KristinMaraHudockMDMSTR

Pulmonology • Cincinnati, OH

Critical Care Medicine

Assistant Professor of Medicine & Pediatrics, University of Cincinnati & Cincinnati Children's

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Office
Division of Pulmonary Biology
Cincinnati Children's Medical Center
Cincinnati, OH 45229
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Education & Training

University of PennsylvaniaMasters in Translational Research, 2011 - 2013
University of Pennsylvania Health SystemFellowship, Pulmonary Disease and Critical Care Medicine, 2007 - 2010
MedStar Health/Georgetown University HospitalResidency, Internal Medicine, 2003 - 2006
Georgetown University School of MedicineClass of 2003

Certifications & Licensure

OH State Medical License 2015 - 2024
PA State Medical License 2007 - 2016
VA State Medical License 2003 - 2008
DC State Medical License 2004 - 2008
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Publications & Presentations

PubMed

Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects.
Collins, M., Imbrogno, M., Kopras, E., Howard, J., Zhang, N., Kramer, E., Hudock, K.> ;International Journal of Molecular Sciences. 2023 Dec 30
Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects.
Margaret S Collins, Michelle A Imbrogno, Elizabeth J Kopras, James A Howard, Nanhua Zhang, Elizabeth L Kramer, Kristin M Hudock> ;Biorxiv. 2023 Nov 5
CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity.
Elizabeth L Kramer, Kristin M Hudock, Cynthia R Davidson, John P Clancy> ;Respiratory Research. 2023 Aug 11
4 citations
Immune and ionic mechanisms mediating the effect of dexamethasone in severe COVID-19.
Ameet A Chimote, Abdulaziz O Alshwimi, Martina Chirra, Vaibhavkumar S Gawali, Margaret V Powers-Fletcher, Kristin M Hudock, Laura Conforti> ;Frontiers in Immunology. 2023 Jan 1
11 citations
Randomized Phase 3 Trial of Ruxolitinib for COVID-19-Associated Acute Respiratory Distress Syndrome.
Lindsay Rein, Karel Calero, Ronak Shah, Charles Ojielo, Kristin M Hudock, Saba Lodhi, Farid Sadaka, Shashi Bellam, Christopher Palma, David N Hager, Jeannie Daniel, Ri...> ;Critical Care Medicine. 2022 Dec 1
3 citations
Role of Acute Thrombosis in Coronavirus Disease 2019.
Derek V Gibbs, Satya S Shreenivas, Kristin M Hudock> ;Critical Care Clinics. 2022 Jul 1
2 citations
Induction of a cytokine storm involves suppression of the Osteopontin-dependent TH1 response.
Gulimirerouzi Fnu, Kristin Hudock, Margaret Powers-Fletcher, Ruo-Pan Huang, Georg F Weber> ;Immunology. 2022 Oct 1
69 citations
Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
Jeffrey S Berger, Lucy Z Kornblith, Michelle N Gong, Harmony R Reynolds, Mary Cushman, Yu Cheng, Bryan J McVerry, Keri S Kim, Renato D Lopes, Bassel Atassi, Scott Berr...> ;JAMA. 2022 Jan 18
50 citations
Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, ...
Paul Cremer, Antonio Abbate, Kristin Hudock, Carla McWilliams, Jinesh Mehta, Steven Y. Chang, Calvin C Sheng, Benjamin W. Van Tassell, Aldo Bonaventura, Alessandra Vec...> ;The Lancet. Rheumatology. 2021 Mar 17
454 citations
Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
, , , Patrick R Lawler, Ewan C Goligher, Jeffrey S Berger, Matthew D Neal, Bryan J McVerry, Jose C Nicolau, Michelle N Gong, Marc Carrier, Robert S Rosenson, Harmony R...> ;The New England Journal of Medicine. 2021 Aug 26
470 citations
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
, , , Ewan C Goligher, Charlotte A Bradbury, Bryan J McVerry, Patrick R Lawler, Jeffrey S Berger, Michelle N Gong, Marc Carrier, Harmony R Reynolds, Anand Kumar, Alexi...> ;The New England Journal of Medicine. 2021 Aug 26
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.
Sevransky JE, Rothman RE, Hager DN, Bernard GR, Brown SM, Buchman TG, Busse LW, Coopersmith CM, DeWilde C, Ely EW, Eyzaguirre LM, Fowler AA, Gaieski DF, Gong MN, Hall ...> ;JAMA.
Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hay...> ;JAMA.
2 citations
Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.
K M Hudock, M S Collins, M A Imbrogno, E L Kramer, J J Brewington, A Ziady, N Zhang, J Snowball, Y Xu, B C Carey, Y Horio, S M O'Grady, E J Kopras, J Meeker, H Morgan,...> ;Frontiers in Immunology. 2022 Jan 1
95 citations
Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies.
Aldo Bonaventura, Alessandra Vecchié, Tisha Wang, Elinor Lee, Paul Cremer, Brenna Carey, Prabalini Rajendram, Kristin M. Hudock, Leslie Korbee, Benjamin W. Van Tassell...> ;Frontiers in Immunology. 2020 Jul 3
4 citations
Subacute TGFβ Exposure Drives Airway Hyperresponsiveness in Cystic Fibrosis Mice through the PI3K Pathway
Elizabeth L. Kramer, Satish K Madala, Kristin M. Hudock, Cynthia Davidson, John P. Clancy> ;American Journal of Respiratory Cell and Molecular Biology. 2020 May 1
37 citations
Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia.
Kristin M. Hudock, Margaret S. Collins, Michelle Imbrogno, John Snowball, Elizabeth L. Kramer, John J. Brewington, Kandace Gollomp, Cormac McCarthy, Alicia J. Ostmann,...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2020 Mar 11
28 citations
Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.
Kandace Gollomp, Amrita Sarkar, Sanjiv Harikumar, Steven H. Seeholzer, Gowthami M. Arepally, Kristin M. Hudock, Lubica Rauova, M. Anna Kowalska, Mortimer Poncz> ;Blood. 2020 Mar 5
16 citations
An update on new and emerging therapies for cystic fibrosis.
Kristin M. Hudock, John P. Clancy> ;Expert Opinion on Emerging Drugs. 2017 Dec 22
45 citations
Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury
Andrew J. Paris, Yuhong Liu, Junjie Mei, Ning Dai, Lei Guo, Lynn A. Spruce, Kristin M. Hudock, Jacob S. Brenner, William J. Zacharias, Hankun D. Mei, April R. Slamowit...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2016 Dec 1
40 citations
Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis.
John P. Reilly, Brian J. Anderson, Kristin M. Hudock, Thomas G. Dunn, Altaf S. Kazi, Anna Tommasini, Dudley Charles, Michael G.S. Shashaty, Mark E. Mikkelsen, Jason D....> ;Critical Care. 2016 Jul 18
2 citations
Generation of poikiloderma with neutropenia (PN) induced pluripotent stem cells (iPSCs)
Jason A. Mills, Kristin M. Hudock, Spencer K. Sullivan, Pamela S. Herrera, Lisa M. Sullivan, Paul Gadue, Deborah L. French> ;Stem Cell Research. 2015 Nov 1
21 citations
Cardiopulmonary bypass and intra-aortic balloon pump use is associated with higher short and long term mortality after transcatheter aortic valve replacement: a PARTNE...
, , , , , , , , , , , , , , , > ;Catheterization and Cardiovascular Interventions. 2015 Aug 1
38 citations
The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells.
Prasuna Paluru, Kristin M. Hudock, Xin Cheng, Jason A. Mills, Lei Ying, Aline M. Galvão, Lin Lu, Amita Tiyaboonchai, Xiuli Sim, Spencer K. Sullivan, Deborah L. French,...> ;Stem Cell Research. 2014 Mar 1
18 citations
Delayed Resolution of Lung Inflammation in Il-1rn−/− Mice Reflects Elevated IL-17A/Granulocyte Colony–Stimulating Factor Expression
Kristin M. Hudock, Yuhong Liu, Junjie Mei, Roberta C. Marino, Jason E. Hale, Ning Dai, G. Scott Worthen> ;American Journal of Respiratory Cell and Molecular Biology. 2012 Nov 29
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Press Mentions

Researchers Identify How Steroids Benefit Severe COVID-19 PatientsMarch 30th, 2023
Researchers Identify How Steroids Benefit Severe COVID-19 PatientsMarch 29th, 2023