LTerrySpencerJr.MD

PubMed

• Letter to the editor: Response to "COVID-19 associated pediatric vasculitis: A systematic review and detailed analysis of the pathogenesis" by Batu et al.
  Maria C Bryant, L Terry Spencer, Ali Yalcindag> ;Seminars in Arthritis and Rheumatism. 2022 Dec 1
• 9 citations
  A case of ANCA-associated vasculitis in a 16-year-old female following SARS-COV-2 infection and a systematic review of the literature.
  Maria C Bryant, L Terry Spencer, Ali Yalcindag> ;Pediatric Rheumatology Online Journal. 2022 Aug 13
• 16 citations
  Cystic fibrosis newborn screening: using experience to optimize the screening algorithm
  Jaime E. Hale, Richard B. Parad, Henry L. Dorkin, Robert S. Gerstle, Allen Lapey, Brian O'Sullivan, L. Terry Spencer, William F. H. Yee, Anne Marie Comeau> ;Journal of Inherited Metabolic Disease. 2010 Jun 3
• 248 citations
  Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy
  Mark L. Brantly, Jeffrey D. Chulay, Lili Wang, Christian Mueller, Margaret Humphries, L. Terry Spencer, Farshid N. Rouhani, Thomas J. Conlon, Roberto Calcedo, Michael ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Sep 22
• 189 citations
  Repeated aerosolized AAV-CFTR for treatment of cystic fibrosis: a randomized placebo-controlled phase 2B trial.
  Richard B. Moss, Carlos Milla, John L. Colombo, Frank J. Accurso, Pamela L. Zeitlin, John P. Clancy, L. Terry Spencer, Joseph M. Pilewski, David A. Waltz, Henry L. Dor...> ;Human Gene Therapy. 2007 Aug 24
• 141 citations
  Phase I Trial of Intramuscular Injection of a Recombinant Adeno-Associated Virus Serotype 2 α1-Antitrypsin (AAT) Vector in AAT-Deficient Adults
  Mark L. Brantly, L. Terry Spencer, Margaret Humphries, Thomas J. Conlon, Carolyn T. Spencer, Amy Poirier, Wendy Garlington, Dawn J. Baker, Sihong Song, Kenneth I. Bern...> ;Human Gene Therapy. 2006 Dec 28
• 76 citations
  Role of human neutrophil peptides in lung inflammation associated with α1-antitrypsin deficiency
  L. Terry Spencer, Gregorino Paone, Peter M. Krein, Farshid N. Rouhani, Jesus Rivera-Nieves, Mark L. Brantly> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2004 Mar 1
• 264 citations
  Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a mult...
  Richard B. Moss, David M. Rodman, L. Terry Spencer, Moira L. Aitken, Pamela L. Zeitlin, David A. Waltz, Carlos Milla, Alan S. Brody, John P. Clancy, Bonnie W. Ramsey, ...> ;Chest. 2004 Feb 1
• 110 citations
  Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults.
  Terence R. Flotte, Mark L. Brantly, Spencer Lt, Barry J. Byrne, Carolyn T. Spencer, Dawn J. Baker, Margaret Humphries> ;Human Gene Therapy. 2004 Jan 1
• 17 citations
  Resolution of hypoxemia in a liver transplant recipient after ligation of a portosystemic shunt
  L. Terry Spencer, Max R. Langham, Mark H. Hoyer, David A. Jones, James G. Caridi, Sarah E. Chesrown> ;The Journal of Pediatrics. 2000 Oct 1
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Journal Articles

• Standard care versus protocol based therapy for new onset Pseudomonas aeruginosa in cystic fibrosis  
  Mayer-Hamblett N, Rosenfeld M, Treggiari MM, Konstan MW, Retsch-Bogart G, Morgan W, Wagener J, Gibson RL, Khan U, Emerson J, Thompson V, Elkin EP, Ramsey BW; EPIC; ESC..., Pediatr Pulmonol, 1/1/2013
• Inhaled aztreonam lysine vs inhaled tobramycin in cystic fibrosis: a comparative efficacy trial  
  Assael BM, Pressler T, Bilton D, Fayon M, Fischer R, Chiron R, LaRosa M, Knoop C, McElvaney N, Lewis SA, Bresnik M, Montgomery AB, Oermann CM; AZLI Active Comparator S..., J Cyst Fibros, 1/1/2013
• Bioavailability of inhaled fluticasone propionate via chambers/masks in young children  
  Blake K, Mehta R, Spencer T, Kunka RL, Hendeles L, Eur Respir J, 1/1/2012
• Initial Pseudomonas aeruginosa treatment failure is associated with exacerbations in cystic fibrosis  
  Mayer-Hamblett N, Kronmal RA, Gibson RL, Rosenfeld M, Retsch-Bogart G, Treggiari MM, Burns JL, Khan U, Ramsey BW; EPIC Investigators, Pediatr Pulmonol, 1/1/2012
• Long term effects of denufosol tetrasodium in patients with cystic fibrosis  
  Ratjen F, Durham T, Navratil T, Schaberg A, Accurso FJ, Wainwright C, Barnes M, Moss RB; TIGER-2 Study Investigator Group, J Cyst Fibros, 1/1/2012
• Infection control knowledge, attitudes, and practices among cystic fibrosis patients and their families  
  Miroballi Y, Garber E, Jia H, Zhou JJ, Alba L, Quittell LM, Angst D, Cabana M, Saiman L; CF Infection Control Study Consortium, Pediatr Pulmonol, 1/1/2012
• Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection  
  Trapnell BC, McColley SA, Kissner DG, Rolfe MW, Rosen JM, McKevitt M, Moorehead L, Montgomery AB, Geller DE; Phase 2 FTI Study Group, Am J Respir Crit Care Med, 1/1/2012
• Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis  
  Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC; National Heart, Lung, and Blood Institute (NHLBI..., Nat Genet, 1/1/2012
• Comparative efficacy and safety of 4 randomized regimens to treat early Pseudomonas aeruginosa infection in children with cystic fibrosis  
  Treggiari MM, Retsch-Bogart G, Mayer-Hamblett N, Khan U, Kulich M, Kronmal R, Williams J, Hiatt P, Gibson RL, Spencer T, Orenstein D, Chatfield BA, Froh DK, Burns JL, ..., Arch Pediatr Adolesc Med, 1/1/2011
• Levofloxacin inhalation solution (MP-376) in patients with cystic fibrosis with Pseudomonas aeruginosa  
  Geller DE, Flume PA, Staab D, Fischer R, Loutit JS, Conrad DJ; Mpex 204 Study Group, Am J Respir Crit Care Med, 1/1/2011
• Cystic fibrosis newborn screening: using experience to optimize the screening algorithm  
  Hale JE, Parad RB, Dorkin HL, Gerstle R, Lapey A, O'Sullivan BP, Spencer T, Yee W, Comeau AM, Journal of Inherited Metabolic Disease, 1/1/2010
• Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial  
  Saiman L, Anstead M, Mayer-Hamblett N, Lands LC, Kloster M, Hocevar-Trnka J, Goss CH, Rose LM, Burns JL, Marshall BC, Ratjen F; AZ0004 Azithromycin Study Group, Journal of the American Medical Association, 1/1/2010
• Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohort  
  Rosenfeld M, Emerson J, McNamara S, Joubran K, Retsch-Bogart G, Graff GR, Gutierrez HH, Kanga JF, Lahiri T, Noyes B, Ramsey B, Ren CL, Schechter M, Morgan W, Gibson RL..., Pediatric Pulmonology, 1/1/2010
• Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy  
  Brantly ML, Chulay JD, Wang L, Mueller C, Humphries M, Spencer LT, Rouhani F, Conlon TJ, Calcedo R, Betts MR, Spencer C, Byrne BJ, Wilson JM, Flotte TR, Proceedings of the National Academy of Sciences USA, 1/1/2009
• Early anti-pseudomonal acquisition in young patients with cystic fibrosis: rationale and design of the EPIC clinical trial and observational study  
  Treggiari MM, Rosenfeld M, Mayer-Hamblett N, Retsch-Bogart G, Gibson RL, Williams J, Emerson J, Kronmal RA, Ramsey BW; EPIC Study Group, Contemporary Clinical Trials, 1/1/2009
• Barriers to adherence to cystic fibrosis infection control guidelines  
  Garber E, Desai M, Zhou J, Alba L, Angst D, Cabana M, Saiman L; CF Infection Control Study Consortium, Pediatric Pulmonology, 1/1/2008
• Alpha1-Antitrypsin Protects Beta-Cells From Apoptosis  
  Zhang B, Lu Y, Campbell-Thompson M, Spencer T, Wasserfall C, Atkinson M, Song S, Diabetes, 1/1/2007
• Comparison of two dosimeters by methacholine challenge  
  Hendeles L, Khan Y, Shuster JJ, Spencer T, Journal of Allergy and Clinical Immunology, 1/1/2007
• Repeated Aerosolized AAV-CFTR for Treatment of Cystic Fibrosis: a Randomized Placebo-Controlled Phase 2B Trial  
  Moss RB, Milla C, Colombo J, Accurso F, Zeitlin PL, Clancy JP, Rodman D, Spencer LT, Pilewski J, Waltz DA, Dorkin H, Ferkol T, Pian M, Ramsey B, Carter BJ, Martin DB, ..., Human Gene Therapy, 1/1/2007
• Phase I Trial of Intramuscular Injection of a Recombinant Adeno-associated Virus Serotype 2 alpha(1)-Antitrypsin (AAT) Vector in AAT-Deficient Adults  
  Brantly ML, Spencer LT, Humphries M, Conlon TJ, Spencer CT, Poirier A, Garlington W, Baker D, Song S, Berns KI, Muzyczka N, Snyder RO, Byrne BJ, Flotte TR, Human Gene Therapy, 1/1/2006
• Lung bioavailability of HFA fluticasone in young children when delivered by anti-static chamber/mask  
  Khan Y, Tang Y, Hochhaus G, Shuster JJ, Spencer T, Chesrown S, Hendeles L, Journal of Pediatrics, 1/1/2006
• Systemic Antibody Response to an Aerosolized Transgenic Human Alpha-1 Antitrypsin Formulation  
  Spencer LT, Humphries JE, Brantly ML, New England Journal of Medicine, 1/1/2005
• The role of human neutrophil peptides in lung inflammation associated with Alpha1-antitrypsin deficiency  
  Spencer LT, Paone G, Krein P, Rouhani F, Rivera-Nieves J, Brantly M, Journal of Physiology- Lung Cellular and Molecular Physiology, 1/1/2004
• Repeated adeno-associated virus serotype 2 aerosolmediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multi...  
  Moss RB, Rodman D, Spencer LT, Aitken ML, Zeitlin PL, Waltz D, Milla C, Brody A, Clancy JP, Ramsey B, Hamblett N, Heald AE, Chest, 1/1/2004
• Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults  
  Flotte TR, Brantly ML, Spencer LT, Byrne BJ, Spencer CT, Baker DJ, Humphries M, Human Gene Therapy, 1/1/2004
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Abstracts/Posters

• Lower respiratory tract biochemical efficacy of intravenous administration of a new form of highly purified alpha1-antitrypsin.
  L.T. Spencer, D.P. Pollock, JM Stocks, M.L. Brantly, Chest, 1/1/2005
• Impact of new anti-static valved-holding chamber on airway delivery of inhaled fluticasone propionate in asthmatic children.
  M.J. Asmus, G. Hochhaus, Y. Yang, L.T. Spencer, S.E. Chesrown, L. Hendeles, Am Jnl Resp Crit Care Med, 1/1/2004
• Validation of Bronchoalveolar Lavage Assays Relevant to the Study of Aerosolized Alpha1-Antitrypsin.
  L.T. Spencer, C.R. Abernathy, D.P. Pollock, Q.W. Rance, M.L. Brantly, Am Jnl Resp Crit Care Med, 1/1/2004
• Neutrophil defensin concentrations in pediatric lung transplant recipients.
  A. Faro, L.T. Spencer, G.A. Visner, M. Brantly, J Heart Lung Transplant, 1/1/2003
• Differential susceptibility of bronchial epithelial cells expressing a cystic fibrosis phenotype to human neutrophil peptide-induced cytotoxicity.
  L.T. Spencer, D.P. Pollock, A.W. Whittaker, M.L. Brantly, Am Jnl Resp Crit Care Med, 1/1/2003
• Dose-dependent restoration of protease: anti-protease homeostasis in Alpha1-antitrypsin deficient patients using Aerosolized dry powder human Alpha1-antitrypsin.
  L.T. Spencer, D.P. Pollock, A.D. Whittaker, V.J. Corcoran, J. M. Stocks, M.L. Brantly, Am Jnl Resp Crit Care Med, 1/1/2002
• Augmentation of lower respiratory tract anti-protease protection in Alpha1-antitrypsin deficient individuals using nebulized transgenic human Alpha1-antitrypsin.
  L.T. Spencer, C.C. Tobias, E. Friskel, M. Newman, G.C. Moen, M.L. Brantly, Am Jnl Resp Crit Care Med, 1/1/2000
• Elevated levels of neutrophil defensins in the lower airways of patients with cystic fibrosis correlate with markers of pulmonary inflammation.
  L.T. Spencer, C.C. Tobias, M.W. Konstan, J.B. Hilliard, T.R. Flotte , M.L. Brantly, Am Jnl Resp Crit Care Med, 1/1/2000
• Interlobar variation in pro-inflammatory factors in Alpha1-antitrypsin deficient individuals.
  L.T. Spencer, C.C. Tobias, E. Friskel, M. Newman, G.C. Moen, M.L. Brantly, Am Jnl Resp Crit Care Med, 1/1/2000
• Transgenic human Alpha1-antitrypsin administered by nebulization augments anti-protease protection and provides anti-inflammatory effects in the lower respiratory trac...
  L.T. Spencer, C.C. Tobias, D.P. Pollock, K.F. Keisling, G.C. Moen, M.L. Brantly, Chest, 1/1/2000
• Cytotoxic and inflammatory effects of human neutrophil peptides in the lower airways of patients with cystic fibrosis.
  L.T. Spencer, G Paone, M.W. Konstan, J.B. Hilliard, T.R. Flotte, M.L. Brantly, Pediatric Pulmonology, 1/1/2000
• Alveolar macrophage dysfunction in patients with Alpha1-antitrypsin deficiency.
  L.T Spencer, ML Brantly, Jnl Investigative Medicine, 1/1/2000
• Elevated levels of human neutrophil peptides in the epithelial lining fluid of patients with cystic fibrosis.
  Spencer LT, Flotte TR, Brantly ML, Pediatric Pulmonology, 1/1/1999
• HIV-1 phenotypes in perinatally infected children.
  Spencer LT, Dankner WM, Spector SA, J Cell Biochem, 1/1/1993
• Clinical significance of HIV-1 phenotypes in infected children.
  Spencer LT, Dankner WM, Spector SA, Pediatric Research, 1/1/1993
• Resolution of hypoxemia in a liver transplant patient following ligation of a portosystemic shunt.
  Spencer LT, Langham MR, Hoyer MH, Jones DA, Caridi JG, Chesrown SE, Chest
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Lectures

• Pulmonary Function Testing in Children 
  Lakes Regional Medical Center, Laconia, NH - 1/1/2014
• Asthma Overview 
  Manchester, NH - 1/1/2013
• Factors Contributing to Asthma Exacerbations 
  Manchester, NH - 1/1/2013
• Evaluation of Cough in Children 
  Elliot Hospital, Manchester, NH - 1/1/2013
• Integrative Approach to Asthma and Vocal Cord Dysfunction in Children: Use of Self Hypnosis 
  Rockport, ME - 1/1/2013
• Office Spirometry 
  1/1/2012
• Pediatric Foreign Body Aspiration 
  Elliot Hospital, Manchester, NH - 1/1/2012
• Pediatric Asthma Management 
  Lakes Regional Medical Center, Laconia, NH - 1/1/2012
• Integrative Approach to Childhood Asthma 
  Elliot Hospital, Manchester, NH - 1/1/2012
• Markers of Lung Inflammation: Role of Flexible Bronchoscopy 
  Harvard Medical School, Boston, MA - 1/1/2009
• Chronic Airway Infection in Cystic Fibrosis: Disease Manifestations and Therapeutic Options 
  Morgantown, WV - 1/1/2009
• Management of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis 
  Tufts Medical Center, Boston, MA - 1/1/2008
• Controlling Infection in the Cystic Fibrosis Patient 
  Tampa, FL - 1/1/2008
• Cystic Fibrosis Clinical and Research Update 
  1/1/2008
• Newborn Screening for Cystic Fibrosis 
  University of Florida College of Medicine, Gainesville, FL - 1/1/2007
• The History of Cystic Fibrosis 
  Gainesville, FL - 1/1/2006
• Cystic Fibrosis: Not the Usual Top 10 Complications 
  Gainesville, FL - 1/1/2005
• Unique Challenges in Managing Pediatric Asthma 
  Miami, FL - 1/1/2004
• Alpha-1 Antitrypsin Deficiency 
  Gainesville, FL - 1/1/2003
• Pediatric Flexible Bronchoscopy 
  Gainesville, FL - 1/1/2003
• Office-Based Spirometry 
  Gainesville, FL - 1/1/2003
• Gene Therapy for Alpha1-Antitrypsin Deficiency 
  Barcelona, Spain - 1/1/2003
• Eradication of Pseudomonas aeruginosa from the Lower Respiratory Tract 
  Gainesville, FL - 1/1/2003
• Update on Airway Clearance Techniques 
  Gainesville, FL - 1/1/2002
• Mild and Moderate Persistent Asthma in Children 
  Gainesville, FL - 1/1/2002
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Other

• The Pediatric Perspective of Lung Disease Associated with Alpha-1 Antitrypsin Deficiency. 
  Spencer LT, Alpha-1 Foundation Research Registry Up
  1/1/2001