Keith R McCrae MD

PubMed

• Validation and Clinical Application of the Hereditary Hemorrhagic Telangiectasia-Specific Quality of Life Scale (HHT-QoL).
  Hanny Al-Samkari, Raj S Kasthuri, Vivek N Iyer, Allyson M Pishko, Jake E Decker
  Journal of Thrombosis and Haemostasis. 2025-10-13
• Standardization of Terminology, Definitions, and Outcome Criteria for Bleeding in Hereditary Hemorrhagic Telangiectasia: International Consensus Report.
  Hanny Al-Samkari, Raj S Kasthuri, Hans-Jurgen Mager, Jenny Y Zhou, Marcelo M Serra
  American Journal of Hematology. 2025-10-01
• Genetic and epigenetic dysregulation of CR1 is associated with catastrophic antiphospholipid syndrome.
  Nikhil Ranjan, Michael A Cole, Gloria F Gerber, Mark A Crowther, Evan M Braunstein
  Annals of the Rheumatic Diseases. 2025-08-20

Journal Articles

• Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura  
  Scully M, Cataland SR, Peyvandi F, Coppo P, Kn�bl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES ..., NEJM, 1/1/2019
• Duration of anticoagulant therapy and VTE recurrence in patients with cancer  
  Khorana AA, McCrae KR, Milentijevic D, Fortier J, Nelson WW, Lalibert� F, Crivera C, Lefebvre P, Schein J., Supportive Care Cancer, 1/1/2019
• Plasma Kallikrein Structure Reveals Apple Domain Disc Rotated Conformation Compared to Factor XI  
  Li C, Voos KM, Pathak M, Hall G, McCrae KR, Dreveny I, Li R, Emsley J., J. Thromb Haemost, 1/1/2019
• The risk of recurrent VTE and major bleeding in a commercially-insured population of cancer patients treated with anticoagulation  
  Khorana AA, McCrae K, Milentijevic D, McCormick N, Lalibert� F, Crivera C, Lefebvre P, Lejeune D, Rozjabek H, Schein J, Streiff MB., Am J Hematol., 1/1/2019
• Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model  
  Yang J, van 't Veer C, Roelofs JJTH, van Heijst JWJ, de Vos AF, McCrae KR, Revenko AS, Crosby J, van der Poll T., Am J Physiol Lung Cell Mol Physiol., 1/1/2019
• Effects of Anti‐β2GPI Antibodies on VWF Release from Human Umbilical Vein Endothelial Cells and ADAMTS13 Activity  
  Christopher J Ng, Keith R McCrae, Research and Practice in Thrombosis and Haemostasis
• Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo  
  Zilberman-Rudenko J, Reitsma SE, Puy C, Rigg RA, Smith SA, Tucker EI, SilasiR, Merkulova A, McCrae KR, Maas C, Urbanus RT, Gailani D, Morrissey JH, Gruber A, Lupu F, S..., Arterioscler Thromb Vasc Biol., 1/1/2018
• Preoperative Anemia in Cardiac Operation: Does Hemoglobin Tell the Whole Story?  
  Dai L, Mick SL, McCrae KR, Houghtaling PL, Sabik JF 3rd, Blackstone EH, Koch CG., Ann Thorac Surg., 1/1/2018
• Limited role of kininogen in the host response during gram-negative pneumonia-derived sepsis  
  Ding C, van 't Veer C, Roelofs JJTH, Shukla M, McCrae KR, Revenko AS, Crosby J, van der Poll T., American J Physiol. Lung cellular and molecular physiology., 1/1/2018
• Novel mechanism of cancer thrombosis induced by microvesicles  
  McCrae KR, ATVB, 1/1/2018
• Effectiveness and safety of anticoagulants for the treatment of venous thromboembolism in patients with cancer  
  Streiff MB, Milentijevic D, McCrae K, Yannicelli D, Fortier J, Nelson WW, Lalibert� F, Crivera C, Lefebvre P, Schein J, Khorana AA., Am J Hematol., 1/1/2018
• Extracellular vesicles in the antiphospholipid syndrome  
  Chaturvedi S, Alluri R, McCrae KR., Semin Throm Haemost., 1/1/2018
• In vitro evaluation of SynthoPlateTM (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice  
  Shukla M, Sekhon UD, Betapudi V, Li W, Hickman DA, Pawlowski CL, Dyer MR, Neal MD, McCrae KR, Sen Gupta A., J Thromb Haemost., 1/1/2017
• Diagnosis and management of the antiphospholipid syndrome  
  Chaturvedi S, McCrae KR., Blood Rev, 1/1/2017
• Predicting risk of venous thromboembolism in hospitalized cancer patients: Utility of a risk assessment tool  
  Patell R, Rybicki L, McCrae KR, Khorana AA., Am J Hematol., 1/1/2017
• Post-traumatic stress disorder and depression in survivors of thrombotic thrombocytopenic purpura  
  Chaturvedi S, Oluwole O, Cataland S, McCrae KR., Thromb Res, 1/1/2017
• Clinical outcomes in a cohort of patients with heparin-induced thrombocytopenia  
  Kuter DJ, Konkle BA, Hamza TH, Uhl L, Assmann SF, Kiss JE, Kaufman RM, Key NS, Sachais BS, Hess JR, Ness P, McCrae KR, Leissinger C, Strauss RG, McFarland JG, Neufeld ..., Am J Hematol., 1/1/2017
• Depression and post-traumatic stress disorder in individuals with hereditary hemorrhagic telangiectasia: a cross-sectional survey  
  Chaturvedi S, Clancy M, McCrae KR, Thromb Res, 1/1/2017
• Centralizing care of cancer-associated thromboembolism; The Cleveland Clinic Experience  
  Rabinovich E, Bartholomew JR, Wilks ML, Tripp BL, McCrae KR, Khorana AA., Thromb Res, 1/1/2016
• Evaluation of US prescription patterns: are treatment guidelines for cancer-associated venous thromboembolism being followed?  
  Khorana AA, McCrae KR, Yanicelli D, Milentijevic D, Crivera C, Nelson WW, Schein JR., J Thromb Haemost, 1/1/2016
• Thrombosis in cancer: research priorities identified by a National Cancer Institute/National Heart, Lung, and Blood Institute strategic working group  
  Key NS, Khorana AA, Mackman N, McCarty OJT, White JC, Francis CF, McCrae KR, Palumbo JS, Raskob GE, Chan AT, Sood AK., Cancer Res, 1/1/2016
• A comparison of the effects of prekallikrein deficiency and FX deficiency on thrombus formation  
  Kokoye Y, Ivanov I, Cheng Q, Matafonov A, Dickeson SK, Mason S, Sexton DJ, Renn� T, McCrae KR, Feener EP, Gailani D., Thromb Res, 1/1/2016
• Circulating microparticles in patients with antiphospholipid antibodies: characterization and associations  
  Chaturvedi S, Cockrell E, Espinola R, Hsi L, Fulton S, Khan M, Li L, Fonseca F, Kundu S, McCrae KR., Thromb Res., 1/1/2015
• Increased morbidity during long-term follow up of survivors of thrombotic thrombocytopenic purpusa  
  Chaturvedi S, Abbas H, McCrae KR., Am J Hematol., 1/1/2015
• The KIST principle of teaching  
  McCrae KR, ASH Clinical News, 1/1/2014
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Books/Book Chapters

• Chesley�s Hypertensive Disorders of Pregnancy 
  Chapter: Platelets, coagulation and the liver. 
  Page 379.0 - 396.0Kenny LC, McCrae KR Cunningham GF.Editors: Taylor RM, Roberts JM, Cunningham FG, Lindheimer MD.Edition 3rd,2015
• Platelets 
  Chapter: Thrombocytopenia in pregnancy. 
  McCrae KR.Editors: Michelson AD.ElsevierEdition 3rd,2013
• Antiphospholipid Syndrome: Insights and Highlights from the 13th International Congress on Antiphospholipid Antibodies. 
  Chapter: What are the target cells and receptors recognized by antiphospholipid antibodies? 
  de Groot PG, Raschi E, McCrae KR, Pierangeli S, Vlachoyiannopoulos, Urbanus RT.Editors: Erkan D, Pierangeli SS.Springer Science2012
• Platelets 
  Chapter: Thrombocytopenia in pregnancy 
  McCrae KR.Editors: Michelson AD.ElsevierEdition 2nd,2007
• Thrombocytopenia 
  Chapter: Thrombotic microangiopathies 
  McCrae KR, Cines DB, Sadler EJ.Editors: McCrae KR..Marcel-Dekker, New York, N.Y.2006
• Thrombocytopenia 
  Chapter: Thrombocytopenia in pregnancy 
  McCrae KR.Editors: McCrae KR.Marcel-Dekker, New York, N.Y.2006
• Hematology: Basic Principles and Practice 
  Chapter: Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome 
  Page 2287. - 2304.McCrae KR, Sadler EJ, Cines DBEditors: Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P.Edition 4th,2005
• Molecular Hematology 
  Chapter: Platelet Disorders 
  Page 210.0 - 224.0Downes KA, McCrae KR.Editors: Provan D, Gribben JG.Blackwell Publishing, Malden, MAEdition 2nd,2005
• Irwin and Rippe�s Intensive Care Medicine 
  Chapter: Acquired bleeding disorders 
  Page 1219. - 1231.McCrae KR, Sarode REditors: Irwin R, Rippe JM.Lippincott Williams and Wilkins, New York, NYEdition 5th,2002
• Thrombosis and Hemorrhage 
  Chapter: Drug-induced thrombocytopenias. 
  Page 457.0 - 475.0McCrae, K.R. and Cines D.B.Editors: Loscalzo, J. and Schaeffer, A.I..Lippincott, Williams & Wilkins., Baltimore, MDEdition 3rd,2002
• Hemostasis and Thrombosis. Basic Principles and Clinical Practice. 
  Chapter: Antiphospholipid Antibodies and the Antiphospholipid Syndrome. 
  Page 1339. - 1358.McCrae KR, Feinstein DI, Cines DB.Editors: Colman RW, Hirsh J, Marder VJ, Salzman EW.Edition 4th,2001
• Textbook of Internal Medicine 
  Chapter: Disorders of Platelet Function 
  Page 1723. - 1732.McCrae KR, Shattil SJ.Editors: Kelley WN.J.B. Lippincott, New York, NYEdition 4th,2000
• Hematology: Basic Principles and Practice 
  Chapter: Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. 
  Page 2126. - 2137.McCrae KR, Cines DB.Editors: Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P.Edition 3rd,1999
• Seminars in Hematology 
  Chapter: Thrombotic microangiopathies in pregnancy 
  McCrae KR and Cines DB.Editors: Kwaan HC.1997
• Textbook of Internal Medicine 
  Chapter: Disorders of Platelet Function. 
  Page 1419. - 1426.McCrae KR, Shattil SJ.Editors: Kelley WN.Lippincott-Raven, New York, NYEdition 3rd,1997
• Textbook of Internal Medicine 
  Chapter: Aproach to the Bleeding Patient. 
  Page 1325. - 1331.McCrae KR.Editors: Kelley WN.Lippincott-Raven, New York, NYEdition 3rd,1997
• Blood: Hemostasis, Transfusion and Alternatives in the Perioperative Period 
  Chapter: Applications of the Clinical Coagulation Laboratory in the Perioperative Period. 
  Feldman MD, McCrae KR.Editors: Lake CL, Moore RA.Raven Press, New York, NY1995
• Advances in Pathology and Laboratory Medicine 
  Chapter: Clinical Aspects of the Plasminogen Activator System. 
  Page 467.0 - 493.0McCrae KR, Aceto J, Cines DB.Editors: Weinstein RS, Graham AR.Mosby Inc., Chicago, IL1994
• Antibodies to Endothelial Cells and Vascular Damage 
  Chapter: Immunologic Properties of Antibodies to Endothelial Cells. 
  Page 45.0 - 70.0McCrae KR, Cines DBEditors: Cervera, R. and Khamashta, M.CRC Press, Boca Raton, FL1993
• Thrombosis and Hemorrhage 
  Chapter: Drug-induced thrombocytopenia 
  Page 545.0 - 572.0McCrae KR, Cines DB.Editors: Loscalzo J, Schafer AI.Blackwell Scientific Publications, Cambridge, MA1993
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Abstracts/Posters

• The Burden of Disease and IMPACT of Immune Thrombocytopenia (ITP) on Patients: Results from an ITP Survey
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Characterization of Recombinant _2GPI Using Hydrogen-Deuterium Exchange and X-Ray Crystallography
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• High Molecular Weight Kininogen but Not Factor XII Deficiency Attenuates Acetaminophen-Induced Liver Injury in Mice
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Cancer Associated Thrombosis Is Associated with Higher Mortality across All Khorana Score Risk Levels
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Mice Deficient in ¤2-Glycoprotein I Have a Delayed Time to Thrombosis
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Biomarker Assessment of Venous Thromboembolism in Cancer Patients Receiving Checkpoint Blockade
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• African American Race Is Associated with Decreased Relapse-Free Survival in Immune Thrombotic Thrombocytopenic Purpura
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Identifying miRNA Biomarkers and Predicted Targets Associated with Venous Thromboembolism in Colorectal Cancer Patients
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Molecular Subtyping to Predict Risk of Venous Thromboembolism in Patients with Advanced Lung Adenocarcinoma: A Cohort Study
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Clinical Outcomes of Cancer-Associated Thrombosis Beyond 6 Months of Anticoagulation
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Differential Effect of Rituximab on Relapse-Free Survival in De Novo and Relapsed Immune Thrombotic Thrombocytopenic Purpura in African-American and Caucasian Populations
  Keith R McCrae, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• The Role of High Molecular Weight Kininogen in Lymphoma Microvascular Density and Growth.
  Erdemir HH, Shukla M, McCrae KR., Blood, 1/1/2018
• Healthcare Costs in Patients with Cancer Increase with Increasing Risk of Venous Thromboembolism.
  Streiff MB, McCrae KR, Kuderer NM, Germain G, Laliberte F, Le N, Lefebre P, Lyman GH, Khorana AA., Blood, 1/1/2018
• Clinical Outcomes with Direct Oral Anticoagulants Compared to Low Molecular Weight Heparins in the Treatment of Cancer-Associated Venous Thromboembolism
  Park DY, Poudel SK, Jia X, Wilks ML, Pinkava V, O�Brien M, Tripp B, Song JM, McCrae KR, Angelini DE, McCrae KR., Blood, 1/1/2018
• Clinical Outcomes with Direct Oral Anticoagulants Compared to Low Molecular Weight Heparins in the Treatment of Cancer-Associated Venous Thromboembolism.
  Park DY, Poudel SK, Jia X, Wilks ML, Pinkava V, O�Brien M, Tripp B, Song JM, McCrae KR, Angelini DE, McCrae KR, Blood, 1/1/2018
• Clinical Outcomes of Isolated Distal Deep Vein Thrombosis Associated with Cancer: The Cleveland Clinic Experience.
  Poudel SK, Jia X, Park DY, Wilks ML, Pinkava V, O�Brien M, Tripp B, Song JM, McCrae KR, Khorana AA, Angelini DE., Blood, 1/1/2018
• Deaths Due to Thrombotic Versus Bleeding Events within 90 Days of Cancer Associated Thrombosis.
  Wilks ML, Poudel SK, Park DY, Jia X, Pinkava V, O�Brien M, Tripp B, Song JM, McCrae KR, Khorana AA, Angelini DE., Blood, 1/1/2018
• Expression of Recombinant beta2GPI and Site-Directed Mutants Provides Insight into the Pathogenesis of Antiphospholipid Syndrome
  Alluri RK, Kundu S, Su J, Kambakam S, Yu E, McCrae KR, Blood, 1/1/2018
• Exosome Polyphosphate Mediates the Activation of FXII by Cancer Cell-Derived Exosomes.
  You D, Kundu S, Schmaier AH, Khorana AA, McCrae KR., Blood, 1/1/2018
• High Molecular Weight Kininogen Contributes to End-Organ Damage and Mortality in a Mouse Model of Sickle Cell Disease.
  Sparkenbaugh E, Wilson K, Kasztan M, Pollock DM, McCrae KR, Pawlinski R., Blood, 1/1/2018
• Heparin Vs Direct Thrombin Inhibitors in Patients with Previous HIT Undergoing Cardiothoracic Surgery: The Cleveland Clinic Experience
  Carlson DS, McCrae KR, Chaturvedi S., Blood, 1/1/2018
• Diastolic but not systolic heart failure is associated with multiple abnormalities on platelet aggregation testing.
  Gopalikrishnan D, Rogers HJ, Elson P, McCrae KR., American Society of Hematology 57th Annual Meeting, 1/1/2015
• Extracellular vesicles derived from HT-29 colorectal cancer cells induce endothelial cell activation and procoagulant activity
  Tian Y, Wu M, Khorana AA, McCrae KR, American Society of Hematology 57th Annual Meeting, 1/1/2015
• Platelet function testing is commonly performed in patients with known confounding factors.
  Gopalikrishnan D, Rogers HJ, Elson P, McCrae KR., American Society of Hematology 57th Annual Meeting, 1/1/2015
• A history of abnormal bleeding correlates with platelet dysfunction in aggregation studies but Not PFA-100 Analyses.
  Gopalikrishnan D, Rogers HJ, Elson P, McCrae KR., American Society of Hematology 57th Annual Meeting, 1/1/2015
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Lectures

• Extracellular vesicles in cancer-associated thrombosis 
  Evans Center, Boston University School of Medicine, Boston MA - 1/1/2019
• Pomalidomide in Hereditary Hemorrhagic Telangiectasia 
  San Juan, PRI - 1/1/2019
• Special Symposium on the Basic Science of Hemostasis and Thrombosis 
  60th American Society of Hematology Annual Meeting - 12/3/2018
• Microparticles and Exosomes: Ready for the Clinic? 
  60th American Society of Hematology Annual Meeting - 12/1/2018
• The Role of High Molecular Weight Kininogen in Lymphoma Microvascular Density and Growth 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Clinical Outcomes with Direct Oral Anticoagulants Compared to Low Molecular Weight Heparins in the Treatment of Cancer-Associated Venous Thromboembolism 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Expression of Recombinant β2GPI and Site-Directed Mutants Provides Insight into the Pathogenesis of Antiphospholipid Syndrome 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Thrombocytopenia 
  Boston, MA - 1/1/2018
• Kininogen: Underappreciated but Not Forgotten 
  Emory School of Medicine, Department of Pediatric Hematology, Atlanta, GA - 1/1/2018
• Selected Abstracts in Thrombosis and Vascular Biology 
  San Diego, CA. - 1/1/2018
• Diagnosis of Antiphospholipid Antibodies 
  UPMC and University of Pittsburgh School of Medicine. - 1/1/2017
• Update on platelets. 
  1/1/2016
• Cancer-Associated Thrombosis 
  1/1/2016
• Hemostatic and non-hemostatic functions of high molecular weight kininogen 
  1/1/2016
• Venous Thromboembolism: Risk Assessment 
  1/1/2016
• Venous Thromboembolism: Prophylaxis and Management 
  1/1/2016
• New Insights into Platelet Disorders. 
  1/1/2015
• Antiphospholipid antibodies: Mechanisms and management 
  Ohio State University James Cancer Center. - 1/1/2015
• High molecular weight kininogen: Overlooked but not forgotten 
  1/1/2015
• Antiphospholipid Antibodies: Still an Enigma 
  1/1/2015
• Immune thrombocytopenias. 
  1/1/2014
• Catastophic bleeding in pregnancy: Diagnosis and Management. 
  Chicago, IL - 1/1/2014
• Thrombocytopenias 
  1/1/2013
• Clinical conundrum: an 80 year old woman with atrial fibrillation 
  Charlotte, N.C. - 1/1/2013
• Antiphospholipid antibodies and pregnancy. 
  Amsterdam, NL - 1/1/2013
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