LarryEdwinPulsMD

Obstetrics & Gynecology • Greenville, SC

Gynecologic Oncology

Professor, Obstetrics and Gynecology, University of South Carolina School of Medicine-Greenville

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Office
900 W Faris Rd
Greenville, SC 29605
Phone+1 864-404-2010

Fax+1 864-404-2012
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Education & Training

University of Kentucky College of MedicineFellowship, Gynecologic Oncology, 1990 - 1992
Texas Tech University (Amarillo)Residency, Obstetrics and Gynecology, 1985 - 1989
University of Texas Southwestern Medical SchoolClass of 1985

Certifications & Licensure

SC State Medical License 1994 - 2025
TX State Medical License 1986 - 1995
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Gynecologic Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification MOSAIQ EMR, Elekta, 2012-2013
Fellow (FACOG) American Congress of Obstetricians and Gynecologists

Clinical Trials

Safety and Efficacy Study of Glufosfamide in Ovarian Cancer Start of enrollment: 2007 Jan 01
Terminated
Phase 2
Paclitaxel and Cisplatin or Topotecan With or Without Bevacizumab in Treating Patients With Stage IVB, Recurrent, or Persistent Cervical Cancer Start of enrollment: 2009 Apr 01
Completed
Phase 3
Pelvic Radiation Therapy or Vaginal Implant Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With High-Risk Stage I or Stage II Endometrial Cancer Start of enrollment: 2009 Mar 23
Active, not recruiting
Phase 3
OPT-821 With or Without Vaccine Therapy in Treating Patients With Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer in Second or Third Complete Remission Start of enrollment: 2010 Jul 01
Completed
Phase 2
Collecting Tumor Samples From Patients With Gynecological Tumors Start of enrollment: 1992 Jun 01
Completed
YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer Receiving Chemotherapy Start of enrollment: 2007 Sep 01
Terminated
Carboplatin and Paclitaxel With or Without Cisplatin and Radiation Therapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IVA Endometrial Cancer Start of enrollment: 2009 Jun 29
Active, not recruiting
Phase 3
Paclitaxel and Carboplatin or Ifosfamide in Treating Patients With Newly Diagnosed, Persistent or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Cavity Cancer Start of enrollment: 2009 Aug 17
Active, not recruiting
Phase 3
Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Start of enrollment: 2010 Apr 01
Completed
Ixabepilone in Treating Patients With Recurrent or Persistent Leiomyosarcoma of the Uterus Previously Treated With Chemotherapy Start of enrollment: 2010 Nov 01
Completed
Phase 2
Bevacizumab With or Without Fosbretabulin Tromethamine in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Peritoneal Cavity Cancer Start of enrollment: 2011 Mar 21
Completed
Phase 2
Quality of Life and Care Needs of Patients With Persistent or Recurrent Ovarian Cancer, Fallopian Tube Cancer, or Peritoneal Cancer Start of enrollment: 2011 Apr 12
Active, not recruiting
Paclitaxel With or Without Pazopanib Hydrochloride in Treating Patients With Persistent or Recurrent Ovarian Epithelial, Fallopian Tube, or Peritoneal Cavity Cancer Start of enrollment: 2011 Dec 12
Completed
Phase 2
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Publications & Presentations

PubMed

11 citations
Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis.
Hanna E. Teasley, Anne Beesley, Tae Hoon Kim, John I. Risinger, Steven L. Young, Jae Wook Jeong, David P. Schammel, Bruce A. Lessey, Jeffrey Elder, Larry Puls> ;Reproductive Sciences. 2020 Jan 1
36 citations
Prospective Validation of an Ex Vivo, Patient-Derived 3D Spheroid Model for Response Predictions in Newly Diagnosed Ovarian Cancer.
Stephen Shuford, Christine Wilhelm, Melissa Rayner, Ashley Elrod, Melissa Millard, Christina Mattingly, Alina Lotstein, Ashley M. Smith, Qi Jin Guo, Lauren O’Donnell, ...> ;Scientific Reports. 2019 Aug 1
37 citations
Cognitive function during and six months following chemotherapy for front-line treatment of ovarian, primary peritoneal or fallopian tube cancer: An NRG oncology/gynec...
Lisa M. Hess, Helen Q. Huang, Alexandra L. Hanlon, William R. Robinson, Rhonda Johnson, Setsuko K. Chambers, Robert S. Mannel, L. E. Puls, Susan A. Davidson, Michael W...> ;Gynecologic Oncology. 2015 Dec 1
4 citations
New-onset congestive heart failure with gemcitabine in ovarian and other solid cancers.
Kara J. P. Shrum, Sarah E. Gill, Laura K. Thompson, Dawn W. Blackhurst, L. E. Puls> ;American Journal of Clinical Oncology. 2014 Aug 1
37 citations
A prospective study evaluating the clinical relevance of a chemoresponse assay for treatment of patients with persistent or recurrent ovarian cancer
Thomas J. Rutherford, James W. Orr, Edward C. Grendys, Robert P. Edwards, Thomas C. Krivak, Robert G. Holloway, Richard G. Moore, L. E. Puls, Todd Tillmanns, Julian C....> ;Gynecologic Oncology. 2013 Nov 1
25 citations
Continuing routine cardiac surveillance in long-term use of pegylated liposomal doxorubicin: Is it necessary?
Sarah E. Gill, Kari Savage, Weiya Z. Wysham, Dawn W. Blackhurst, William E. Winter, Larry Puls> ;Gynecologic Oncology. 2013 Jun 1
3 citations
Simultaneous occurrence of well differentiated papillary mesothelioma and endometrioid ovarian cancer: A case report.
Sarah E. Gill, Shawna M. Ruple, C. Michael Wolff, Larry Puls> ;Gynecologic Oncology Case Reports. 2013 Jan 23
8 citations
A multicenter, randomized, phase 2 clinical trial to evaluate the efficacy and safety of combination docetaxel and carboplatin and sequential therapy with docetaxel th...
Angeles Alvarez Secord, Andrew Berchuck, Robert V. Higgins, Lawrence R. Nycum, Matthew F. Kohler, L. E. Puls, Robert W. Holloway, George S. Lewandowski, Fidel A. Valea...> ;Cancer. 2012 Jul 1
15 citations
A phase II evaluation of docetaxel and carboplatin followed by tumor volume directed pelvic plus or minus paraaortic irradiation for stage III endometrial cancer
Dennis R. Scribner, Larry Puls, Michael A. Gold> ;Gynecologic Oncology. 2012 May 1
3 citations
Health-related quality of life outcomes of docetaxel/carboplatin combination therapy vs. sequential therapy with docetaxel then carboplatin in patients with relapsed, ...
Robin Pokrzywinski, Angeles Alvarez Secord, Laura J. Havrilesky, L. E. Puls, Robert W. Holloway, George S. Lewandowski, Robert V. Higgins, Lawrence R. Nycum, Matthew F...> ;Gynecologic Oncology. 2011 Dec 1
4 citations
A phase I-II trial of weekly topotecan in the treatment of recurrent cervical carcinoma.
L. E. Puls, Bunny Phillips, Chris Schammel, J.E. Hunter, David Griffin> ;Medical Oncology. 2010 Jun 1
Tolerability of docetaxel and carboplatin followed by tumor directed radiation for advanced stage uterine cancer.
Scribner DR, Puls L, Gold MA, Gould NS> ;J. Clin. Oncol.. 2008-05-20
A comparison of combination docetaxel/carboplatin versus sequential docetaxel then carboplatin in patients with recurrent platinum-sensitive ovarian cancer.
Alvarez Secord A, Havrilesky LJ, Higgins RV, Nycum LR, Kohler MF, Puls LE, Holloway R, Soper JT, Valea FA, Berchuck A> ;J. Clin. Oncol.. 2006-06-20
51 citations
The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC).
Charles S. Dietrich, Susan C. Modesitt, Paul D. DePriest, Frederick R. Ueland, James L Wilder, M. B. Reedy, Edward J. Pavlik, Richard J. Kryscio, Michael L. Cibull, J....> ;Gynecologic Oncology. 2005 Dec 1
66 citations
Closure of long surgical incisions with a new formulation of 2-octylcyanoacrylate tissue adhesive versus commercially available methods ☆
Phillip Blondeel, John W. Murphy, Denis Debrosse, James C. Nix, Larry E. Puls, Nicholas Theodore, Paul Coulthard> ;American Journal of Surgery. 2004 Sep 1
11 citations
Confirmatory chest radiographs after central line placement: are they warranted?
Larry Puls, Carrie Ann Twedt, J.E. Hunter, Eugene M. Langan, Martin M. Crane> ;Southern Medical Journal. 2003 Nov 1
5 citations
Effect of topotecan infusion duration on hematologic toxicity in recurrent ovarian carcinoma.
Larry Puls, James E. Hunter, Martin M. Crane> ;Medical Oncology. 2002 Jan 1
40 citations
The accuracy of frozen section by tumor weight for ovarian epithelial neoplasms.
Larry Puls, Edward Heidtman, James E. Hunter, Martin M. Crane, Jesse Stafford> ;Gynecologic Oncology. 1997 Oct 1
1 citations
Removal of a 130 pound ovarian neoplasm.
Larry Puls, Hunter Je, Heidtman Ep, Stafford, Parker Hb> ;Journal of the South Carolina Medical Association. 1996 May 1
5 citations
Small bowel herniation after laparoscopically assisted vaginal hysterectomy.
Larry E. Puls, Robert C. Henderson> ;Acta Obstetricia Et Gynecologica Scandinavica. 1995 Apr 1
Metastatic gastric cancer presenting as a pelvic mass.
Paul D. DePriest, L. E. Puls, R W Schwartz, J.R. van Nagell> ;The Journal of the Kentucky Medical Association. 1993 May 1
54 citations
Current concepts in epithelial ovarian tumors: does benign to malignant transformation occur?
Deborah E. Powell, L. E. Puls, John R. van Nagell> ;Human Pathology. 1992 Aug 1
9 citations
Malignant schwannoma in pregnancy.
Lary E. Puls, Pamela A. Chandler> ;Acta Obstetricia Et Gynecologica Scandinavica. 1991 Jan 1
89 citations
Ovarian cancer screening in asymptomatic postmenopausal women by transvaginal sonography.
J.R. van Nagell, Paul D. DePriest, L. E. Puls, Elvis S. Donaldson, Holly H. Gallion, Edward J. Pavlik, Deborah E. Powell, Richard J. Kryscio> ;Cancer. 1991 Aug 1
22 citations
Recurrent Ovarian Sex Cord Tumor with Annular Tubules: Tumor Marker and Chemotherapy Experience
L. E. Puls, James Hampus, Marilyn Sue Morrow, Alan L. Schneyer, David T. MacLaughlin, V.Daniel Castracane> ;Gynecologic Oncology. 1994 Sep 1
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Press Mentions

Clemson Researchers, Prisma Health Doctor Collaborate on Ovarian Cancer Screening ToolJune 4th, 2019

Professional Memberships

American College of Obstetricians and Gynecologists
Fellow

Other Languages

French

Hospital Affiliations

Prisma Health Greenville Memorial HospitalGreenville, South Carolina
Prisma Health Patewood HospitalGreenville, South Carolina