LarryWTsaiMD

Pulmonology • Boston, MA

Critical Care Medicine, Pleural Disease

Instructor in Medicine, Brigham and Women's Hospital

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Office
75 Francis Street Pbb Clinics 3
Brigham And Women's Hospital Pulmonary Division
Boston, MA 02115
Phone+1 617-732-5500
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Education & Training

Massachusetts General Hospital/BIDMC/Harvard Medical SchoolFellowship, Pulmonary Disease and Critical Care Medicine, 2001 - 2003
Brigham and Women's HospitalResidency, Internal Medicine, 1997 - 2000
Harvard Medical SchoolClass of 1997

Certifications & Licensure

CA State Medical License 2000 - 2025
MA State Medical License 1999 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Pulmonary Disease

Clinical Trials

A Phase 1 TP-271 Oral PK Multiple Ascending Dose Study Start of enrollment: 2018 Mar 20
Completed
Phase 1

Publications & Presentations

PubMed

18 citations
Prognostic and Predictive Biomarkers in Patients With Coronavirus Disease 2019 Treated With Tocilizumab in a Randomized Controlled Trial.
, , , , , , , , , , , , , , , , , , , , , > ;Critical Care Medicine. 2021 Oct 12
7 citations
Mass Balance and Drug Interaction Potential of Intravenous Eravacycline Administered to Healthy Subjects.
Joseph V. Newman, Jian Zhou, Sergey Izmailyan, Larry W. Tsai> ;Antimicrobial Agents and Chemotherapy. 2019 Feb 26
24 citations
Randomized, Double-Blind, Placebo-Controlled Studies of the Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Eravacycline.
Joseph V. Newman, Jian Zhou, Sergey Izmailyan, Larry Tsai> ;Antimicrobial Agents and Chemotherapy. 2018 Oct 24
86 citations
A randomised trial of lung sealant versus medical therapy for advanced emphysema.
Carolyn E. Come, Mordechai R. Kramer, Mark T. Dransfield, Muhanned Abu-Hijleh, David M. Berkowitz, Michela Bezzi, Surya P. Bhatt, Michael Boyd, Enrique Cases, Alexande...> ;The European Respiratory Journal. 2015 Apr 2
48 citations
Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema.
Edward P. Ingenito, Larry W. Tsai, Shankar Murthy, Shivraj Tyagi, Melissa R. Mazan, Andrew M. Hoffman> ;Cell Transplantation. 2012 Jan 1
24 citations
PPARγ deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution
Dawn M Simon, Larry W. Tsai, Edward P. Ingenito, Barry Starcher, Thomas J. Mariani> ;Respiratory Research. 2010 Jun 2
40 citations
Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice
Andrew M. Hoffman, Adrian Shifren, Melissa R. Mazan, Alisha M. Gruntman, Kara M. Lascola, R. D. Nolen-Walston, Carla F. Kim, Larry W. Tsai, R.A. Pierce, Robert P. Mech...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2010 Feb 1
19 citations
Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung.
Edward P. Ingenito, Elif Sen, Larry W. Tsai, Shankar Murthy, Andrew M. Hoffman> ;Journal of Tissue Engineering and Regenerative Medicine. 2009 Dec 17
52 citations
Epithelial cell apoptosis causes acute lung injury masquerading as emphysema.
Majd Mouded, Eduardo E. Egea, Matthew J. Brown, Shane M. Hanlon, A. McGarry Houghton, Larry W. Tsai, Edward P. Ingenito, Steven D. Shapiro> ;American Journal of Respiratory Cell and Molecular Biology. 2009 Feb 2
75 citations
Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration
Rose Nolen-Walston, Carla F. Kim, Melissa R. Mazan, Edward P. Ingenito, Alisha M. Gruntman, Larry W. Tsai, Raymond C. Boston, Amber Woolfenden, Tyler Jacks, Andrew M. ...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2008 Jun 1
7 citations
Impact of Positive End-Expiratory Pressure During Heterogeneous Lung Injury: Insights from Computed Tomographic Image Functional Modeling
C. L. Bellardine Black, Andrew M. Hoffman, Larry W. Tsai, Edward P. Ingenito, Béla Suki, David W. Kaczka, Brett A. Simon, Kenneth R. Lutchen> ;Annals of Biomedical Engineering. 2008 Mar 14
10 citations
Evolving endoscopic approaches for treatment of emphysema.
Edward P. Ingenito, Larry W. Tsai> ;Seminars in Thoracic and Cardiovascular Surgery. 2007 Jun 1
46 citations
Relationship between dynamic respiratory mechanics and disease heterogeneity in sheep lavage injury.
Carissa L. Bellardine Black, Andrew M. Hoffman, Larry W. Tsai, Edward P. Ingenito, Béla Suki, David W. Kaczka, Brett A. Simon, Kenneth R. Lutchen> ;Critical Care Medicine. 2007 Mar 1
16 citations
Bronchoscopic Measurement of Collateral Ventilation in a Sheep Model of Emphysema
Larry W. Tsai, Andrew M. Hoffman, Melissa R. Mazan, Edward P. Ingenito> ;Respiration; International Review of Thoracic Diseases. 2007 Jan 1
78 citations
Epithelial cell PPARγ contributes to normal lung maturation
Dawn M. Simon, Meltem C. Arikan, Sorachai Srisuma, Soumyaroop Bhattacharya, Larry W. Tsai, Edward P. Ingenito, Frank J. Gonzalez, Steven D. Shapiro, Thomas J. Mariani> ;FASEB Journal. 2006 Jul 1
54 citations
Comparison of variable and conventional ventilation in a sheep saline lavage lung injury model.
Carissa Bellardine, Andrew M. Hoffman, Larry W. Tsai, Edward P. Ingenito, Stephen P. Arold, Kenneth R. Lutchen, Béla Suki> ;Critical Care Medicine. 2006 Feb 1
6 citations
Respiratory impedance following bronchoscopic or surgical lung volume reduction for emphysema
Edward P. Ingenito, Larry W. Tsai, Steven J. Mentzer, Michael T. Jaklitsch, John J. Reilly, Kenneth R. Lutchen, Melissa R. Mazan, Andrew M. Hoffman> ;Respiration; International Review of Thoracic Diseases. 2005 Jul 1
2 citations
Pulmonary function tests versus computed tomography in sheep with experimental emphysema.
Andrew M. Hoffman, Larry W. Tsai, Melissa R. Mazan, Carissa Bellardine, Allison Bell, Kenneth R. Lutchen, Edward P. Ingenito> ;Experimental Lung Research. 2005 Jun 1
Pulmonary function tests fail to predict exercise intolerance in sheep with emphysema.
Melissa R. Mazan, Edward P. Ingenito, Larry W. Tsai, Andrew M. Hoffman> ;Medicine and Science in Sports and Exercise. 2005 Apr 1
27 citations
On the role of surface tension in the pathophysiology of emphysema.
Edward P. Ingenito, Larry W. Tsai, Arnab Majumdar, Béla Suki> ;American Journal of Respiratory and Critical Care Medicine. 2005 Feb 15
9 citations
Evaluation of head-out constant volume body plethysmography for measurement of specific airway resistance in conscious, sedated sheep.
Daniela Bedenice, Ephraim Bar-Yishay, Edward P. Ingenito, Larry W. Tsai, Melissa R. Mazan, Andrew M. Hoffman> ;American Journal of Veterinary Research. 2004 Sep 1
5 citations
Physiologic Responses of Sheep to Two Different Methods of Papain Exposure
Andrew M. Hoffman, A. Courtney Henderson, Larry W. Tsai, Edward P. Ingenito> ;Inhalation Toxicology. 2003 Jul 1
88 citations
Bronchoscopic lung volume reduction using tissue engineering principles.
Edward P. Ingenito, Robert L. Berger, A. Cortney Henderson, John J. Reilly, Larry W. Tsai, Andrew M. Hoffman> ;American Journal of Respiratory and Critical Care Medicine. 2003 Mar 1
9 citations
Skeletal muscle ECF pH error signal for exercise ventilatory control
Allison B. Evans, Larry W. Tsai, David A. Oelberg, Homayoun Kazemi, David M. Systrom> ;Journal of Applied Physiology. 1998 Jan 1
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Journal Articles

Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia
Ivan O Rosas, Ronaldo C Go, Ivor S Douglas, Larry Tsai, Atul Malhotra, The New England Journal of Medicine

Press Mentions

Tetraphase Pharmaceuticals Announces Corporate Reorganization Aimed at Maximizing XERAVA™ (Eravacycline) Commercial OpportunityJune 12th, 2019
Tetraphase Pharmaceuticals Announces New XERAVA™ (Eravacycline) Data at the 39June 10th, 2019
Weekly Tetraphase Pharmaceuticals, Inc. (NASDAQ:TTPH) Ratings on Dec 15, 2018December 15th, 2018
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