KimENicholsMD

PubMed

• Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.
  Ayse Bahar Ercan, Melyssa Aronson, Nicholas R Fernandez, Yuan Chang, Adrian Levine, Zhihui Amy Liu, Logine Negm, Melissa Edwards, Vanessa Bianchi, Lucie Stengs, Jiil C...> ;The Lancet. Oncology. 2024 Mar 26
• Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti-PD-1 Monotherapy: A Report from the International RRD Con...
  Das, A., Fernandez, N., Levine, A., Bianchi, V., Stengs, L., Chung, J., Negm, L., Dimayacyac, J., Chang, Y., Nobre, L., Ercan, A., Sanchez-Ramirez, S., Sudhaman, S., E...> ;Cancer Discovery. 2024 Feb 8
• Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children's Oncology Group AREN18B5-Q.
  Murphy, A., Cheng, C., Williams, J., Shaw, T., Pinto, E., Dieseldorff-Jones, K., Brzezinski, J., Renfro, L., Tornwall, B., Huff, V., Hong, A., Mullen, E., Crompton, B....> ;Nature Communications. 2023 Dec 18
• Parental Understanding of Their Child's Germline Genomic Testing: Intent of Disclosure to Their Child and Family.
  Mandrell, B., Blake, A., Sharp, K., Gattuso, J., McGee, R., Harrison, L., Ouma, A., Caples, M., Johnson, L., Nichols, K.> ;Journal of Personalized Medicine. 2023 Nov 28
• 2 citations
  Cancer germline predisposing variants and late mortality from subsequent malignant neoplasms among long-term childhood cancer survivors: a report from the St Jude Life...
  Chen, C., Qin, N., Wang, M., Dong, Q., Tithi, S., Hui, Y., Chen, W., Wu, G., Kennetz, D., Edmonson, M., Rusch, M., Thrasher, A., Easton, J., Mulder, H., Song, N., Plon...> ;The Lancet. Oncology. 2023 Oct 1
• 2 citations
  Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice.
  Marta Isidro-Hernández, Ana Casado-García, Ninad Oak, Silvia Alemán-Arteaga, Belén Ruiz-Corzo, Jorge Martínez-Cano, Andrea Mayado, Elena G Sánchez, Oscar Blanco, Ma Lu...> ;Nature Communications. 2023 Aug 24
• 4 citations
  The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected Haemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome (...
  Bita Shakoory, Ashley Geerlinks, Marta Wilejto, Kate Kernan, Melissa Hines, Micol Romano, David Piskin, Angelo Ravelli, Rashmi Sinha, Daniel Aletaha, Carl Allen, Hamid...> ;Arthritis & Rheumatology. 2023 Oct 1
• 9 citations
  The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (...
  Bita Shakoory, Ashley Geerlinks, Marta Wilejto, Kate Kernan, Melissa Hines, Micol Romano, David Piskin, Angelo Ravelli, Rashmi Sinha, Daniel Aletaha, Carl Allen, Hamid...> ;Annals of the Rheumatic Diseases. 2023 Oct 1
• Germline GeneticVariation and Predisposition to B-cell Acute Lymphoblastic Leukemia in Children.
  Carolin Escherich, Wenan Chen, Yizhen Li, Wenjian Yang, Rina Nishii, Zhenhua Li, Elizabeth A Raetz, Meenakshi Devidas, Gang Wu, Kim E Nichols, Hiroto Inaba, Ching-Hon ...> ;Research Square. 2023 Jul 21
• 1 citations
  How I communicate with patients and families about germ line genetic information.
  Kayla V Hamilton, Lucy C Fox, Kim E Nichols> ;Blood. 2023 Jun 29
• 1 citations
  Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome.
  Vallijah Subasri, Nicholas Light, Nisha Kanwar, Jack Brzezinski, Ping Luo, Jordan R Hansford, Elizabeth Cairney, Carol Portwine, Christine Elser, Jonathan L Finlay, Ki...> ;Cancer Research Communications. 2023 May 1
• Germline genomic findings in children and young adults with melanocytic tumors.
  Margaret B Nagel, Melissa R Perrino, Regina Nuccio, Alise K Blake, Lynn Harrison, Kim E Nichols, Alberto S Pappo> ;Pediatric Blood & Cancer. 2023 Jul 1
• 3 citations
  Germline pathogenicvariants in neuroblastoma.
  Leora Witkowski, Kim E Nichols, Marjolijn Jongmans, Nienke van Engelen, Ronald R de Krijger, Jennifer Herrera-Mullar, Lieve Tytgat, Armita Bahrami, Helen Mar Fan, Aime...> ;Journal of Medical Genetics. 2023 Oct 1
• 1 citations
  Pathogenic Variants in Adult-Onset Cancer Predisposition Genes in Pediatric Cancer: Prevalence and Impact on Tumor Molecular Features and Clinical Management.
  Rose B McGee, Ninad Oak, Lynn Harrison, Ke Xu, Regina Nuccio, Alise K Blake, Roya Mostafavi, Sara Lewis, Leslie M Taylor, Manish Kubal, Annastasia Ouma, Stacy J Hines-...> ;Clinical Cancer Research. 2023 Apr 3
• 2 citations
  Insights into the cellular pathophysiology of familial hemophagocytic lymphohistiocytosis.
  Erica A Steen, Kim E Nichols, Lauren K Meyer> ;Frontiers in Immunology. 2023 Jan 1
• Germline landscape ofvariants in pediatric malignancies: identification ofas a novel cancer predisposition candidate gene.
  Richa Sharma, Ninad Oak, Wenan Chen, Rose Gogal, Martin Kirschner, Fabian Beier, Michael J Schnieders, Maria Spies, Kim E Nichols, Marcin Wlodarski> ;Frontiers in Oncology. 2023 Jan 1
• Cellular and transcriptional impacts of Janus kinase and/or IFN-gamma inhibition in a mouse model of primary hemophagocytic lymphohistiocytosis.
  Sabrin Albeituni, Ninad Oak, Heather S Tillman, Alexa Stroh, Camille Keenan, Mackenzie Bloom, Kim E Nichols> ;Frontiers in Immunology. 2023 Jan 1
• 3 citations
  Recent advances in the treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome.
  Rohith Jesudas, Kim E Nichols> ;Current Opinion in Allergy and Clinical Immunology. 2022 Dec 1
• 2 citations
  Parental Preferences Surrounding Timing and Content of Consent Conversations for Clinical Germline Genetic Testing Following a Child's New Cancer Diagnosis.
  Belinda N Mandrell, Liza Marie Johnson, Mary Caples, Jami Gattuso, Jamie L Maciaszek, Roya Mostafavi, Katianne M Howard Sharp, Kim E Nichols> ;JCO Precision Oncology. 2022 Oct 1
• 1 citations
  Collaboration to Promote Research and Improve Clinical Care in the Evolving Field of Childhood Cancer Predisposition.
  Suzanne P MacFarland, Luke Maese, Surya P Rednam, Junne Kamihara, Melissa R Perrino, Kim E Nichols, Garrett M Brodeur, Joshua D Schiffman, Sharon E Plon, Lisa R Diller...> ;Cancer Prevention Research. 2022 Oct 4
• 9 citations
  Discovery of novel predisposing coding and noncoding variants in familial Hodgkin lymphoma.
  Jamie E Flerlage, Jason R Myers, Jamie L Maciaszek, Ninad Oak, Sara R Rashkin, Yawei Hui, Yong-Dong Wang, Wenan Chen, Gang Wu, Ti-Cheng Chang, Kayla Hamilton, Saima S ...> ;Blood. 2023 Mar 16
• 7 citations
  Phase II study of alisertib as a single agent for treating recurrent or progressive atypical teratoid/rhabdoid tumor.
  Santhosh A Upadhyaya, Olivia Campagne, Catherine A Billups, Brent A Orr, Arzu Onar-Thomas, Ruth G Tatevossian, Roya Mostafavi, Jason R Myers, Anna Vinitsky, Daniel C M...> ;Neuro-Oncology. 2023 Feb 14
• Case Series: Neurobehavioral Profile of Adolescents with PTEN Hamartoma Tumor Syndrome.
  Holly M Hasler, Alise Murray, Kristin E Canavera, Kendra R Parris, Kim E Nichols, Lisa M Jacola> ;Journal of Pediatric Neuropsychology. 2022 Jun 1
• 6 citations
  Managing Pandora's Box: Familial Expectations around the Return of (Future) Germline Results.
  Liza-Marie Johnson, Belinda N Mandrell, Chen Li, Zhaohua Lu, Jami Gattuso, Lynn W Harrison, Motomi Mori, Annastasia A Ouma, Michele Pritchard, Katianne M Howard Sharp,...> ;AJOB Empirical Bioethics. 2022 Apr 26
• 6 citations
  Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice.
  Ana Casado-García, Marta Isidro-Hernández, Ninad Oak, Andrea Mayado, Christine Mann-Ran, Javier Raboso-Gallego, Silvia Alemán-Arteaga, Alexandra Buhles, Dario Sterker,...> ;Cancer Research. 2022 Mar 15
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Journal Articles

• Clinical Genome Sequencing Uncovers Potentially Targetable Truncations and Fusions of MAP3K8 in Spitzoid and Other Melanomas  
  Alberto Pappo, Armita Bahrami, Elizabeth M Azzato, Kim E Nichols, David W Ellison, Nature
• Polygenic Determinants for Subsequent Breast Cancer Risk in Survivors of Childhood Cancer: The St Jude Lifetime Cohort Study (SJLIFE)  
  Kim E Nichols, Melissa M Hudson, Chimene A Kesserwan, Matthew J Ehrhardt, James R Downing, Clinical Cancer Research
• The Influence of Adolescence on Parents’ Perspectives of Testing and Discussing Inherited Cancer Predisposition  
  Melissa A Alderfer, Carol A Ford, Corinna L Schultz, Kim E Nichols, Kristin Zelley, Robert B Lindell, Journal of Genetic Counseling
• Stepwise phosphorylation of p65 promotes NF-?B activation and NK cell responses during target cell recognition  
  Kwon HJ, Choi GE, Ryu S, Kwon SJ, Kim SC, Booth C, Nichols KE, Kim HS, Nat Commun, 1/1/2016
• Reply to: Germline mutations in predisposition genes in children with cancer  
  Zhang J, Nichols KE, Downing J, New Engl J Med, 1/1/2016
• Hemophagocytic lymphohistiocytosis caused by dominant negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion  
  Spessott WA, Sanmillan ML, McCormick ME, Patel N, Villanueva J, Zhang K, Nichols KE, Giraudo CG, Blood, 1/1/2015
• Parent decision-making around genetic testing of children for germline TP53 mutations  
  Alderfer MA, Zelley K, Lindell RB, Novokmet A, Mai PL, Garber JE, Nathan D, Scollon S, Chun NM, Patenaude AF, Ford JM, Plon SE, Schiffman JD, Diller LR, Savage SA, Mal..., Cancer, 1/1/2015
• Germline Genetic Variation in ETV6 and Risk of Childhood Acute Lymphoblastic Leukemia: a Systematic Genetic Study  
  Moriyama T, Metzger ML, Wu G, Nishii R, Qian M, Devidas M, Yang W, Cheng C, Quinn E, Raimondi S, Gastier-Foster JM, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, ..., Lancet Oncol, 1/1/2015
• Germline Mutations in Predisposition Genes in Pediatric Cancer  
  Zhang J, Walsh MF, Wu G, Edmonson MN, Gruber TA, Easton J, Hedges D, Ma X, Zhou X, Yergeau DA, Wilkinson MR, Vadodaria B, Chen X, McGee RB, Hines-Dowell S, Nuccio R, Q..., New Engl J Med, 1/1/2015
• Germline ETV6 mutations confer susceptibility to acute lymphoblastic leukemia and thrombocytopenia  
  Topka S, Vijai J, Walsh MF, Jacobs L, Maria A Villano D, Gaddam P, Wu G, McGee RB, Quinn E, Inaba H, Hartford C, Pui CH, Pappo AS, Edmonson M, Zhang M, Stepensky P, St..., PLOS Genetics, 1/1/2015
• Clinical features of three girls with mosaic genome-wide paternal uniparental isodisomy  
  Kalish JM, Conlin LK, Bhatti TR, Dubbs HA, Harris MC, Izumi K, Mostoufi-Moab S, Mulchandani S, Saitta S, States LJ, Swarr DT, Wilkens AB, Zackai EH, Zelley K, Bartolom..., Am J Hum Genet, 1/1/2013
• Bilateral pheochromocytomas, hemihyperplasia, and subtle somatic mosaicism: the importance of detecting low-level uniparental disomy  
  Kalish JM, Conlin LK, Mostoufi-Moab S, Wilkens AB, Mulchandani S, Zelley K, Kowalski M, Bhatti TR, Russo P, Mattei P, Mackenzie WG, LiVolsi V, Nichols KE, Biegel JA, S..., Am J Med Genet, 1/1/2013
• Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy  
  Teachey DT, Rheingold SR, Maude SL, Zugmaier G, Barrett DM, Seif AE, Nichols KE, Suppa EK, Kalos M, Berg RA, Fitzgerald JC, Aplenc R, Gore L, Grupp SA, Blood, 1/1/2013
• Treatment of Epstein-Barr virus-induced haemophagocytic lymphohistiocytosis with rituximab-containing chemo-immunotherapeutic regimens  
  Chellapandian D, Das R, Zelley K, Wiener SJ, Zhao H, Teachey DT, Nichols KE; EBV-HLH Rituximab Study Group, Br J Haematol, 1/1/2013
• X-linked lymphoproliferative disease (XLP)  
  Bassiri H, Nichols KE, Atlas Genet Cytogenet Oncol Haematol, 1/1/2012
• Expansion of somatically reverted memory CD8+ T cells in X-linked lymphoproliferative disease caused by selective pressure from Epstein Barr virus  
  Palendira U, Low C, Bell AI, Ma CS, Abbott RJ, Phan TG, Riminton DS, Choo S, Smart JM, Lougaris V, Giliani S, Buckley RH, Grimbacher B, Alvaro F, Klion AD, Nichols KE,..., J Exp Med, 1/1/2012
• X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: A Multicentre Study on the manifestations, management and outcome of the disease  
  Booth C, Gilmour KC, Veys P, Gennery AR, Slatter MA, Chapel H, Heath PT, Steward CG, Smith O, O'Meara A, Kerrigan H, Mahlaoui N, Cavazzana-Calvo M, Fischer A, Moshous ..., Blood, 1/1/2011
• SAP-mediated inhibition of diacylglycerol kinase alpha regulates TCR-induced diacylglycerol signalling  
  Baldanzi G, Pighini A, Bettio V, Rainero E, Traini S, Chianale F, Porporato P, Filigheddu N, Mesturini R, Song S, Schweighoffer T, Patrussi L, Baldari CT, Zhong XP, va..., J Immunol, 1/1/2011
• Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10 secreting NKT2 cells in nonobese diabeti...  
  Baev DV, Caielli S, Ronchi F, Coccia M, Facciotti F, Nichols KE, Falcone M, J Immunol, 1/1/2008
• In FHL4, NK cells pack less of a punch  
  Nichols K, Blood, 1/1/2007
• Selective generation of functionally somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease  
  Ma CS, Pittalugia S, Avery DT, Hare NJ, Maric I, Klion AD, Nichols KE, Tangye SG, J Clin Invest, 1/1/2006
• Signaling via the T cell receptor  
  Singer AL, Jordan MS, Judd BA, Myung PS, Newbrough SA, Nichols KE, Olenchock BA, Peterson EJ, Wu JN, Zhong XP, Koretzky GA, Sci STKE, 1/1/2003
• The expression of WT1 in the differentiation of rhabdomyosarcoma from other pediatric small round blue cell tumors  
  Carpentieri DF, Nichols KE, Chou PM, Matthews M, Pawel B, Huff D, Mod Pathol, 1/1/2002
• X-linked lymphoproliferative disease  
  Nichols KE, Gross TG, Immunol Allergy Clin North Am, 1/1/2002
• CDw150 is a signaling molecule that modulates CD95-mediated apoptosis  
  Sidorenko, SP, Yurchenko ON, Shlapatskaya LN, Mikhalap SV, Berdova AG, Yun TJ, Nichols KE, Clark EA, Exp Oncol, 1/1/2000
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Books/Book Chapters

• Brain Tumors in Children. 
  Chapter: Predisposition to central nervous system cancers. 
  Broniscer A, Nichols KEEditors: Gajjar A, Reaman GH, Racadio JM, Smith F.Springer Press2016
• Nathan and Oski’s Hematology and Oncology of Childhood 
  Chapter: Genetic predisposition to cancer. 
  Zelley K, Lindell RB, Schiffman JD, Nichols KEEditors: Orkin SH, Nathan DG, Ginsburg D, Look AT, Lux SE.Elsevier Saunders PressEdition 8th,2014
• Immunologic Disorders in Infants and Children, 
  Chapter: The X-linked lymphoproliferative syndromes. 
  Nichols KE, Marsh RMEditors: Stiehm R, Ochs HD, Winkelstein JA.Elsevier Saunders PressEdition 6th,2013
• Cancer Immunology: Translational Medicine from Bench to Bedside. 
  Chapter: Primary immunodeficiencies and cancers. 
  Hedayat M, Al-Herz W, Aghamohammadi A, Nichols KE, Rezaei NEditors: Rezaei N.Springer Press2013
• Retinoblastoma 
  Chapter: The genetics of retinoblastoma: molecular and clinical aspects. 
  Ganguly A, Nichols KEEditors: Ramasubramanian A, Shields CL.Jaypee Brothers Medical Publishers, New Delhi, IndiaEdition 1st,2011
• Childhood Leukemias, 
  Chapter: Inherited predisposition to childhood leukemia. 
  Seif A, Biegel J, Lange BJ, Nichols KEEditors: Pui CH.Cambridge University Press, Cambridge, EnglandEdition 3rd,2010
• Requisites in Pediatrics: Hematology and Oncology. 
  Chapter: Retinoblastoma. 
  Nichols KE, Leahey A, Meadows ATEditors: Brodeur G, Manno C.Elsevier Health Sciences-Mosby Publisher, Philadelphia, PA2007
• Requisites in Pediatrics: Hematology and Oncology. 
  Chapter: The Childhood Histiocytoses: Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis. 
  Goldsmith K, Hogarty M, Nichols KEEditors: Brodeur G, Manno C.Elsevier Health Sciences-Mosby Publisher, Philadelphia, PA2007
• Modern Aspects of Immunobiology. 
  Chapter: Summary of the 13th Nikolas Symposium. The Macrophage and Dendritic Cell Newsletter. 
  Page 3 - 6Nichols KE, Perry VH, Arceci R, Pritchard J, Jaffe R, Egeler RM, Leenen PJM2004
• Leukocyte Typing VII. 
  Chapter: CDw150 modulates CD95-mediated apoptosis. 
  Page 60 - 63Shlapatskaya LM, Berdova GG. Mikhalap SV, Yun TJ, Nichols KE, Clark EA, Sidorenko SPOxford University Press2002
• Leukocyte Typing VII. 
  Chapter: CDw150 association with SHIP versus SHP-2 in B cells. 
  Page 109 - 111Mikhalap SV, Shlapatska LM, Berdova GG, Yun TJ, Nichols KE, Clark EA, Sidorenko SPOxford University Press2002
• Encyclopedia of Molecular Medicine. 
  Chapter: Function of the T-cell co-stimulatory molecule, SLAM. 
  Page 2916 - 2919Tangye SG, Nichols, KEJohn Wiley & Sons, Inc., New York, NY2001
• Encyclopedia of Molecular Medicine. 
  Chapter: The X-linked lymphoproliferative disease gene, SH2D1A. 
  Page 2986 - 2989Nichols KE, Tangye SJohn Wiley & Sons, Inc., New York, NY2001
• Principles of Molecular Medicine. 
  Chapter: Molecular genetics of renal neoplasms: Wilms’ tumor and renal cell carcinoma. 
  Page 685 - 691Nichols KE, Haber DAHumana Press1998
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Abstracts/Posters

• The Combination of Dexamethasone and Ruxolitinib Synergistically Attenuates Disease Manifestations in a Preclinical Model of Hemophagocytic Lymphohistiocytosis
  Kim E. Nichols, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Germline mutations in cancer predisposition genes and risk for subsequent neoplasms among long-term survivors of childhood cancer in the St. Jude Lifetime Cohort.
  Wang Z, Wilson CL, Easton J, Hedges D, Liu Q, Wu G, Rusch M, Edmonson M, Levy S, Lanctot J, Caron E, Shelton K, Currie K, Lear M, Mulder H, Yergeau D, Rosencrance C, V..., American Association for Cancer Research Annual Meeting, 1/1/2017
• Enhancing the Anti-Leukemia Functions of Invariant Natural Killer T Cells Using a Tumor Antigen-Specific Model.
  Gohl T, Guan P, Mack RM, Evans E, Zauderer M, Das R, Nichols KE, 16th annual CHI Peptalk, Bispecific antibody Therapeutics, 1/1/2017
• Considerations for Genetic Counseling of Adult Survivors of Childhood Cancer.
  Lewis CP, Nichols KE, 15th International Conference on Long-Term Complications of Treatment of Children and Adolescents for Cancer, 1/1/2017
• Analysis of Germline Variants of Uncertain Significance from Paired Tumor-Germline Samples in a Pediatric Genomic Sequencing Research Study.
  Kesserwan C, Hedges D, Newman S, Hamilton K, McGee R, Quinn E, Nuccio R, Valdez J, Foy S, Nakitandwe J, Harrison L, Ouma A, Hines-Dowell S, Shurtleff S, Azzato E, Elli..., Curating the Clinical Genome Meeting, 1/1/2017
• Pediatric Malignant Neoplasms Involving Horseshoe Kidneys: An Institutional Experience Including The First Case of Clear Cell Sarcoma of Kidney and The First Reported ...
  Santiago T, Clay MR, Azzato EM, Newman S, Fernandez-Pineda I, Nichols KE, Zhang J, Downing JR, Davidoff AM, Brennan RC, Ellison DW, United States and Canadian Academy of Pathology, 1/1/2017
• Dampened inflammation with ruxolitinib treatment leads to CD8+ T cell exhaustion and induction of T regulatory cells in a murine model of HLH.
  Albeituni S, Verbist K, Tedrick P, Tillman H, Nichols KE, American Association of Immunologist Annual Meeting, 1/1/2017
• Predictive Genomic Sequencing: The Impact of a Structured Informed Consent Model on Parental Understanding.
  Johnson LM, Valdez J, Nichols KE, Mandrell B, Baker J, Pediatric Academic Societies Meeting, 1/1/2017
• Genomes for Kids (G4K): A feasibility study using Whole exome (WES), Whole genome (WGS) and RNA sequencing on tumor and germline samples.
  Hines-Dowell S, Ouma A, Harrison L, Johnson L, Kubal M, Mandrell B, Kesserwan C, Zhang J, Downing JR, Nichols KE, International Society of Nurses in Genetics Annual Meeting, Dublin, Ireland, 1/1/2016
• Clinician knowledge and utilization of genome sequencing results.
  Mandrell B, Johnson L, Valdez J, Hines-Dowell S, Nichols KE, International Society of Nurses in Genetics Annual Meeting, Dublin, Ireland, 1/1/2016
• Hemophagocytic Lymphohistiocytosis (HLH) in Langerhans cell histiocytosis (LCH): A multicenter retrospective descriptional study.
  Chellapandian D, Zhang R, Jeng M, van den Bos C, Santa Maria A, Lehmberg K, Sieni E, Wang Y, Nakano TA, Williams J, Fustino NJ, Astigarraga I, Dunkel IJ, An QA, Cheng ..., 32nd Annual Meeting of the Histiocyte Society, Dublin, Ireland, 1/1/2016
• A combination of ATG and Etoposide for the treatment of HLH: Results of the HIT-HLH trial.
  Jordan MB, Henry M, Allen CE, McClain K, Greenberg J, Ladisch S, Hermiston ML, Jeng M, Degar BA, Kanter J, Naqvi A, Joyce M, Nichols KE, Teachey DT, Marsh RA, Grimley ..., 32nd Annual Meeting of the Histiocyte Society, Dublin, Ireland, 1/1/2016
• Parent-child communication and testing for cancer predisposition.
  Mandrell B, Valdez J, Gattuso J, Ogg S, Nichols KE, Association of Pediatric Hematology Oncology Nurses Annual Meeting, Providence, RI, 1/1/2016
• Hemophagocytic Lymphohistiocytosis (HLH) in Langerhans cell histiocytosis (LCH): A multicenter retrospective descriptional study.
  Chellapandian D, Zhang R, Jeng M, van den Bos C, Santa-María López V, Lehmberg K, Sieni E, Wang Y, Nakano T, Williams J, Fustino N, Astigarraga I, Dunkel I, An Q, Chen..., American Society of Hematology Annual Meeting, San Diego, CA, 1/1/2016
• Germline Genetic Variation in IKZF1 and Predisposition to Childhood Acute Lymphoblastic Leukemia.
  Churchman ML, Qian M, Zhang R, te Kronnie G, Yang W, Hui Z, Lana T, Tedrick P, Baskin R, Devidas M, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, Mardis E, Fulton..., American Society of Hematology Annual Meeting, San Diego, CA, 1/1/2016
• Comprehensive Functional Characterization of Germline ETV6 Variants Associated with Inherited Predisposition to Acute Lymphoblastic Leukemia in Children.
  Nishii R, Baskin R, Moriyama T, Hoshitsukid K, Metzger ML, Wu G, Devidas M, Yang W, Tedrick P, Quinn E, Gastier-Foster JM, Raetz E, Larsen E, Martin PL, Bowman WP, Win..., American Society of Hematology Annual Meeting, San Diego, CA, 1/1/2016
• Expanding the Phenotype of DICER1 Syndrome: Two Years of DICER1 Testing in a Pediatric Cancer Genetics Clinic.
  McGee R, QuinnE, Nuccio R, Hines-Dowell S, Kesserwan C, Nichols KE, 35th Annual Educ. Conf; Nat. Soc. of Genetic Counselors, Seattle, WA, 1/1/2016
• Unknown consanguinity reveals homozygous CLCN7 mutations previously reported with autosomal dominant osteopetrosis type II: a case report.
  Nuccio R, Hines-Dowell S, Boals M, McGee R, Quinn E, Reiss U, Nichols KE, 35th Annual Educ. Conf; Nat. Soc. of Genetic Counselors, Seattle, WA, 1/1/2016
• Assessing clinician confidence and preferences when incorporating genomics in the pediatric oncology clinic: Insights from an institutional survey.
  Quinn E, Johnson L-M, Valdez JM, McGee RB, Nuccio R, Hines-Dowell S, Kesserwan C, Mandrell BN, Nichols KE, 35th Annual Educ. Conf; Nat. Soc. of Genetic Counselors, Seattle, WA, 1/1/2016
• Mosaic Monosomy 7: A New Syndrome with Increased Risk of Hematologic Disease.
  Akgumus GT, Fan J, Wertheim GB, Mulchandani S, Nichols KE, Wilmoth DM, Gleason AG, Zackai EH, Biegel JA, Spinner NB, Li M, Conlin LK, Deardorff MA, Luo M, America College of Medical Genetics Annual Meeting, Tampa, FL, 1/1/2016
• Preemptive Clinical Pharmacogenetic Testing in Children: Patient and Parent Preferences.
  Ring S, Haidar CE, Kornegay N, Hoffman JM, Broeckel U, Evans WE, Nichols KE, Relling MV, Crews KR, American Society of Human Genetics, Vancouver, Canada, 1/1/2016
• Clinical utilization of whole-genome, whole exome and transcriptome sequencing integrative analysis for pediatric oncology molecular diagnostics.
  Azzato EM, Shurtleff SA, Nakitandwe J, Rusch M, Hedges D, Newman S, Zhang Z, Edmonson M, Thrasher A, Becksfort JB, Kesserwan C, Raimondi S, Nichols KE, Ellison DW, Z..., Association for Molecular Pathology, 1/1/2016
• Change in expert consensus based on availability of additional laboratory data over the course of MAS.
  Davì S, Minoia F, Martini A, Ruperto N, Ravelli A, Horne AC, Henter JI, Wulffraat NM, Wouters C, Wallace C, Uziel Y, Sterba G, Schneider R, Russo R, Ramanan AV, Pachlo..., 23rd European Paediatric Rheumatology Congress, 1/1/2016
• Inhibition of diacylglycerol kinase alpha restores sensitivity to TCR-induced cell death and lessens immunopathology in a murine model of ZLP-associated hemophagocytic...
  31st Annual Meeting of the Histiocyte Society, Athens, Greece, 1/1/2015
• North American Consortium for Histiocytosis (NACHO) providing a mechanism to enhance clinical and translational research in Langerhans cell Histiocytosis.
  Rodriguez Galindo C, Abla O, Arceci R, Campbell P, Degar B, Filipovich A, Greenberg J, Hermiston M, Hogarty M, Jacobsen E, Jordan M, Jubran R, Ladisch S, McClain K, Me..., Hisiocyte Society Annual Meeting, Athens, Greece, 1/1/2015
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Lectures

• Pediatric Leukemia Predisposition Syndromes 
  60th American Society of Hematology Annual Meeting - 12/1/2018
• Therapeutic Candidate Alpn-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Human/NSG Mouse Xenograft Graft Vs. Host Disease (GvHD) in a Dose Ranging Study and Re... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Inherited Hematopoietic Malignancies 
  60th American Society of Hematology Annual Meeting - 11/30/2018
• Childhood Cancer Predisposition: At the Tip of the Iceberg 
  Dana Farber Cancer Institute, Boston, MA - 1/17/2017
• Recommendations for Surveillance for Leukemia Predisposing Conditions 
  Washington, DC - 1/2/2017
• Targeting Jak-STAT Pathway in MAS and HLH 
  Mandarin Oriental, Washington, DC - 1/23/2016
• Pre-clinical studies of JAK inhibition in HLH 
  St. Jude Children’s Research Hospital, Memphis, TN - 1/21/2016
• Bioethical aspects of genomic studies 
  Rio de Janeiro, Brazil - 1/18/2016
• Genes that predispose to pediatric cancer 
  Rio de Janeiro, Brazil - 1/18/2016
• Looking back and to the future; Janus kinase inhibition as a novel therapy for hemophagocytic lymphohistiocytosis 
  Dublin, Ireland - 1/17/2016
• Meet the Expert: HLH and MAS 
  Dublin, Ireland - 1/17/2016
• Hereditary Syndromes associated with leukemia predisposition 
  Boston, MA - 1/8/2016
• Germline genetic testing in the pediatric oncology clinic: who, what and when? 
  Chicago, IL - 1/4/2016
• Evaluation and management of cancer predisposition syndromes 
  Singapore - 1/4/2016
• Introduction to cancer susceptibility syndromes that predispose to leukemia 
  San Diego, CA - 1/3/2016
• HLH genetics: what every family needs to know 
  Cincinnati, OH - 1/1/2016
• Update on the biology and treatment of X-linked lymphoproliferative syndrome, type 1/SAP deficiency 
  Cincinnati, OH - 1/1/2016
• New insights into the diagnosis and management of EBV-HLH 
  Athens, Greece - 1/29/2015
• Inhibition of diacylglycerol kinase alpha restores sensitivity to TCR-induced cell death and lessens immunopathology in a murine model of X-linked lymphoproliferative ... 
  Athens, Greece - 1/28/2015
• Clinical applications of Cancer Genomic Testing 
  San Diego, CA - 1/27/2015
• Translational studies in anti-tumor immunity and hyper-inflammation 
  St. Jude Children’s Research Hospital, Memphis, TN - 1/26/2015
• Genetic testing and exome sequencing: their roles in the diagnosis of HLH 
  Cincinnati, OH - 1/19/2015
• HLH Genetics: what does it mean for my family? 
  Cincinnati, OH - 1/19/2015
• SAP deficiency: Update on diagnosis, pathogenesis and management 
  Cincinnati, OH - 1/19/2015
• Harnessing the immunostimulatory properties of invariant natural killer T (iNKT) cells in novel iNKT cell-based therapies for cancer 
  Boston, MA - 1/8/2015
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Other

• Li-Fraumeni Syndrome. GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. 
  Schneider K, Zelley K, Nichols KE, Garber J
  http://www.genetests.org
  University of Washington, Seattle, WA - 1/1/2013
• 13th annual Nikolas Symposium - Langerhans cell histiocytosis (LCH): neoplasia or immune dysregulation? 
  Nichols K, Symposium Proceedings
  http://nikolas.info/index.html
  1/1/2003
• 12th annual Nikolas Symposium - Dendritic cell differentiation: signals, signaling and functional consequences as clues to possible therapy. 
  Nichols KE, Egeler RM, Perry VH, Arceci RJ, Symposium Proceedings
  http://nikolas.info/index.html
  1/1/2002
• 11th annual Nikolas Symposium – Cytokine networks in acute and chronic inflammation. 
  Nichols K, Symposium Proceedings
  http://nikolas.info/index.html
  1/1/2001
• AMSTERDAM 2000: A Joint Meeting of the Histiocyte Society and Nikolas Symposium. 
  Nichols K, Symposium Proceedings
  http://nikolas.info/index.html
  1/1/2000
• 10th annual Nikolas Symposium – Inflammation and the central nervous system. 
  Nichols K, Symposium Proceedings
  http://nikolas.info/index.html
  1/1/1999
• Ataxia Telangiectasia. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/ataxia-telangiectasia.html
• Beckwith Wiedeman Syndrome. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/beckwith-weidemann-syndrome.html
• Familial Adenomatous Polyposis. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/familial-adenomatous-polyposis.html
• Hereditary Neuroblastoma. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/hereditary-neuroblastoma.html
• Hereditary paraganglioma pheochromocytoma syndrome. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/hereditary-paraganglioma-pheochromocytoma-syndrome.html
• Juvenile polyposis syndrome. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/juvenile-polyposis.html
• Li Fraumeni syndrome. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/li-fraumeni-syndrome.html
• Multiple endocrine neoplasia, Type 1. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/multiple-endocrine-neoplasia-type-1.html
• Multiple endocrine neoplasia syndrome, Type 2. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/multiple-endocrine-neoplasia-type-2.html
• Neurofibromatosis, Type 1. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/neurofibromatosis-type-1.html
• Neurofibromatosis, Type 2. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/neurofibromatosis-type-1.html
• Nevoid basal cell carcinoma syndrome. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/nevoid-basal-cell-carcinoma-syndrome.html
• Peutz-jeghers syndrome. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/peutz-jeghers-syndrome-pjs.html
• PTEN hamartoma tumor syndrome. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/pten-hamartoma-tumor-syndrome.html
• Von Hippel-Lindau syndrome. 
  K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/von-hippel-lindau-syndrome.html
• Wilms tumor related syndromes. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/wt1-related-wilms-tumor-wt-syndromes.html
• X-linked lymphoproliferative syndrome. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/x-linked-lymphoproliferative-syndrome.html
• Retinoblastoma. 
  Zelley K, Nichols KE
  http://www.chop.edu/service/oncology/cancers-explained/retinoblastoma-diagnosing-and-treating-retinoblastoma-in-children.html
• Pleuropulmonary blastoma family tumor and dysplasia syndrome (DICER1 syndrome). 
  Wiley S, Zelley K, Nichols KE
  http://www.chop.edu/service/oncology/our-programs/hereditary-cancer-predisposition-program/genetic-syndromes-with-cancer-risks/dicer1-syndrome.html
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