KawsarRasmyTalaatMD

Medicine/Pediatrics • Baltimore, MD

Associate Professor

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Office
4940 Eastern Avenue
Baltimore, MD 21224
Phone+1 410-550-0501
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Education & Training

National Institutes of Health Clinical CenterFellowship, Infectious Disease, 2001 - 2007
Medical College of Wisconsin Affiliated HospitalsResidency, Internal Medicine/Pediatrics, 1997 - 2001
University of Washington School of MedicineClass of 1997

Certifications & Licensure

MD State Medical License 2007 - 2025
WI State Medical License 1998 - 2019
DC State Medical License Active through 2013
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease
American Board of Pediatrics Pediatrics

Clinical Trials

Single Group Study of the Safety of and Immune Response to a Bird Flu Vaccine (H7N3) in Healthy Adults Start of enrollment: 2007 Sep 01
Completed
Phase 1
Safety of and Immune Response to Recombinant Live-Attenuated Influenza H6N1 Virus Vaccine Vaccine Start of enrollment: 2008 Sep 01
Completed
Phase 1
Evaluating the Safety and Immune Response to an H5N1 Influenza Vaccine in People Who Have Previously Received an H5N1 or H7N3 Influenza Vaccine and in People Who Have Never Received a Live Attenuated Influenza Vaccine Start of enrollment: 2011 Oct 01
Completed
Phase 1
Early Immune Responses to Inactivated Influenza Vaccine: a Pilot Study Start of enrollment: 2012 Jan 01
Completed
Not Applicable
Evaluating the Safety and Immune Response to a Live H7N9 Influenza Virus Vaccine Followed by an Inactivated H7N9 Influenza Virus Vaccine, Given at Varying Intervals Start of enrollment: 2014 May 01
Completed
Phase 1
Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2a Start of enrollment: 2015 Dec 01
Completed
Phase 2
Human Challenge Model Refinement With Enterotoxigenic Escherichia Coli Strain B7A Start of enrollment: 2016 Apr 01
Completed
Not Applicable
Efficacy of B7A BSIgG Against E. Coli Strain B7A Challenge Start of enrollment: 2017 Jan 01
Completed
Phase 1
Evaluating the Live-Attenuated Human Parainfluenza Virus Type 3 Vectored Vaccine Candidate Expressing Ebolavirus Zaire Glycoprotein as the Sole Envelope Glycoprotein Start of enrollment: 2018 Mar 05
Suspended
Phase 1
Inpatient Challenge Study of rRSV A/Maryland/001/11, a Human Respiratory Syncytial Virus Challenge Strain, Administered to Healthy Adult Volunteers Start of enrollment: 2018 Jul 31
Suspended
Phase 1
Immunogenicity and Safety Study of Inactivated Subunit H5N1 Influenza Vaccine in Prior Recipients of Live Attenuated H2N2, H6N1 and H9N2 Influenza Vaccines and in H5N1 and Live Attenuated Vaccine Naïve Individuals Start of enrollment: 2019 Jan 08
Completed
Phase 1
Controlled Human Infection Model Challenge/Rechallenge Start of enrollment: 2022 Apr 26
Completed
Phase 1
Roles: Principal Investigator, Contact
Phase I Safety Study of B/HPIV3/S-6P Vaccine Via Nasal Spray in Adults Start of enrollment: 2023 Sep 18
Recruiting
Phase 1
Roles: Contact
Pre-Study of Wild Type Enterotoxigenic E. Coli (ETEC) Strain for Verification of a Planned Challenge Dose Start of enrollment: 2024 Feb 12
Recruiting
Not Applicable
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Validation of a Human Challenge Model Using an LT-Expressing EnterotoxigenicStrain (LSN03-016011) and Characterization of Potential Amelioration of Disease by an Inves...
Chad K Porter, Subhra Chakraborty, Brittany L Feijoo, Jessica Brubaker, Brittany M Adjoodani, Barbara DeNearing, Michael G Prouty, Steven T Poole, A Louis Bourgeois, M...> ;Microorganisms. 2024 Apr 3
Fourth Controlled Human Infection Model (CHIM) meeting - CHIMs in endemic countries, May 22-23, 2023.
Melissa Kapulu, Lucinda Manda-Taylor, Shobana Balasingam, Gary Means, Mikal Ayiro Malungu, Philip Bejon, Primus Che Chi, Christopher Chiu, E Chandler Church, Rodrigo C...> ;Biologicals. 2024 Feb 1
Fourth Controlled Human Infection Model (CHIM) meeting, CHIM regulatory issues, May 24, 2023.
Marco Cavaleri, David Kaslow, Eric Boateng, Wilbur H Chen, Christopher Chiu, Robert K M Choy, Rodrigo Correa-Oliveira, Anna Durbin, Moses Egesa, Malick Gibani, Melissa...> ;Biologicals. 2024 Feb 1
Regulatory workshop on challenge strain development and GMP manufacture - A stakeholder meeting report.
Nicoletta Corti, Christopher Chiu, Rebecca J Cox, Clarisse Demont, Jeanne-Marie Devaster, Othmar G Engelhardt, Andrew Gorringe, Khaole Hassan, Marcel Hoefnagel, Ingrid...> ;Biologicals. 2024 Feb 1
Efficacy Evaluation of an Intradermally Delivered EnterotoxigenicCF Antigen I Fimbrial Tip Adhesin Vaccine Coadministered with Heat-Labile Enterotoxin with LT(R192G) a...
Riddle, M. S., Ramiro L Gutiérrez, Chad K Porter, Clayton Harro, Kawsar Talaat, Mark S Riddle, Barbara DeNearing, Jessica Brubaker, Milton Maciel Jr, Renee M Laird, St...> ;Microorganisms. 2024 Jan 29
3 citations
Vaccine value profile for Shigella.
William P Hausdorff, John D Anderson 4th, Karoun H Bagamian, A Louis Bourgeois, Melody Mills, Frederick Sawe, Suzanne Scheele, Kawsar Talaat, Birgitte K Giersing> ;Vaccine. 2023 Nov 3
Immunologic changes are detectable in the peripheral blood transcriptome of clinically asymptomatic Chagas cardiomyopathy patients.
Carolina Duque, Jaime So, Yagahira E Castro-Sesquen, Kelly DeToy, Sneider A Gutierrez Guarnizo, Fatemeh Jahanbakhsh, Edith Malaga Machaca, Monica Miranda-Schaeubinger,...> ;Biorxiv. 2023 Oct 5
1 citations
Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in commun...
Bettina Wunderlich, Thomas Laskow, Huifen Li, Li Zhang, Engle Abrams, Jing Tian, Jun Yu, Yiyin Chen, Juliette Tavenier, Yushu Huang, Kawsar Talaat, Jay H Bream, Qian-L...> ;Immunity & Ageing. 2023 Jul 31
Editorial: Immunological aspects of vaccine safety.
Michael Vajdy, Barbara A Rath, Kawsar R Talaat> ;Frontiers in Immunology. 2023 Jan 1
5 citations
Hepatitis E vaccine-Illuminating the barriers to use.
Julia A Lynch, Jacqueline Kyungah Lim, Philomena E Peter Asaga, T Anh Wartel, Melanie Marti, Beno Yakubu, Helen Rees, Kawsar Talaat, Brittany Kmush, Rakesh Aggarwal, I...> ;Plos Neglected Tropical Diseases. 2023 Jan 1
Sleep duration prior to an enterotoxigenic Escherichia coli challenge predicts diarrhea severity during infection.
Janna Mantua, Ramiro L Gutierrez, Sandra D Isidean, Ashley N Alcala, Kayla J Testa, Kawsar R Talaat, Tracy Jill Doty, Chad K Porter> ;Sleep Medicine. 2022 Dec 1
2 citations
Shigella-Controlled Human Infection Models: Current and Future Perspectives.
Kristen A Clarkson, Chad K Porter, Kawsar R Talaat, Melissa C Kapulu, Wilbur H Chen, Robert W Frenck Jr, A Louis Bourgeois, Robert W Kaminski, Laura B Martin> ;Current Topics in Microbiology and Immunology. 2022 May 27
82 citations
Case Series of Thrombosis With Thrombocytopenia Syndrome After COVID-19 Vaccination-United States, December 2020 to August 2021.
Isaac See, Allison Lale, Paige Marquez, Michael B Streiff, Allison P Wheeler, Naomi K Tepper, Emily Jane Woo, Karen R Broder, Kathryn M Edwards, Ruth Gallego, Andrew I...> ;Annals of Internal Medicine. 2022 Apr 1
9 citations
Multisystem Inflammatory Syndrome in Adults after SARS-CoV-2 infection and COVID-19 vaccination.
Ermias D. Belay, Shana Godfred Cato, Agam K Rao, Joseph Y. Abrams, W Wyatt Wilson, Sarah Lim, Christopher Newton-Cheh, Michael Melgar, Jennifer DeCuir, Brandon J. Webb...> ;Clinical Infectious Diseases. 2021 Nov 28
316 citations
Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age.
Emmanuel B. Walter, Kawsar R. Talaat, Charu Sabharwal, Alejandra Gurtman, Stephen Lockhart, Grant Paulsen, Elizabeth D. Barnett, Flor M. Munoz, Yvonne Maldonado, Barba...> ;The New England Journal of Medicine. 2021 Nov 9
A site assessment tool for inpatient controlled human infection models for enteric disease pathogens.
Chad K. Porter, Katherine J Detizio, Nicole Maier, Kayla J. Testa, Kawsar R. Talaat, Wilbur H. Chen, Caroline E. Lyon, Ramiro L. Gutierrez, Robert W. Frenck, Sandra D....> ;Clinical Trials. 2021 Oct 28
1 citations
The Controlled Human Infection Model for Enterotoxigenic Escherichia coli
Chad K. Porter, Kawsar R. Talaat, Sandra D. Isidean, Alwine Kardinaal, Subhra Chakraborty, Ramiro L. Gutierrez, David A. Sack, A. Louis Bourgeois> ;Current Topics in Microbiology and Immunology. 2021 Oct 21
10 citations
Critical needs in advancing Shigella vaccines for global health
Calman A. MacLennan, Kawsar R. Talaat, Robert W. Kaminski, Dani Cohen, Mark S. Riddle, Birgitte K. Giersing> ;The Journal of Infectious Diseases. 2021 Sep 24
5 citations
Exploring Changes in the Host Gut Microbiota During a Controlled Human Infection Model for Campylobacter jejuni.
Blake W. Stamps, Janelle Kuroiwa, Sandra D. Isidean, Megan A. Schilling, Clayton Harro, Kawsar R. Talaat, David A. Sack, David R. Tribble, Alexander C. Maue, Joanna E....> ;Frontiers in Cellular and Infection Microbiology. 2021 Aug 31
10 citations
Shigella-Specific Immune Profiles Induced after Parenteral Immunization or Oral Challenge with Either Shigella flexneri 2a or Shigella sonnei.
Kristen A. Clarkson, Chad K. Porter, Kawsar R. Talaat, Robert W. Frenck, Cristina Alaimo, Patricia Martin, A. Louis Bourgeois, Robert W. Kaminski> ;Msphere. 2021 Jul 14
29 citations
Immune response characterization in a human challenge study with a Shigella flexneri 2a bioconjugate vaccine.
Kristen A. Clarkson, Kawsar R. Talaat, Cristina Alaimo, Patricia Martin, A. Louis Bourgeois, Anita M. Dreyer, Chad K. Porter, Subhra Chakraborty, Jessica Brubaker, Dan...> ;Ebiomedicine. 2021 Apr 1
48 citations
Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection
Kawsar R. Talaat, Cristina Alaimo, Patricia Martin, A. Louis Bourgeois, Anita M. Dreyer, Robert W. Kaminski, Chad K. Porter, Subhra Chakraborty, Kristen A. Clarkson, J...> ;Ebiomedicine. 2021 Apr 1
3 citations
Evaluation of 2 Lateral Flow Rapid Tests in the Diagnosis of Chagas Disease in the Washington Metropolitan Area.
Yagahira E. Castro-Sesquen, Antonella Saldaña, Dhayanna Patino Nava, Diana Paulette Evans, Tabitha Bayangos, Kelly DeToy, Alexia Trevino, Rachel Marcus, Caryn Bern, Ro...> ;Open Forum Infectious Diseases. 2021 Mar 2
5 citations
Refinement of the CS6-expressing enterotoxigenic Escherichia coli strain B7A human challenge model: A randomized trial.
Kawsar R. Talaat, Chad K. Porter, Kayla Jaep, Christopher A. Duplessis, Ramiro L. Gutierrez, Milton Maciel, Brittany Adjoodani, Brittany Feijoo, Subhra Chakraborty, Je...> ;Plos One. 2020 Dec 2
17 citations
Efficacy and Tolerability of Miltefosine in the Treatment of Cutaneous Leishmaniasis.
JeanAnne Ware, Elise M. O’Connell, Tom Brown, Lauren Wetzler, Kawsar R. Talaat, Thomas B. Nutman, Theodore E. Nash> ;Clinical Infectious Diseases. 2021 Oct 5
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Journal Articles

Enterotoxigenic E. Coli Virulence Gene Regulation in Human Infections
Kawsar R Talaat, Mark S Riddle, Stephen J Savarino, Proceedings of the National Academy of Sciences

Press Mentions

Game Changers: 5 Global Vaccine Innovations on the HorizonApril 27th, 2023
A ‘Very, Very Bad Bill’: Why This Texas Vaccine Bill Has Health Workers WorriedApril 16th, 2023
Here’s What Experts Are Saying About Timing Flu and Covid InjectionsOctober 25th, 2022
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