
Kirk U Knowlton MD FACC, FAHA
Non-Invasive Cardiology, Preventive Cardiology, Cardiovascular Disease Genetics
Director of Cardiovascular Research Intermountain Health. Professor, Clinical Investigation, Intermountain Health. Adjunct Professor of Medicine, University of Utah
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5121 South Cottonwood StreetBuilding 1Salt Lake City, UT 84107
Phone+1 801-507-4000
Fax+1 801-507-3505
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Summary
- I have a strong interest in understanding how and why patients develop heart failure, including abnormalities in DNA, infections of the heart like viral myocarditis, and the role of immune function in heart cells that affect cardiac performance. I've also made discoveries related to how heart cells communicate with each other to establish normal conduction. Clinically, I practice as a general cardiologist with a focus on heart failure and pulmonary hypertension, where I apply my research efforts to preventing the development of heart disease, promoting optimal recovery, and advancing the use of a person’s own biological characteristics to provide precision medicine.
Education & Training
UC San Diego Medical Center Molecular Cardiology Research Fellowship, 1989 - 1991
University of California (San Diego) Medical CenterFellowship, Cardiovascular Disease, 1987 - 1989
Duke University HospitalResidency, Internal Medicine, 1984 - 1987
University of Utah School of MedicineClass of 1984
Brigham Young UniversityBA, Chemistry, 1977 - 1980
Certifications & Licensure
UT State Medical License 2015 - 2028
CA State Medical License 1987 - 2027
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease
Awards, Honors, & Recognition
- Fellow American Heart Association
- American Heart Association "Heart of Gold" Physician Honoree Utah Heart Association Gala, 2017
- Inaugural Frederic C. Shean Endowed Lecturer University of Utah Grand Rounds, 2016
Clinical Trials
- Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term
- Pilot and Feasibility Study of a MAWDS (Medications, Activity, Weight, Diet and Symptoms) Heart Failure Mobile Platform Start of enrollment: 2017 Sep 28
- Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events Start of enrollment: 2018 Mar 26
Publications & Presentations
PubMed
- CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design a...Jeffrey L Anderson, Heidi T May, Tyler Winslow, Viet T Le, Leslie Iverson
American Heart Journal. 2026-09-01 - Resistant Hypertension Variants Link to Hyperaldosteronism and Potassium Levels.Vinicius Tragante, Patrick Sulem, Gudmar Thorleifsson, Michael L Frigge, Joseph G Arthur
Hypertension. 2026-09-01 - The genetic architecture of fibromyalgia across 2.5 million individuals.Isabel Kerrebijn, Gyda Bjornsdottir, Keon Arbabi, Lea Urpa, Hele Haapaniemi
Nature Medicine. 2026-08-01
Press Mentions
Inclisiran plus Usual Care Improves LDL Control in ACS: VICTORION-INCEPTIONJune 4th, 2025
Reduction in BP Drives Treatment Preference for Hypertensive PatientsDecember 20th, 2022
Gout Flares Linked to Temporary Increase in Cardiovascular RiskApril 8th, 2022
Grant Support
- Training In Cardiovascular Physiology And PharmacologyNational Heart, Lung, And Blood Institute2007–2011
- Administative CoreNational Heart, Lung, And Blood Institute2007–2011
- Adhesion Molecules Of The Intercalated DISC In CardiomyopathyNational Heart, Lung, And Blood Institute2007–2011
- Molecular Pathways For Hypertrophy And CardiomyopathyNational Heart, Lung, And Blood Institute2005–2011
- Cardiac SOCS Proteins: A Role In Enterovirus InfectionNational Heart, Lung, And Blood Institute2004–2007
Committees
- Committee Member, Chair Nominating Committee, American Heart Association, Western States Affiliate 2017 - Present
- Chair, Scientific Advisory Committee, The Medical Heart and Lung Foundation, Intermountain 2017 - Present
- Member, Research Guidance Council, Intermountain Healthcare 2017 - Present
- Member, National Research Committee, American Heart Association 2015 - 2016
- President, American Heart Association, Western States Affiliate 2014 - 2016
Professional Memberships
- Member
- Immediate Past President of the Board of Directors, Western States Affiliate; Member, Precision Medicine Task Force
- American Society of Clinical InvestigationMember
- International Society for Heart Research - ISHRMember
- Association of Professors of CardiologyPresident 2015-2016
Other Languages
- Spanish
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