KathleenJoanneHaleyMD

Pulmonology • Boston, MA

Critical Care Medicine, Pleural Disease

Assistant Professor of Medicine, Brigham and Women's Hospital

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Office
75 Francis Street Pbb Clinics 3
Brigham And Women's Hospital Pulmonary Division
Boston, MA 02115
Phone+1 617-732-7420
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Education & Training

Brigham and Women's HospitalFellowship, Pulmonary Disease and Critical Care Medicine, 1991 - 1992
Beth Israel Deaconess Medical CenterFellowship, Pulmonary Disease, 1989 - 1991
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1986 - 1989
Pennsylvania State University College of MedicineClass of 1986

Certifications & Licensure

MA State Medical License 1991 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Publications & Presentations

PubMed

3 citations
Evidence of Advanced Pulmonary Vascular Remodeling in Obstructive Hypertrophic Cardiomyopathy With Pulmonary Hypertension.
Bradley A Maron, David E Kleiner, Elena Arons, Bradley M Wertheim, Nirmal S Sharma, Kathleen J Haley, Andriy O Samokhin, Ethan J Rowin, Martin S Maron, Douglas R Rosin...> ;Chest. 2023 Mar 1
6 citations
Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS-CoV-2 infection.
George A Alba, Andriy O Samokhin, Rui-Sheng Wang, Bradley M Wertheim, Kathleen J Haley, Robert F Padera, Sara O Vargas, Ivan O Rosas, Lida P Hariri, Angela Shih, Boyd ...> ;Pulmonary Circulation. 2022 Apr 1
8 citations
NEDD9 Is a Novel and Modifiable Mediator of Platelet-Endothelial Adhesion in the Pulmonary Circulation.
George A. Alba, Andriy O Samokhin, Rui-Sheng Wang, Ying-Yi Zhang, Bradley M. Wertheim, Elena Arons, Edward A. Greenfield, Martina H Lundberg Slingsby, Julia R. Ceglows...> ;American Journal of Respiratory and Critical Care Medicine. 2021 Jun 25
5 citations
Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk.
Sunita Sharma, Alvin T. Kho, Divya Chhabra, Kathleen J. Haley, Carrie A. Vyhlidal, Roger Gaedigk, J. Steven Leeder, Kelan G. Tantisira, Benjamin A. Raby, Scott T. Weiss> ;Healthcare. 2020 Dec 4
3 citations
Erratum: Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction (Journal of Clinical Investigation (2013) 123:12 (5212-5230) DO...
Hilaire C. Lam, Suzanne M. Cloonan, Abhiram R. Bhashyam, Jeffery A. Haspel, Anju Singh, J. Fah Sathirapongsasuti, Morgan Cervo, Hongwei Yao, Anna L. Chung, Kenji Mizum...> ;The Journal of Clinical Investigation. 2020 Nov 2
48 citations
BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.
Qiujun Yu, Yi Yin Tai, Ying Tang, Jingsi Zhao, Vinny Negi, Miranda K. Culley, Jyotsna Pilli, Wei Sun, Karin Brugger, Johannes A. Mayr, Rajeev Saggar, Rajan Saggar, W. ...> ;Circulation. 2019 May 7
79 citations
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension
Andriy O. Samokhin, Thomas E. Stephens, Bradley M. Wertheim, Rui-Sheng Wang, Sara O. Vargas, Lai Ming Yung, Minwei Cao, Marcel G Brown, Elena Arons, Paul B. Dieffenbac...> ;Science Translational Medicine. 2018 Jun 13
270 citations
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension
Thomas Bertero, William M. Oldham, Katherine A. Cottrill, Sabrina Pisano, Rebecca Vanderpool, Qiujun Yu, Jingsi Zhao, Yi-Yin Tai, Ying Tang, Ying Yi Zhang, Sofiya Rehm...> ;The Journal of Clinical Investigation. 2016 Sep 1
48 citations
A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions
Thomas Bertero, Katherine A. Cottrill, Sofia Annis, Balkrishen Bhat, Bernadette R. Gochuico, Juan C. Osorio, Ivan O. Rosas, Kathleen J. Haley, Kathleen E. Corey, Raymo...> ;Scientific Reports. 2015 Dec 15
172 citations
Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit
Thomas Bertero, Katherine A. Cottrill, Yu Lu, Christina Mallarino Haeger, Paul B. Dieffenbach, Sofia Annis, Andrew E. Hale, Balkrishen Bhat, Vivek Kaimal, Ying Yi Zhan...> ;Cell Reports. 2015 Nov 3
107 citations
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension
Kevin P. White, Yu Lu, Sofia Annis, Andrew E. Hale, B. Nelson Chau, James E. Dahlman, Craig Hemann, Alexander R. Opotowsky, Sara O. Vargas, Ivan O. Rosas, Mark A. Perr...> ;EMBO Molecular Medicine. 2015 Jun 1
163 citations
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension
Thomas Bertero, Yu Lu, Sofia Annis, Andrew E. Hale, Balkrishen Bhat, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Sara O. Vargas, Brian B. Graham, Raje...> ;The Journal of Clinical Investigation. 2014 Aug 1
18 citations
Progesterone and estradiol synergistically promote the lung metastasis of tuberin-deficient cells in a preclinical model of lymphangioleiomyomatosis.
Yang Sun, Erik Zhang, Taotao Lao, Ana Pereira, Chenggang Li, Li Xiong, Tasha Morrison, Kathleen J. Haley, Xiaobo Zhou, Jane J. Yu> ;Hormones & Cancer. 2014 Jul 29
102 citations
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.
Hilaire C Lam, Suzanne M Cloonan, Abhiram R Bhashyam, Jeffery A Haspel, Anju Singh, J Fah Sathirapongsasuti, Morgan Cervo, Hongwei Yao, Anna L Chung, Kenji Mizumura, C...> ;The Journal of Clinical Investigation. 2013 Dec 1
23 citations
Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Carrie A. Vyhlidal, Amanda K. Riffel, Kathleen J. Haley, Sunita Sharma, Hongying Dai, Kelan G. Tantisira, Scott T. Weiss, J. Steven Leeder> ;Drug Metabolism and Disposition. 2013 Feb 1
21 citations
Maternal smoking and the retinoid pathway in the developing lung.
Sara E. Manoli, Lacey A. Smith, Carrie A. Vyhlidal, Chang Hyeok An, Yolanda Porrata, Wellington V. Cardoso, Rebecca M. Baron, Kathleen J. Haley> ;Respiratory Research. 2012 Jun 1
214 citations
MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension Results of a Network Bioinformatics Approach
Victoria N. Parikh, Richard C. Jin, Sabrina Rabello, Natali Gulbahce, Kevin P. White, Andrew E. Hale, Katherine A. Cottrill, Rahamthulla S. Shaik, Aaron B. Waxman, Yin...> ;Circulation. 2012 Mar 27
47 citations
RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking
Kathleen J. Haley, Jessica Lasky-Su, Sara E. Manoli, Lacey A. Smith, Aliakbar Shahsafaei, Scott T. Weiss, Kelan G. Tantisira> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2011 Jul 29
270 citations
Evidence for Human Lung Stem Cells
Jan Kajstura, Marcello Rota, Sean Hall, Toru Hosoda, Domenico D'Amario, Fumihiro Sanada, Hanqiao Zheng, Barbara Ogorek, Carlos Rondon-Clavo, João Ferreira-Martins, Ale...> ;The New England Journal of Medicine. 2011 May 11
10 citations
Ontogeny of the eotaxins in human lung.
Kathleen J. Haley, Mary E. Sunday, Yolanda Porrata, Colleen Kelley, Anne Twomey, Aliakbar Shahsafaei, Benjamin Galper, Larry A. Sonna, Craig M. Lilly> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2008 Feb 1
114 citations
ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol
Michael L. Fitzgerald, Ramnik J. Xavier, Kathleen J. Haley, Ruth Welti, Julie L. Goss, Cari E. Brown, Debbie Z. Zhuang, Susan A. Bell, Naifang Lu, Mary McKee, Brian Se...> ;Journal of Lipid Research. 2007 Mar 1
251 citations
Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness
Bruce D. Levy, Payal Kohli, Katherine H. Gotlinger, Oliver Haworth, Song Hong, Shamsah Kazani, Elliot Israel, Kathleen J. Haley, Charles N. Serhan> ;Journal of Immunology. 2007 Jan 1
14 citations
Stage-specific effects of cAMP signaling during distal lung epithelial development.
Jingsong Xu, Jun Tian, Sandra Grumelli, Kathleen J. Haley, Steven D. Shapiro> ;The Journal of Biological Chemistry. 2006 Dec 15
60 citations
Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells.
Eric K. Chu, Jason Cheng, John S. Foley, Brigham H. Mecham, Caroline A. Owen, Kathleen J. Haley, Thomas J. Mariani, Isaac S. Kohane, Daniel J. Tschumperlin, Jeffrey M....> ;American Journal of Respiratory Cell and Molecular Biology. 2006 Jun 22
130 citations
The SERPINE2 Gene Is Associated with Chronic Obstructive Pulmonary Disease
Dawn L. DeMeo, Thomas J. Mariani, Christoph Lange, Sorachai Srisuma, Augusto A. Litonjua, Juan C. Celedón, Stephen L. Lake, John J. Reilly, Harold A. Chapman, Brigham ...> ;American Journal of Human Genetics. 2006 Feb 1
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Press Mentions

New Dean Named for Connell School of NursingApril 8th, 2021

Grant Support

Maternal Smoking And The Developing LungNational Institute Of Environmental Health Sciences2009–2010
Effects Of Tobacco-Induced Mediators In Developing LungNational Heart, Lung, And Blood Institute2001–2005

Hospital Affiliations

Brigham and Women's HospitalBoston, Massachusetts
Spaulding Hospital for Continuing Medical Care CambridgeCambridge, Massachusetts