LaurenceHerbertKedesMD

PubMed

• 160 citations
  Research ethics recommendations for whole-genome research: consensus statement.
  Timothy Caulfield, Amy L. McGuire, Mildred K. Cho, Janet A. Buchanan, Michael M. Burgess, Ursula Danilczyk, Christina M. Diaz, Kelly Fryer-Edwards, Shane K. Green, Mar...> ;Plos Biology. 2008 Mar 25
• New cellular and molecular approaches for the treatment of cardiac disease.
  Laurence Kedes, Robert A. Kloner, Kimi Y. Kong, Coralie Poizat, Boris Z. Simkhovich, Tatsuya Iso, Yasuo Hamamori> ;Seminars in Nephrology. 2004 Sep 1
• 890 citations
  Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution.
  Israel M. Barbash, Pierre Chouraqui, Jack Baron, Micha S. Feinberg, Sharon Etzion, Ariel Tessone, Liron Miller, Esther Guetta, Dov Zipori, Laurence H. Kedes, Robert A....> ;Circulation. 2003 Aug 19
• 13 citations
  Gene expression profiling--a new approach in the study of myocardial ischemia.
  Boris Z. Simkhovich, Robert A. Kloner, Coralie Poizat, Paul Marjoram, Laurence H. Kedes> ;Cardiovascular Pathology. 2003 Jul 1
• 42 citations
  Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function
  Mu Yao, Thomas Dieterle, Sharon L. Hale, Joan Dow, Laurence H. Kedes, Kirk L. Peterson, Robert A. Kloner> ;Journal of Molecular and Cellular Cardiology. 2003 Jun 1
• 33 citations
  Cellular Cardiomyoplasty of Cardiac Fibroblasts by Adenoviral Delivery of MyoD Ex Vivo: An Unlimited Source of Cells for Myocardial Repair
  Sharon Etzion, Israel M. Barbash, Micha S. Feinberg, Parvin Zarin, Liron Miller, Esther Guetta, Radka Holbova, Robert A. Kloner, Laurence H. Kedes, Jonathan Leor> ;Circulation. 2002 Sep 24
• 22 citations
  Cellular Cardiomyoplasty—A Novel Approach to Treat Heart Disease
  Jochen Müller-Ehmsen, Laurence H. Kedes, Robert H. G. Schwinger, Robert A. Kloner> ;Congestive Heart Failure. 2002 Jul 1
• 16 citations
  Gene activity changes in ischemically preconditioned rabbit heart gene: discovery array study.
  Boris Z. Simkhovich, Serge Abdishoo, Coralie Poizat, Sharon L. Hale, Laurence H. Kedes, Robert A. Kloner> ;Heart Disease. 2002 Mar 1
• 138 citations
  Influence of embryonic cardiomyocyte transplantation on the progression of heart failure in a rat model of extensive myocardial infarction.
  Sharon Etzion, Alexander Battler, Israel M. Barbash, Emanuela Cagnano, Parvin Zarin, Yosef Granot, Laurence H. Kedes, Robert A. Kloner, Jonathan Leor> ;Journal of Molecular and Cellular Cardiology. 2001 Jul 1
• 23 citations
  Myocardial regeneration: present and future trends.
  Sharon Etzion, Laurence H. Kedes, Robert A. Kloner, Jonathan Leor> ;American Journal of Cardiovascular Drugs. 2001 Jan 1
• 216 citations
  Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat—angiogen...
  Ernst R. Schwarz, Mark T. Speakman, Mike Patterson, Sharon Hale, Jeffrey M. Isner, Laurence H. Kedes, Robert A. Kloner> ;Journal of the American College of Cardiology. 2000 Apr 1
• 34 citations
  BIONETtm: national computer resource for molecular biology
  Dennis H. Smith, Douglas L. Brutlag, Peter Friedland, Laurence H. Kedes> ;Nucleic Acids Research. 1986 Jan 10
• 1 citations
  Expression of Isoforms from Cloned Skeletal and Cardiac Actin Genes
  Laurence H. Kedes> ;Advances in Experimental Medicine and Biology. 1985 Jan 1
• 26 citations
  The nucleotide and amino acid coding sequence of a gene for H1 histone that interacts with euchromatin. The early embryonic H1 gene of the sea urchin Strongylocentrotu...
  Shoshana Levy, I Sures, Laurence H. Kedes> ;The Journal of Biological Chemistry. 1982 Aug 25
• 4 citations
  MAXAMIZE. A DNA sequencing strategy advisor
  René Bach, Peter Friedland, Douglas L. Brutlag, Laurence H. Kedes> ;Nucleic Acids Research. 1982 Jan 11
• 8 citations
  GENESIS, a knowledge-based genetic engineering simulation system for representation of genetic data and experiment planning.
  Peter Friedland, Laurence H. Kedes, Douglas L. Brutlag, Yumi Iwasaki, René Bach> ;Nucleic Acids Research. 1982 Jan 11
• 118 citations
  SEQ: a nucleotide sequence analysis and recombination system
  Douglas L. Brutlag, J. Clayton, Peter Friedland, Laurence H. Kedes> ;Nucleic Acids Research. 1982 Jan 11
• 58 citations
  Isolation of two clusters of mouse histone genes
  Donald B. Sittman, Ing-Ming Chiu, Chi-Jiunn Pan, Ronald H. Cohn, Laurence H. Kedes, William F. Marzluff> ;Proceedings of the National Academy of Sciences of the United States of America. 1981 Jul 1
• 41 citations
  Leader sequences of Strongylocentrotus purpuratus histone mRNAs start at a unique heptanucleotide common to all five histone genes
  Irmingard Sures, Shoshana Levy, Laurence H. Kedes> ;Proceedings of the National Academy of Sciences of the United States of America. 1980 Mar 1
• 15 citations
  Nonallelic histone gene clusters of individual sea urchins (Lytechinus pictus): polarity and gene organization.
  Ronald H. Cohn, Laurence H. Kedes> ;Cell. 1979 Nov 1
• 104 citations
  Histone gene expression during sea urchin embryogenesis: Isolation and characterization of early and late messenger RNAs ofStrongylocentrotus purpuratus by gene-specif...
  Geoffrey Childs, Robert E. Maxson, Laurence H. Kedes> ;Developmental Biology. 1979 Nov 1
• 18 citations
  Nonallelic histone gene clusters of individual sea urchins (Lytechinus pictus): Mapping of homologies in coding and spacer DNA
  Ronald H. Cohn, Laurence H. Kedes> ;Cell. 1979 Nov 1
• 38 citations
  Genes coding for histone proteins in man are located on the distal end of the long arm of chromosome 7.
  Mary E. Chandler, Laurence H. Kedes, Ronald H. Cohn, Jorge J. Yunis> ;Science. 1979 Aug 31
• 18 citations
  Sequence of the 5'-end of Strongylocentrotus purpuratus H2b histone mRNA and its location within histone DNA.
  Shoshana Levy, Irmi Sures, Laurence H. Kedes> ;Nature. 1979 Jun 21
• 20 citations
  Rapid purification of biologically active individual histone messenger RNAs by hybridization to cloned DNA linked to cellulose.
  Geoffrey Childs, Shoshana Levy, Laurence H. Kedes> ;Biochemistry. 1979 Jan 9
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Journal Articles

• A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes.  
  Sakoda T, Kasahara N, Hamamori Y, Kedes L., J Mol Cell Cardiol
• Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat--angioge...  
  Schwarz ER, Speakman MT, Patterson M, Hale SS, Isner JM, Kedes LH, Kloner RA, J Am Coll Cardiol
• Intramyocardial injection of DNA encoding vascular endothelial growth factor in a myocardial infarction model.  
  Kloner RA, Dow J, Chung G, Kedes LH, J Thromb Thrombolysis
• Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium.  
  Muller-Ehmsen J, Whittaker P, Kloner RA, Dow JS, Sakoda T, Long TI, Laird PW, Kedes L., J Mol Cell
• HERP1 is a cell type-specific primary target of Notch.  
  Iso T, Chung G, Hamamori Y, Kedes L., J Biol Chem
• HES and HERP families: multiple effectors of the Notch signaling pathway.  
  Iso T, Kedes L, and Hamamori Y., J Cell Physiol
• Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function.  
  Yao M, Dieterle T, Hale SL, Dow JS, Kedes LH, Peterson KL, Kloner RA., . J Mol Cell Cardiol.
• Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.  
  Itoh F, Itoh S, Goumans MJ, Valdimarsdottir G, Iso T, Dotto GP, Hamamori Y, Kedes L, Kato M, Dijke Pt P., EMBO J.
• Cytoplasmic nuclear transfer of the actin-capping protein tropomodulin.  
  Kong KY, Kedes L., J Biol Chem.
• Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres.  
  Kong, K. Y., and Kedes, L., J Biol Chem 281
• Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase.  
  Tanaka, T., Nishimura, D., Wu, R. C., Amano, M., Iso, T., Kedes, L., Nishida, H., Kaibuchi, K., and Hamamori, Y., J Biol Chem 281
• Critical Role of Nuclear Calcium/Calmodulin-dependent Protein Kinase II{delta}B in Cardiomyocyte Survival in Cardiomyopathy.  
  Little GH, Saw A, Bai Y, Dow J, Marjoram P, Simkhovich B, Leeka J, Kedes L, Kloner RA, Poizat C., J Biol Chem.
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Abstracts/Posters

• Cardiomyocyte transplantation into the failing heart-new therapeutic approach for heart failure?
  Reffelmann T, Leor J, Muller-Ehmsen J, Kedes L, Kloner RA., Heart Fail Rev.
• Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A.
  Hamamori Y, Sartorelli V, Ogryzko V, Puri PL, Wu HY, Wang JY, Nakatani Y, Kedes L, Cell
• Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-acti...
  Biesiada E, Hamamori Y, Kedes L, Sartorelli V., Mol Cell Biol
• Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program.
  Sartorelli V, Puri PL, Hamamori Y, Ogryzko V, Chung G, Nakatani Y, Wang JY, Kedes L., Mol Cell
• Molecular cloning of rabbit CARP cDNA and its regulated expression in adriamycin-cardiomyopathy.
  Aihara Y, Kurabayashi M, Arai M, Kedes L, Nagai R., Biochim Biophys Acta
• Twist is a potential oncogene that inhibits apoptosis.
  Maestro R, Dei Tos AP, Hamamori Y, Krasnokutsky S, Sartorelli V, Kedes L, Doglioni C, Beach DH, Hannon GJ., Genes Dev
• The myogenic regulatory circuit that controls cardiac/slow twitch troponin C gene transcription in skeletal muscle involves E-box, MEF-2, and MEF-3 motifs.
  Christensen TH, Kedes L., Gene Expr
• Assessing the binding and endocytosis activity of cellular receptors using GFP-ligand fusions.
  Medina-Kauwe LK, Leung V, Wu L, Kedes L., Biotechniques
• Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription.
  Poizat C, Sartorelli V, Chung G, Kloner RA, Kedes L., Mol Cell Biol
• 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins.
  Medina-Kauwe LK, Kasahara N, Kedes L., Gene Ther
• HERP, a new primary target of Notch regulated by ligand binding.
  Iso T, Sartorelli V, Chung G, Shichinohe T, Kedes L, Hamamori Y., Mol Cell Biol
• HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.
  Iso T, Sartorelli V, Poizat C, Iezzi S, Wu HY, Chung G, Kedes L, Hamamori Y., Mol Cell Biol
• Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis.
  Puri PL, Iezzi S, Stiegler P, Chen TT, Schiltz RL, Muscat GE, Giordano A, Kedes L, Wang JY, Sartorelli V., Mol Cell
• Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins.
  Medina-Kauwe LK, Maguire M, Kasahara N, Kedes L., Gene Ther
• Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function.
  Muller-Ehmsen J, Peterson KL, Kedes L, Whittaker P, Dow JS, Long TI, Laird PW, Kloner RA., Circulation
• Development of abnormal tissue architecture in transplanted neonatal rat myocytes.
  Whittaker P, Muller-Ehmsen J, Dow JS, Kedes LH, Kloner RA., Ann Thorac Surg.
• Notch signaling in vascular development.
  Iso T, Hamamori Y, Kedes L., Arterioscler Thromb Vasc Biol.
• Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion.
  Simkhovich BZ, Marjoram P, Poizat C, Kedes L, Kloner RA., Arch Biochem Biophys.
• HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box.
  Doi, H., Iso, T., Yamazaki, M., Akiyama, H., Kanai, H., Sato, H., Kawai-Kowase, K., Tanaka, T., Maeno, T., Okamoto, E., and et al., Arterioscler Thromb Vasc Biol 25
• Washout of transplanted cells from the heart: a potential new hurdle for cell transplantation therapy.
  Dow, J., Simkhovich, B. Z., Kedes, L., and Kloner, and R. A., Cardiovasc Res 67
• Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells.
  Poizat, C., Puri, P. L., Bai, Y., and Kedes, L., Mol Cell Biol 25
• The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway.
  Rentsendorj, A., Agadjanian, H., Chen, X., Cirivello, M., Macveigh, M., Kedes, L., Hamm-Alvarez, S., and Medina-Kauwe, L. K., Gene Ther
• Lentiviral vector-mediated gene transfer to endothelial cells compared with adenoviral and retroviral vectors.
  Sakoda, T., Kasahara, N., Kedes, L., and Ohyanagi, M., Prep Biochem Biotechnol 37
• Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD.
  Wu, H. Y., Hamamori, Y., Xu, J., Chang, S. C., Saluna, T., Chang, M. F., O'Malley, B. W., and Kedes, L., J Biol Chem 280
• Calcium phosphate coprecipitation greatly enhances transduction of cardiac myocytes and vascular smooth muscle cells by lentivirus vectors.
  Sakoda T, Kasahara N, Kedes L, Ohyanagi M., Exp Clin Cardiol.
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Lectures

• Genomics prize—the X PRIZE Foundation. 
  Rejuvenation Res.