KeaneLaiMD

PubMed

• Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose.
  Soo-Mi Kweon, Jose Irimia-Dominguez, Gayeoun Kim, Patrick T Fueger, Kinji Asahina, Keith K Lai, Daniela S Allende, Quincy R Lai, Chih-Hong Lou, Walter M Tsark, Ju Dong...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2023 Aug 1
• 1 citations
  Midnolin Regulates Liver Cancer Cell Growth In Vitro and In Vivo.
  Soo-Mi Kweon, Gayeoun Kim, Yunseong Jeong, Wendong Huang, Ju-Seog Lee, Keane K Y Lai> ;Cancers. 2022 Mar 10
• Magnetic resonance imaging for characterization of hepatocellular carcinoma metabolism.
  Lixia Wang, Ju Dong Yang, Charles C Yoo, Keane K Y Lai, Jonathan Braun, Dermot P B McGovern, Yibin Xie, Stephen J Pandol, Shelly C Lu, Debiao Li> ;Frontiers in Physiology. 2022 Jan 1
• 4 citations
  Differential Kat3 Usage Orchestrates the Integration of Cellular Metabolism with Differentiation
  Xiaohui Hu, Masaya Ono, Nyam-Osor Chimge, Keisuke Chosa, Cu Nguyen, Elizabeth Melendez, Chih-Hong Lou, Punnajit Lim, John Termini, Keane K. Y. Lai, Patrick T. Fueger, ...> ;Cancers. 2021 Nov 23
• 3 citations
  Thioacetamide-induced norepinephrine production by hepatocytes is associated with hepatic stellate cell activation and liver fibrosis
  Wei-Chien Tang, Ya-Wen Chang, Mingtian Che, Mei-Hui Wang, Keith Lai, Patrick T. Fueger, Wendong Huang, Shwu-Bin Lin, Keane K Y Lai> ;Current Molecular Pharmacology. 2021 Apr 12
• 7 citations
  P300 serine 89: A critical signaling integrator and its effects on intestinal homeostasis and repair
  Keane K Y Lai, Xiaohui Hu, Keisuke Chosa, Cu Nguyen, David P. Lin, Keith Lai, Nobuo Kato, Yusuke Higuchi, Sarah K. Highlander, Elizabeth Melendez, Yoshihiro Eriguchi, ...> ;Cancers. 2021 Mar 14
• 4 citations
  Pharmacologically Targeting the WNT/β-Catenin Signaling Cascade: Avoiding the Sword of Damocles
  Keane K Y Lai, Michael Kahn> ;Handbook of Experimental Pharmacology. 2021 Jan 1
• 11 citations
  Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells.
  Mingtian Che, Soo-Mi Kweon, Jia-Ling Teo, Yate-Ching Yuan, Laleh G. Melstrom, Richard T. Waldron, Aurelia Lugea, Raul Urrutia, Stephen J. Pandol, Keane K Y Lai> ;Cancers. 2020 Jun 5
• 10 citations
  Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras
  Kinji Asahina, Steven Balog, Edward Hwang, Eugene Moon, Emily Wan, Kaitlin Skrypek, Yibu Chen, Jay Fernandez, Janet Romo, Qihong Yang, Keane Lai, Samuel Wheeler French...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2020 Feb 1
• 18 citations
  HBV X protein mutations affect HBV transcription and association of histone-modifying enzymes with covalently closed circular DNA.
  Chun Kong Chong, Ching Yan Serene Cheng, Sin Yi Jasmine Tsoi, Fung-Yu Huang, Fen Liu, James Fung, Wai-Kay Seto, Keane K.-Y. Lai, Ching-Lung Lai, Man-Fung Yuen, Danny K...> ;Scientific Reports. 2020 Jan 21
• 16 citations
  Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage.
  Keane K Y Lai, Cu Nguyen, Kyung Soon Lee, Albert Lee, David P Lin, Jia-Ling Teo, Michael Kahn> ;Current Molecular Pharmacology. 2019 Jul 31
• 9 citations
  The Mode of Stem Cell Division Is Dependent on the Differential Interaction of β-Catenin with the Kat3 Coactivators CBP or p300.
  Agnes I. Lukaszewicz, Cu Nguyen, Elizabeth Melendez, David P. Lin, Jia-Ling Teo, Keane K Y Lai, Wieland B. Huttner, Song-Hai Shi, Michael G. Kahn> ;Cancers. 2019 Jul 9
• 16 citations
  Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer
  Jami L. Saloman, Kathryn M. Albers, Zobeida Cruz-Monserrate, Brian M. Davis, Mouad Edderkaoui, Guido Eibl, Ariel Y Epouhe, Jeremy Y. Gedeon, Fred S. Gorelick, Paul J. ...> ;Pancreas. 2019 Jul 1
• 15 citations
  Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage
  Masaya Ono, Keane K. Y. Lai, Kaijin Wu, Cu Nguyen, David Po-Yi Lin, Ramachandran Murali, Michael G. Kahn> ;Plos One. 2018 Jul 18
• 35 citations
  Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer.
  Philipp C. Manegold, Keane K. Y. Lai, Yongfeng Wu, Jia-Ling Teo, Heinz-Josef Lenz, Yuri Genyk, Stephen J. Pandol, Kaijin Wu, David P. Lin, Yi-Bu Chen, Cu Nguyen, Yi Zh...> ;Cancers. 2018 Mar 29
• 14 citations
  Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1.
  Noriko Matsushita, Mohamed T. Hassanein, Marcos Martinez-Clemente, Raul Lazaro, Samuel W. French, Wen Xie, Keane Lai, Michael Karin, Hidekazu Tsukamoto> ;Plos One. 2017 Aug 10
• 120 citations
  Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Re...
  Keane K. Y. Lai, Soo-Mi Kweon, Feng Chi, Edward Hwang, Yasuaki Kabe, Reiichi Higashiyama, Lan Qin, Rui Yan, Raymond Wu, Keith Lai, Naoaki Fujii, Samuel W. French, Jun ...> ;Gastroenterology. 2017 May 1
• 18 citations
  Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells.
  Soo-Mi Kweon, Feng Chi, Reiichi Higashiyama, Keane Lai, Hidekazu Tsukamoto> ;Plos One. 2016 May 23
• 29 citations
  Simultaneous detection of 19 drugs of abuse on dried urine spot by liquid chromatography–tandem mass spectrometry
  Yungkang Lee, Keane K.Y. Lai, S.M. Hossein Sadrzadeh> ;Clinical Biochemistry. 2013 Aug 1
• 110 citations
  Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK
  Jun Xu, Keane K. Y. Lai, Alla Verlinsky, Aurelia Lugea, Samuel W. French, Marcus P. Cooper, Cheng Ji, Hidekazu Tsukamoto> ;Journal of Hepatology. 2011 Sep 1
• 24 citations
  Improved reflexive testing algorithm for hepatitis C infection using signal-to-cutoff ratios of a hepatitis C virus antibody assay.
  Keane K.Y. Lai, Ming Jin, Shan Yuan, Meaghan F. Larson, Jason A. Dominitz, Daniel D. Bankson> ;Clinical Chemistry. 2011 Jul 1
• 68 citations
  Extracellular Matrix Dynamics in Hepatocarcinogenesis: a Comparative Proteomics Study of PDGFC Transgenic and Pten Null Mouse Models
  Keane K. Y. Lai, Sufen Shang, Neha Lohia, Garrett C. Booth, Derek J. Masse, Nelson Fausto, Jean S. Campbell, Laura Beretta> ;Plos Genetics. 2011 Jun 23
• 58 citations
  Comprehensive and quantitative proteome profiling of the mouse liver and plasma.
  Keane K. Y. Lai, Deepak Kolippakkam, Laura Beretta> ;Hepatology. 2008 Mar 1
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