KevinO.HicksMD

PubMed

• 21 citations
  A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity
  Kashyap Patel, Steve Choy, Kevin O. Hicks, Teresa J. Melink, Nicholas H. G. Holford, William R. Wilson> ;Cancer Chemotherapy and Pharmacology. 2011 May 1
• 92 citations
  Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors
  Kevin O. Hicks, Bronwyn G. Siim, Jagdish K. Jaiswal, Frederik B. Pruijn, Annie M. Fraser, Alison Hogg, H. D. Sarath Liyanage, Mary Jo Dorie, J. Martin Brown, William A...> ;Clinical Cancer Research. 2010 Oct 15
• 45 citations
  Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.
  Michael P. Hay, Kevin O. Hicks, Karin Pchalek, Ho H. Lee, Adrian Blaser, Frederik B. Pruijn, Robert F. Anderson, Sujata S. Shinde, William R. Wilson, William A. Denny> ;Journal of Medicinal Chemistry. 2008 Oct 11
• 33 citations
  Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity.
  Michael P. Hay, Karin Pchalek, Frederik B. Pruijn, Kevin O. Hicks, Bronwyn G. Siim, Robert F. Anderson, Sujata S. Shinde, Victoria Phillips, William A. Denny, William ...> ;Journal of Medicinal Chemistry. 2007 Dec 6
• 30 citations
  Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular tr...
  Michael P. Hay, Kevin O. Hicks, Frederik B. Pruijn, Karin Pchalek, Bronwyn G. Siim, William R. Wilson, William A. Denny> ;Journal of Medicinal Chemistry. 2007 Nov 15
• 51 citations
  Oxygen Dependence and Extravascular Transport of Hypoxia-Activated Prodrugs: Comparison of the Dinitrobenzamide Mustard PR-104A and Tirapazamine
  Kevin O. Hicks, Hilary Myint, Adam V. Patterson, Frederik B. Pruijn, Bronwyn G. Siim, Kashyap Patel, William R. Wilson> ;International Journal of Radiation Oncology, Biology, Physics. 2007 Oct 1
• 23 citations
  Analysis of the hypoxia-activated dinitrobenzamide mustard phosphate pre-prodrug PR-104 and its alcohol metabolite PR-104A in plasma and tissues by liquid chromatograp...
  Kashyap Patel, David Lewiston, Yongchuan Gu, Kevin O. Hicks, William R. Wilson> ;Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2007 Sep 1
• 175 citations
  Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104
  Adam V. Patterson, Dianne M. Ferry, Shelley J. Edmunds, Yongchuan Gu, Rachelle S. Singleton, Kashyap Patel, Susan M. Pullen, Kevin O. Hicks, Sophie P. Syddall, Graham ...> ;Clinical Cancer Research. 2007 Jul 1
• 52 citations
  Bystander Effects of Bioreductive Drugs: Potential for Exploiting Pathological Tumor Hypoxia with Dinitrobenzamide Mustards
  William R. Wilson, Kevin O. Hicks, Susan M. Pullen, Dianne M. Ferry, Nuala A. Helsby, Adam V. Patterson> ;Radiation Research. 2007 Jun 1
• 109 citations
  Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs.
  Kevin O. Hicks, Frederik B. Pruijn, Timothy W. Secomb, Michael P. Hay, Richard Hsu, J. Martin Brown, William A. Denny, Mark W. Dewhirst, William R. Wilson> ;Journal of the National Cancer Institute. 2006 Aug 16
• 35 citations
  Extravascular Transport of Drugs in Tumor Tissue: Effect of Lipophilicity on Diffusion of Tirapazamine Analogues in Multicellular Layer Cultures
  Frederik B. Pruijn, Sturman, Liyanage Hd, Kevin O. Hicks, Michael P. Hay, William R. Wilson> ;Journal of Medicinal Chemistry. 2005 Jan 27
• 35 citations
  Oxygen Dependence of the Metabolic Activation and Cytotoxicity of Tirapazamine: Implications for Extravascular Transport andActivity in Tumors
  Kevin O. Hicks, Bronwyn G. Siim, Frederik B. Pruijn, William R. Wilson> ;Radiation Research. 2004 Jun 1
• 18 citations
  In Vitro and In Vivo Models for Evaluation of GDEPT
  William R. Wilson, Susan M. Pullen, Alison Hogg, Stephen M. Hobbs, Frederik B. Pruijn, Kevin O. Hicks> ;Methods in Molecular Medicine. 2004 Jan 1
• 78 citations
  Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures.
  Kevin O. Hicks, Frederik B. Pruijn, Joanna R. Sturman, William A. Denny, William R. Wilson> ;Cancer Research. 2003 Sep 15
• 55 citations
  Quantitation of Bystander Effects in Nitroreductase Suicide Gene Therapy Using Three-Dimensional Cell Cultures
  William R. Wilson, Susan M. Pullen, Alison Hogg, Nuala A. Helsby, Kevin O. Hicks, William A. Denny> ;Cancer Research. 2002 Mar 1
• 33 citations
  Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicell...
  Kevin O. Hicks, Frederik B. Pruijn, Bruce C. Baguley, William R. Wilson> ;The Journal of Pharmacology and Experimental Therapeutics. 2001 Jun 1
• 22 citations
  Comparison of aromatic and tertiary amine N-oxides of acridine DNA intercalators as bioreductive drugs. Cytotoxicity, DNA binding, cellular uptake, and metabolism.
  Bronwyn G. Siim, Kevin O. Hicks, Susan M. Pullen, Pierre L van Zijl, William A. Denny, William R. Wilson> ;Biochemical Pharmacology. 2000 Oct 1
• 21 citations
  Measurement of extravascular drug diffusion in multicellular layers.
  William R. Wilson, Kevin O. Hicks> ;British Journal of Cancer. 1999 Mar 1
• 75 citations
  Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model.
  Kevin O. Hicks, Yvette Fleming, Bronwyn G. Siim, Cameron J. Koch, William R. Wilson> ;International Journal of Radiation Oncology, Biology, Physics. 1998 Oct 1
• 71 citations
  An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours
  Kevin O. Hicks, Stephen J. Ohms, PL Van zijl, William A. Denny, Peter Hunter, William R. Wilson> ;British Journal of Cancer. 1997 Jan 1
• 64 citations
  Multicellular membranes as an in vitro model for extravascular diffusion in tumours.
  D. S. Cowan, Kevin O. Hicks, William R. Wilson> ;The British Journal of Cancer. Supplement. 1996 Jul 1
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