Keith R McCrae MD

Hematologic Oncology

Director, Benign Hematology, Professor of Molecular Medicine, Cleveland Clinic

11100 Euclid AveCleveland, OH 44106
Phone+1 216-844-8500
Fax+1 216-286-6341

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Education & Training

University of Pennsylvania Health SystemFellowship, Hematology and Medical Oncology, 1985 - 1988
Duke University HospitalResidency, Internal Medicine, 1982 - 1985
Duke University School of MedicineClass of 1982
Dartmouth CollegeBA, Summa Cum Laude, 1978

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Certifications & Licensure

OH State Medical License 1999 - 2028
PA State Medical License 1985 - 2002
NC State Medical License 1982 - 1985
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 2 Certification Beacon Oncology 2014 Certified Module, Epic Systems Corporation, 2011, 2013-2014, 2016-2017
CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2011, 2013-2014, 2016-2017
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2011, 2013-2014, 2016-2017

Clinical Trials

Optimal Platelet Dose Strategy for Management of Thrombocytopenia
COMPLETED
PHASE3
Rituximab to Treat Severe Hemophilia A
COMPLETED
PHASE2
Evaluating the Presence of Blood Clots in People With Heparin-Induced Thrombocytopenia (HIT) (The HOT Study)
TERMINATED

Publications & Presentations

PubMed

American Society of Hematology 2026 Guidelines for Immune Thrombocytopenia (ITP): Initial and Second-Line Therapy in Adults with Primary ITP.
Adam Cuker, Deirdra R Terrell, Honieh Sowdagar, Donald M Arnold, Sylvain Audia
Blood Advances. 2026-08-19
Thrombin reprograms endothelial extracellular vesicles.
Paresh Kulkarni, Keith R McCrae
Blood Advances. 2026-08-11
A call to action for the use of composite hematologic measurements in hereditary hemorrhagic telangiectasia and other chronic bleeding disorders.
Hanny Al-Samkari, Raj S Kasthuri, Jenny Y Zhou, Layla N Van Doren, Keith R McCrae
Expert Review of Hematology. 2026-08-01

Journal Articles

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura
Scully M, Cataland SR, Peyvandi F, Coppo P, Kn�bl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES ..., NEJM, 1/1/2019
Duration of anticoagulant therapy and VTE recurrence in patients with cancer
Khorana AA, McCrae KR, Milentijevic D, Fortier J, Nelson WW, Lalibert� F, Crivera C, Lefebvre P, Schein J., Supportive Care Cancer, 1/1/2019
Plasma Kallikrein Structure Reveals Apple Domain Disc Rotated Conformation Compared to Factor XI
Li C, Voos KM, Pathak M, Hall G, McCrae KR, Dreveny I, Li R, Emsley J., J. Thromb Haemost, 1/1/2019

Books/Book Chapters

Chesley�s Hypertensive Disorders of Pregnancy
Chapter: Platelets, coagulation and the liver.
Page 379.0 - 396.0Kenny LC, McCrae KR Cunningham GF.Editors: Taylor RM, Roberts JM, Cunningham FG, Lindheimer MD.Edition 3rd,2015
Platelets
Chapter: Thrombocytopenia in pregnancy.
McCrae KR.Editors: Michelson AD.ElsevierEdition 3rd,2013
Antiphospholipid Syndrome: Insights and Highlights from the 13th International Congress on Antiphospholipid Antibodies.
Chapter: What are the target cells and receptors recognized by antiphospholipid antibodies?
de Groot PG, Raschi E, McCrae KR, Pierangeli S, Vlachoyiannopoulos, Urbanus RT.Editors: Erkan D, Pierangeli SS.Springer Science2012

Abstracts/Posters

The Burden of Disease and IMPACT of Immune Thrombocytopenia (ITP) on Patients: Results from an ITP Survey
Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Characterization of Recombinant _2GPI Using Hydrogen-Deuterium Exchange and X-Ray Crystallography
Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
High Molecular Weight Kininogen but Not Factor XII Deficiency Attenuates Acetaminophen-Induced Liver Injury in Mice
Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

Extracellular vesicles in cancer-associated thrombosis
Evans Center, Boston University School of Medicine, Boston MA - 1/1/2019
Pomalidomide in Hereditary Hemorrhagic Telangiectasia
San Juan, PRI - 1/1/2019
Special Symposium on the Basic Science of Hemostasis and Thrombosis
60th American Society of Hematology Annual Meeting - 12/3/2018

Press Mentions

Cleveland Clinic Trial Shows Promise in Treating Bleeding DisorderSeptember 20th, 2024
Cure HHT's Advocacy Effort, Support Helps NIH-Sponsored PATH Trial Become First Successful, Large-Scale Randomized Trial for HHTSeptember 19th, 2024
Clinical Trial Successfully Repurposes Cancer Drug for Hereditary Bleeding DisorderSeptember 18th, 2024

Grant Support

Mechanisms of cancer immunotherapy-associated thrombosisCLEVELAND CLINIC LERNER COM-CWRU2023–2027
1/2 Pomalidomide for Bleeding in Patients with Hereditary Hemorrhagic Telangiectasia (HHT)CLEVELAND CLINIC LERNER COM-CWRU2020–2025
Novel approaches to improve prediction of cancer-associated thrombosisCLEVELAND CLINIC LERNER COM-CWRU2018–2025
Regulation Of Angiogenesis By KininogenNational Heart, Lung, And Blood Institute2010–2012
Regulation Of Angiogenesis By KininogenNational Heart, Lung, And Blood Institute2009–2010