KristineBPattersonMD

Infectious Disease • Little Rock, AR

HIV/AIDS Medicine, STD Medicine

Associate Professor

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Office
UAMS Medical Center
4110 Outpatient Circle Outpatient Center, Second Floor, Suite 2P
Little Rock, AR 72205
Phone+1 501-603-1616
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Education & Training

University of North Carolina HospitalsFellowship, Infectious Disease, 2000 - 2003
University of Texas Medical Branch HospitalsResidency, Internal Medicine, 1996 - 1999
Emory University School of MedicineClass of 1996

Certifications & Licensure

AR State Medical License 2019 - 2025
NY State Medical License 2015 - 2019
NC State Medical License 2000 - 2016
TX State Medical License 1999 - 2000

Clinical Trials

Sex, Aging and Antiretroviral Pharmacokinetics Start of enrollment: 2008 Mar 01
Completed
The Effect of Pregnancy on the Pharmacokinetics of the Kaletra Tablet Start of enrollment: 2007 Jan 01
Completed
Phase 1
A Pilot Study to Characterize the Pharmacokinetics of Raltegravir in the Cervicovaginal Fluids of HIV-infected Women Start of enrollment: 2008 Aug 01
Completed
Study in Healthy Males to Measure Maraviroc in Blood, Saliva, Seminal Fluid, and Rectal Tissue Start of enrollment: 2008 May 01
Completed
Phase 1
Study in Healthy Males to Measure Darunavir and Etravirine in Blood, Seminal Fluid, and Rectal Tissue Start of enrollment: 2009 Jul 01
Completed
Phase 1
IMPAACT 1077HS: Examining Benefits of HAART Continuation in Postpartum Women Start of enrollment: 2010 Jan 01
Completed
Phase 4
Evaluating the Pharmacokinetics of 400 mg Oral Dose of Raltegravir in HIV-Infected Pre-Menopausal Women Start of enrollment: 2009 Jul 01
Completed
The Effect of Pregnancy on the PK of Isentress®: A Longitudinal Investigation in the Second and Third Trimesters Start of enrollment: 2010 Nov 01
Withdrawn
Dose-Proportionality and Intra-Individual Variability of Intracellular TFV-DP and FTC-TP in Healthy Volunteers Start of enrollment: 2011 Jan 01
Completed
Phase 1
Study to Characterize the Pharmacokinetics of Raltegravir in the Gastrointestinal (GI) Tract of Healthy Male Volunteers Start of enrollment: 2011 Apr 01
Completed
Phase 1
Single Dose Truvada in HIV-negative Men and Women Start of enrollment: 2008 Oct 01
Completed
GSK1349572 Exposure in Blood, Seminal Fluid, and Rectal Fluid and Tissue in Healthy Male Subjects Start of enrollment: 2011 Nov 01
Completed
Phase 1
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Publications & Presentations

PubMed

16 citations
Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design.
Mackenzie L. Cottrell, Heather M.A. Prince, Andrew G. Allmon, Katie R. Mollan, Michael G. Hudgens, Craig Sykes, Nicole White, Stephanie Malone, Evan S. Dellon, Ryan D....> ;Journal of Acquired Immune Deficiency Syndromes. 2016 Aug 15
213 citations
A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Withou...
Mackenzie L. Cottrell, Kuo-Hsiung. Yang, Heather M.A. Prince, Craig Sykes, Nicole White, Stephanie Malone, Evan S. Dellon, Ryan D. Madanick, Nicholas J. Shaheen, Micha...> ;The Journal of Infectious Diseases. 2016 Jul 1
3 citations
Model-Based Analysis of Unbound Lopinavir Pharmacokinetics in HIV-Infected Pregnant Women Supports Standard Dosing in the Third Trimester
Jingxian Chen, Stephanie Malone, Heather M.A. Prince, Kristine B. Patterson, Julie B. Dumond> ;CPT. 2016 Mar 1
136 citations
Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)
Craig W. Hendrix, Adriana Andrade, Namandjé N. Bumpus, Angela D. M. Kashuba, Mark A. Marzinke, Ayana Moore, Peter L. Anderson, Lane R. Bushman, Edward J. Fuchs, Ilene ...> ;AIDS Research and Human Retroviruses. 2016 Jan 1
5 citations
No Need for Lopinavir Dose Adjustment during Pregnancy: a Population Pharmacokinetic and Exposure-Response Analysis in Pregnant and Nonpregnant HIV-Infected Subjects
Ahmed Salem, Aksana K. Jones, Marilia Santini-Oliveira, Graham P. Taylor, Kristine B. Patterson, Angela M. Nilius, Cheri E. Klein> ;Antimicrobial Agents and Chemotherapy. 2016 Jan 1
16 citations
Models for predicting effective HIV chemoprevention in women.
Melanie R. Nicol, Cindi W. Emerson, Heather M.A. Prince, Julie A. E. Nelson, Yuri Fedoriw, Craig Sykes, Elizabeth J. Geller, Kristine B. Patterson, Myron S. Cohen, Ang...> ;Journal of Acquired Immune Deficiency Syndromes. 2015 Apr 1
6 citations
Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.
Lisa Rahangdale, Kristina De Paris, Angela D. M. Kashuba, Julie A. E. Nelson, Mackenzie L. Cottrell, Craig Sykes, Cindi W. Emerson, Steven L. Young, Trenton Stevens, K...> ;Journal of Acquired Immune Deficiency Syndromes. 2015 Apr 1
42 citations
Expression of Six Drug Transporters in Vaginal, Cervical, and Colorectal Tissues: Implications for Drug Disposition in HIV Prevention
Melanie R. Nicol, Yuri Fedoriw, Michelle Mathews, Heather M.A. Prince, Kristine B. Patterson, Elizabeth J. Geller, Katie R. Mollan, Stephanie P. Mathews, Deanna L. Kro...> ;Journal of Clinical Pharmacology. 2014 May 1
39 citations
Dolutegravir Pharmacokinetics in the Genital Tract and Colorectum of HIV Negative Men After Single and Multiple Dosing
Benjamin N. Greener, Kristine B. Patterson, Heather M.A. Prince, Craig Sykes, Jessica L. Adams, Julie B. Dumond, Nicholas J. Shaheen, Ryan D. Madanick, Evan S. Dellon,...> ;Journal of Acquired Immune Deficiency Syndromes. 2013 Sep 1
50 citations
Differential penetration of raltegravir throughout gastrointestinal tissue: implications for eradication and cure.
Kristine B. Patterson, Heather M.A. Prince, Trenton Stevens, Nicholas J. Shaheen, Evan S. Dellon, Ryan D. Madanick, Steven H. Jennings, Myron S. Cohen, Angela D. M. Ka...> ;AIDS. 2013 Jun 1
33 citations
Protein binding of lopinavir and ritonavir during 4 phases of pregnancy: implications for treatment guidelines.
Kristine B. Patterson, Julie B. Dumond, Heather M.A. Prince, Amanda J. Jenkins, Kimberly K. Scarsi, Ruili Wang, Stephanie Malone, Michael G. Hudgens, Angela D. M. Kashuba> ;Journal of Acquired Immune Deficiency Syndromes. 2013 May 1
19 citations
Immune Activation While on Potent Antiretroviral Therapy Can Predict Subsequent CD4+ T-Cell Increases Through 15 Years of Treatment
Xinyan Zhang, Peter W. Hunt, Scott M. Hammer, Michelle S. Cespedes, Kristine B. Patterson, Ronald J. Bosch> ;HIV Clinical Trials. 2013 Jan 1
31 citations
Tenofovir diphosphate and emtricitabine triphosphate concentrations in blood cells compared with isolated peripheral blood mononuclear cells: a new measure of antiretr...
Jessica L. Adams, Craig Sykes, Prema Menezes, Heather M.A. Prince, Kristine B. Patterson, Katrien Fransen, Tania Crucitti, Irith De Baetselier, Lut Van Damme, Angela D...> ;Journal of Acquired Immune Deficiency Syndromes. 2013 Mar 1
20 citations
Pharmacokinetics of two common antiretroviral regimens in older HIV-infected patients: a pilot study
Julie B. Dumond, Jessica L. Adams, Heather M.A. Prince, Racheal L. Kendrick, Ruili Wang, Steven H. Jennings, Stephanie Malone, Nicole White, Craig Sykes, Amanda H Corb...> ;HIV Medicine. 2013 Aug 1
28 citations
Single and multiple dose pharmacokinetics of dolutegravir in the genital tract of HIV-negative women.
Jessica L. Adams, Kristine B. Patterson, Heather M.A. Prince, Craig Sykes, Benjamin N. Greener, Julie B. Dumond, Angela D. M. Kashuba> ;Antiviral Therapy. 2013 Jul 31
20 citations
Pharmacokinetic modelling of efavirenz, atazanavir, lamivudine and tenofovir in the female genital tract of HIV-infected pre-menopausal women.
Julie B. Dumond, Melanie R. Nicol, Racheal N. Kendrick, Samira M. Garonzik, Kristine B. Patterson, Myron S. Cohen, Alan Forrest, Angela D. M. Kashuba> ;Clinical Pharmacokinetics. 2012 Oct 9
23 citations
Single- and multiple-dose pharmacokinetics of darunavir plus ritonavir and etravirine in semen and rectal tissue of HIV-negative men.
Kevin C. Brown, Kristine B. Patterson, Steven H. Jennings, Stephanie Malone, Nicholas J. Shaheen, Heather M.A. Prince, Melissa Spacek, Myron S. Cohen, Angela D. M. Kas...> ;Journal of Acquired Immune Deficiency Syndromes. 2012 Oct 1
62 citations
Pre-exposure prophylaxis for HIV prevention: how to predict success.
Angela D. M. Kashuba, Kristine B. Patterson, Julie B. Dumond, Myron S. Cohen> ;Lancet. 2012 Jun 30
272 citations
Penetration of Tenofovir and Emtricitabine in Mucosal Tissues: Implications for Prevention of HIV-1 Transmission
Kristine B. Patterson, Heather M.A. Prince, Eric Kraft, Amanda J. Jenkins, Nicholas J. Shaheen, James F. Rooney, Myron S. Cohen, Angela D. M. Kashuba> ;Science Translational Medicine. 2011 Dec 7
41 citations
Longitudinal Effects of SafeTalk, a Motivational Interviewing-Based Program to Improve Safer Sex Practices Among People Living with HIV/AIDS
Carol E. Golin, Jo Anne Earp, Catherine A. Grodensky, Shilpa N. Patel, Chirayath M. Suchindran, Megha A. Parikh, Seth C. Kalichman, Kristine B. Patterson, Heidi Swygar...> ;AIDS and Behavior. 2012 Jul 1
11 citations
Effects of the H2-Receptor Antagonist Famotidine on the Pharmacokinetics of Atazanavir-Ritonavir With or Without Tenofovir in HIV-Infected Patients
Xiaodong Wang, Marta Boffito, Jenny Zhang, Ellen Chung, Li Zhu, Yaoshi Wu, Kristine B. Patterson, Angela D. M. Kashuba, Pablo Tebas, Michael Child, Lisa Mahnke, Richar...> ;AIDS Patient Care and Stds. 2011 Aug 18
73 citations
Single and Multiple Dose Pharmacokinetics of Maraviroc in Saliva, Semen, and Rectal Tissue of Healthy HIV-Negative Men
Kevin C. Brown, Kristine B. Patterson, Stephanie Malone, Nicholas J. Shaheen, Heather M.A. Prince, Julie B. Dumond, Melissa Spacek, Paris Heidt, Myron S. Cohen, Angela...> ;The Journal of Infectious Diseases. 2011 May 15
17 citations
Darunavir, Ritonavir, and Etravirine Pharmacokinetics in the Cervicovaginal Fluid and Blood Plasma of HIV-Infected Women
Kristine B. Patterson, Steven H. Jennings, Ron Falcon, Joseph M. Mrus, Angela D. M. Kashuba> ;Antimicrobial Agents and Chemotherapy. 2011 Mar 1
44 citations
Contraceptive efficacy of oral and transdermal hormones when co-administered with protease inhibitors in HIV-1-infected women: pharmacokinetic results of ACTG trial A5...
Mary A. Vogler, Kristine B. Patterson, Lori Kamemoto, Jeong Gun Park, Heather Watts, Francesca T. Aweeka, Karin L. Klingman, Susan E. Cohn> ;Journal of Acquired Immune Deficiency Syndromes. 2010 Dec 1
48 citations
A Phenotype–Genotype Approach to Predicting CYP450 and P-Glycoprotein Drug Interactions With the Mixed Inhibitor/Inducer Tipranavir/Ritonavir
Julie B. Dumond, Manoli Vourvahis, Naser L. Rezk, Kristine B. Patterson, Hsiao Chuan Tien, Nicholas J. White, Steven H. Jennings, S. O. Choi, J. Li, Michael J. Wagner,...> ;Clinical Pharmacology and Therapeutics. 2010 Jun 1
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Press Mentions

Comparison of Tenofovir Plasma and Tissue Exposure Using a Population Pharmacokinetic Model and Bootstrap: A Simulation Study from Observed DataNovember 8th, 2017

Grant Support

SEX, Aging And Antiretroviral PharmacologyNational Institute Of Allergy And Infectious Diseases2008–2012
Clinical Trial: Sex Differences In Lopinavir/Ritonavir Pharmaco Among HIV-1 MenNational Center For Research Resources2008
Clinical Trial: Sch47690 In Hiv-Infected, Treatment Experienced SubjectsNational Center For Research Resources2008
Clinical Trial: Phase II Study To Compare Twice Daily And Once Daily Therapy AndNational Center For Research Resources2008
Clinical Trial: Aactg 5202 - Phase IIIB Trial Of Open-Label Efavirenz Or AtazanaNational Center For Research Resources2008
Clinical Trial: Aactg 5188 - Phase II Transdermal Contraceptive System In HIV-1National Center For Research Resources2008
CID 0705 - Vaccine Screening RegistryNational Center For Research Resources2008
Sex Differences In Lopinavir/Ritonavir Pharmaco Among HIV-1 Men And WomenNational Center For Research Resources2007
Immunologic And Virologic Differences Between Pre- And Post-Men HIV WomenNational Center For Research Resources2006–2007
Aactg 5202 - Phase IIIB Trial Of Open-Label Efavirenz Or AtazanaviNational Center For Research Resources2006–2007
Aactg 5188 - Phase II Transdermal Contraceptive System In HIV-1 WomenNational Center For Research Resources2006–2007
Sch47690 In Hiv-Infected, Treatment Experienced SubjectsNational Center For Research Resources2005–2007
Phase II Study To Compare Twice Daily And Once Daily Therapy And Self-AdministerNational Center For Research Resources2005–2007
PK Interactions Between Dmpa, Depo-Provera And Selected Protease InhibsNational Center For Research Resources2004–2007
Virologic And Immunologic Changes In Hiv-Infected Women During PostpartumNational Center For Research Resources2006
Phase I/II Trial Of Anti-Hiv Activity Amp;Safety Of Mifepristone (Aactg 5200)National Center For Research Resources2006
Impact Of Therapeutic Drug Monitoring On Virologic Response To A Salvage RegimenNational Center For Research Resources2004–2006
Therapeutic Drug Monitoring On Virologic Response To A Salvage Regimen: AIDSNational Center For Research Resources2005

Hospital Affiliations

UAMS Medical CenterLittle Rock, Arkansas

KristineBPattersonMD

Dr. Patterson is on Doximity

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Press Mentions

Grant Support

Hospital Affiliations

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