LanceAWellsMD

Emergency Medicine • Jefferson, IA

Physician

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Office
1000 W Lincoln Way
Jefferson, IA 50129
Phone+1 515-386-2114
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Summary

Dr. Lance Wells, MD is a board certified emergency medicine physician in Jefferson, Iowa. He is currently licensed to practice medicine in Iowa, Michigan, and Pennsylvania. He is affiliated with Greene County Medical Center.

Education & Training

Allegheny Health Network Medical Education Consortium (AGH)Residency, Internal Medicine/Emergency Medicine, 2010 - 2015
Wayne State University School of MedicineClass of 2010

Certifications & Licensure

MI State Medical License 2015 - 2025
IA State Medical License 2021 - 2024
PA State Medical License 2010 - 2015
American Board of Emergency Medicine Emergency Medicine
American Board of Internal Medicine Internal Medicine

Publications & Presentations

PubMed

11 citations
Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing.
Elsenoor J. Klaver, Peng Zhao, Melanie May, Heather Flanagan-Steet, Hudson H. Freeze, Reid Gilmore, Lance Wells, Joseph N. Contessa, Richard Steet> ;Disease Models & Mechanisms. 2019 Jun 5
39 citations
O-GlcNAc transferase missense mutations linked to X-linked intellectual disability deregulate genes involved in cell fate determination and signaling
Nithya Selvan, Stephan N. George, Fatema J. Serajee, Marie Shaw, Lynne Hobson, Vera M. Kalscheuer, Nripesh Prasad, Shawn Levy, Juliet Taylor, Salim Aftimos, Charles E....> ;The Journal of Biological Chemistry. 2018 Jul 6
59 citations
Recent advancements in understanding mammalian O-mannosylation.
M. Osman Sheikh, Stephanie M. Halmo, Lance Wells> ;Glycobiology. 2017 Sep 1
63 citations
Identification and characterization of a missense mutation in the O-linked β-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual...
Krithika Vaidyanathan, Tejasvi Niranjan, Nithya Selvan, Chin Fen Teo, Melanie May, Sneha Patel, Brent Weatherly, Cindy Skinner, John Opitz, John C. Carey, David Viskoc...> ;The Journal of Biological Chemistry. 2017 May 26
6 citations
Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin.
Chin Fen Teo, Enas Gad El-Karim, Lance Wells> ;Glycobiology. 2016 Apr 12
26 citations
O-Linked β-N-acetylglucosamine (O-GlcNAc) Acts as a Glucose Sensor to Epigenetically Regulate the Insulin Gene in Pancreatic Beta Cells
Sean P. Durning, Heather Flanagan-Steet, Nripesh Prasad, Lance Wells> ;The Journal of Biological Chemistry. 2016 Jan 29
65 citations
Multiple tissue-specific roles for the O-GlcNAc post-translational modification in the induction of and complications arising from type II diabetes.
Krithika Vaidyanathan, Lance Wells> ;The Journal of Biological Chemistry. 2014 Dec 12
56 citations
O-glycosylation regulates polarized secretion by modulating Tango1 stability.
Liping Zhang, Zulfeqhar Syed, Iris van Dijk Härd, Jae-Min Lim, Lance Wells, Kelly G. Ten Hagen> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 May 20
55 citations
Functional O-GlcNAc modifications: Implications in molecular regulation and pathophysiology
Krithika Vaidyanathan, Sean P. Durning, Lance Wells> ;Critical Reviews in Biochemistry and Molecular Biology. 2014 Mar 14
31 citations
Discrimination between Adenocarcinoma and Normal Pancreatic Ductal Fluid by Proteomic and Glycomic Analysis
Mindy Porterfield, Peng Zhao, Haiyong Han, John T. Cunningham, Kazuhiro Aoki, Daniel D. Von Hoff, Michael J. Demeure, J. Michael Pierce, Michael Tiemeyer, Lance Wells> ;Journal of Proteome Research. 2014 Feb 7
10 citations
Protein O‐Mannosylation in Metazoan Organisms
Vladislav M. Panin, Lance Wells> ;Current Protocols in Protein Science. 2014 Feb 3
24 citations
Dissecting the Molecular Basis of the Role of the O‐Mannosylation Pathway in Disease: α‐Dystroglycan and Forms of Muscular Dystrophy
David Live, Lance Wells, Geert-Jan Boons> ;Chembiochem. 2013 Dec 16
61 citations
The O-Mannosylation Pathway: Glycosyltransferases and Proteins Implicated in Congenital Muscular Dystrophy
Lance Wells> ;The Journal of Biological Chemistry. 2013 Mar 8
45 citations
O-Mannosylation and human disease.
Christina M. Dobson, Samuel J. Hempel, Stephanie H. Stalnaker, Ryan Stuart, Lance Wells> ;Cellular and Molecular Life Sciences. 2013 Aug 1
30 citations
Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with tho...
Jin Kyu Lee, Russell T. Matthews, Jae-Min Lim, Kiara Swanier, Lance Wells, J. Michael Pierce> ;The Journal of Biological Chemistry. 2012 Aug 17
26 citations
Mammalian O-mannosylation: unsolved questions of structure/function.
Stephanie H. Stalnaker, Ryan Stuart, Lance Wells> ;Current Opinion in Structural Biology. 2011 Oct 1
95 citations
Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis.
Karen L. Abbott, Jae-Min Lim, Lance Wells, Benedict B. Benigno, John F. McDonald, Michael Pierce> ;Proteomics. 2010 Feb 1
59 citations
Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes
Chin Fen Teo, Edith E. Wollaston-Hayden, Lance Wells> ;Molecular and Cellular Endocrinology. 2010 Apr 29
19 citations
Use of cancer-specific yeast-secreted in vivo biotinylated recombinant antibodies for serum biomarker discovery
Nathalie Scholler, Jennifer A. Gross, Barbara Garvik, Lance Wells, Yan Liu, Christian M. Loch, Arturo B. Ramirez, Martin W. McIntosh, Paul D. Lampe, Nicole Urban> ;Journal of Translational Medicine. 2008 Jul 24
110 citations
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination.
Natalia G. Starostina, Jae-Min Lim, Mara Schvarzstein, Lance Wells, Andrew M. Spence, Edward T. Kipreos> ;Developmental Cell. 2007 Jul 1
78 citations
Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the ...
Yoshihiro Akimoto, Gerald W. Hart, Lance Wells, Keith Vosseller, Koji Yamamoto, Eiji Munetomo, Mica Ohara-Imaizumi, Chiyono Nishiwaki, Shinya Nagamatsu, Hiroshi Hirano...> ;Glycobiology. 2007 Feb 1
153 citations
O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar.
Lance Wells, Gerald W. Hart> ;FEBS Letters. 2003 Jul 3
170 citations
A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance.
Lance Wells, Keith Vosseller, Gerald W. Hart> ;Cellular and Molecular Life Sciences. 2003 Feb 1
375 citations
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes
Keith Vosseller, Lance Wells, M. Daniel Lane, Gerald W. Hart> ;Proceedings of the National Academy of Sciences of the United States of America. 2002 Apr 16
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Press Mentions

The Salt Lake Tribune’s Quarantine Film Festival: 29 Films About Isolation, Hand-Washing and Having a LaughMay 10th, 2020
The Dark Side of Development: A Systems Characterization of the Negative Mentoring Experiences of Doctoral StudentsMarch 25th, 2021

Hospital Affiliations

Three Rivers Health HospitalThree Rivers, Michigan
Ascension Macomb-Oakland Hospital, Warren CampusWarren, Michigan
Hillsdale HospitalHillsdale, Michigan
Greene County Medical CenterJefferson, Iowa