LauraVictoriaBownesMD

Resident Physician • Birmingham, AL

UAB General Surgery Resident, Post-doctoral Research Fellow at the Beierle Lab

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Office
U of AL Sch of Med
Birmingham, AL 35201
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Summary

UAB General Surgery Resident, Post-doctoral Research Fellow in the Beierle Lab

Education & Training

University of Alabama Medical CenterResidency, Surgery, 2017
University of Alabama School of MedicineClass of 2017

Certifications & Licensure

AL State Medical License 2018 - 2024

Publications & Presentations

PubMed

CDK4/6 Inhibition With Lerociclib is a Potential Therapeutic Strategy for the Treatment of Pediatric Sarcomas.
Janet R Julson, Sara C Horton, Colin H Quinn, Andee M Beierle, Laura V Bownes, Jerry E Stewart, Jamie Aye, Karina J Yoon, Elizabeth A Beierle> ;Journal of Pediatric Surgery. 2024 Mar 1
3 citations
The Effects of Protein Phosphatase 2A Activation with Novel Tricyclic Sulfonamides on Hepatoblastoma.
Laura V Bownes, Janet R Julson, Colin H Quinn, Sara Claire Hutchins, Michael H Erwin, Hooper R Markert, Jerry E Stewart, Elizabeth Mroczek-Musulman, Jamie Aye, Karina ...> ;Journal of Pediatric Surgery. 2023 Jun 1
2 citations
Inhibition of PIM Kinases Promotes Neuroblastoma Cell Differentiation to a Neuronal Phenotype.
Janet R Julson, Colin H Quinn, Laura V Bownes, Sara C Hutchins, Jerry E Stewart, Jamie Aye, Karina J Yoon, Elizabeth A Beierle> ;Journal of Pediatric Surgery. 2023 Jun 1
Using 3D-bioprinted models to study pediatric neural crest-derived tumors.
Colin H Quinn, Andee M Beierle, Janet R Julson, Michael E Erwin, Hasan Alrefai, Hooper R Markert, Jerry E Stewart, Sara Claire Hutchins, Laura V Bownes, Jamie M Aye, E...> ;International Journal of Bioprinting. 2023 Jan 1
2 citations
PIM3 kinase promotes tumor metastasis in hepatoblastoma by upregulating cell surface expression of chemokine receptor cxcr4.
Raoud Marayati, Janet Julson, Laura V Bownes, Colin H Quinn, Laura L Stafman, Andee M Beierle, Hooper R Markert, Sara C Hutchins, Jerry E Stewart, David K Crossman, An...> ;Clinical & Experimental Metastasis. 2022 Dec 1
Rapid Characterization of Solid Tumors Using Resonant Sensors.
Andee M Beierle, Colin H Quinn, Hooper R Markert, Adam Carr, Raoud Marayati, Laura V Bownes, Sara Claire Hutchins, Jerry E Stewart, Benjamin Hill, Michael Ohlmeyer, Ni...> ;ACS Omega. 2022 Sep 13
3 citations
Metastatic human hepatoblastoma cells exhibit enhanced tumorigenicity, invasiveness and a stem cell-like phenotype.
Raoud Marayati, Janet R Julson, Laura V Bownes, Colin H Quinn, Sara C Hutchins, Adele P Williams, Hooper R Markert, Andee M Beierle, Jerry E Stewart, Anita B Hjelmelan...> ;Journal of Pediatric Surgery. 2022 Jun 1
2 citations
Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK).
Laura V Bownes, Raoud Marayati, Colin H Quinn, Sara C Hutchins, Jerry E Stewart, Joshua C Anderson, Christopher D Willey, Pran K Datta, Elizabeth A Beierle> ;Journal of Pediatric Surgery. 2022 Jun 1
7 citations
Pre-Clinical Study Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Neuroblastoma.
Laura V Bownes, Raoud Marayati, Colin H Quinn, Andee M Beierle, Sara C Hutchins, Janet R Julson, Michael H Erwin, Jerry E Stewart, Elizabeth Mroczek-Musulman, Michael ...> ;Cancers. 2022 Apr 13
7 citations
Targeting High-Risk Neuroblastoma Patient-Derived Xenografts with Oncolytic Virotherapy.
Colin H Quinn, Andee M Beierle, Sara Claire Hutchins, Raoud Marayati, Laura V Bownes, Jerry E Stewart, Hooper R Markert, Michael H Erwin, Jamie M Aye, Karina J Yoon, G...> ;Cancers. 2022 Feb 1
6 citations
Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma Cell Lines.
Laura V. Bownes, Adele P. Williams, Raoud Marayati, Colin H. Quinn, Sara C. Hutchins, Jerry E. Stewart, Trung Vu, Juliet L. Easlick, Elizabeth Mroczek-Musulman, David ...> ;Cancers. 2021 Jun 26
3 citations
Downregulation of PDGFRß Signaling Overcomes Crizotinib Resistance in a TYRO3 and ALK Mutated Neuroendocrine-Like Tumor.
Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Markert, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Da...> ;Translational Oncology. 2021 Apr 19
11 citations
CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells
Raoud Marayati, Laura L. Stafman, Adele P. Williams, Laura V. Bownes, Colin H. Quinn, Hooper R. Markert, Juliet L. Easlick, Jerry E. Stewart, David K. Crossman, Elizab...> ;Cancer Gene Therapy. 2021 Apr 16
8 citations
PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma.
Raoud Marayati, Laura L. Stafman, Adele P. Williams, Laura V. Bownes, Colin H. Quinn, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Joshua C. Anderson, Christopher D...> ;Scientific Reports. 2021 Mar 16
14 citations
EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth.
Laura V. Bownes, Adele P. Williams, Raoud Marayati, Laura L. Stafman, Hooper R. Markert, Colin H. Quinn, Nikita Wadhwani, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoo...> ;Plos One. 2021 Mar 9
3 citations
PIM447 inhibits oncogenesis and potentiates cisplatin effects in hepatoblastoma.
Nikita Wadhwani, Hooper R. Markert, Raoud Marayati, Laura V. Bownes, Colin H. Quinn, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Elizabeth A. Beierle> ;Journal of Pediatric Surgery. 2021 Feb 24
4 citations
Novel second-generation rexinoid induces growth arrest and reduces cancer cell stemness in human neuroblastoma patient-derived xenografts.
Raoud Marayati, Laura V. Bownes, Colin H. Quinn, Nikita Wadhwani, Adele P. Williams, Hooper R. Markert, Venkatram R. Atigadda, Jamie M. Aye, Jerry E. Stewart, Karina J...> ;Journal of Pediatric Surgery. 2021 Feb 24
2 citations
9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts.
Raoud Marayati, Laura V. Bownes, Laura L. Stafman, Adele P. Williams, Colin H. Quinn, Venkatram R. Atigadda, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Elizabeth ...> ;Translational Oncology. 2021 Jan 1
4 citations
Pleuropulmonary blastoma in an adolescent.
Laura V. Bownes, Sara C. Hutchins, Agustin M. Cardenas, David R. Kelly, Elizabeth A. Beierle> ;Journal of Pediatric Surgery Case Reports. 2020 May 23
5 citations
Novel retinoic acid derivative induces differentiation and growth arrest in neuroblastoma.
Raoud Marayati, Adele P. Williams, Laura V. Bownes, Colin H. Quinn, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Venkatram R. Atigadda, Elizabeth A. Beierle> ;Journal of Pediatric Surgery. 2020 Feb 28
10 citations
Socioeconomic disparities affect survival in malignant ovarian germ cell tumors in AYA population.
Laura V. Bownes, Laura L. Stafman, Ilan I. Maizlin, Matthew Dellinger, Kenneth W. Gow, Adam B. Goldin, Melanie Goldfarb, Monica Langer, Mehul V. Raval, John J. Doski, ...> ;The Journal of Surgical Research. 2018 Feb 1
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Journal Articles

Pleuropulmonary blastoma in an adolescent
Laura V. Bownes, Sara C. Hutchins, Agustin M. Cardenas, David R. Kelly and Elizabeth A. Beierle, Journal of Pediatric Surgery Case Reports