Kian HuatLimMD

PubMed

• Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer.
  Ashenafi Bulle, Peng Liu, Kuljeet Seehra, Sapana Bansod, Yali Chen, Kiran Zahra, Vikas Somani, Iftikhar Ali Khawar, Hung-Po Chen, Paarth B Dodhiawala, Lin Li, Yutong G...> ;Nature Communications. 2024 Mar 20
• Chemokine Receptor 2 Targeted PET/CT Imaging Distant Metastases in Pancreatic Ductal Adenocarcinoma.
  Lim, K., Xiaohui Zhang, Lisa Detering, Gyu Seong Heo, Deborah Sultan, Hannah Luehmann, Lin Li, Vikas Somani, Josie Lesser, Joan Tao, Liang-I Kang, Alexandria Li, Divan...> ;ACS Pharmacology & Translational Science. 2024 Jan 12
• Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carc...
  Lim, K., Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Yuefan Wang, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun,...> ;Cancer Research. 2023 Dec 15
• 2 citations
  High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival.
  Lim, K., Erik P Storrs, Prathamesh Chati, Abul Usmani, Ian Sloan, Bradley A Krasnick, Ramandeep Babbra, Peter K Harris, Chloe M Sachs, Faridi Qaium, Deyali Chatterjee,...> ;NPJ Precision Oncology. 2023 Oct 19
• A Pilot Study of Paricalcitol plus Nanoliposomal Irinotecan and 5-FU/LV in Advanced Pancreatic Cancer Patients after Progression on Gemcitabine-Based Therapy.
  Patrick M Grierson, Rama Suresh, Benjamin Tan, Katrina S Pedersen, Manik Amin, Haeseong Park, Nikolaos A Trikalinos, Jingxia Liu, Nicholas Boice, Amberly Brown, Sapana...> ;Clinical Cancer Research. 2023 Dec 1
• 7 citations
  Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy.
  Lim, K., Chong Zuo, John M Baer, Brett L Knolhoff, Jad I Belle, Xiuting Liu, Angela Alarcon De La Lastra, Christina Fu, Graham D Hogg, Natalie L Kingston, Marcus A Bre...> ;The Journal of Experimental Medicine. 2023 Jun 5
• 3 citations
  Safety, tolerability, and effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in combination with standard chemotherapy for patients w...
  Lauren K Park, Kian-Huat Lim, Jonas Volkman, Mina Abdiannia, Hannah Johnston, Zack Nigogosyan, Marilyn J Siegel, Janet B McGill, Alexis M McKee, Maamoun Salam, Rong M ...> ;Cancer & Metabolism. 2023 May 18
• Induction of cancer neoantigens facilitates development of clinically relevant models for the study of pancreatic cancer immunobiology.
  Usman Y Panni, Michael Y Chen, Felicia Zhang, Darren R Cullinan, Lijin Li, C Alston James, Xiuli Zhang, S Rogers, A Alarcon, John M Baer, Daoxiang Zhang, Feng Gao, Chr...> ;Cancer Immunology, Immunotherapy. 2023 Aug 1
• 8 citations
  Phase Ib Study of Ulixertinib Plus Gemcitabine and Nab-Paclitaxel in Patients with Metastatic Pancreatic Adenocarcinoma.
  Patrick M Grierson, Benjamin Tan, Katrina S Pedersen, Haeseong Park, Rama Suresh, Manik A Amin, Nikolaos A Trikalinos, Deborah Knoerzer, Brent Kreider, Anupama Reddy, ...> ;The Oncologist. 2023 Feb 8
• 1 citations
  A Preclinical and Phase Ib Study of Palbociclib plus Nab-Paclitaxel in Patients with Metastatic Adenocarcinoma of the Pancreas.
  Manuel Hidalgo, Rocio Garcia-Carbonero, Kian-Huat Lim, Wells A Messersmith, Ignacio Garrido-Laguna, Erkut Borazanci, Andrew M Lowy, Laura Medina Rodriguez, Daniel Lahe...> ;Cancer Research Communications. 2022 Nov 1
• 22 citations
  Defactinib, Pembrolizumab, and Gemcitabine in Patients with Advanced Treatment Refractory Pancreatic Cancer: A Phase I Dose Escalation and Expansion Study.
  Andrea Wang-Gillam, Kian-Huat Lim, Robert McWilliams, Rama Suresh, Albert C Lockhart, Amberly Brown, Marcus Breden, Jad I Belle, John Herndon, Savannah J Bogner, Katri...> ;Clinical Cancer Research. 2022 Dec 15
• 3 citations
  MR-Guided Radiation Therapy With Concurrent Gemcitabine/Nab-Paclitaxel Chemotherapy in Inoperable Pancreatic Cancer: A TITE-CRM Phase I Trial.
  Hyun Kim, Jeffrey R Olsen, Olga L Green, Re-I Chin, William G Hawkins, Ryan C Fields, Chet Hammill, Majella B Doyle, William Chapman, Rama Suresh, Benjamin Tan, Katrin...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Jan 1
• 14 citations
  IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma.
  Vikas K Somani, Daoxiang Zhang, Paarth B Dodhiawala, Varintra E Lander, Xiuting Liu, Liang-I Kang, Hung-Po Chen, Brett L Knolhoff, Lin Li, Patrick M Grierson, Marianna...> ;Gastroenterology. 2022 Jun 1
• 6 citations
  Evolving Paradigms in the Systemic Treatment of Advanced Gallbladder Cancer: Updates in Year 2022.
  Zishuo Ian Hu, Kian-Huat Lim> ;Cancers. 2022 Feb 28
• 1 citations
  Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment.
  Hua Sun, Song Cao, R Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C Wendl, Sherri R Davies, Matthew H Bailey, Tina M Primeau, Jeremy Hoog, Jacqueline L Mudd, Denn...> ;Nature Communications. 2022 Jan 7
• A Data-Driven Pipeline to Discover Treatment Variations and the Associated Contributing Factors Balanced with Optimal Granularity.
  Hao Fan, Kian-Huat Lim, Po-Yin Yen> ;AMIA ... Annual Symposium Proceedings. AMIA Symposium. 2022 Jan 1
• 8 citations
  The MK2/Hsp27 axis is a major survival mechanism for pancreatic ductal adenocarcinoma under genotoxic stress.
  Patrick M. Grierson, Paarth B. Dodhiawala, Yi Cheng, Tim Hung-Po Chen, Iftikhar Ali Khawar, Qing Wei, Daoxiang Zhang, Lin Li, John M. Herndon, Joseph B Monahan, Marian...> ;Science Translational Medicine. 2021 Dec 1
• 8 citations
  Oncogenic KRAS-Induced Feedback Inflammatory Signaling in Pancreatic Cancer: An Overview and New Therapeutic Opportunities
  Sapana Bansod, Paarth B. Dodhiawala, Kian-Huat Lim> ;Cancers. 2021 Oct 31
• 2 citations
  Phospho-Ser784-VCP Drives Resistance of Pancreatic Ductal Adenocarcinoma to Genotoxic Chemotherapies and Predicts the Chemo-Sensitizing Effect of VCP Inhibitor
  Faliang Wang, Kiran Vij, Lin Li, Paarth B. Dodhiawala, Kian-Huat Lim, Jieya Shao> ;Cancers. 2021 Oct 11
• 2 citations
  A Case of a Pathological Complete Response to Neoadjuvant Nivolumab plus Ipilimumab in Periampullary Adenocarcinoma
  Vikram Pothuri, John M. Herndon, Samuel Ballentine, Kian-Huat Lim, Ryan C. Fields> ;The Oncologist. 2021 Sep 1
• 48 citations
  Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment
  Hua Sun, Song Cao, R. Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C. Wendl, Sherri R. Davies, Matthew H. Bailey, Tina Primeau, Jeremy Hoog, Jacqueline Mudd, Denn...> ;Nature Communications. 2021 Aug 24
• 5 citations
  Phase 1 study combining alisertib with nab-paclitaxel in patients with advanced solid malignancies.
  Kian-Huat Lim, Mateusz Opyrchal, Abhi Acharya, Nick Boice, Ningying Wu, Feng Gao, Jace Webster, Albert C. Lockhart, Saiama N. Waqar, Ramaswamy Govindan, Daniel Morgens...> ;European Journal of Cancer. 2021 Jul 10
• 17 citations
  Stroma-targeting strategies in pancreatic cancer: Past lessons, challenges and prospects.
  Faran Salim Polani, Patrick M. Grierson, Kian-Huat Lim, Lim, K.> ;World Journal of Gastroenterology. 2021 May 14
• 15 citations
  Nonoperative Rectal Cancer Management With Short-Course Radiation Followed by Chemotherapy: A Nonrandomized Control Trial.
  Hyun Jik Kim, Katrina S. Pedersen, Jeffrey R. Olsen, Matthew G. Mutch, R.I. Chin, Sean C. Glasgow, Paul E. Wise, Matthew L. Silviera, Benjamin R. Tan, Andrea Wang-Gill...> ;Clinical Colorectal Cancer. 2021 Apr 7
• 6 citations
  Combined Systemic and Hepatic Artery Infusion Pump Chemo-Therapy as a Liver-Directed Therapy for Colorectal Liver Metastasis-Review of Literature and Case Discussion
  Salman Chaudhry, Ryan C. Fields, Patrick M. Grierson, Kian-Huat Lim> ;Cancers. 2021 Mar 13
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