KarleyYatesLittleMD

Psychiatry • Georgetown, TX

Addiction

Associate Professor, Psychiatry, Baylor College of Medicine

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Office
101 W Cooperative Way
Ste 110
Georgetown, TX 78626
Phone+1 512-535-3777

Fax+1 512-765-9153
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Education & Training

University of North Carolina HospitalsResidency, Psychiatry, 1980 - 1984
Medical College of Georgia at Augusta UniversityClass of 1980

Certifications & Licensure

TX State Medical License 2012 - 2026
CA State Medical License 2016 - 2024
MI State Medical License 1993 - 2018
GA State Medical License 2014 - 2017
NC State Medical License 1983 - 2007
American Board of Psychiatry and Neurology Psychiatry

Publications & Presentations

PubMed

77 citations
Decreased brain dopamine cell numbers in human cocaine users.
Karley Y. Little, Eric Ramssen, Ryan Welchko, Vitaly Volberg, Courtney J. Roland, Bader J. Cassin> ;Psychiatry Research. 2009 Aug 15
13 citations
Fluoxetine-induced alterations in human platelet serotonin transporter expression: serotonin transporter polymorphism effects.
Karley Y. Little, Lian Zhang, Edwin H. Cook> ;Journal of Psychiatry & Neuroscience. 2006 Sep 1
58 citations
Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users
Karley Y. Little, David M. Krolewski, Lian Zhang, Bader J. Cassin> ;The American Journal of Psychiatry. 2003 Jan 1
111 citations
Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism
Scott F. Stoltenberg, Geoffrey R. Twitchell, Gregory L. Hanna, Edwin H. Cook, Hiram E. Fitzgerald, Robert A. Zucker, Karley Y. Little> ;American Journal of Medical Genetics. 2002 Mar 8
141 citations
Cocaine Induction of Dopamine Transporter Trafficking to the Plasma Membrane
Karley Y. Little, Lawrence Elmer, Huailing Zhong, Joshua O. Scheys, Lian Zhang> ;Molecular Pharmacology. 2002 Feb 1
82 citations
Striatal dopaminergic abnormalities in human cocaine users
Karley Y. Little, Lian Zhang, Timothy J. Desmond, Kirk A. Frey, Gregory W. Dalack, Bader J. Cassin> ;The American Journal of Psychiatry. 1999 Feb 1
15 citations
Overt behavior problems and serotonergic function in middle childhood among male and female offspring of alcoholic fathers
Geoffrey R. Twitchell, Gregory L. Hanna, Edwin H. Cook, Hiram E. Fitzgerald, Karley Y. Little, Robert A. Zucker> ;Alcoholism, Clinical and Experimental Research. 1998 Sep 1
57 citations
Brain dopamine transporter messenger RNA and binding sites in cocaine users: A postmortem study
Karley Y. Little, Daniel P. McLaughlin, Lian Zhang, Patrick R. McFinton, Gregory W. Dalack, Edwin H. Cook, Stanley J. Watson, Bader J. Cassin> ;Archives of General Psychiatry. 1998 Sep 1
24 citations
Expression and regulation of the human dopamine transporter in a neuronal cell line
Lian Zhang, Lawrence W. Elmer, Karley Y. Little> ;Brain Research. Molecular Brain Research. 1998 Aug 15
27 citations
Species Differences in Regional Patterns of 3H-8-OH-DPAT and 3H-Zolpidem Binding in the Rat and Human Brain
Gary E. Duncan, Darin J. Knapp, George R. Breese, Fulton T. Crews, Karley Y. Little> ;Pharmacology, Biochemistry, and Behavior. 1998 Jun 1
41 citations
GABA(A) receptor alpha1, alpha4, and beta3 subunit mRNA and protein expression in the frontal cortex of human alcoholics.
Hiroki Mitsuyama, Karley Y. Little, Werner Sieghart, Leslie L. Devaud, A. Leslie Morrow> ;Alcoholism, Clinical and Experimental Research. 1998 Jun 1
519 citations
Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression
Juan F. Lopez, Derek T. Chalmers, Karley Y. Little, Stanley J. Watson> ;Biological Psychiatry. 1998 Apr 15
13 citations
Striatal [125I]RTI-55 binding sites in cocaine-abusing humans
Karley Y. Little, F. Ivy Carroll, John D. Butts> ;Progress in Neuro-Psychopharmacology & Biological Psychiatry. 1998 Apr 1
321 citations
Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels
Karley Y. Little, Daniel P. McLaughlin, Lian Zhang, Cynthia S. Livermore, Gregory W. Dalack, Patrick R. McFinton, Zachary S. DelProposto, Elizabeth M. Hill, Stanley J....> ;The American Journal of Psychiatry. 1998 Feb 1
Up-regulation of fast-axonally transported proteins in retinal ganglion cells of adult rats with optic-peroneal nerve grafts.
Wouters BC, Bock-Samson S, Little K, Norden JJ> ;Brain Res. Mol. Brain Res.. 1998-01-01
52 citations
Serotonin transporter binding sites and mRNA levels in depressed persons committing suicide.
Karley Y. Little, Daniel P. McLauglin, Jean Ranc, John H. Gilmore, Juan F. Lopez, Stanley J. Watson, F. Ivy Carroll, John D. Butts> ;Biological Psychiatry. 1997 Jun 15
11 citations
Lack of pineal β-adrenergic receptor alterations in suicide victims with major depression
Karley Y. Little, Jean Ranc, John H. Gilmore, Amish Patel, Thomas B. Clark> ;Psychoneuroendocrinology. 1997 Jan 1
14 citations
Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites.
Karley Y. Little, Jenifer Gorebig, F. Ivy Carroll, John Mapili, James H. Meador-Woodruff> ;Brain Research. 1996 Dec 2
25 citations
Expression of serotonin transporter mRNA in human brainstem raphe nuclei
Daniel P. McLaughlin, Karley Y. Little, Juan F. Lopez, Stanley J. Watson> ;Neuropsychopharmacology. 1996 Nov 1
27 citations
Alteration of brain dopamine and serotonin levels in cocaine users: A preliminary report.
Karley Y. Little, Umesh N. Patel, Thomas B. Clark, John D. Butts> ;The American Journal of Psychiatry. 1996 Sep 1
Acute stimulant response prediction of chronic trazodone effects
Karley Y. Little> ;Progress in Neuro-Psychopharmacology & Biological Psychiatry. 1996 Jul 1
11 citations
Dose‐Response Studies with Thyrotropin‐Releasing Hormone: Evidence for Differential Pituitary Responses in Men with Major Depression, Alcoholism, or No Psychopathology
James C. Garbutt, James P. Mayo, Karley Y. Little, Gregory M. Gillette, George A. Mason, Bess Dew, Arthur J. Prange> ;Alcoholism, Clinical and Experimental Research. 1996 Jun 1
24 citations
Effect of Cocaine on Dopamine Transporter Receptors Depends on Routes of Chronic Cocaine Administration
Ana Hitri, Karley Y. Little, Everett H. Ellinwood> ;Neuropsychopharmacology. 1996 Mar 1
15 citations
Increased Manganese-Superoxide Dismutase Activity in Postmortem Brain from Neuroleptic-Treated Psychotic Patients
Dean P. Loven, J. Frank James, Lisa Biggs, Karley Y. Little> ;Biological Psychiatry. 1996 Jan 8
9 citations
(β‐Adrenergic receptor subtypes in human pineal gland
Karley Y. Little, Jacob A. Kirkman, Gary E. Duncan> ;Journal of Pineal Research. 1996 Jan 1
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Grant Support

Brain Dopamine Alterations In Human Cocaine UsersNational Institute On Drug Abuse2006
Brain Dopamine Alterations In Human Cocaine UsersNational Institute On Drug Abuse2004–2006
Brain Dat/5-Htt Dysregulation In Human Cocaine UsersNational Institute On Drug Abuse1997–1999
Brain Dat/5-Htt Dysregulation In Cocaine UsersNational Institute On Drug Abuse1994–1996

Hospital Affiliations

Austin Oaks HospitalAustin, Texas

KarleyYatesLittleMD

Dr. Little is on Doximity

Education & Training

Certifications & Licensure

Publications & Presentations

Grant Support

Hospital Affiliations

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