KennethDWestoverMDPhD

PubMed

• Adapt-On-Demand: A Novel Strategy for Personalized Adaptive Radiotherapy for Locally Advance Lung Cancer.
  Ruiqi Li, Tingliang Zhuang, Kai Wang, David Parsons, Jing Wang, Andrew Godley, Bin Cai, Mu-Han Lin, Steven Montalvo, Yuanyuan Zhang, Puneeth Iyengar, Kenneth Westover> ;Practical Radiation Oncology. 2024 Apr 3
• Another KRAS variant trapped.
  Kenneth Westover> ;Nature Chemical Biology. 2024 Mar 5
• CheckMate Check-In: Playbook for a Cancelled Surgery.
  Badiyan, S., Westover, K.> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Mar 1
• 1 citations
  GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
  Dong-Min Yu, Eunice E Lee, Dohun Kim, Ruchika Mahapatra, Elysha K Rose, Zhiwei Zhou, Calvin Hosler, Abdullah El Kurdi, Jun-Yong Choe, E Dale Abel, Gerta Hoxhaj, Kennet...> ;The Journal of Clinical Investigation. 2023 Nov 1
• Dynamic ultrasound molecular-targeted imaging of senescence in evaluation of lapatinib resistance in HER2-positive breast cancer.
  Xiaoyu Chen, Ying Li, Zhiwei Zhou, Yanqiu Zhang, Luchen Chang, Xiujun Gao, Qing Li, Hao Luo, Kenneth D Westover, Jialin Zhu, Xi Wei> ;Cancer Medicine. 2023 Oct 1
• 5 citations
  Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1.
  Wenchao Lu, Yao Liu, Yang Gao, Qixiang Geng, Deepak Gurbani, Lianbo Li, Scott B Ficarro, Cynthia J Meyer, Dhiraj Sinha, Inchul You, Jason Tse, Zhixiang He, Wenzhi Ji, ...> ;Journal of Medicinal Chemistry. 2023 Mar 9
• 9 citations
  Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability.
  Kari Kopra, Salla Valtonen, Randa Mahran, Jonas N Kapp, Nazia Hassan, William Gillette, Bryce Dennis, Lianbo Li, Kenneth D Westover, Andreas Plückthun, Harri Härmä> ;International Journal of Molecular Sciences. 2022 Jun 26
• T Stage and Pretreatment Standardized Uptake Values Predict Tumor Recurrence With 5-Fraction SABR in Early-Stage Non-Small Cell Lung Cancer.
  Eric J Hsu, Jameson T Mendel, Kristin A Ward, Mariam El-Ashmawy, Minjae Lee, Hak Choy, Kenneth D Westover, Dat T Vo, Robert D Timmerman, David J Sher, Puneeth Iyengar> ;Advances in Radiation Oncology. 2022 May 21
• 3 citations
  Therapeutic Targeting the Allosteric Cysteinome of RAS and Kinase Families.
  Lianbo Li, Cynthia Meyer, Zhi-Wei Zhou, Ammar Elmezayen, Kenneth Westover> ;Journal of Molecular Biology. 2022 Sep 15
• 1 citations
  Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.
  Zhengnian Li, Ryosuke Ishida, Yan Liu, Jinhua Wang, Yina Li, Yang Gao, Jie Jiang, Jianwei Che, Jason M Sheltzer, Matthew B Robers, Tinghu Zhang, Kenneth D Westover, Be...> ;European Journal of Medicinal Chemistry. 2022 Aug 5
• 2 citations
  ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis.
  Nora-Guadalupe P Ramirez, Jeon Lee, Yue Zheng, Lianbo Li, Bryce Dennis, Didi Chen, Ashwini Challa, Vicente Planelles, Kenneth D Westover, Neal M Alto, Iván D'Orso> ;Nature Communications. 2022 Mar 1
• Acid-Catalyzed Synthesis of Isatoic Anhydride-8-Secondary Amides Enables IASA Transformations for Medicinal Chemistry.
  Sudershan R Gondi, Althaf Shaik, Kenneth D Westover> ;The Journal of Organic Chemistry. 2022 Jan 7
• Case Report: Resolution of radiation pneumonitis with androgens and growth hormone.
  Allen Yen, Kenneth D Westover> ;Frontiers in Oncology. 2022 Jan 1
• 30 citations
  Accelerated Hypofractionated Image-Guided vs Conventional Radiotherapy for Patients With Stage II/III Non-Small Cell Lung Cancer and Poor Performance Status: A Randomi...
  Puneeth Iyengar, E.R. Zhang-Velten, Laurence E. Court, Kenneth D. Westover, Yulong Yan, Mu-Han Lin, Zhenyu Xiong, M.K. Patel, Douglas Rivera, Joe Chang, Mark W. Saunde...> ;JAMA Oncology. 2021 Oct 1
• 30 citations
  A structural model of a Ras-Raf signalosome.
  Venkatesh Mysore, Zhi Wei Zhou, Chiara Ambrogio, Lianbo Li, Jonas N. Kapp, Chunya Lu, Qi Wang, Maxwell R. Tucker, Jeffrey J. Okoro, Gabriela Nagy-Davidescu, Xiao Chen ...> ;Nature Structural & Molecular Biology. 2021 Oct 1
• 16 citations
  PD-L1P146R is prognostic and a negative predictor of response to immunotherapy in gastric cancer.
  Qing Li, Zhi Wei Zhou, Jia Lu, Hao Luo, Shu Nan Wang, Yu Peng, Meng Sheng Deng, Guan Bin Song, Jian-Min Wang, Xi Wei, Dong Wang, Kenneth D. Westover, Cheng Xiong Xu> ;Molecular Therapy. 2021 Sep 18
• 5 citations
  Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations.
  Paul Yenerall, Rahul K. Kollipara, Kimberley Avila, Michael Peyton, Christopher A. Eide, Daniel Bottomly, Shannon K. McWeeney, Yan Liu, Kenneth D. Westover, Brian J. D...> ;Cancer Research. 2021 Sep 15
• 26 citations
  Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT
  Qing Li, Zhi Wei Zhou, Wei Duan, Cheng Yuan Qian, Shu Nan Wang, Meng Sheng Deng, Dan Zi, Jian-Min Wang, Cheng Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover, Che...> ;Journal of Experimental & Clinical Cancer Research. 2021 Jul 1
• 1 citations
  Rapid assessment of DCLK1 inhibitors using a peptide substrate mobility shift assay.
  Yan Liu, Kenneth D. Westover> ;STAR Protocols. 2021 Jun 9
• The to and fro of Rho.
  Kenneth D. Westover> ;Structure. 2021 Jun 3
• 7 citations
  The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51
  Jung Mi Park, Seung Wook Yang, Wei Zhuang, Asim K. Bera, Yan Liu, Deepak Gurbani, Sergei J. von Hoyningen-Huene, Sadie Miki Sakurada, Haiyun Gan, Shondra M. Pruett-Mil...> ;Plos Biology. 2021 Jun 2
• 2 citations
  Contact Tracing in Healthcare Settings During the COVID-19 Pandemic Using Bluetooth Low Energy and Artificial Intelligence-A Viewpoint
  Guanglin Tang, Kenneth D. Westover, Steve B. Jiang> ;Frontiers in Artificial Intelligence. 2021 Apr 23
• 7 citations
  Loss of wild type KRAS in KRASMUT lung adenocarcinoma is associated with cancer mortality and confers sensitivity to FASN inhibitors
  Yan Liu, Galen F. Gao, John D. Minna, Noelle S. Williams, Kenneth D. Westover> ;Lung Cancer. 2021 Mar 1
• 21 citations
  Phase II trial of hippocampal-sparing whole brain irradiation with simultaneous integrated boost for metastatic cancer
  Kenneth D. Westover, J. Travis Mendel, Tu Dan, K.A. Kumar, Ang Gao, Suprabha Pulipparacharuv, Puneeth Iyengar, Lucien A. Nedzi, Raquibul Hannan, John Anderson, Kevin S...> ;Neuro-Oncology. 2020 Dec 18
• 1 citations
  Correction: Synthesis and structure−activity relationships of DCLK1 kinase inhibitors based on a 5,11-dihydro‑6H‑benzo[e]pyrimido[5,4‑b][1,4]diazepin-6-one Scaffold (J...
  Fleur M. Ferguson, Yan Liu, Wayne Harshbarger, Ling Huang, Jinhua Wang, Xianming Deng, Stephen J. Capuzzi, Eugene N. Muratov, Alexander Tropsha, Senthil K. Muthuswamy,...> ;Journal of Medicinal Chemistry. 2020 Sep 10
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Journal Articles

• Consolidative Radiotherapy for Limited Metastatic Non�Small-Cell Lung CancerA Phase 2 Randomized Clinical Trial  
  Iyengar P, Wardak Z, Gerber DE, Tumati V, Ahn C, Hughes RS, Dowell JE, Cheedella N, Nedzi L, Westover KD, Pulipparacharuvil S, Choy H, Timmerman RD., JAMA Oncol., 1/1/2018
• A pilot study using kernelled support tensor machine for distant failure prediction in lung SBRT  
  Li S, Yang N, Li B, Zhou Z, Hao H, Folkert MR, Iyengar P, Westover K, Choy H, Timmerman R, Jiang S, Wang J., Med Image Anal., 1/1/2018
• Shell feature: a new radiomics descriptor for predicting distant failure after radiotherapy in non-small cell lung cancer and cervix cancer  
  Hao H, Zhou Z, Li S, Maquilan G, Folkert MR, Iyengar P, Westover KD, Albuquerque K, Liu F, Choy H, Timmerman R, Yang L, Wang J, Medical Physics, 1/1/2017
• Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and alpha-Mangostin  
  Xia Y, Li Y, Westover KD, Sun J, Chen H, Zhang J, Fisher DE., PLOS one., 1/1/2016
• Predicting distant failure in early stage NSCLC treated with SBRT using clinical parameters  
  Zhou Z, Folkert M, Cannon N, Iyengar P, Westover K, Zhang Y, Choy H, Timmerman R, Yan J, Xie XJ, Jiang S, Wang J, Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology, 1/1/2016
• Data publication with the structural biology data grid supports live analysis  
  Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin A,..., Nature Communications., 1/1/2016
• A PHGDH inhibitor reveals coordination between serine synthesis and 1-carbon unit fate  
  Pacold ME, Brimacombe K, Chan SH, Rohde J, Lewis CA, Swier L, Possemato R, Fiske B, Cho SW, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul Y, Liu CM, Chung H, Davidson S..., Nature Chemical Biology, 1/1/2016
• Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair  
  Udayakumar D, Pandita RK, Horikoshi N, Liu Y, Liu Q, Wong KK, Hunt CR, Gray NS, Minna JD, , PanditaTK,*, Westover KD*., Radiation Research., 1/1/2016
• Progress on Covalent Inhibition of KRAS G12C  
  Westover KD, Janne P, Gray NS, Cancer Discovery, 1/1/2016
• Discovery of Type II inhibitors of TGF-beta-activated kinase 1 (TAK1) and Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)  
  Tan L, Nomanbhoy TK, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Wes..., J Med Chem, 1/1/2015
• Neutrophil-lymphocyte and platelet-lymphocyte ratios as prognostic factors following stereotactic radiation therapy for early-stage non-small cell lung cancer  
  Cannon NA, Meyer J, Iyengar P, Ahn C, Westover KD, Choy H, Timmerman R, J Thorac Oncol, 1/1/2015
• Structural dataset for the fast-exchanging KRAS G13D  
  Lu J, Hunter J, Manandhar A, Gurbani D, Westover KD, Data in brief, 1/1/2015
• SABR for aggressive local therapy of metastatic cancer: A new paradigm for metastatic non-small cell lung cancer  
  Westover KD, Iyengar P, Sharma AN, Timmerman R., Lung Cancer, 1/1/2015
• Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor  
  Lim SM,* Westover KD*, Ficarro SB, Harrison RA, Choi HG, Choi HG, Pacold, ME, Carrasco M, Hunter J, Kim ND, Xie T, Sim T, Janne PA, Meyerson M, Marto JA, Engen JR, Gra..., Angew Chem Int Ed Engl., 1/1/2014
• Pharmacological Targeting of the Pseudokinase Her3  
  Xie T, Lim SM, Westover KD, Dodge ME, Ercan D, Ficarro SB, Udayakumar D, Gurbani D, Tae HS,. Riddle SM, Sim T, Marto JA, J�nne PA, Crews CM, Gray NS., Nat Chem Biol., 1/1/2014
• Radiation therapy as a backbone of treatment of locally advanced non-small cell lung cancer  
  Laine AM, Westover KD, Choy H, Semin Oncol, 1/1/2014
• Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics  
  Liu Q, Kirubakaran S, Hur W, Niepel M, Westover KD, Thoreen CC, Wang J, Ni1 J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J..., J Biol Chem, 1/1/2012
• Proton SBRT for Medically Inoperable Stage I NSCLC  
  Westover KD, Seco J, Adams JA, Lanuti M, Choi NC, Engelsman M, Willers H., J Thorac Oncol.: official publication of the International Association for the Study of Lung Cancer, 1/1/2012
• Quantitative analysis of Hsp90::client interactions reveals principles of substrate recognition  
  Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, and Lindquist S., Cell, 1/1/2012
• Radical Prostatectomy vs Radiation Therapy and Androgen Suppression Therapy in High Risk Prostate Cancer  
  Westover KD, Chen M, Moul J, Robertson C, Polascik T, Dosoretz D, Katin M, Salenius S, D�Amico AV., BJU Int., 1/1/2012
• Should a sentinel node biopsy be performed in patients with high risk breast cancer?  
  Westover KD, Westover MB, Winer EP, Richardson AL, Iglehart JD, Punglia RS., Int J Breast Cancer, 1/1/2011
• Significance testing as perverse probabilistic reasoning  
  Westover MB, Westover KD, Bianchi MT., BMC Medicine., 1/1/2011
• Comprehensive and efficient HBB mutation analysis for detection of beta-hemoglobinopathies in a pan-ethnic population  
  Chan OT, Westover KD, Dietz L, Zehnder JL, Schrijver I., Am J Clin Pathol., 1/1/2010
• Structural basis of transcription: backtracked RNA polymerase II at 34 angstrom resolution  
  Wang D, Bushnell DA, Huang X, Westover KD, Levitt M, Kornberg RD., Science, 1/1/2009
• Mycotic aneurysm of the left main coronary artery producing acute coronary occlusion and purulent pericarditis  
  Westover K, Benedick B., Int J Cardiol, 1/1/2007
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Books/Book Chapters

• Conquering RAS: From Biology to Cancer Therapy 
  Chapter: GTP-competitive inhibitors of RAS family members 
  Hunter JC, Westover KDElsevier2016
• Human Radiation Injury 
  Chapter: Radiation Induced Liver Disease 
  Westover KD, Hong TS.Editors: Shrieve D and Loeffler JS.Lippincott Williams & Wilkins2011
• MGH Pocket Neurology 
  Chapter: Neurooncology 
  Rinne M, Westover KDEditors: David Greer.Lippincott Williams & Wilkins2010

Abstracts/Posters

• Safety Analysis From a Prospective Registry Study of Stereotactic Body Radiation Therapy for Aggressive Management of Late-Stage Disease.
  Maquilan G, Westover KD, Wardak Z, Timmerman RD, Hannan R, Iyengar P, Schwartz DL, Meyer JJ, Abdulrahman RE, Folkert MR, Laine AM, Desai NB, Albuquerque KV, Choy H, Ah..., Int J Radiat Oncol Biol Phys., 1/1/2016
• Distinctive structural dynamics in Ras and related proteins by hydrogen exchange mass spectrometry
  Harrison R, Carrasco M, Hunter J, Manandhar A, Westover KD, Engen J., 63rd Annual Meeting, American Society for Mass Spectrometry, 1/1/2015
• Outcomes of proton beam based SBRT in medically inoperable stage I NSCLC
  Westover KD, Engelsman M, Adams J, Lanuti M, Choi N, Willers H., 53rd Annual Meeting American Society for Radiation Oncology, 1/1/2011
• Assessing the impact of proton range uncertainties on nsclc lung patients treated with proton beam-based SBRT.
  Seco J*, Panahandeh H*, Westover KD, Adams J, Willers H, 53rd Annual Meeting of American Association of Physicists in Medicine, 1/1/2011
• Should a sentinel node biopsy be performed in patients with high risk breast cancer?
  Westover KD, Westover MB, Weiner E, Richardson A, Iglehart J, Punglia R, 52nd Annual Meeting American Society for Radiation Oncology, 1/1/2010
• Impact of Superposition/convolution Dose Algorithm Inaccuracies in SBRT of Patients with Early Stage NSCLC: A Monte Carlo Study
  Seco J, Westover K, Willers H., 52nd Annual Meeting American Society for Radiation Oncology, 1/1/2010
• Dosimetric benefit of a combination of respiratory-gating, image-guidance and intensity modulated radiation therapy for pancreatic cancer treatment.
  Park SJ, O�Farrell D, Westover KD, Mamon H, Berbecco R., 51st Annual Meeting of American Association of Physicists in Medicine, 1/1/2009
• Biochemical profiling of cancer-associated KRAS mutants: clues towards an understanding of differential clinical outcomes
  Hunter JC, Gurbani D, Carrasco M, Manandhar A, Gondi S, Westover KD, AACR 106th Annual Meeting, Philadelphia, PA, 1/18/2015
• Torin2 suppresses ionizing radiation induced DNA damage repair
  Udayakumar D, Pandita RK, Horikoshi N, Hunt CR, Liu Q, Wong KK, Gray NS, Pandita TK, Westover KD., Proceedings: AACR 106th Annual Meeting, Philadelphia, PA, 1/18/2015
• Structure guided development of irreversible inhibitors for TAK1.
  Gurbani D, Tan L, Ficarro S, Hunter JC, Singer W, Vazquez FB, Xie T, Lim SM, Marto J, Gray NS,. Westover KD., AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, Boston, MA, 1/5./2015
• Predicting Distant Failure in Lung Stereotactic Body Radiation Therapy Using Multiobjective Radiomics Model.
  Zhou Z, Folkert MR, Iyengar P, Zhang Y, Westover KD, Wang J, Int J Radiat Oncol Biol Phys., 1/1./2016
• A Phase III Randomized Study of Image Guided Conventional (60 Gy/30 fx) Versus Accelerated, Hypofractionated (60 Gy/15 fx) Radiation for Poor Performance Status Stage ...
  Iyengar P, Westover KD, Court LE, Patel MK, Shivnani AT, Saunders MW, Li Y, Chang JY, Gao A, Ahn C, Choy H, Timmerman RD., Int J Radiat Oncol Biol Phys, 1/1./2016
• Patterns of Failure after 5 Fraction Stereotactic Ablative Radiation Therapy in Early Stage Non-Small Cell Lung Cancer
  J.T. Mendel, K. Ward, K.D. Westover, R.D. Timmerman, H. Choy, P. Iyengar, L.A. Nedzi, D.J. Sher., Int J Radiat Oncol Biol Phys
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Lectures

• Targeting RAS in an Allele-Specific Manner 
  First Affiliated Hospital of Chengdu Medical College, Chengdu, China - 1/1/2018
• Allele-Specific Approaches to targeting RAS 
  San Francisco, CA - 1/1/2018
• KRAS Q61H signals in a RAF dimer-dependent manner 
  San Diego, CA - 1/1/2018
• Structural Biology of RAS Mutants Found in RASopathies 
  Indianapolis, IN - 1/1/2017
• RAS Structure and biochemistry � opportunities for allele-tailored therapy 
  Lake Geneva, WI - 1/1/2017
• Progress on Tailored KRAS Therapy 
  Princess Margaret Hospital, Toronto, Canada - 1/1/2016
• Mutation-Specific RAS Therapies: How we are Getting There 
  Memorial Sloan Kettering Cancer Center, New York, NY - 1/1/2016
• Crystal structure of K-Ras G12C bound to an active site inhibitor 
  Orlando, FL - 1/1/2014
• Development of Covalent GTP-Competitive Inhibitors of K-Ras G12C 
  Frederick, MD - 1/1/2014
• Structural Basis of Initiation and Elongation by RNA Polymerase II. 
  Brigham Young University, Provo, UT. - 1/1/2005
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