LauraLDuganMD

Geriatrics • Nashville, TN

Dementia

Professor, Medicine, Vanderbilt University Medical Center

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Office
1211 22nd Ave
Nashville, TN 37232
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Education & Training

Stanford Health Care-Sponsored Stanford UniversityFellowship, Geriatric Medicine (Internal Medicine), 1990 - 1993
California Pacific Medical CenterResidency, Internal Medicine, 1987 - 1990
Ohio State University College of MedicineClass of 1987

Certifications & Licensure

TN State Medical License 2014 - 2024
CA State Medical License 1989 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Geriatric Medicine

Publications & Presentations

PubMed

4 citations
Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
Lei Fan, Xiangzhu Zhu, Shan Sun, Chang Yu, Xiang Huang, Reid Ness, Laura L Dugan, Lihua Shu, Douglas L Seidner, Harvey J Murff, Anthony A Fodor, M Andrea Azcarate-Peri...> ;Clinical Nutrition. 2022 Nov 1
21 citations
Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality.
Mohamed A Badawy, Basma Yasseen, Riem M El-Messiery, Engy A. Abdel-Rahman, Aya A Elkhodiry, Azza G Kamel, Hajar El-sayed, Asmaa M. Shedra, Rehab Hamdy, Mona Zidan, Dia...> ;Elife. 2021 Nov 25
66 citations
Parvalbumin interneuron vulnerability and brain disorders
Jacob B. Ruden, Laura L. Dugan, Christine Konradi> ;Neuropsychopharmacology. 2021 Jan 1
10 citations
Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging.
Naazneen Khan, Stuart K. Kim, Pascal Gagneux, Laura L. Dugan, Ajit Varki> ;FASEB Journal. 2020 Feb 1
1 citations
Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia.
Jacob B. Ruden, Kevin L. Quick, Ernesto R. Gonzales, Aarti R. Shah, Tae Sung Park, Nan Kennedy, Laura L. Dugan, Jeffrey M. Gidday> ;Frontiers in Neurology. 2019 May 1
Mass Spectral Studies of the Biologically Active Stereoisomer Family of e,e,e-(Methanofullerene(60-63)-Carboxylic Acids
Michael A. Grayson, Joshua I. Hardt, Michael L. Gross, Subhasish K. Chakraborty, Laura L. Dugan> ;Current Analytical Chemistry. 2018 Jul 31
3 citations
Corrigendum to: Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.
Evan C. Hadley, George A. Kuchel, Anne B. Newman, Heather G. Allore, Jenna M. Bartley, Cindy S. Bergeman, Michael L. Blinov, Cathleen S. Colón-Emeric, Firdaus S Dabhar...> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2018 Jun 14
6 citations
Pharmacokinetics and Toxicology of the Neuroprotective e,e,e -Methanofullerene(60)-63-tris Malonic Acid [C 3 ] in Mice and Primates
Joshua I. Hardt, Joel S. Perlmutter, Christopher J. Smith, Kevin L. Quick, Ling Wei, Subhasish K. Chakraborty, Laura L. Dugan> ;European Journal of Drug Metabolism and Pharmacokinetics. 2018 Oct 1
3 citations
When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data.
Jill M. Pulley, Rebecca N Jerome, Nicole M. Zaleski, Jana K. Shirey-Rice, Andrea J. Pruijssers, Robert R. Lavieri, Somsundaram N. Chettiar, Helen M. Naylor, David M. A...> ;Assay and Drug Development Technologies. 2017 Dec 1
46 citations
Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation
Catherine Hou, Chia-Ju Hsieh, Shihong Li, Hsiaoju Lee, Thomas J. A. Graham, Kuiying Xu, Chi-Chang Weng, Robert K. Doot, Wenhua Chu, Subhasish K. Chakraborty, Laura L. ...> ;ACS Chemical Neuroscience. 2018 Mar 21
90 citations
Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging
Evan C. Hadley, George A. Kuchel, Anne B. Newman, Heather G. Allore, Jenna M. Bartley, Cindy S. Bergeman, Michael L. Blinov, Cathleen S. Colón-Emeric, Firdaus S Dabhar...> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2017 Jul 1
39 citations
Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates
Laura L. Dugan, LinLin Tian, Kevin L. Quick, Josh I. Hardt, Morvarid Karimi, Christopher A. Brown, Susan K. Loftin, Hugh Flores, Stephen M. Moerlein, John Polich, Same...> ;Annals of Neurology. 2014 Sep 1
58 citations
Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo.
Wenhua Chu, Andre Chepetan, Dong Zhou, Kooresh I. Shoghi, Jinbin Xu, Laura L. Dugan, Robert J. Gropler, Mark A. Mintun, Robert H. Mach> ;Organic & Biomolecular Chemistry. 2014 Jun 4
334 citations
AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function
Laura L. Dugan, Young Hyun You, Sameh S. Ali, Maggie Diamond-Stanic, Satoshi Miyamoto, Anne-Emilie Decleves, Aleksander Andreyev, Tammy Quach, San Ly, Grigory Shekhtma...> ;The Journal of Clinical Investigation. 2013 Nov 1
17 citations
nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an ex...
Lorella M.T. Canzoniero, Alberto Granzotto, Dorothy M. Turetsky, Dennis W. Choi, Laura L. Dugan, Stefano L. Sensi> ;Frontiers in Physiology. 2013 May 16
120 citations
Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model
Robert K. Naviaux, Zarazuela Zolkipli, Lin Wang, Tomohiro Nakayama, Jane C. Naviaux, Thuy Le, Michael A. Schuchbauer, Mihael Rogac, Qingbo Tang, Laura L. Dugan, Susan ...> ;Plos One. 2013 Mar 13
56 citations
Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage.
Sameh S. Ali, Mary Hsiao, Huiwen W. Zhao, Laura L. Dugan, Gabriel G. Haddad, Dan Zhou> ;Plos One. 2012 May 4
18 citations
An in vitro ischemic penumbral mimic perfusate increases NADPH oxidase-mediated superoxide production in cultured hippocampal neurons.
Matthew E. Pamenter, Sameh S. Ali, Qingbo Tang, J. Cameron Finley, Xiang Q. Gu, Laura L. Dugan, Gabriel G. Haddad> ;Brain Research. 2012 May 3
Dynamic optical imaging of metabolic and NADPH oxidase-derived superoxide in live mouse brain using fluorescence lifetime unmixing.
Hall, D.J., Han, S., Chepetan, A.M., Inui, E.G., Rogers, M., Dugan, L.L.> ;J Cereb Blood Flow Metab. 2012-02-01
47 citations
Dynamic optical imaging of metabolic and NADPH oxidase-derived superoxide in live mouse brain using fluorescence lifetime unmixing
David J. Hall, Sung-Ho Han, Andre Chepetan, Edny G Inui, Mike Rogers, Laura L. Dugan> ;Journal of Cerebral Blood Flow and Metabolism. 2012 Feb 1
29 citations
Initial evidence linking synaptic superoxide production with poor short-term memory in aged mice
Sameh S. Ali, Jared W. Young, Chelsea K. Wallace, Jodi E. Gresack, Dilip V. Jeste, Mark A. Geyer, Laura L. Dugan, Victoria B. Risbrough> ;Brain Research. 2011 Jan 12
48 citations
Metabolic Depression and Increased Reactive Oxygen Species Production by Isolated Mitochondria at Moderately Lower Temperatures
Sameh S. Ali, Maria Cecilia Garibaldi Marcondes, Hilda Bajova, Laura L. Dugan, Bruno Conti> ;The Journal of Biological Chemistry. 2010 Oct 15
64 citations
Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.
Robert M. Douglas, Julie Ryu, Amjad Kanaan, Maria del Carmen Rivero, Laura L. Dugan, Gabriel G. Haddad, Sameh S. Ali> ;American Journal of Physiology. Cell Physiology. 2010 Jun 1
125 citations
IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase
Laura L. Dugan, Sameh S. Ali, Grigoriy Shekhtman, Amanda J. Roberts, Jacinta Lucero, Kevin L. Quick, M. Margarita Behrens> ;Plos One. 2009 May 13
196 citations
Interleukin-6 Mediates the Increase in NADPH-Oxidase in the Ketamine Model of Schizophrenia
M. Margarita Behrens, Sameh S. Ali, Laura L. Dugan> ;The Journal of Neuroscience. 2008 Dec 17
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Grant Support

Systemic Inflammation And Central Nervous System DysfunctionNational Institute On Aging2010–2011
Improved Spin Probes For Magnetic Resonance Imaging Of Oxygen And Reactive OxygenNational Institute On Aging2007–2009
Characterization Of Neuroprotective CarboxyfullerenesNational Center For Research Resources2004–2009
Ucp5-- Balancing Metabolism And Oxidation In Aging BrainNational Institute Of Neurological Disorders And Stroke2004
Ucp5-- Balancing Metabolism And Oxidation In Aging BrainNational Institute Of Neurological Disorders And Stroke2001–2004
Mechanisms Of Neuroprotection By C60 DerivativesNational Institute Of Neurological Disorders And Stroke1998–2001
Free Radical Mechanisms In Neural Injury In VitroNational Institute On Aging1994–1998

Hospital Affiliations

Vanderbilt University Medical CenterNashville, Tennessee
Tennessee Valley HCS - Nashville and MurfreesboroNashville, Tennessee

LauraLDuganMD

Dr. Dugan is on Doximity

Education & Training

Certifications & Licensure

Publications & Presentations

Grant Support

Hospital Affiliations

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