KelvinDMacDonaldMD

PubMed

• 18 citations
  Inhaled mRNA therapy for treatment of cystic fibrosis: Interim results of a randomized, double-blind, placebo-controlled phase 1/2 clinical study.
  Rowe, S., Zuckerman, J., Dorgan, D., Lascano, J., McCoy, K., Jain, M., Schechter, M., Lommatzsch, S., Indihar, V., Lechtzin, N., McBennett, K., Callison, C., Brown, C....> ;Journal of Cystic Fibrosis. 2023 Jul 1
• 5 citations
  Functional evaluation of the cystic fibrosis transmembrane conductance regulator in the endocervix†.
  Leo Han, Mackenzie Roberts, Addie Luo, Shuhao Wei, Ov D Slayden, Kelvin D Macdonald> ;Biology of Reproduction. 2022 Sep 12
• 7 citations
  Effect of Vitamin C Supplementation for Pregnant Smokers on Offspring Airway Function and Wheeze at Age 5 Years: Follow-up of a Randomized Clinical Trial.
  Cindy T McEvoy, Lyndsey E Shorey-Kendrick, Kristin Milner, Julia Harris, Brittany Vuylsteke, Michelle Cunningham, Christina Tiller, Jaclene Stewart, Diane Schilling, J...> ;JAMA Pediatrics. 2023 Jan 1
• 48 citations
  Engineering Lipid Nanoparticles for Enhanced Intracellular Delivery of mRNA through Inhalation.
  Jeonghwan Kim, Antony Jozic, Yuxin Lin, Yulia Eygeris, Elissa Bloom, Xiaochen Tan, Christopher Acosta, Kelvin D MacDonald, Kevin D Welsher, Gaurav Sahay> ;ACS Nano. 2022 Sep 27
• 2 citations
  Evaluation of rescue oral glucocorticoid therapy during inpatient cystic fibrosis exacerbations.
  Corinne A. Muirhead, Natalie Lanocha, Sheila Markwardt, Kelvin D. MacDonald> ;Pediatric Pulmonology. 2021 May 1
• 11 citations
  Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis-based cell and mice models
  Anindit Mukherjee, Kelvin D. MacDonald, Jeonghwan Kim, Michael I. Henderson, Yulia Eygeris, Gaurav Sahay> ;Science Advances. 2020 Nov 18
• 3 citations
  Chinstraps are needed for neonatal nasal CPAP: Reflections from a non-human primate model
  Kelvin D. MacDonald, Michael H. Davies, Ryan Lam, Kelli Lund, Byung Park, Eliot R. Spindel, Robert S. Tepper, Cindy T. McEvoy> ;Pediatric Pulmonology. 2020 Mar 6
• 33 citations
  The Effect of Extended Continuous Positive Airway Pressure on Changes in Lung Volumes in Stable Premature Infants: A Randomized Controlled Trial.
  Ryan Lam, Diane Schilling, Brian Scottoline, Astrid S. Platteau, Meike Niederhausen, Kelli Lund, Robert L. Schelonka, Kelvin D. MacDonald, Cindy T. McEvoy> ;The Journal of Pediatrics. 2020 Feb 1
• 145 citations
  Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis
  Ema Robinson, Kelvin D. MacDonald, Kai Slaughter, Madison McKinney, Siddharth Patel, Conroy Sun, Gaurav Sahay> ;Molecular Therapy. 2018 Aug 1
• 7 citations
  Cost effectiveness of vitamin c supplementation for pregnant smokers to improve offspring lung function at birth and reduce childhood wheeze/asthma
  Leah Yieh, Cindy T. McEvoy, Scott W. Hoffman, Aaron B. Caughey, Kelvin D. MacDonald, Dmitry Dukhovny> ;Journal of Perinatology. 2018 May 22
• 3 citations
  Evaluation of the Risk for Acute Kidney Injury in Adult Cystic Fibrosis Patients Receiving Concomitant Vancomycin and Tobramycin.
  Corinne A. Muirhead, Jeong Y Lim, Jodi Lapidus, Kelvin D. MacDonald> ;Cureus. 2017 Dec 6
• 16 citations
  Maternal high-fat diet in mice leads to innate airway hyperresponsiveness in the adult offspring.
  Kelvin D. MacDonald, Aurelia R. Moran, Ashley Scherman, Cindy T. McEvoy, Astrid S. Platteau> ;Physiological Reports. 2017 Mar 1
• 6 citations
  Maternal body mass index before pregnancy is associated with increased bronchodilator dispensing in early childhood: A cross-sectional study.
  Kelvin D. MacDonald, Kimberly K Vesco, Kristine L. Funk, Jerena Donovan, Thuan Nguyen, Zunqiu Chen, Jodi Lapidus, Victor J. Stevens, Cindy T. McEvoy> ;Pediatric Pulmonology. 2016 Jan 21
• 3 citations
  One Center's Guide to Outpatient Management of Pediatric Cystic Fibrosis Acute Pulmonary Exacerbation
  Corinne A. Muirhead, Jillian N. Sanford, Benjamin G. McCullar, Dawn Nolt, Kelvin D. MacDonald> ;Clinical Medicine Insights. Pediatrics. 2016 Jul 12
• 15 citations
  Aqueous cigarette smoke extract induces a voltage-dependent inhibition of CFTR expressed in Xenopus oocytes
  Aurelia R. Moran, Yohei Norimatsu, David C. Dawson, Kelvin D. MacDonald> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2014 Feb 1
• 37 citations
  A simple method of mouse lung intubation.
  Sandhya Das, Kelvin D. MacDonald, Herng Yu Sucie Chang, Wayne Mitzner> ;Journal of Visualized Experiments. 2013 Mar 21
• 31 citations
  Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP4)
  Yohei Norimatsu, Aurelia R. Moran, Kelvin D. MacDonald> ;Biochemical and Biophysical Research Communications. 2012 Sep 28
• 18 citations
  DNA Double-Strand Breaks and DNA Recombination in Benzene Metabolite–Induced Genotoxicity
  Emily W.Y. Tung, Nicola A. Philbrook, Katharine D. D. MacDonald, Louise M. Winn> ;Toxicological Sciences. 2012 Apr 1
• 18 citations
  Oral antimicrobial use in outpatient cystic fibrosis pulmonary exacerbation management: a single‐center experience
  Elissa Charlotte Briggs, Thuan Nguyen, Michael A. Wall, Kelvin D. MacDonald> ;The Clinical Respiratory Journal. 2012 Jan 1
• 4 citations
  Primary snoring and growth failure in a patient with cystic fibrosis.
  Kelvin D. MacDonald, Brian M. McGinley, David J. Brown, Laura M. Sterni, Beryl J. Rosenstein, Peter J. Mogayzel> ;Respiratory Care. 2009 Dec 1
• 40 citations
  An improved simple method of mouse lung intubation
  Kelvin D. MacDonald, Herng Yu Sucie Chang, Wayne Mitzner> ;Journal of Applied Physiology. 2009 Mar 1
• 1 citations
  Tracheal bronchus in a 6-month-old infant identified by CT with three-dimensional airway reconstruction
  W A Gower, S A McGrath-Morrow, Kelvin D. MacDonald, E K Fishman> ;BMJ Case Reports. 2009 Jan 1
• 13 citations
  Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway.
  Lihua Liang, Kelvin D. MacDonald, Erik M. Schwiebert, Pamela L. Zeitlin, William B. Guggino> ;American Journal of Physiology. Cell Physiology. 2009 Jan 1
• 29 citations
  Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice
  Kelvin D. MacDonald, Karen R. McKenzie, Mark J. Henderson, Charles E. Hawkins, Neeraj Vij, Pamela L. Zeitlin> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2008 Sep 19
• 4 citations
  Tracheal bronchus in a 6-month-old infant identified by CT with three-dimensional airway reconstruction
  W A Gower, S A McGrath-Morrow, Kelvin D. MacDonald, E K Fishman> ;Thorax. 2008 Jan 1
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Journal Articles

• Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway  
  Liang L, Macdonald K, Schwiebert EM, Zeitlin PL, Guggino WB, Am J Physiol Cell Physiol, 1/1/2009
• Lubiprostone Activates non-CFTR dependent Respiratory Epithelial Chloride Secretion in Cystic Fibrosis Mice  
  Macdonald KD, McKenzie KR, Zeitlin PL, Am J Physiol Lung Cell Mol Physiol, 1/1/2008
• Cystic Fibrosis Transmembrane Regulator [CFTR] Protein mutations “Class” Opportunity for Novel Drug Innovation  
  Macdonald KD, McKenzie KR, Zeitlin PL, Paediatr Drugs, 1/1/2007
• Electrolyte Determination on Arterial Blood Gas Samples: More Tools for the RCP  
  MacDonald KD. Cockerham C, RT Journal, 1/1/1999
• Applied Pulmonary Mechanics  
  MacDonald KD, Wirtschafter DD, Neo Inten Care, 1/1/1992
• Just in Time: Infant Synchronous Ventilation  
  MacDonald KD, Wagner W, RT Journal, 1/1/1992
• Pulmonary Mechanics Measurements Improve Neonatal Ventilation  
  MacDonald KD, RC Advance, 1/1/1992
• Considerations when Using the Novametrix C/D Adaptor During HFOV Letter to the Editor  
  MacDonald KD, Wagner W, Resp Care, 1/1/1991
• Pediatric PFT carts, is there a “Gold standard”? Letter to the Editor  
  MacDonald KD, Wang PB, Resp Care, 1/1/1989
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Books/Book Chapters

• Respiratory Care Clinics of North America 
  Chapter: Volume and Pressure Controlled Ventilation in PICU 
  Page 607 - 618MacDonald KD, Johnson SEditors: Sayler J.WB Saunders1996
• Neonatal Pulmonary Mechanics: A Casebook 
  Cventnic W, MacDonald, KDBicore Professional Publications1994
• Year Book of Neonatal and Perinatal Medicine 
  Chapter: Computerized Pulse Oximetry and Pulmonary Mechanics in Intubated Low birth Weight Infants with Acute and Chronic Lung Disease (CLD) 
  Page 246 - 248Durand M, McEvoy C, MacDonald KEditors: Klaus MH, Fanaroff AA.Mosby, Baltimore, MD1993

Abstracts/Posters

• So You Think You Can Dance: Pilot Testing Of Exergaming With Youth In The Inpatient Setting
  Wilson AC, Cusick J, Klein, B, MacDonald, KD, Pediatric Pulm, 1/1/2016
• High-Fat Diet Before And During Pregnancy Increases Airway Hyperreactivity In Offspring
  MacDonald KD, Moran AR, Plateau A, McEvoy CR, Am. J. Respir. Crit. Care Med., 1/1/2015
• Maternal Obesity Before Pregnancy Is Associated With Increased Steroid Prescriptions In Early Childhood
  MacDonald KD, Vesco K, Nguyen T, Funk K , Donovan J, Webster J, Stevens V, McEvoy CR, Am. J. Respir. Crit. Care Med., 1/1/2015
• Vancomycin and Tobramycin Concomitant Therapy Does Not Lead to Reduction in GFR Compared To Monotherapy in CF Patients
  Muirhead C, Lim JY, Lapidus JA, MacDonald KD, Pediatr. Pulmonol., 1/1/2014
• Cigarette Smoke Extract Induces A Rapid, Voltage-Dependent Block of CFTR
  MacDonald KD, Moran AR, Norimatsu Y, Dawson DC, Am. J. Respir. Crit. Care Med., 1/1/2013
• Excessive Gestational Weight Gain in Women with a Normal Pregravid Body Mass Index is Associated with Increased Bronchodilator Prescriptions in Early Childhood
  McEvoy C, MacDonald KD, Vesco K, Nguyen T, Funk K, Donovan J, V Stevens V, PAS Annual Meeting, 1/1/2012
• Increased Pregravid Body Mass Index Is Associated With Subsequent Bronchodilator Prescriptions In Early Childhood
  MacDonald KD, Vesco K, Nguyen T, Funk K, Stevens V, McEvoy C, Am. J. Respir. Crit. Care Med., 1/1/2012
• Acute inhibition of CFTR by aqueous components of cigarette smoke and rescue by PG-01, a CFTR potentiator
  MacDonald KD, Moran AR, Dawson DC, National Institute of Child Health and Human Development (NICHD) Child Health Research Centers Annual Meeting, Santa Monica, CA, 1/1/2012
• Nasal Potential Difference (NPD) Is A Useful Diagnostic Modality For Individuals With Some Features Of Classic CF And Non-diagnostic Sweat Electrolytes or CFTR Mutatio...
  Callahan KA, Sturner RA, Walker DM, Curtin-Brosnan J, MacDonald KD, Zeitlin PL, Pediatr. Pulmonol., 1/1/2012
• Aerosol Delivery Of Methacholine During Oral Intubated Measurement Of Murine Lung Mechanics
  MacDonald KD, McEvoy C, Minor NC, Scott GD, Am. J. Respir. Crit. Care Med., 1/1/2012
• Butyrate derivatives increase short circuit current in F508del CFTR expressing Fisher Rat thyroid cells
  MacDonald KD, Moran AR, Mason AK, Zeitlin PL, Pediatric Pulm, 1/1/2011
• Pulmonary exacerbation scoring during telephone triage: a single center experience
  MacDonald KD, McCullar BG, Kraynack NC, Pediatric Pulm, 1/1/2011
• Lubiprostone activates CFTR via EP4, not ClC-2
  MacDonald KD, Norimatsu Y, Moran AR, Dawson D, National Institute of Child Health and Human Development (NICHD) Child Health Research Centers Annual Meeting, Raleigh – Durham, NC, 1/1/2011
• Cobiprostone induces CFTR dependent and independent currents in Calu-3 airway epithelial cells
  MacDonald KD, Moran AR, Dawson D, National Institute of Child Health and Human Development (NICHD) Child Health Research Centers Annual Meeting, Philadelphia, PA, 1/1/2010
• Patient factors associated with failure of oral antibiotic therapy in cystic fibrosis pulmonary exacerbation
  MacDonald, KD, Briggs EC, Nguyen T, Wall MA, Pediatric Pulm, 1/1/2010
• A Novel Oral Short Chain Fatty Acid Restores Chloride Transport In F508del Cystic Fibrosis Mice
  MacDonald KD, Henderson M, Kamal M, Nguyen T, Perrine SP, Zeitlin PL, Am. J. Respir. Crit. Care Med., 1/1/2010
• MacDonald KD, Shin G, Flotte TR, Zeitlin PL, Fischer AC, Mol Ther, 1/1/2008
• ClC-2 Expression Impacts Perinatal Survival in Cystic Fibrosis Knockout Mice.
  Zeitlin PL, MacDonald KD, Vij N, Am. J. Respir. Crit. Care Med., 1/1/2008
• Lung Mechanics in Heterozygous CF Mice after Repeated LPS Dosing
  MacDonald KD, McKenzie KR, Mitzner W, Zeitlin PL, Proceedings of the American Thoracic Society International Meeting, 1/1/2007
• 3H-Adenosine 5’-Monophosphate (3H-AMP) Lung Uptake as a Marker of Normal Pulmonary Function in a Mouse Model of LPS Induced Lung Inflammation
  Cho S, MacDonald KD, Zeitlin PL, Wahl R, J Nucl Med, 1/1/2007
• Zeitlin, P.L. Activation of nasal epithelial ClC-2 channels rescues chloride transport in cystic fibrosis mice
  MacDonald KD, McKenzie KR, Vij N, Henderson MJ, Zeitlin PL, Pediatric Pulm, 1/1/2007
• Functional Expression of hClC2 in a Transgenic Murine Model
  Macdonald KD, Vij N, Zeitlin PL, Proc of ATS, 1/1/2006
• Repeated Measure of Murine Lung Mechanics by End Inflation Occlusion
  Macdonald KD, Mitzner W, Zeitlin PL, Proc of ATS, 1/1/2006
• Enhanced ClC-2 Mediated Chloride Transport in K18rtTAhClC-2 Mouse Nasal Epithelia
  MacDonald KD, Vij N, Zeitlin PL, North American Cystic Fibrosis Conference, 1/1/2006
• Use of a Hot Wire Anemometer in the Differential Diagnosis of Neonatal Endotracheal Tube Obstruction
  MacDonald KD, Wirtschafter DD, Franceschini R, McEvoy C, Resp Care, 1/1/1988
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Lectures

• Maternal Obesity and Childhood Lung Health 
  Portland, OR - 1/1/2017
• Maternal Obesity and Airway Hyperreactivity in the Offspring 
  Seattle, WA - 1/1/2015
• Maternal Origins of Pediatric Asthma 
  Portland, OR - 1/1/2015
• CFTR Modulators 
  1/1/2014
• Cystic Fibrosis New and Updated Therapeutics 
  Portland, OR - 1/1/2011
• Cystic Fibrosis Therapeutics Update 
  Portland, OR - 1/1/2011
• Alternate chloride channels in Cystic Fibrosis 
  Seattle, WA - 1/1/2010
• Otolaryngologic Manifestations of Cystic Fibrosis 
  1/1/2009
• Primary snoring and growth failure in a patient with Cystic Fibrosis 
  1/1/2008
• Home Respiratory Care 
  1/1/2008
• Thirteen Month Old Premature Infant with Chronic Lung Disease and Snoring 
  1/1/2006
• Synchronous Infant Ventilation and Pressure Support Ventilation in Children 
  Fukuoka, Japan - 1/1/1992
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Other

• Contributor to Basic Science of Cystic Fibrosis and Living with CF: Medications 
  MacDonald KD, Johns Hopkins CF Information website
  www.hopkinscf.org
  1/1/2006