KevinHenryToomerMDPhD

PubMed

• 2 citations
  SARS-CoV-2 infection results in upregulation of Plasminogen Activator Inhibitor-1 and Neuroserpin in the lungs, and an increase in fibrinolysis inhibitors associated w...
  Gloria F Gerber, Yifan Zhang, Laetitia Daou, Michael Tushek, Ivo M B Francischetti, Kevin H Toomer, Jody E Hooper> ;Ejhaem. 2023 May 1
• 43 citations
  Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection
  Ivo M.B. Francischetti, Kevin Toomer, Yifan Zhang, Jayesh Jani, Zishan K. Siddiqui, Daniel J. Brotman, Jody E. Hooper, Thomas S. Kickler> ;Eclinicalmedicine. 2021 Aug 6
• 11 citations
  Sustained IL-2R signaling of limited duration by high-dose mIL-2/mCD25 fusion protein amplifies tumor-reactive CD8+ T cells to enhance antitumor immunity
  Rosmely Hernandez, Kevin H. Toomer, Janika Põder, Alicia Santos Savio, Sunnie Hsiung, Thomas R. Malek> ;Cancer Immunology, Immunotherapy. 2021 Apr 1
• 2 citations
  A New Delhi metallo-β-lactamase (NDM)-positive isolate of Klebsiella pneumoniae causing catheter-related bloodstream infection in an ambulatory hemodialysis patient
  Kevin H. Toomer, Daniela de Lima Corvino, Katie A. McCrink, Jose Armando Gonzales Zamora> ;Idcases. 2020 May 12
• 58 citations
  Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells.
  Kevin H. Toomer, Jen Bon Lui, Norman H. Altman, Yuguang Ban, Xi Chen, Thomas R. Malek> ;Nature Communications. 2019 Mar 4
• 10 citations
  Distribution and population structure of endobacteria in arbuscular mycorrhizal fungi at North Atlantic dunes
  Olga A. Lastovetsky, Ezekiel Ahn, Stephen J. Mondo, Kevin H. Toomer, Aolin Zhang, Lynn M. Johnson, Teresa E. Pawlowska> ;The ISME Journal. 2018 Aug 10
• 15 citations
  Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines.
  Jason Miska, Jen Bon Lui, Kevin H. Toomer, Priyadharshini Devarajan, Xiaodong Cai, JeanMarie Houghton, Diana M. Lopez, Maria T. Abreu, Gaofeng Wang, Zhibin Chen> ;The Journal of Experimental Medicine. 2018 Mar 5
• 10 citations
  Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.
  Connor J. Dwyer, Allison L. Bayer, Carmen Fotino, Liping Yu, Cecilia Cabello-Kindelan, Natasha C. Ward, Kevin H. Toomer, Zhibin Chen, Thomas R. Malek> ;Science Signaling. 2017 Dec 19
• 49 citations
  Cytokine Signaling in the Development and Homeostasis of Regulatory T cells
  Kevin H. Toomer, Thomas R. Malek> ;Cold Spring Harbor Perspectives in Biology. 2018 Mar 1
• 24 citations
  Developmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets
  Kevin H. Toomer, Xiaomei Yuan, Jing Yang, Michael J. Dee, Aixin Yu, Thomas R. Malek> ;Journal of Immunology. 2016 Mar 23
• 17 citations
  Molecular evolution patterns reveal life history features of mycoplasma‐related endobacteria associated with arbuscular mycorrhizal fungi
  Kevin H. Toomer, Xiuhua Chen, Mizue Naito, Stephen J. Mondo, Henk C. den Bakker, Nicholas W. VanKuren, Ylva Lekberg, Joseph B. Morton, Teresa E. Pawlowska> ;Molecular Ecology. 2015 Jul 1
• 23 citations
  Genome-wide analysis of alternative transcripts in human breast cancer.
  Ji Wen, Kevin H. Toomer, Zhibin Chen, Xiaodong Cai> ;Breast Cancer Research and Treatment. 2015 Apr 26
• 32 citations
  Autoimmunity as a double agent in tumor killing and cancer promotion.
  Kevin H. Toomer, Zhibin Chen> ;Frontiers in Immunology. 2014 Mar 18
• 47 citations
  EVOLUTIONARY STABILITY IN A 400-MILLION-YEAR-OLD HERITABLE FACULTATIVE MUTUALISM
  Stephen J. Mondo, Kevin H. Toomer, Joseph B. Morton, Ylva Lekberg, Teresa E. Pawlowska> ;Evolution; International Journal of Organic Evolution. 2012 Aug 1
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Journal Articles

• SARS-CoV-2 infection results in upregulation of Plasminogen Activator Inhibitor-1 and Neuroserpin in the lungs, and an increase in fibrinolysis inhibitors associated w...  
  Toomer KH, Gerber GF, Zhang Y, Daou L, Tushek M, Hooper JE, Francischetti IMB., EJHaem., 2/2023
• Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection.  
  Francischetti IMB, Toomer K, Zhang Y, Jani J, Siddiqui Z, Brotman DJ, Hooper JE, Kickler TS., EClinicalMedicine., 8/2021
• Sustained IL-2R signaling of limited duration by high-dose mIL-2/mCD25 fusion protein amplifies tumor-reactive CD8(+) T cells to enhance antitumor immunity.  
  Hernandez R, Toomer KH, Põder J, Santos Savio A, Hsiung S, Malek TR., Cancer Immunol Immunother., 10/2020
• A New Delhi metallo-β-lactamase (NDM)-positive isolate of Klebsiella pneumoniae causing catheter-related bloodstream infection in an ambulatory hemodialysis patient.  
  Toomer KH, de Lima Corvino D, McCrink KA, Gonzales Zamora JA., IDCases., 5/2020
• Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells.  
  Toomer KH, Lui JB, Altman NH, Ban Y, Chen X, Malek TR., Nat Commun., 3/2019
• Distribution and population structure of endobacteria in arbuscular mycorrhizal fungi at North Atlantic dunes.  
  Lastovetsky OA, Ahn E, Mondo SJ, Toomer KH, Zhang A, Johnson LM, Pawlowska TE., ISME J., 12/2018
• Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines.  
  Miska J, Lui JB, Toomer KH, Devarajan P, Cai X, Houghton J, Lopez DM, Abreu MT, Wang G, Chen Z., J Exp Med., 1/2018
• Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.  
  Dwyer CJ, Bayer AL, Fotino C, Yu L, Cabello-Kindelan C, Ward NC, Toomer KH, Chen Z, Malek TR., Sci Signal., 12/2017
• Cytokine Signaling in the Development and Homeostasis of Regulatory T cells.  
  Toomer KH, Malek TR., Cold Spring Harb Perspect Biol., 6/2017
• Developmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets.  
  Toomer KH, Yuan X, Yang J, Dee MJ, Yu A, Malek TR., J Immunol., 5/2016
• Molecular evolution patterns reveal life history features of mycoplasma-related endobacteria associated with arbuscular mycorrhizal fungi.  
  Toomer KH, Chen X, Naito M, Mondo SJ, den Bakker HC, VanKuren NW, Lekberg Y, Morton JB, Pawlowska TE., Mol Ecol., 5/2015
• Genome-wide analysis of alternative transcripts in human breast cancer  
  Wen J, Toomer KH, Chen Z, Cai X., Breast Cancer Res Treat., 4/2015
• Autoimmunity as a double agent in tumor killing and cancer promotion  
  Toomer KH, Chen Z., Front Immunol., 3/2014
• Evolutionary stability in a 400-million-year-old heritable facultative mutualism.  
  Mondo SJ, Toomer KH, Morton JB, Lekberg Y, Pawlowska TE., Evolution, 8/2012
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Abstracts/Posters

• Correlation between HER2 immunohistochemistry (IHC) staining pattern and HER2/neu copy-number amplification in primary and metastatic non-small cell lung carcinoma (NS...
  Toomer KH (presenting author), Tang G, Cheng J, Gong Y, Lih TM, Zhang H, Zhang B, Chan DW, Li QK., United States and Canadian Academy of Pathology (USCAP) 112th Annual Meeting (2023), New Orleans, LA, 3/2023
• Conditional deletion of CD25 in Tregs abrogates their suppressive function independently of Foxp3.
  Kevin H. Toomer MD PhD (presenting author), Thomas R. Malek PhD, American Association of Immunologists (AAI) 2018 Annual Meeting, Austin, TX, 5/2018

Lectures

• The clinical course of autoimmunity in IL-2 receptor alpha deficiency is shaped by effects on both regulatory T cells and autoreactive T conventional cells. 
  Oral Presentation: 32nd Annual MD/PhD National Student Conference, Keystone, CO - 7/2017