KatherineHannaTkaczukMD

Breast Cancer, Hematologic Oncology

Professor of Medicine, University Maryland School of Medicine; Director, Breast Evaluation and Treatment Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center

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Office
22 S Greene St
Baltimore, MD 21201
Phone+1 410-328-7394

Fax+1 410-328-6896
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Education & Training

University of MarylandFellowship, Hematology and Medical Oncology, 1989 - 1992
St Agnes HealthCareResidency, Internal Medicine, 1986 - 1989
St Agnes HealthCareInternship, Internal Medicine, 1986 - 1987
Wroclaw Medical UniversityClass of 1984

Certifications & Licensure

MD State Medical License 1987 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Top Doctors:Baltimore Area Castle Connolly, 2012
Top Doctors:Washington-Baltimore Castle Connolly, 2012
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Clinical Trials

A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer Start of enrollment: 2010 Aug 13
Completed
Phase 3
Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer Start of enrollment: 2011 Jan 06
Active, not recruiting
Phase 3
A Phase III Study of BKM120 With Fulvestrant in Patients With HR+,HER2-, AI Treated, Locally Advanced or Metastatic Breast Cancer Who Progressed on or After mTORi Start of enrollment: 2012 Oct 03
Terminated
Phase 3
S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer Start of enrollment: 2013 Sep 12
Active, not recruiting
Phase 3
Study of Glembatumumab Vedotin (CDX-011) in Patients With Metastatic, gpNMB Over-Expressing, Triple Negative Breast Cancer Start of enrollment: 2013 Nov 01
Completed
Phase 2
1303GCC: Trastuzmab & Pertuzumab With Hormonal Therapy or Chemotherapy in Women Aged 60 and Over. Start of enrollment: 2014 Jan 01
Terminated
Phase 2
1380GCC: Prospective Study of GP-88 Blood Test in Healthy Women With Baseline Gail Model Risk Assessment Undergoing Screening for Breast Cancer Start of enrollment: 2014 Apr 01
Terminated
Trilaciclib (G1T28), a CDK 4/6 Inhibitor, in Combination With Gemcitabine and Carboplatin in Metastatic Triple Negative Breast Cancer (mTNBC) Start of enrollment: 2017 Feb 02
Terminated
Phase 2
TPIV100 and Sargramostim for the Treatment of HER2 Positive, Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery Start of enrollment: 2020 Feb 20
Recruiting
Phase 2
Roles: Contact, Principal Investigator
First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies Start of enrollment: 2022 Feb 14
Recruiting
Phase 1
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

13 citations
In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy.
Wenquan Ou, Samantha Stewart, Alisa White, Elyahb A Kwizera, Jiangsheng Xu, Yuanzhang Fang, James G Shamul, Changqing Xie, Suliat Nurudeen, Nikki P Tirada, Xiongbin Lu...> ;Nature Communications. 2023 Jan 24
11 citations
Greatly Enhanced CTC Culture Enabled by Capturing CTC Heterogeneity Using a PEGylated PDMS-Titanium-Gold Electromicrofluidic Device with Glutathione-Controlled Gentle ...
Elyahb A Kwizera, Wenquan Ou, Sojeong Lee, Samantha Stewart, James G Shamul, Jiangsheng Xu, Nancy Tait, Katherine H R Tkaczuk, Xiaoming He> ;ACS Nano. 2022 Jul 26
6 citations
Metformin Bicarbonate-Mediated Efficient RNAi for Precise Targeting ofDeficiency in Colon and Rectal Cancers.
Jiangsheng Xu, Yunhua Liu, Sheng Liu, Wenquan Ou, Alisa White, Samantha Stewart, Katherine H R Tkaczuk, Lee M Ellis, Jun Wan, Xiongbin Lu, Xiaoming He> ;Nano Today. 2022 Apr 1
24 citations
Circulating Biomarkers in Breast Cancer.
Katelyn N Seale, Katherine Tkaczuk> ;Clinical Breast Cancer. 2021 Sep 22
Patterns of Failure in Triple Negative Breast Cancer Patients in an Urban, Predominately Black Population
Hua-Ren Cherng, Stephanie R. Rice, Muhammad Hamza, Shruti Murali, Paula Rosenblatt, Katherine Tkaczuk, Emily C. Bellavance, Sally B. Cheston, Neha P. Amin, Elizabeth M...> ;Journal of Racial and Ethnic Health Disparities. 2021 Aug 1
16 citations
Targeted Heating of Mitochondria Greatly Augments Nanoparticle‐Mediated Cancer Chemotherapy
Jiangsheng Xu, James G. Shamul, Hai Wang, John Lin, Pranay Agarwal, Mingrui Sun, Xiongbin Lu, Katherine Tkaczuk, Xiaoming He> ;Advanced Healthcare Materials. 2020 Jun 17
112 citations
ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases.
Priya Kumthekar, Shou-Ching Tang, Andrew Brenner, Santosh Kesari, David Piccioni, Carey K. Anders, Jose Carrillo, Pavani Chalasani, Peter Kabos, Shannon Puhalla, Kathe...> ;Clinical Cancer Research. 2020 Jun 15
11 citations
Association of Serum Progranulin Levels With Disease Progression, Therapy Response and Survival in Patients With Metastatic Breast Cancer.
K. Tkaczuk, Douglas M. Hawkins, Binbin Yue, David G. Hicks, N Tait, Ginette Serrero> ;Clinical Breast Cancer. 2020 Jun 1
13 citations
Bioinspired One Cell Culture Isolates Highly Tumorigenic and Metastatic Cancer Stem Cells Capable of Multilineage Differentiation.
Hai Wang, Pranay Agarwal, Bin Jiang, Samantha Stewart, Xuanyou Liu, Yutong Liang, Baris Hancioglu, Amy Webb, John P. Fisher, Zhenguo Liu, Xiongbin Lu, Katherine Tkaczu...> ;Advanced Science. 2020 Apr 28
An Unusual Cause of a Pathological Vertebral Fracture: Solitary Plasmacytoma.
Andrew Y. Li, Gabriela Sanchez-Petitto, K. Tkaczuk, Monika Nageshwar, Zeba N. Singh, Mehmet Hakan Kocoglu> ;The American Journal of the Medical Sciences. 2020 Apr 11
2 citations
Trends in utilization of hypofractionated whole breast irradiation (HF-WBI) in triple negative breast cancer (TNBC): a national cancer database (NCDB) analysis
Stephanie R. Rice, Steven J. Feigenberg, Muhammad Hamza, Jason K. Molitoris, Søren M. Bentzen, Katherine Tkaczuk, Paula M Rosenblatt, Emily C. Bellavance, Elizabeth M....> ;Breast Cancer Research and Treatment. 2019 Feb 22
11 citations
Neratinib in Combination With Trastuzumab for the Treatment of Patients With Advanced HER2-positive Breast Cancer: A Phase I/II Study.
Kimberly L. Blackwell, Khalil Zaman, Shukui Qin, K. Tkaczuk, Mario Campone, Daniel Hunt, Richard Bryce, Lori J. Goldstein> ;Clinical Breast Cancer. 2019 Apr 1
16 citations
Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled by one nanoplatform
Hai Wang, Pranay Agarwal, Yutong Liang, Jiangsheng Xu, Gang Zhao, Katherine Tkaczuk, Xiongbin Lu, Xiaoming He> ;Biomaterials. 2018 Jul 17
7 citations
Prevalence and risk of skeletal complications and use of radiation therapy in elderly women diagnosed with metastatic breast cancer.
Arif Hussain, Candice Yong, Katherine H R Tkaczuk, Yi Qian, Jorge Arellano, C. Daniel Mullins, Eberechukwu Onukwugha> ;Plos One. 2018 Mar 1
20 citations
Factors Influencing Management and Outcome in Patients with Occult Breast Cancer with Axillary Lymph Node Involvement: Analysis of the National Cancer Database.
Lindsay K. Hessler, Jason K. Molitoris, Paula Rosenblatt, Emily C. Bellavance, Elizabeth M. Nichols, Katherine Tkaczuk, Steven J. Feigenberg, Søren M. Bentzen, Susan B...> ;Annals of Surgical Oncology. 2017 Aug 1
3 citations
Increasing utilization of regional nodal irradiation in elderly node-positive women and declining emphasis on demographic factors.
Jason K. Molitoris, Tejan Diwanji, James W. Snider, Emily C. Bellavance, Susan B. Kesmodel, Paula Rosenblatt, Katherine Tkaczuk, Søren M. Bentzen, R.J. Cohen, Elizabet...> ;Breast Cancer Research and Treatment. 2017 Jun 23
8 citations
Utilization of hypofractionated whole-breast radiation therapy in patients receiving chemotherapy: a National Cancer Database analysis.
Tejan Diwanji, Jason K. Molitoris, Arpit M. Chhabra, James W. Snider, Søren M. Bentzen, Katherine Tkaczuk, Paula Rosenblatt, Susan B. Kesmodel, Emily C. Bellavance, R....> ;Breast Cancer Research and Treatment. 2017 Jun 21
40 citations
Preoperative Accelerated Partial Breast Irradiation for Early-Stage Breast Cancer: Preliminary Results of a Prospective, Phase 2 Trial
Elizabeth M. Nichols, Susan B. Kesmodel, Emily C. Bellavance, C. Drogula, Katherine Tkaczuk, R.J. Cohen, W. Citron, M. Morgan, Paul N. Staats, Steven J. Feigenberg, Wi...> ;International Journal of Radiation Oncology, Biology, Physics. 2017 Mar 15
1 citations
Effect of reduction mammoplasty on acute radiation side effects and use of lumpectomy cavity boosts
Jolinta Y. Lin, Rachel Bluebond-Langner, Enid Choi, Sally B. Cheston, Elizabeth M. Nichols, R.J. Cohen, Søren M. Bentzen, C. Drogula, Susan B. Kesmodel, Emily C. Bella...> ;Practical Radiation Oncology. 2017 Sep 1
11 citations
Patient-reported Adherence to Adjuvant Aromatase Inhibitor Therapy Using the Morisky Medication Adherence Scale: An Evaluation of Predictors.
Susan B. Kesmodel, Olga Goloubeva, Paula Rosenblatt, Brian Heiss, Emily C. Bellavance, Saranya Chumsri, Ting Bao, Jennifer Thompson, Ginah Nightingale, Nancy Tait, Eli...> ;American Journal of Clinical Oncology. 2016 Jun 17
27 citations
Weight loss with mindful eating in African American women following treatment for breast cancer: a longitudinal study.
Seon-Yoon Chung, Shijun Zhu, Erika Friedmann, Catherine McArdle Kelleher, Adriane Kozlovsky, Karen W Macfarlane, Katherine Tkaczuk, Alice S. Ryan, Kathleen A. Griffith> ;Supportive Care in Cancer. 2016 Apr 1
39 citations
Breast magnetic resonance imaging (MRI) surveillance in breast cancer survivors
Chana Weinstock, Cristina Campassi, Olga Goloubeva, Kathleen Wooten, Susan B. Kesmodel, Emily Bellevance, Steven J. Feigenberg, Olga B. Ioffe, Katherine Tkaczuk> ;Springerplus. 2015 Aug 28
19 citations
Brain Metastasis and Response to Ado-Trastuzumab Emtansine: A Case Report and Literature Review
Richa Kalsi, Steven J. Feigenberg, Young Kwok, Katherine Tkaczuk, Minesh P. Mehta, Saranya Chumsri> ;Clinical Breast Cancer. 2015 Apr 1
9 citations
Invariant natural killer T cells generated from human adult hematopoietic stem-progenitor cells are poly-functional.
Wenji Sun, Yi Wang, James E. East, Amy S. Kimball, Katherine Tkaczuk, Susan B. Kesmodel, Scott E. Strome, Tonya J. Webb> ;Cytokine. 2015 Mar 1
89 citations
Chemotherapy dose reduction due to chemotherapy induced peripheral neuropathy in breast cancer patients receiving chemotherapy in the neoadjuvant or adjuvant settings:...
Bhavana Bhatnagar, Steven Gilmore, Olga Goloubeva, Colleen Pelser, Michelle Medeiros, Saranya Chumsri, Katherine Tkaczuk, Martin J. Edelman, Ting Bao> ;Springerplus. 2014 Jul 16
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Press Mentions

Post-ASCO News Alert: AstraZeneca’s/Merck’s Lynparza Use in Niche HR+ gBRCA-Mutant Breast Cancer Subgroup Could Compete with VerzenioJune 21st, 2021
Is There Medication to Prevent Breast Cancer?December 1st, 2023