LauraKayeAguilarMDPhD

PubMed

• 4 citations
  Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma.
  Marilin S Koch, Mykola Zdioruk, Michal O Nowicki, Alec M Griffith, Estuardo Aguilar-Cordova, Laura K Aguilar, Brian W Guzik, Francesca Barone, Paul Peter Tak, Katharin...> ;Molecular Therapy Oncolytics. 2022 Sep 15
• 7 citations
  Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models.
  Marilin S Koch, Mykola Zdioruk, Michal O Nowicki, Alec M Griffith, Estuardo Aguilar, Laura K Aguilar, Brian W Guzik, Francesca Barone, Paul P Tak, Ghazaleh Tabatabai, ...> ;Journal for Immunotherapy of Cancer. 2022 Jan 1
• 34 citations
  Leveraging external data in the design and analysis of clinical trials in neuro-oncology.
  Rifaquat Rahman, Steffen Ventz, Jon McDunn, Bill Louv, Irmarie Reyes-Rivera, Mei Yin C. Polley, Fahar Merchant, Lauren E. Abrey, Joshua E. Allen, Laura K. Aguilar, Est...> ;The Lancet. Oncology. 2021 Oct 1
• 5 citations
  Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity.
  Jarrod D. Predina, Andrew R. Haas, Marina Martinez, Shaun O'Brien, Edmund K. Moon, Patrick Woodruff, Jason Stadanlick, Christopher Corbett, Lydia G. Frenzel-Sulyok, Mi...> ;Molecular Therapy. 2021 Feb 3
• 19 citations
  Phase I Study of Intrapleural Gene-Mediated Cytotoxic Immunotherapy in Patients with Malignant Pleural Effusion.
  Charu Aggarwal, Andrew R. Haas, Susan Metzger, Laura K. Aguilar, Estuardo Aguilar-Cordova, Andrea G. Manzanera, Gregoria Gómez-Hernández, Sharyn I. Katz, Evan W. Alley...> ;Molecular Therapy. 2018 May 2
• 45 citations
  Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma.
  Maria Carmela Speranza, Carmela Passaro, Franz Ricklefs, Kazue Kasai, Sarah R. Klein, Hiroshi Nakashima, Johanna K. Kaufmann, Abdul-Kareem Ahmed, Michał Nowicki, Prisc...> ;Neuro-Oncology. 2018 Jan 22
• 113 citations
  Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma.
  Lee A. Wheeler, Andrea G. Manzanera, Susan Bell, Robert Cavaliere, John M. McGregor, John C. Grecula, Herbert B. Newton, Simon S. Lo, Behnam Badie, Jana Portnow, Bin S...> ;Neuro-Oncology. 2015 Nov 1
• 42 citations
  Gene-mediated cytotoxic immunotherapy as adjuvant to surgery or chemoradiation for pancreatic adenocarcinoma
  Laura K. Aguilar, Lawrence A. Shirley, Vincent Chung, Christopher L. Marsh, Jon P. Walker, Walter J. Coyle, Howard Marx, Tanios Bekaii-Saab, Gregory B. Lesinski, Benja...> ;Cancer Immunology, Immunotherapy. 2015 Mar 21
• 27 citations
  Intraprostatic distribution and long-term follow-up after AdV-tk immunotherapy as neoadjuvant to surgery in patients with prostate cancer.
  Augusto Rojas-Martinez, Andrea G. Manzanera, S. W. Sukin, J. Esteban-María, Juan Francisco González-Guerrero, Lauro S. Gómez-Guerra, Raquel Garza-Guajardo, Juan Pablo ...> ;Cancer Gene Therapy. 2013 Nov 1
• 10 citations
  Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma
  Lawrence A. Shirley, Laura K. Aguilar, Estuardo Aguilar-Cordova, Mark Bloomston, Jon P. Walker> ;Gastroenterology Research and Practice. 2013 Mar 27
• 19 citations
  The spectrum of vaccine therapies for patients with glioblastoma multiforme.
  Laura K. Aguilar, Mariel Arvizu, Estuardo Aguilar-Cordova, E. Antonio Chiocca> ;Current Treatment Options in Oncology. 2012 Aug 18
• 27 citations
  Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models.
  Jarrod D. Predina, Brendan F. Judy, Louis A. Aliperti, Zvi G. Fridlender, Aaron Blouin, Veena Kapoor, Benjamin Laguna, H Nakagawa, Anil K. Rustgi, Laura K. Aguilar, Es...> ;Cancer Gene Therapy. 2011 Dec 1
• 106 citations
  Phase IB Study of Gene-Mediated Cytotoxic Immunotherapy Adjuvant to Up-Front Surgery and Intensive Timing Radiation for Malignant Glioma
  E. Antonio Chiocca, Laura K. Aguilar, Susan Bell, Balveen Kaur, Jayson Hardcastle, Robert Cavaliere, John M. McGregor, Simon S. Lo, Abhik Ray-Chaudhuri, Arnab Chakrava...> ;Journal of Clinical Oncology. 2011 Sep 20
• 57 citations
  Cytotoxic immunotherapy strategies for cancer: mechanisms and clinical development
  Laura K. Aguilar, Brian W. Guzik, Estuardo Aguilar-Cordova> ;Journal of Cellular Biochemistry. 2011 Aug 1
• 286 citations
  Cytotoxic T lymphocyte therapy for epstein-barr virus+ Hodgkin's disease
  Catherine M. Bollard, Laura K. Aguilar, Karin Straathof, Benedikt Gahn, M. Helen Huls, Alexandra Rousseau, John W. Sixbey, M. Victoria Gresik, George Carrum, Melissa M...> ;The Journal of Experimental Medicine. 2004 Dec 20
• 45 citations
  Phase I–II trial evaluating combined intensity-modulated radiotherapy and in situ gene therapy with or without hormonal therapy in treatment of prostate cancer—interim...
  Bin S. Teh, Gustavo Ayala, Laura K. Aguilar, Wei Yuan Mai, Terry L. Timme, Maria T. Vlachaki, Brian J. Miles, Dov Kadmon, Thomas M. Wheeler, James Caillouet, Maria Dav...> ;International Journal of Radiation Oncology, Biology, Physics. 2004 Apr 1
• 20 citations
  The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects.
  Ulf Nestler, Hiroaki Wakimoto, Fernando Siller-López, Laura K. Aguilar, Arnab Chakravarti, Alona Muzikansky, Anat Stemmer-Rachamimov, E. Antonio Chiocca, Estuardo Agui...> ;Journal of Neuro-Oncology. 2004 Mar 1
• 8 citations
  Evolution of a gene therapy clinical trial. From bench to bedside and back.
  Laura K. Aguilar, Estuardo Aguilar-Cordova> ;Journal of Neuro-Oncology. 2003 Dec 1
• 24 citations
  Combining Radiotherapy with Gene Therapy (From the Bench to the Bedside): A Novel Treatment Strategy for Prostate Cancer
  Bin S. Teh, Estuardo Aguilar-Cordova, Maria T. Vlachaki, Laura K. Aguilar, Wei Yuan Mai, James Caillouet, Maria Davis, Brian J. Miles, Dov Kadmon, Gustavo Ayala, Hsin ...> ;The Oncologist. 2002 Oct 1
• 49 citations
  Impact of preimmunization on adenoviral vector expression and toxicity in a subcutaneous mouse cancer model
  Maria T. Vlachaki, Andres Hernandez-Garcia, Michael Ittmann, Madhu Chhikara, Laura K. Aguilar, Xiaohong Zhu, E. Brian Butler, Shiao Y. Woo, Timothy C. Thompson, Hugo A...> ;Molecular Therapy. 2002 Sep 1
• 65 citations
  Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversion
  Jesús García-Bañuelos, Fernando Siller-López, Alejandra Miranda, Laura K. Aguilar, Estuardo Aguilar-Cordova, Juan Armendáriz-Borunda> ;Gene Therapy. 2002 Jan 1
• 27 citations
  Enhanced therapeutic effect of mutiple injections of HSV-TK + GCV gene therapy in combination with ionizing radiation in a mouse mammary tumor model
  Maria T. Vlachaki, Madhu Chhikara, Laura K. Aguilar, Xiaohong Zhu, Kam J. Chiu, Shiao Y. Woo, Bin S. Teh, Timothy C. Thompson, E. Brian Butler, Estuardo Aguilar-Cordova> ;International Journal of Radiation Oncology, Biology, Physics. 2001 Nov 15
• 55 citations
  Enhanced therapeutic effect of HSV-tk+GCV gene therapy and ionizing radiation for prostate cancer.
  Madhu Chhikara, Hanxian Huang, Maria T. Vlachaki, Xiaohong Zhu, Bin Teh, Kam J. Chiu, Shiao Y. Woo, Barry M. Berner, E. O'Brian Smith, Kerby C. Oberg, Laura K. Aguilar...> ;Molecular Therapy. 2001 Apr 1
• 7 citations
  In Vivo Surgical Resection Plus Adjuvant Gene Therapy in the Treatment of Mammary and Prostate Cancer
  Steven W. Sukin, Madhu Chhikara, Xiaohong Zhu, Gustavo Ayala, Laura K. Aguilar, E. O'Brian Smith, Brian J. Miles, Timothy C. Thompson, Dov Kadmon, Estuardo Aguilar-Cor...> ;Molecular Therapy. 2001 Apr 1
• 34 citations
  Adoptive immunotherapy of EBV-associated malignancies with EBV-specific cytotoxic T-cell lines.
  Cliona M. Rooney, Laura K. Aguilar, M. H. Huls, Malcolm K. Brenner, Helen E. Heslop> ;Current Topics in Microbiology and Immunology. 2001 Jan 1
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