KathrynACoughlin-KelleyMD

PubMed

• 20 citations
  Association of Increased Serum Lipopolysaccharide but not Microbial Dysbiosis with Obesity-related Osteoarthritis.
  Richard F. Loeser, Liubov Arbeeva, Kathryn L. Kelley, Anthony A. Fodor, Shan Sun, Veronica Ulici, Lara Longobardi, Yang Cui, Delisha A. Stewart, Susan Sumner, M. Andre...> ;Arthritis & Rheumatology. 2021 Aug 23
• 12 citations
  A novel placental tissue biologic, PTP-001, inhibits inflammatory and catabolic responses in vitro and prevents pain and cartilage degeneration in a rat model of osteo...
  Carl R. Flannery, Scott A. Seaman, Kelly E. Buddin, Michael A. Nasert, Eric J. Semler, Kathryn L. Kelley, Long Marc, Jacob Favret, Alessandra Pavesio, Richard F. Loeser> ;Osteoarthritis and Cartilage. 2021 May 20
• 19 citations
  Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice.
  Richard F. Loeser, Kathryn L. Kelley, Alexandra R. Armstrong, John A. Collins, Brian O. Diekman, Cathy S. Carlson> ;Arthritis & Rheumatology. 2020 May 17
• 10 citations
  Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of c-Jun NH2-Terminal Kinases 1 and 2.
  Veronica Ulici, Kathryn L. Kelley, Lara Longobardi, Margaret A. McNulty, Eric W. Livingston, Ted A. Bateman, Cheryle A. Séguin, Craig R. Louer, Richard F. Loeser> ;The American Journal of Pathology. 2019 Apr 1
• 58 citations
  Osteoarthritis induced by destabilization of the medial meniscus is reduced in germ-free mice
  Veronica Ulici, Kathryn L. Kelley, M.A. Azcarate-Peril, Rebecca J. Cleveland, R.B. Sartor, Todd A. Schwartz, Richard F. Loeser> ;Osteoarthritis and Cartilage. 2017 Apr 1
• 2 citations
  Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss
  Manya Warrier, Jun Zhang, Kanwardeep S. Bura, Kathryn Kelley, Martha D. Wilson, Lawrence L. Rudel, J. Mark Brown> ;Lipids. 2016 Jan 4
• 3 citations
  Targeted Knockdown of Hepatic SOAT2 With Antisense Oligonucleotides Stabilizes Atherosclerotic Plaque in ApoB100-only LDLr−/− Mice
  John T. Melchior, John Olson, Kathryn L. Kelley, Martha D. Wilson, Janet K. Sawyer, Kerry M. Link, Lawrence L. Rudel> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2015 Sep 1
• 23 citations
  Cholesterol Esters (CE) Derived From Hepatic Sterol O-Acyltransferase 2 (SOAT2) Are Associated With More Atherosclerosis Than CE From Intestinal SOAT2
  Jun Zhang, Janet K. Sawyer, Stephanie M. Marshall, Kathryn L. Kelley, Matthew A. Davis, Martha D. Wilson, J. Mark Brown, Lawrence L. Rudel> ;Circulation Research. 2014 Oct 24
• 20 citations
  Acute Sterol O-Acyltransferase 2 (SOAT2) Knockdown Rapidly Mobilizes Hepatic Cholesterol for Fecal Excretion
  Stephanie M. Marshall, Anthony D. Gromovsky, Kathryn L. Kelley, Matthew A. Davis, Martha D. Wilson, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Lawrence L. Rude...> ;Plos One. 2014 Jun 5
• 11 citations
  Reduction of VLDL secretion decreases cholesterol excretion in Niemann-Pick C1-like 1 hepatic transgenic mice.
  Stephanie M. Marshall, Kathryn L. Kelley, Matthew A. Davis, Martha D. Wilson, Allison L. McDaniel, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Lawrence L. Rudel...> ;Plos One. 2014 Jan 3
• 24 citations
  LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.
  John T. Melchior, Janet K. Sawyer, Kathryn L. Kelley, Ramesh Shah, Martha D. Wilson, Roy R. Hantgan, Lawrence L. Rudel> ;Journal of Lipid Research. 2013 Sep 1
• 32 citations
  Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice.
  Allison L. McDaniel, Heather M. Alger, Janet K. Sawyer, Kathryn L. Kelley, Nancy D. Kock, J. Mark Brown, Ryan E. Temel, Lawrence L. Rudel> ;The American Journal of Pathology. 2013 Apr 1
• 18 citations
  ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.
  Tam Nguyen, Janet K. Sawyer, Kathryn L. Kelley, Matthew A. Davis, Carol R. Kent, Lawrence L. Rudel> ;Journal of Lipid Research. 2012 Aug 1
• 31 citations
  Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood
  Jun Zhang, Kathryn L. Kelley, Stephanie M. Marshall, Matthew A. Davis, Martha D. Wilson, Janet K. Sawyer, Robert V. Farese, J. Mark Brown, Lawrence L. Rudel> ;Journal of Lipid Research. 2012 Jun 1
• 57 citations
  Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation.
  Tam Nguyen, Janet K. Sawyer, Kathryn L. Kelley, Matthew A. Davis, Lawrence L. Rudel> ;Journal of Lipid Research. 2012 Jan 1
• 71 citations
  Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
  Rachael Thomas, Eric L. Seiser, Alison A. Motsinger-Reif, Luke B. Borst, Victor E. Valli, Kathryn Kelley, Steven E. Suter, David J. Argyle, Kristine Burgess, Jerold Be...> ;Leukemia & Lymphoma. 2011 Jun 23
• 20 citations
  Dietary n-3 LCPUFA from fish oil but not α-linolenic acid-derived LCPUFA confers atheroprotection in mice
  Chiara Degirolamo, Kathryn L. Kelley, Martha D. Wilson, Lawrence L. Rudel> ;Journal of Lipid Research. 2010 Jul 1
• 56 citations
  Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.
  Heather M. Alger, J. Mark Brown, Janet K. Sawyer, Kathryn L. Kelley, Ramesh Shah, Martha D. Wilson, Mark C. Willingham, Lawrence L. Rudel> ;The Journal of Biological Chemistry. 2010 May 7
• 43 citations
  Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 Inhibition Prevents the Metabolic Syndrome and Atherosclerosis
  J. Mark Brown, Soonkyu Chung, Janet K. Sawyer, Chiara Degirolamo, Heather M. Alger, Tam Nguyen, Xuewei Zhu, My Ngan Duong, Amanda L. Brown, Caleb C. Lord, Ramesh Shah,...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2010 Jan 1
• 126 citations
  Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis
  J. Mark Brown, Soonkyu Chung, Janet K. Sawyer, Chiara Degirolamo, Heather M. Alger, Tam Nguyen, Xuewei Zhu, My Ngan Duong, Amanda L. Wibley, Ramesh Shah, Matthew A. Da...> ;Circulation. 2008 Sep 30
• 89 citations
  Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss.
  J. Mark Brown, Thomas A. Bell, Heather M. Alger, Janet K. Sawyer, Thomas L. Smith, Kathryn Kelley, Ramesh Shah, Martha D. Wilson, Matthew A. Davis, Richard G. Lee, Mar...> ;The Journal of Biological Chemistry. 2008 Apr 18
• 126 citations
  Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys.
  Kylie Kavanagh, Kate L. Jones, Janet K. Sawyer, Kathryn Kelley, J. Jeffrey Carr, Janice D. Wagner, Lawrence L. Rudel> ;Obesity. 2007 Jul 1
• 43 citations
  Dietary Fat–Induced Alterations in Atherosclerosis Are Abolished by ACAT2-Deficiency in ApoB100 Only, LDLr−/− Mice
  Thomas A. Bell, Kathryn Kelley, Martha D. Wilson, Janet K. Sawyer, Lawrence L. Rudel> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2007 Jun 1
• 13 citations
  Monounsaturated fatty acyl-coenzyme A is predictive of atherosclerosis in human apoB-100 transgenic, LDLr-/- mice.
  Thomas A. Bell, Martha D. Wilson, Kathryn Kelley, Janet K. Sawyer, Lawrence L. Rudel> ;Journal of Lipid Research. 2007 May 1
• 88 citations
  Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2
  Ryan E. Temel, Richard G. Lee, Kathryn L. Kelley, Matthew A. Davis, Ramesh Shah, Janet K. Sawyer, Martha D. Wilson, Lawrence L. Rudel> ;Journal of Lipid Research. 2005 Nov 1
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