AnabolismNIH2016–2020
- Administrative CoreNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2012
- Targeting Thrombospondin 1 In Bone ResorptionNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2011–2012
- Core Center. Yale Core Center For Musculoskeletal DisordersNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009–2012
Professional Memberships
- American Society for Bone and Mineral Research (ASBMR)Member
- International Society for Clinical DensitometryMember
- Member
- Member
- National Osteoporosis FoundationBoard of Trustees
External Links
- Insogna Labhttp://medicine.yale.edu/lab/insogna/
- A Personal Perspective on Clinical Practicehttps://www.youtube.com/watch?v=cvEzQxocRgA
- Research Perspectiveshttps://www.youtube.com/watch?v=ISlw-i1reqk
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