KevinRobertFlahertyMDMS

Pulmonology • Ann Arbor, MI

Critical Care Medicine, Pleural Disease

Associate Professor, Internal Medicine, University of Michigan Medical School

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Office
1500 East Medical Center Dr
3rd Floor Taubman Ctr Recp C
Ann Arbor, MI 48109
Phone+1 734-647-9342

Fax+1 734-615-5348
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Education & Training

University of Michigan Health SystemFellowship, Pulmonary Disease and Critical Care Medicine, 1997 - 2000
Indiana University School of MedicineResidency, Internal Medicine, 1993 - 1997
Indiana University School of MedicineClass of 1993

Certifications & Licensure

MI State Medical License 1997 - 2025
IN State Medical License 1994 - 2003
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Safety Study of Tetrathiomolybdate in Patients With Idiopathic Pulmonary Fibrosis Start of enrollment: 2003 Mar 01
Completed
Phase 1, Phase 2
Correlating Outcomes With Biochemical Markers to Estimate Time-progression in Idiopathic Pulmonary Fibrosis (IPF) Start of enrollment: 2009 Dec 01
Completed
Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry Start of enrollment: 2014 Jun 01
Recruiting
Treatment of IPF With Laparoscopic Anti-Reflux Surgery Start of enrollment: 2013 Dec 01
Completed
Not Applicable
Prospective Evaluation of Biomarker Profiles in Idiopathic Pulmonary Fibrosis Start of enrollment: 2013 Aug 01
Completed
GKT137831 in IPF Patients With Idiopathic Pulmonary Fibrosis Start of enrollment: 2020 Sep 07
Recruiting
Phase 2
Roles: Contact
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Publications & Presentations

PubMed

A Multi-dimensional Classifier to Support Lung Transplant Referral in Patients with Pulmonary Fibrosis.
Shwu-Fan Ma, Angela L Linderholm, Ching-Hsien Chen, Daniel F Dilling, Timothy P M Whelan, Fernando J Martinez, Janelle Vu Pugashetti, John S Kim, Michael P Combs, Ayod...> ;The Journal of Heart and Lung Transplantation. 2024 Mar 29
Meaningful Endpoints for Idiopathic Pulmonary Fibrosis (IPF) Clinical Trials: Emphasis on 'Feels, Functions, Survives'. Report of a Collaborative Discussion in a Sympo...
Ganesh Raghu, Marya Ghazipura, Thomas R Fleming, Kerri I Aronson, Jürgen Behr, Kevin K Brown, Kevin R Flaherty, Ella A Kazerooni, Toby M Maher, Luca Richeldi, Joseph A...> ;American Journal of Respiratory and Critical Care Medicine. 2024 Mar 15
Use of Race-Specific Equations in Pulmonary Function Tests Impedes Potential Eligibility for Care and Treatment of Pulmonary Fibrosis.
Ayodeji Adegunsoye, Wendi Mason Bachman, Kevin R Flaherty, Zhongze Li, Sachin Gupta> ;Annals of the American Thoracic Society. 2024 Feb 22
1 citations
Deep Learning-based Fibrosis Extent on Computed Tomography Predicts Outcome of Fibrosing Interstitial Lung Disease Independent of Visually Assessed Computed Tomography...
Andrea S Oh, David A Lynch, Jeffrey J Swigris, David Baraghoshi, Debra S Dyer, Valerie A Hale, Tilman L Koelsch, Cristina Marrocchio, Katherine N Parker, Stephen M Hum...> ;Annals of the American Thoracic Society. 2024 Feb 1
1 citations
Effects of nintedanib on symptoms in patients with progressive pulmonary fibrosis.
Wijsenbeek, M., Inoue, Y., Kreuter, M., Maher, T., Suda, T., Baldwin, M., Mueller, H., Rohr, K., , Swigris, J., Flaherty, K.> ;The European Respiratory Journal. 2024 Feb 1
Comparison of Pirfenidone and Nintedanib: Post Hoc Analysis of the CleanUP-IPF Study.
John S Kim, Susan Murray, Eric Yow, Hyun J Kim, Kevin R Flaherty, Fernando J Martinez, Imre Noth, Kevin J Anstrom> ;Chest. 2023 Nov 27
2 citations
Clonal Somatic Mutations in Chronic Lung Diseases Are Associated with Reduced Lung Function.
Jeong H Yun, M A Wasay Khan, Auyon Ghosh, Brian D Hobbs, Peter J Castaldi, Craig P Hersh, Peter G Miller, Carlyne D Cool, Frank Sciurba, Lucas Barwick, Andrew H Limper...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Dec 1
Effect of Nintedanib in Patients with Progressive Pulmonary Fibrosis in Subgroups with Differing Baseline Characteristics.
Martin Kolb, Kevin R Flaherty, Rafael S Silva, Antje Prasse, Carlo Vancheri, Heiko Mueller, Kamila Sroka-Saidi, Athol U Wells> ;Advances in Therapy. 2023 Dec 1
1 citations
External validation and longitudinal application of the DO-GAP index to individualise survival prediction in idiopathic pulmonary fibrosis.
Abhimanyu Chandel, Christopher S King, Rosalinda V Ignacio, Jean Pastre, Oksana A Shlobin, Vikramjit Khangoora, Alan Nyquist, Anju Singhal, Kevin R Flaherty, Steven D ...> ;ERJ Open Research. 2023 May 1
13 citations
Evaluation of Pulmonary Fibrosis Outcomes by Race and Ethnicity in US Adults.
Ayodeji Adegunsoye, Elizabeth Freiheit, Emily N White, Bhavika Kaul, Chad A Newton, Cathryn T Lee, Jonathan Chung, Nicole Garcia, Sahand Ghodrati, Rekha Vij, Renea Jab...> ;JAMA Network Open. 2023 Mar 1
23 citations
Expert consensus on the management of systemic sclerosis-associated interstitial lung disease.
Franck F Rahaghi, Vivien M Hsu, Robert J Kaner, Maureen D Mayes, Ivan O Rosas, Rajan Saggar, Virginia D Steen, Mary E Strek, Elana J Bernstein, Nitin Bhatt, Flavia V C...> ;Respiratory Research. 2023 Jan 9
22 citations
Progressive pulmonary fibrosis: an expert group consensus statement.
Sujeet K Rajan, Vincent Cottin, Raja Dhar, Sonye Danoff, Kevin R Flaherty, Kevin K Brown, Anant Mohan, Elizabeth Renzoni, Murali Mohan, Zarir Udwadia, Padmanabha Sheno...> ;The European Respiratory Journal. 2023 Mar 1
6 citations
Design and rationale for the prospective treatment efficacy in IPF using genotype for NAC selection (PRECISIONS) clinical trial.
Anna J Podolanczuk, John S Kim, Christopher B Cooper, Joseph A Lasky, Susan Murray, Ganesh Raghu, Kevin R Flaherty, Cathie Spino, Imre Noth, Fernando J Martinez, , Old...> ;BMC Pulmonary Medicine. 2022 Dec 13
6 citations
Risk factors for lung function decline in systemic sclerosis-associated interstitial lung disease in a large single-centre cohort.
Ahmad Ramahi, Alain Lescoat, David Roofeh, Vivek Nagaraja, Rajaie Namas, Suiyuan Huang, John Varga, David O'Dwyer, Bonnie Wang, Kevin Flaherty, Ella Kazerooni, Dinesh ...> ;Rheumatology. 2023 Jul 5
Hypothyroidism Is Associated with Increased Mortality in Interstitial Pneumonia with Autoimmune Features.
David N O'Dwyer, Bonnie R Wang, Vivek Nagaraja, Kevin R Flaherty, Dinesh Khanna, Susan Murray, Pier Valerio Mari, Eric S White> ;Annals of the American Thoracic Society. 2022 Oct 1
24 citations
Nintedanib in children and adolescents with fibrosing interstitial lung diseases.
Robin Deterding, Lisa R Young, Emily M DeBoer, David Warburton, Steven Cunningham, Nicolaus Schwerk, Kevin R Flaherty, Kevin K Brown, Mihaela Dumistracel, Elvira Erhar...> ;The European Respiratory Journal. 2023 Feb 1
40 citations
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-contr...
Joshua J Solomon, Sonye K Danoff, Felix A Woodhead, Shelley Hurwitz, Rie Maurer, Ian Glaspole, Paul F Dellaripa, Bibek Gooptu, Robert Vassallo, P Gerard Cox, Kevin R F...> ;The Lancet. Respiratory Medicine. 2023 Jan 1
12 citations
Integrating Clinical Probability into the Diagnostic Approach to Idiopathic Pulmonary Fibrosis: An International Working Group Perspective.
Vincent Cottin, Sara Tomassetti, Claudia Valenzuela, Simon L F Walsh, Katerina M Antoniou, Francesco Bonella, Kevin K Brown, Harold R Collard, Tamera J Corte, Kevin R ...> ;American Journal of Respiratory and Critical Care Medicine. 2022 Aug 1
6 citations
Progressive Pulmonary Fibrosis: Should the Timelines Be Taken Out of the Definition?
Vincent Cottin, Kevin K Brown, Kevin R Flaherty, Athol U Wells> ;American Journal of Respiratory and Critical Care Medicine. 2022 Nov 15
Toll-Interacting Protein and Altered Lung Microbiota in Idiopathic Pulmonary Fibrosis.
Jay H Lipinski, John R Erb-Downward, Gary B Huffnagle, Kevin R Flaherty, Fernando J Martinez, Bethany B Moore, Robert P Dickson, Imre Noth, David N O'Dwyer> ;American Journal of Respiratory and Critical Care Medicine. 2022 Jul 15
21 citations
Screening Strategies for Pulmonary Hypertension in Patients With Interstitial Lung Disease: A Multidisciplinary Delphi Study.
Franck F Rahaghi, Nicholas A Kolaitis, Ayodeji Adegunsoye, Joao A de Andrade, Kevin R Flaherty, Lisa H Lancaster, Joyce S Lee, Deborah J Levine, Ioana R Preston, Zeena...> ;Chest. 2022 Jul 1
13 citations
Study design and rationale for the TETON phase 3, randomised, controlled clinical trials of inhaled treprostinil in the treatment of idiopathic pulmonary fibrosis.
Steven D Nathan, Jurgen Behr, Vincent Cottin, Lisa Lancaster, Peter Smith, C Q Deng, Natalie Pearce, Heidi Bell, Leigh Peterson, Kevin R Flaherty> ;BMJ Open Respiratory Research. 2022 Jul 1
32 citations
Nintedanib in Patients With Autoimmune Disease-Related Progressive Fibrosing Interstitial Lung Diseases: Subgroup Analysis of the INBUILD Trial.
Eric L Matteson, Clive Kelly, Jörg H W Distler, Anna-Maria Hoffmann-Vold, James R Seibold, Shikha Mittoo, Paul F Dellaripa, Martin Aringer, Janet Pope, Oliver Distler,...> ;Arthritis & Rheumatology. 2022 Jun 1
2 citations
Phase 2B Study of Inhaled RVT-1601 for Chronic Cough in Idiopathic Pulmonary Fibrosis: A Multicenter, Randomized, Placebo-controlled Study (SCENIC Trial).
Fernando J Martinez, Marlies S Wijsenbeek, Ganesh Raghu, Kevin R Flaherty, Toby M Maher, Wim A Wuyts, Michael Kreuter, Martin Kolb, Daniel C Chambers, Charles Fogarty,...> ;American Journal of Respiratory and Critical Care Medicine. 2022 May 1
1 citations
Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.
Auyon J Ghosh, Brian D Hobbs, Jeong H Yun, Aabida Saferali, Matthew Moll, Zhonghui Xu, Robert P Chase, Jarrett Morrow, John Ziniti, Frank Sciurba, Lucas Barwick, Andre...> ;Respiratory Research. 2022 Apr 21
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Journal Articles

Quantitative HRCT Fibrosis Score: Performance Characteristics in Idiopathic Pulmonary Fibrosis
Marvin I Schwarz, Kevin R Flaherty, Ganesh Raghu, The European Respiratory Journal
Stability or Improvement in Forced Vital Capacity with Nintedanib in Patients with IPF
Kevin R Flaherty, Craig S Conoscenti, The European Respiratory Journal

Other

Nonspecific interstitial pneumonia
Flaherty KR
http://www.uptodate.com/contents/nonspecific-interstitial-pneumonia
UpToDate, Wolters Kluwer Health - 2012-05-11

Press Mentions

New Analyses of Ofev® Data in Patients with Chronic Fibrosing ILDs Available During American Thoracic Society CongressAugust 5th, 2020
Nintedanib Approved for Chronic Fibrosing Interstitial Lung Disease with Progressive PhenotypeMarch 18th, 2020
INBUILD: Nintedanib Slows Progression of Fibrosing ILDOctober 3rd, 2019
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Grant Support

Forging A Road To Personalized Medicine In Interstitial Lung DiseasesNational Heart, Lung, And Blood Institute2012
Longitudinal, Computer Assisted Analysis In IPFNational Heart, Lung, And Blood Institute2008–2011
Ctrip: Molecular Phenotypes Of Rapidly Progressive Idiopathic Pulmonary FibrosisNational Heart, Lung, And Blood Institute2009–2010
Phase I/II Trial Tetrathiomolybdate (TM) In PTS W/ Usual Interstitial PneumoniaNational Center For Research Resources2004–2007
Prognostication In Idiopathic Interstitial PneumoniaNational Heart, Lung, And Blood Institute2002–2006