KarolBomsztykMD

Nephrology • Seattle, WA

Physician

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Office
1959 NE Pacific St
Seattle, WA 98195
Phone+1 206-598-5068

Fax+1 206-598-6963
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Summary

Dr. Karol Bomsztyk, MD is a nephrologist in Seattle, Washington. He is currently licensed to practice medicine in Washington and Maine. He is affiliated with UW Medicine/University of Washington Medical Center and UW Medicine/Harborview Medical Center.

Education & Training

Yale-New Haven Medical CenterFellowship, Nephrology, 1980 - 1983
Yale-New Haven Medical Center (Primary Care)Residency, Internal Medicine, 1978 - 1980
University of Rochester School of Medicine and DentistryClass of 1977

Certifications & Licensure

WA State Medical License 1983 - 2026
ME State Medical License Active through 1980
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Nephrology

Publications & Presentations

PubMed

Regulation of Versican Expression in Macrophages is Mediated by Canonical Type I Interferon Signaling via ISGF3.
Mary Y Chang, Christina K Chan, Jourdan E Brune, Charles W Frevert, William A Altemeier, Anne M Manicone, Karol Bomsztyk> ;Biorxiv. 2024 Mar 14
1 citations
A High-Throughput PIXUL-Matrix-Based Toolbox to Profile Frozen and Formalin-Fixed Paraffin-Embedded Tissues Multiomes.
Daniel Mar, Ilona M Babenko, Ran Zhang, William Stafford Noble, Oleg Denisenko, Tomas Vaisar, Karol Bomsztyk> ;Laboratory Investigation; a Journal of Technical Methods and Pathology. 2024 Jan 1
3 citations
CryoGrid-PIXUL-RNA: high throughput RNA isolation platform for tissue transcript analysis.
Scott A Schactler, Stephen J Scheuerman, Andrea Lius, William A Altemeier, Dowon An, Thomas J Matula, Michal Mikula, Maria Kulecka, Oleg Denisenko, Daniel Mar, Karol B...> ;BMC Genomics. 2023 Aug 8
13 citations
dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region.
Shiri Levy, Logeshwaran Somasundaram, Infencia Xavier Raj, Diego Ic-Mex, Ashish Phal, Sven Schmidt, Weng I Ng, Daniel Mar, Justin Decarreau, Nicholas Moss, Ammar Algha...> ;Cell Reports. 2022 Mar 1
6 citations
Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs S...
Michal Kopczynski, Izabela Rumienczyk, Maria Kulecka, Malgorzata Statkiewicz, Kazimiera Pysniak, Zuzanna Sandowska-Markiewicz, Urszula Wojcik-Trechcinska, Krzysztof Go...> ;International Journal of Molecular Sciences. 2021 Sep 22
13 citations
Multi-Organ Transcriptome Dynamics in a Mouse Model of Cecal Ligation and Puncture-Induced Polymicrobial Sepsis.
Izabela Rumienczyk, Maria Kulecka, Jerzy Ostrowski, Daniel Mar, Karol Bomsztyk, Stephen W Standage, Michal Mikula> ;Journal of Inflammation Research. 2021 Jun 3
6 citations
Single cell epigenetic visualization assay
Sam Kint, Wim Van Criekinge, Linos Vandekerckhove, Winnok H. De Vos, Karol Bomsztyk, Diane S. Krause, Oleg Denisenko> ;Nucleic Acids Research. 2021 May 7
63 citations
Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes.
Jenny E. Kanter, Baohai Shao, Farah Kramer, Shelley Barnhart, Masami Shimizu-Albergine, Tomas Vaisar, Mark J. Graham, Rosanne M. Crooke, Clarence R. Manuel, Rebecca A....> ;The Journal of Clinical Investigation. 2019 Oct 1
1 citations
Genome-bound enzymes as epigenetic drug targets in cancer.
Karol Bomsztyk, Yuliang Wang> ;Epigenomics. 2019 Sep 19
10 citations
PIXUL-ChIP: integrated high-throughput sample preparation and analytical platform for epigenetic studies.
Karol Bomsztyk, Daniel Mar, Yuliang Wang, Oleg Denisenko, Carol B. Ware, Christian D. Frazar, Adam Blattler, Adam D. Maxwell, Brian MacConaghy, Thomas J. Matula> ;Nucleic Acids Research. 2019 Jul 9
22 citations
Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury
Roya Sharifian, Daryl M. Okamura, Oleg Denisenko, Richard A. Zager, Ali C.M. Johnson, Sina A. Gharib, Karol Bomsztyk> ;Scientific Reports. 2018 Dec 14
21 citations
Sporadic DUX4 expression in FSHD myocytes is associated with incomplete repression by the PRC2 complex and gain of H3K9 acetylation on the contracted D4Z4 allele
Premi Haynes, Karol Bomsztyk, Daniel G. Miller> ;Epigenetics & Chromatin. 2018 Aug 20
7 citations
DNA methylation yields epigenetic clues into the diabetic nephropathy of Pima Indians
Karol Bomsztyk, Oleg Denisenko, Yuliang Wang> ;Kidney International. 2018 Jun 1
8 citations
Chromatin changes trigger laminin genes dysregulation in aging kidneys.
Oleg Denisenko, Daniel Mar, Matthew Trawczynski, Karol Bomsztyk> ;Aging. 2018 May 29
30 citations
Engineering a multicellular vascular niche to model hematopoietic cell trafficking.
Surya Kotha, Brian Hayes, Kiet T. Phong, Meredith A. Redd, Karol Bomsztyk, Aravind Ramakrishnan, Beverly Torok-Storb, Ying Zheng> ;Stem Cell Research & Therapy. 2018 Mar 23
19 citations
Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy.
Michal Mikula, Magdalena Skrzypczak, Krzysztof Goryca, Katarzyna Paczkowska, Joanna Karolina Ledwon, Malgorzata Statkiewicz, Maria Kulecka, Marta Grzelak, Michalina Da...> ;Nucleic Acids Research. 2016 Sep 1
29 citations
Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation
Oleg Denisenko, Emma S. Lucas, Congshan Sun, Adam J. Watkins, Daniel Mar, Karol Bomsztyk, Tom P. Fleming> ;Biochimica Et Biophysica Acta. 2016 Apr 7
10 citations
System-wide mapping of activated circuitry in experimental systemic inflammatory response syndrome
Sina A. Gharib, Daniel Mar, Karol Bomsztyk, Oleg Denisenko, Shireesha Dhanireddy, W. Conrad Liles, William A. Altemeier> ;Shock. 2016 Feb 1
65 citations
Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation
Bita Zamiri, Mila Mirceta, Karol Bomsztyk, Robert B. Macgregor, Christopher E. Pearson> ;Nucleic Acids Research. 2015 Nov 16
37 citations
Heterogeneity of epigenetic changes at ischemia/reperfusion- and endotoxin-induced acute kidney injury genes.
Daniel Mar, Sina A. Gharib, Richard A. Zager, Ali C.M. Johnson, Oleg Denisenko, Karol Bomsztyk> ;Kidney International. 2015 Oct 1
13 citations
Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis
Michal Mikula, Tymon Rubel, Jakub Karczmarski, Malgorzata Statkiewicz, Karol Bomsztyk, Jerzy Ostrowski> ;Proteome Science. 2015 Sep 2
5 citations
Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation.
Daniel P. Morris, Beilei Lei, Lawrence D. Longo, Karol Bomsztyk, Debra A. Schwinn, Gregory A. Michelotti> ;Plos One. 2015 Aug 5
68 citations
M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling
Woo J e Lee, Sanshiro Tateya, Andrew M. Cheng, Norma Rizzo-DeLeon, Nicholas F. Wang, Priya Handa, Carole L. Wilson, Alexander W. Clowes, Ian R. Sweet, Karol Bomsztyk, ...> ;Diabetes. 2015 Aug 1
37 citations
Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction
Karol Bomsztyk, Daniel Mar, Dowon An, Roya Sharifian, Michal Mikula, Sina A. Gharib, William A. Altemeier, W. Conrad Liles, Oleg Denisenko> ;Critical Care. 2015 May 11
96 citations
Losartan reverses permissive epigenetic changes in renal glomeruli of diabetic db/db mice
Marpadga A. Reddy, Putta Sumanth, Linda Lanting, Hang Yuan, Mei Wang, Daniel Mar, Charles E. Alpers, Karol Bomsztyk, Rama Natarajan> ;Kidney International. 2014 Jan 1
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Hospital Affiliations

UW Medicine/University of Washington Medical CenterSeattle, Washington
UW Medicine/Harborview Medical CenterSeattle, Washington