LakshmiM.R.NarasimhanMD

PubMed

• 34 citations
  Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics
  Wan F. Lau, Jane M. Withka, David Hepworth, Magee Thomas Victor, Yuhua J. Du, Gregory A. Bakken, Michael D. Miller, Zachary S. Hendsch, Venkataraman Thanabal, Steve A....> ;Journal of Computer-Aided Molecular Design. 2011 May 21
• 63 citations
  Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches.
  Igor Mochalkin, J. Richard Miller, Lakshmi Narasimhan, Venkataraman Thanabal, Paul Erdman, Philip B. Cox, J.V.N. Vara Prasad, Sandra Lightle, Michael D. Huband, C. Ken...> ;ACS Chemical Biology. 2009 May 19
• 14 citations
  Exploration of 4,4-Disubstituted Pyrrolidine-1,2-Dicarboxamides as Potent, Orally Active Factor Xa Inhibitors with Extended Duration of Action.
  Chad A. Van Huis, Agustin Casimiro-Garcia, Christopher F. Bigge, Wayne L. Cody, Danette Dudley, Kevin J. Filipski, Ronald J. Heemstra, Jeffrey T. Kohrt, Robert J. Lead...> ;Bioorganic & Medicinal Chemistry. 2009 Mar 15
• 99 citations
  A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore
  J. Richard Miller, Steve Dunham, Igor Mochalkin, Craig Banotai, Matthew Bowman, Susan Buist, Bill Dunkle, Debra Hanna, H. James Harwood, Michael D. Huband, Alla Karnov...> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Feb 10
• 11 citations
  Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase.
  Justin I. Montgomery, Peter L. Toogood, Kim Hutchings, Jia Liu, Lakshmi Narasimhan, Timothy Braden, Michael R. Dermyer, Angela D. Kulynych, Smith Yvonne Dorothy, Josep...> ;Bioorganic & Medicinal Chemistry Letters. 2009 Feb 1
• 15 citations
  Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
  Artem G. Evdokimov, Marlene Mekel, Kim Hutchings, Lakshmi Narasimhan, Tod P. Holler, Teresa McGrath, Bryan Beattie, Eric B. Fauman, Chunhong Yan, H. Heaslet, R.L. Walt...> ;Journal of Structural Biology. 2008 Apr 1
• 38 citations
  Structure of a small‐molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site
  Igor Mochalkin, Sandra Lightle, Lakshmi Narasimhan, Dirk Bornemeier, Michael Melnick, Steven VanderRoest, Laura McDowell> ;Protein Science. 2008 Mar 1
• 6 citations
  Structural biology approaches to antibacterial drug discovery.
  Tod P. Holler, Artem G. Evdokimov, Lakshmi Narasimhan> ;Expert Opinion on Drug Discovery. 2007 Aug 17
• 33 citations
  The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious fa...
  Jeffrey T. Kohrt, Christopher F. Bigge, John W. Bryant, Agustin Casimiro-Garcia, Liguo Chi, Wayne L. Cody, Tawny K. Dahring, Danette Dudley, Kevin J. Filipski, Staci H...> ;Chemical Biology & Drug Design. 2007 Aug 1
• 11 citations
  Structure‐based Drug Design of Pyrrolidine‐1, 2‐dicarboxamides as a Novel Series of Orally Bioavailable Factor Xa Inhibitors
  Chad A. Van Huis, Christopher F. Bigge, Agustin Casimiro-Garcia, Wayne L. Cody, Danette Dudley, Kevin J. Filipski, Ronald J. Heemstra, Jeffrey T. Kohrt, Lakshmi Narasi...> ;Chemical Biology & Drug Design. 2007 Jun 1
• 10 citations
  The discovery of glycine and related amino acid-based factor Xa inhibitors.
  Jeffrey T. Kohrt, Kevin J. Filipski, Wayne L. Cody, Christopher F. Bigge, Frances La, Kathleen M. Welch, Tawny K. Dahring, John W. Bryant, Daniele M. Leonard, Gary Lou...> ;Bioorganic & Medicinal Chemistry. 2006 Jul 1
• 2 citations
  The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex--Part 2.
  Jeffrey T Kohrt, Kevin J Filipski, Wayne L Cody, Cuiman Cai, Danette A Dudley, Chad A Van Huis, J Adam Willardsen, Lakshmi S Narasimhan, Erli Zhang, Stephen T Rapundal...> ;Bioorganic & Medicinal Chemistry Letters. 2006 Feb 15
• The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.
  Jeffrey T Kohrt, Kevin J Filipski, Wayne L Cody, Cuiman Cai, Danette A Dudley, Chad A Van Huis, J Adam Willardsen, Stephen T Rapundalo, Kamlai Saiya-Cork, Robert J Lea...> ;Bioorganic & Medicinal Chemistry Letters. 2005 Nov 1
• 12 citations
  Co-crystal structure and inhibition of factor Xa by PD0313052 identifies structurally stabilized active site residues of factor Xa and prothrombinase.
  Weston R. Gould, Edward Cladera, Melissa S. Harris, Erli Zhang, Lakshmi Narasimhan, Jennifer Marie Thorn, Robert J. Leadley> ;Biochemistry. 2005 Jul 5
• 34 citations
  Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa.
  J. Adam Willardsen, Danette Dudley, Wayne L. Cody, Liguo Chi, Thomas B. McClanahan, Thomas E. Mertz, Ronald E. Potoczak, Lakshmi Narasimhan, Debra R. Holland, Stephen ...> ;Journal of Medicinal Chemistry. 2004 Jul 29
• 42 citations
  A novel database of disulfide patterns and its application to the discovery of distantly related homologs.
  Herman W. T. van Vlijmen, Abhas Gupta, Lakshmi Narasimhan, Juswinder Singh> ;Journal of Molecular Biology. 2004 Jan 23
• 23 citations
  Rational design, synthesis, and biological activity of benzoxazinones as novel factor Xa inhibitors.
  Danette Dudley, Amy Mae Bunker, Liguo Chi, Wayne L. Cody, Debra R. Holland, Diane P. Ignasiak, Nancy Janiczek-Dolphin, Thomas B. McClanahan, Thomas E. Mertz, Lakshmi N...> ;Journal of Medicinal Chemistry. 2000 Sep 27
• 11 citations
  Structural Basis of the Thrombin Selectivity of a Ligand That Contains the Constrained Arginine Mimic (2S)-2-Amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic A...
  Lakshmi S. Narasimhan, J. Ronald Rubin, Debra R. Holland, Janet S. Plummer, Stephen T. Rapundalo, Jeremy E. Edmunds, ‡ Yves St-Denis, and M. Arshad Siddiqui, Christine...> ;Journal of Medicinal Chemistry. 2000 Jan 26
• 1 citations
  The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 2.
  Wayne L. Cody, Corinne E. Augelli-Szafran, Kent A. Berryman, Cuiman Cai, Annette Marian Doherty, Jeremy J. Edmunds, John X. He, Lakshmi S. Narasimhan, J.R. Penvose-Yi,...> ;Bioorganic & Medicinal Chemistry Letters. 1999 Sep 6
• 4 citations
  The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 1.
  Wayne L. Cody, Cuiman Cai, Annette Marian Doherty, Jeremy J. Edmunds, John X. He, Lakshmi S. Narasimhan, Janet S. Plummer, Stephen T. Rapundalo, J. Ronald Rubin, Chad ...> ;Bioorganic & Medicinal Chemistry Letters. 1999 Sep 6
• 11 citations
  Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease.
  Janet S. Plummer, Cuiman Cai, Sheryl J. Hays, John L. Gilmore, Mark R. Emmerling, Walter Michael, Lakshmi S. Narasimhan, M. Desiree Watson, Kevin K.W. Wang, Rathna Nat...> ;Bioorganic & Medicinal Chemistry Letters. 1999 Mar 22
• 10 citations
  Potent and selective bicyclic lactam inhibitors of thrombin : Part 3 : P1' modifications
  Janet S. Plummer, Kent A. Berryman, Cuiman Cai, Wayne L. Cody, John DiMaio, Annette Marian Doherty, Scott R. Eaton, Jeremy J. Edmunds, Debra R. Holland, D. Lafleur, So...> ;Bioorganic & Medicinal Chemistry Letters. 1999 Mar 22
• 13 citations
  Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications.
  Janet S. Plummer, Kent A. Berryman, Cuiman Cai, Wayne L. Cody, John DiMaio, Annette Marian Doherty, Jeremy J. Edmunds, John X. He, Debra R. Holland, Sophie Levesque, D...> ;Bioorganic & Medicinal Chemistry Letters. 1998 Dec 1
• 13 citations
  Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications
  Yves St-Denis, C.E. Augelli-Szafran, Benoit Bachand, Kent A. Berryman, John DiMaio, Annette Marian Doherty, Jeremy J. Edmunds, Lorraine Leblond, Sophie Levesque, Laksh...> ;Bioorganic & Medicinal Chemistry Letters. 1998 Nov 17
• 50 citations
  Sodium Channels and Therapy of Central Nervous System Diseases
  Charles P. Taylor, Lakshmi S. Narasimhan> ;Advances in Pharmacology. 1997 Jan 1
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