KennethE.ShermanMDPhD

Hepatology & Liver Transplantation

Distinguished University Research Professor and Emeritus Professor of Medicine- University of Cincinnati College of Medicine Physician in Medicine- Massachusetts General Hospital

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Office
Gastroenterology Division
55 Fruit Street
Boston, MA 02114
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Education & Training

Fitzsimons Army Medical CenterGastroenterology, 1989 - 1991
Tripler Army Medical CenterResidency, Internal Medicine, 1985 - 1988
George Washington University School of Medicine and Health SciencesClass of 1985
Rutgers UniversityPhD, Microbiology, Busch Pre-doctoral Fellowship, 1976 - 1980

Certifications & Licensure

OH State Medical License 1994 - 2026
MA State Medical License 2019 - 2024
CO State Medical License 1991 - 2011
NJ State Medical License 1987 - 1995
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Fellow American Gastroenterologic Association, 2017
AOA Alpha Omega Alpha- University of Cincinnati
Fellow, American Association for the Study of Liver Diseases AASLD, 2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012
Fellow (FACG) American College of Gastroenterology
Fellow, American College of Physicians American College of Physicians
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Clinical Trials

Treatment of Hepatitis in Patients Who Are Triple-Infected With HIV, Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV)
Withdrawn
Phase 2
Treatment of Hepatitis C in Hemophilic Patients With HIV Start of enrollment: 2002 Mar 01
Completed
Phase 2
Pegylated Interferon Alfa-2a Maintenance Therapy and Liver Disease Progression in People Infected With Both HIV and Hepatitis C Virus (HCV) Start of enrollment: 2004 Jul 01
Completed
Phase 2
Effects of Anti-HIV Drugs on the Hepatitis C Virus (HCV) in Adults Infected With Both HCV and HIV Start of enrollment: 2006 Apr 01
Completed
Phase 1
A Study Evaluating 24-Week and 48-Week Telaprevir-Based Regimen in Treatment Naïve Subjects With Genotype 1 Chronic Hepatitis C Who Achieve an Extended Rapid Viral Response Start of enrollment: 2008 Oct 01
Completed
Phase 3
HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network Start of enrollment: 2011 Nov 01
Completed
Evaluating the Effectiveness of Boceprevir, Pegylated-Interferon Alfa 2b and Ribavirin in Treating Hepatitis C Virus (HCV) Infection in Adults With HIV and HCV Infection Start of enrollment: 2012 Apr 01
Completed
Phase 3
Viral Kinetics in HCV Clearance in Subjects With Hemophilia Start of enrollment: 2012 Dec 01
Completed
Phase 1
Study of Oral Treatments for Hepatitis C Start of enrollment: 2016 Jun 01
Completed
Phase 4
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Publications & Presentations

PubMed

1 citations
Triple Threat: HDV, HBV, HIV Coinfection.
Debra W Yen, Vicente Soriano, Pablo Barreiro, Kenneth E Sherman> ;Clinics in Liver Disease. 2023 Nov 1
5 citations
Hepatitis E virus: has anything changed?
Alexandra N Willauer, Kenneth E Sherman> ;Current Opinion in Gastroenterology. 2023 May 1
3 citations
Impact of Prior Drug Allergies on the Risk, Clinical Features, and Outcomes of Idiosyncratic Drug-Induced Liver Injury in Adults.
Amoah Yeboah-Korang, Ahmed Memon, Neil Patel, Andrea Portocarrero-Castillo, Askanda Osman, David Kleesattel, Carmen Lopez, Jeremy Louissaint, Kenneth Sherman, Robert F...> ;Digestive Diseases and Sciences. 2022 Nov 1
4 citations
Cocaethylene, simultaneous alcohol and cocaine use, and liver fibrosis in people living with and without HIV.
Javier A Tamargo, Kenneth E Sherman, Rafick-Pierre Sékaly, Rebeka Bordi, Daniela Schlatzer, Shenghan Lai, Jag H Khalsa, Raul N Mandler, Richard L Ehman, Marianna K Baum> ;Drug and Alcohol Dependence. 2022 Mar 1
1 citations
Long-term Follow-up of Hepatitis C Patients Who Achieved Sustained Virologic Response in the Pragmatic PRIORITIZE Study.
Anna S Lok, Juhi Moon, Kenneth E Sherman, Mandana Khalili, Dawn Fishbein, K Rajender Reddy> ;Clinical Gastroenterology and Hepatology. 2023 Feb 1
8 citations
Drugs of Abuse and Their Impact on Viral Pathogenesis
Jason T. Blackard, Kenneth E. Sherman> ;Viruses. 2021 Nov 29
2 citations
Predictors of outcomes following liver transplant in hepatopulmonary syndrome: An OPTN database analysis.
Arun Jose, Shimul A. Shah, Nadeem Anwar, Courtney R. Jones, Francis X. McCormack, Kenneth E. Sherman, Jean M. Elwing> ;Respiratory Medicine. 2021 Nov 11
1 citations
Incorporating Patients' Values and Preferences Into Decision Making About Transplantation of HCV-Naïve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility S...
Mark H. Eckman, Adeboye A. Adejare, Heather J. Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway, Kenneth E. Sherman> ;MDM Policy & Practice. 2021 Oct 29
1 citations
CCR5+ T-Cells Homed to the Liver Exhibit Inflammatory and Profibrogenic Signatures in Chronic HIV/HCV-Coinfected Patients.
Shikha Shrivastava, Shyam Kottilil, Kenneth E. Sherman, Henry Masur, Lydia Tang> ;Viruses. 2021 Oct 14
3 citations
A Pragmatic, Randomized Controlled Trial of Oral Antivirals for the Treatment of Chronic Hepatitis C: The PRIORITIZE Study.
Mark S. Sulkowski, Juhi S Moon, Kenneth E. Sherman, Giuseppe Morelli, Jama M. Darling, Andrew J. Muir, Mandana Khalili, Dawn Fishbein, Federico Hinestrosa, Mitchell L....> ;Hepatology. 2021 Aug 26
2 citations
Immune activation: A link between food insecurity and chronic disease in people living with HIV.
Javier Tamargo, Jacqueline Hernandez-Boyer, Colby Teeman, Haley R Martin, Yongjun Huang, Angelique Johnson, Adriana Campa, Sabrina Sales Martinez, Tan Li, Susan D. Rou...> ;The Journal of Infectious Diseases. 2021 May 16
11 citations
Pulmonary Vascular Resistance Predicts Mortality and Graft Failure in Transplantation Patients With Portopulmonary Hypertension.
Arun Jose, Shimul A. Shah, Nadeem Anwar, Courtney R. Jones, Kenneth E. Sherman, Jean M. Elwing> ;Liver Transplantation. 2021 Jun 29
9 citations
Soluble CD163 Identifies Those at Risk for Increased Hepatic Inflammation & Fibrosis.
Kenneth E. Sherman, Heidi L Meeds, Susan D. Rouster, Enass A. Abdel-hameed, Jacqueline Hernandez, Javier Tamargo, Jun Chen, Richard L. Ehman, Marianna K Baum> ;Open Forum Infectious Diseases. 2021 Apr 22
5 citations
The synthetic opioid fentanyl enhances viral replication in vitro.
Ling Kong, Rebekah Karns, Mohamed T. Shata, Jennifer L. Brown, Michael S. Lyons, Kenneth E. Sherman, Jason T. Blackard> ;Plos One. 2021 Apr 14
2 citations
Hepatitis E Infection in a Longitudinal Cohort of Hepatitis C Virus and HCV/HIV Coinfected Persons.
Kenneth E. Sherman, Shyam Kottilil, Susan D. Rouster, Enass A. Abdel-hameed, Ceejay L. Boyce, Heidi L Meeds, Norah A. Terrault, M. Tarek Shata> ;AIDS Research and Human Retroviruses. 2021 Jul 1
2 citations
PNPLA3 Single Nucleotide Polymorphism Prevalence and Association with Liver Disease in a Diverse Cohort of Persons Living with HIV.
Kenneth E. Sherman, Susan D. Rouster, Heidi L Meeds, Javier Tamargo, Jun Chen, Richard L. Ehman, Marianna Baum> ;Biology. 2021 Mar 21
3 citations
Food Insecurity and Cognitive Impairment in the Miami Adult Studies on HIV (MASH) Cohort.
Javier Tamargo, Christina S. Meade, Adriana Campa, Sabrina Sales Martinez, Tan Li, Kenneth E. Sherman, Marianna Baum> ;The Journal of Nutrition. 2021 Apr 8
17 citations
Food insecurity is associated with magnetic resonance-determined nonalcoholic fatty liver and liver fibrosis in low-income, middle-aged adults with and without HIV.
Javier Tamargo, Kenneth E. Sherman, Adriana Campa, Sabrina Sales Martinez, Tan Li, Jacqueline Hernandez, Colby Teeman, Raul N. Mandler, Jun Chen, Richard L. Ehman, Mar...> ;The American Journal of Clinical Nutrition. 2021 Mar 11
10 citations
Heroin use is associated with liver fibrosis in the Miami Adult Studies on HIV (MASH) cohort.
Marianna Baum, Javier Tamargo, Richard L. Ehman, Kenneth E. Sherman, Jun Chen, Qingyun Liu, Raul N. Mandler, Colby Teeman, Sabrina Sales Martinez, Adriana Campa> ;Drug and Alcohol Dependence. 2021 Mar 1
4 citations
Cognitive Impairment among People Who Use Heroin and Fentanyl: Findings from the Miami Adult Studies on HIV (MASH) Cohort.
Javier A. Tamargo Ms, Adriana Campa, Sabrina Sales Martinez, Tan Li, Kenneth E. Sherman, Gustavo G. Zarini, Christina S. Meade, Raul N. Mandler, Marianna Baum> ;Journal of Psychoactive Drugs. 2021 May 27
3 citations
Safety and Efficacy of Budesonide for Liver Transplant Immune Suppression: Results of a Pilot Phase 2a Trial.
Khurram Bari, Shimul A. Shah, Tiffany E. Kaiser, Robert M. Cohen, Nadeem Anwar, David Kleesattel, Kenneth E. Sherman> ;Liver Transplantation. 2020 Nov 1
Sustained Virologic Response of Patients Hospitalized Compared With Those Not Hospitalized During Treatment for Hepatitis C Virus With Direct-Acting Antivirals:
Anthony J Gentene, Allison M. Bell, Alicia Pence, Kelly M. Thomas, Collin Jakubecz, Elizabeth Stacy, Brittany Woolf, Maria Guido, Eric W. Mueller, Kenneth E. Sherman> ;The Annals of Pharmacotherapy. 2021 May 1
8 citations
Sex Differences, Cocaine Use, and Liver Fibrosis Among African Americans in the Miami Adult Studies on HIV Cohort.
Gustavo G. Zarini, Sabrina Sales Martinez, Adriana Campa, Kenneth E. Sherman, Javier Tamargo, Jacqueline Hernandez Boyer, Colby Teeman, Angelique Johnson, Abraham Dega...> ;Journal of Women's Health. 2020 Sep 14
45 citations
Multicenter study to transplant hepatitis C-infected kidneys (mythic): An open-label study of combined glecaprevir and pibrentasvir to treat recipients of transplanted...
Meghan E. Sise, David S. Goldberg, Jens Kort, Douglas E. Schaubel, Rita R. Alloway, Christine M. Durand, Robert J. Fontana, Robert S. Brown, John J. Friedewald, Stacey...> ;Journal of the American Society of Nephrology. 2020 Aug 25
28 citations
Treatment of HCV reduces viral hepatitis-associated liver-related mortality in patients: An ERCHIVES study.
Adeel A. Butt, Peng Yan, Obaid S. Shaikh, Vincent Lo Re, Abdul-Badi Abou-Samra, Kenneth E. Sherman> ;Journal of Hepatology. 2020 Aug 1
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Other

Monitoring the HIV-infected patient with chronic hepatitis B virus infection
Sherman KE, McGovern BH
http://www.uptodate.com/contents/monitoring-the-hiv-infected-patient-with-chronic-hepatitis-b-virus-
UpToDate, Wolters Kluwer Health - 2013-01-03
Prevention of hepatitis B virus infection in the HIV-infected adult
Sherman KE, McGovern BH
http://www.uptodate.com/contents/prevention-of-hepatitis-b-virus-infection-in-the-hiv-infected-adult
UpToDate, Wolters Kluwer Health - 2013-02-05
Treatment of hepatitis B in the HIV-infected patient
Sherman KE, McGovern BH
http://www.uptodate.com/contents/treatment-of-hepatitis-b-in-the-hiv-infected-patient
UpToDate, Wolters Kluwer Health - 2012-09-28
Epidemiology, clinical manifestations, and diagnosis of hepatitis B in the HIV-infected patient
Sherman KE, McGovern BH
http://www.uptodate.com/contents/epidemiology-clinical-manifestations-and-diagnosis-of-hepatitis-b-i
UpToDate, Wolters Kluwer Health - 2013-01-31
Antiviral medications for the treatment of hepatitis B in the HIV-infected patient
Sherman KE, McGovern BH
http://www.uptodate.com/contents/antiviral-medications-for-the-treatment-of-hepatitis-b-in-the-hiv-i
UpToDate, Wolters Kluwer Health - 2011-02-18
Evaluation of chronic hepatitis B virus infection in the HIV-infected patient
Sherman KE, McGovern BH
http://www.uptodate.com/contents/evaluation-of-chronic-hepatitis-b-virus-infection-in-the-hiv-infect
UpToDate, Wolters Kluwer Health - 2013-01-10
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Press Mentions

People with HIV Can Be Protected Against Hepatitis B with a Three-Dose Vaccine RegimenOctober 24th, 2022
Extra Hep B Vaccine Dose Exceeds Expectations for People with HIVOctober 23rd, 2022
Medical News Today: Liver Health in HIV: This Gene Indicates New Therapeutic TargetsDecember 14th, 2019
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Grant Support

Liver Disease And HIVNational Institute Of Allergy And Infectious Diseases2006–2012
Mentorship In Liver DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2005–2012
Antiretroviral Therapy And The Hepatitis C VirusNational Institute Of Allergy And Infectious Diseases2006–2010
Antiretroviral Therapy And HCV/HIVNational Center For Research Resources2008
Response Of Hepatitis C Virus To Interferon In Hemophilic PatientsNational Center For Research Resources2005–2006
Hepatitis C Virus Response To Interferon In HemophiliaNational Center For Research Resources2004
HCV Genomic Variability In HIV Infected HemophiliacsNational Institute Of Allergy And Infectious Diseases2001–2004
Health Utilities In Hepatitis C Infected PatientsAgency For Healthcare Research And Quality1999