LauraA.MitchellMD

PubMed

• 20 citations
  Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease.
  Jianming Liao, Chun Chen, Eun Hee Ahn, Xia Liu, Hua Li, Laura E. Edgington-Mitchell, Zhonghua Lu, Shuping Ming, Keqiang Ye> ;Neuropharmacology. 2021 Oct 1
• 17 citations
  Cathepsin S Evokes PAR2-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models.
  Nguyen Huu Tu, Kenji Inoue, Elyssa Chen, Bethany M. Anderson, Caroline M. Sawicki, Nicole N. Scheff, Hung D. Tran, Dong H. Kim, Robel G. Alemu, Lei Yang, John C. Dolan...> ;Cancers. 2021 Sep 19
• 24 citations
  Mitochondrial dysfunction triggers the pathogenesis of Parkinson's disease in neuronal C/EBPβ transgenic mice.
  Eun Hee Ahn, Kecheng Lei, Seong Su Kang, Zhi-Hao Wang, Xia Liu, Wei Hong, Yu Tian Wang, Laura E. Edgington-Mitchell, Lingjing Jin, Keqiang Ye> ;Molecular Psychiatry. 2021 Sep 6
• 12 citations
  C/EBPβ/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis
  Kecheng Lei, Seong Su Kang, Eun Hee Ahn, Chun Chen, Jianming Liao, Xia Liu, Hua Li, Laura E. Edgington-Mitchell, Lingjing Jin, Keqiang Ye> ;Molecular Cancer Therapeutics. 2021 Jun 22
• 23 citations
  ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease.
  Zhi-Hao Wang, Yiyuan Xia, Pai Liu, Xia Liu, Laura E. Edgington-Mitchell, Kecheng Lei, Shan Ping Yu, Xiaochuan Wang, Keqiang Ye> ;Progress in Neurobiology. 2021 Mar 11
• 1 citations
  Editorial overview: Systems biology and the rise and rise of omics approaches.
  Nichollas E Scott, Laura E Edgington-Mitchell> ;Current Opinion in Chemical Biology. 2021 Feb 1
• 26 citations
  Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.
  Nguyen Huu Tu, Dane D. Jensen, Bethany M. Anderson, Elyssa Chen, Nestor N. Jiménez-Vargas, Nicole N. Scheff, Kenji Inoue, Hung D. Tran, John C. Dolan, Tamaryn A. Meek,...> ;The Journal of Neuroscience. 2021 Jan 6
• 1 citations
  WITHDRAWN: Editorial Overview: Systems biology and the rise and rise of omics approaches
  Nichollas E. Scott, Laura E. Edgington-Mitchell> ;Current Opinion in Chemical Biology. 2021 Jan 6
• 16 citations
  TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies.
  Yiyuan Xia, Zhi-Hao Wang, Pai Liu, Laura E. Edgington-Mitchell, Xia Liu, Xiaochuan Wang, Keqiang Ye> ;Molecular Psychiatry. 2021 Jul 1
• 14 citations
  System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion.
  Carlo Giannangelo, Ghizal Siddiqui, Amanda De Paoli, Bethany M. Anderson, Laura E. Edgington-Mitchell, Susan A. Charman, Darren J. Creek> ;Plos Pathogens. 2020 Jun 26
• Correction: Novel broad-spectrum activity-based probes to profile malarial cysteine proteases.
  Michele S. Y. Tan, Dara Davison, Mateo I. Sánchez, Bethany M. Anderson, Stephen H. Howell, Ambrosius P. Snijders, Laura E. Edgington-Mitchell, Edgar Deu> ;Plos One. 2020 Mar 26
• 28 citations
  Lysosomal degradation products induce Coxiella burnetii virulence
  Patrice Newton, David R. Thomas, Shawna C. O. Reed, Nicole Lau, Bangyan Xu, Sze Ying Ong, Shivani Pasricha, Piyush B. Madhamshettiwar, Laura E. Edgington-Mitchell, Kay...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Mar 24
• 9 citations
  Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes.
  Simon J. Mountford, Bethany M. Anderson, Bangyan Xu, Elean S.V. Tay, Monika Szabo, My Linh Hoang, Jiayin Diao, Luigi Aurelio, Rhiannon I. Campden, Erik Lindström, Eric...> ;ACS Chemical Biology. 2020 Mar 20
• 3 citations
  High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tum...
  Niina Aaltonen, Prosanta K. Singha, Hermina Jakupović, Thomas Wirth, Haritha Samaranayake, Sanna Pasonen-Seppänen, Kirsi Rilla, Markku Varjosalo, Laura E. Edgington-Mi...> ;Biological Procedures Online. 2020 Mar 15
• 7 citations
  Proteomics and Imaging in Crohn’s Disease: TAILS of Unlikely Allies
  B Mainoli, Simon A. Hirota, Laura E. Edgington-Mitchell, Cathy Lu, Antoine Dufour> ;Trends in Pharmacological Sciences. 2020 Feb 1
• 10 citations
  N-Terminomics/TAILS Profiling of Macrophages after Chemical Inhibition of Legumain
  Bethany M. Anderson, Luiz Gustavo de Almeida, Henna Sekhon, Daniel Young, Antoine Dufour, Laura E. Edgington-Mitchell> ;Biochemistry. 2020 Jan 28
• 5 citations
  Novel broad-spectrum activity-based probes to profile malarial cysteine proteases.
  Michele S. Y. Tan, Dara Davison, Mateo I. Sánchez, Bethany M. Anderson, Stephen Howell, Ambrosius P. Snijders, Laura E. Edgington-Mitchell, Edgar Deu> ;Plos One. 2020 Jan 10
• 10 citations
  Loss of O -Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators.
  Cameron C. Oppy, Leila Jebeli, Miku Kuba, Clare V. Oates, Richard A. Strugnell, Laura E. Edgington-Mitchell, Miguel A. Valvano, Elizabeth L. Hartland, Hayley J. Newton...> ;Msphere. 2019 Nov 13
• 20 citations
  Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease
  Bethany M. Anderson, Daniel P. Poole, Luigi Aurelio, Garrett Z. Ng, Markus Fleischmann, Paulina Kasperkiewicz, Celine Morissette, Marcin Drag, Ian R. van Driel, Brian ...> ;Scientific Reports. 2019 Sep 16
• 13 citations
  N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis.
  Marilyn Gordon, Anthonia Anowai, Daniel Young, Nabangshu Das, Rhiannon I. Campden, Henna Sekhon, Zoe Myers, B Mainoli, Sameeksha Chopra, Peter S. Thuy-Boun, Jayachandr...> ;ACS Chemical Biology. 2019 Aug 8
• 4 citations
  Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associated conditions.
  Maria Roitman, Laura E. Edgington-Mitchell, Jon E. Mangum, James Ziogas, Alexios A. Adamides, Paul S. Myles, Hearan Choo-Bunnett, Nigel W. Bunnett, Jenny M. Gunnersen> ;Pain Reports. 2019 Mar 1
• 86 citations
  PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells.
  Chaido Stathopoulou, Arunakumar Gangaplara, Grace Mallett, Francis A. Flomerfelt, Lukasz P. Liniany, David Knight, Leigh Samsel, Rolando Berlinguer-Palmini, Joshua J. ...> ;Immunity. 2018 Aug 21
• 100 citations
  Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
  Nestor N. Jiménez-Vargas, Luke A. Pattison, Peishen Zhao, Tina Marie Lieu, Rocco Latorre, Dane D. Jensen, Joel Castro, Luigi Aurelio, Giang Thanh Le, Bernard L. Flynn,...> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Jul 31
• 40 citations
  Myoepithelial cell‐specific expression of stefin A as a suppressor of early breast cancer invasion
  Hendrika M. Duivenvoorden, Jai Rautela, Laura E. Edgington-Mitchell, Alex Spurling, David W. Greening, Cameron J. Nowell, Timothy J. Molloy, Elizabeth Robbins, Natasha...> ;The Journal of Pathology. 2017 Oct 31
• 21 citations
  Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation.
  Laura E. Edgington-Mitchell, Nicholas Barlow, Luigi Aurelio, Aminath Samha, Monika Szabo, Bim Graham, Nigel W. Bunnett> ;Bioorganic & Medicinal Chemistry Letters. 2017 Jan 15
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