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Lawrence Appel, MD, Internal Medicine, Baltimore, MD, Johns Hopkins Hospital

LawrenceJohnAppelMDFACP, FAHA

Internal Medicine • Baltimore, MD

Professor of Medicine, Johns Hopkins University School of Medicine; Director, Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins University, The C. David Molina, M.D., M.P.H. Professor of Medicine with Joint Appointments in Epidemiology, International Health, and Nursing

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Summary

  • Dr. Appel is the C. David Molina Professor of Medicine and Director of the Welch Center for Prevention, Epidemiology and Clinical Research, a joint program of the Schools of Medicine and Public Health at Johns Hopkins. Dr. Appel holds a primary faculty appointment in Division of General Internal Medicine with joint appointments in Epidemiology, International Health, and Nursing. He also directs the ProHealth Clinical Research Unit.

    The focus of Dr. Appel’s investigative career is the conduct of clinical, epidemiologic, and translational research pertaining to the prevention of hypertension, cardiovascular-kidney diseases, and other chronic conditions. He has conducted over 50 studies and published over 350 papers. Many of his research findings have had a substantial influence on health and health care policy. His main research interests include:
    •    controlled feeding trials, such as the DASH trial,
    •    behavioral intervention trials, such as the POWER trial, which test novel strategies to accomplish lifestyle modification, often focused on obesity;
    •    trials and observational studies, such as AASK and CRIC, which identify risk factors for progression of chronic kidney disease and its complications.

    Dr. Appel has also been actively involved in shaping health care policy. He was a member of the 2005 and 2010 U.S. Dietary Guidelines Scientific Advisory Committees. For the American Heart Association, he has served on numerous committees, and chaired its Council on Lifestyle and Cardiometabolic Health. He has served on several NIH and Institute of Medicine Committees and chaired the committee that set dietary reference intakes for sodium, potassium, and water. Among his awards are membership in the Association of American Physicians and National Academy of Medicine; several mentoring and teaching awards; and acknowledgement by Thomson Reuters as a Most Influential Scientist, based on the number of most highly cited papers (top 1% of his field).

Education & Training

  • Johns Hopkins University
    Johns Hopkins UniversityResidency, Internal Medicine, 1986 - 1989
  • Johns Hopkins University
    Johns Hopkins UniversityMPH, 1985 - 1989
  • Johns Hopkins University/Bayview Medical Center
    Johns Hopkins University/Bayview Medical CenterResidency, Internal Medicine, 1981 - 1985
  • New York University School of Medicine
    New York University School of MedicineClass of 1981
  • Dartmouth College
    Dartmouth CollegeBA, Biochemistry with High Distinction, Magna Cum Laude, 1973 - 1977

Certifications & Licensure

  • MD State Medical License
    MD State Medical License 1983 - 2024
  • American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

  • Elected Member Association of American Physicians, 2015
  • Elected Member Instutute of Medicine, 2011
  • Two ‘Top Ten' Papers in 2014 American Heart Association Council on Lifestyle and Cardiometabolic Health, 2015
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Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Blood Pressure Goals in Patients with Chronic Kidney Disease  
    Lawrence Appel, MD, Journal of the American Society of Nephrology
  • Sodium Excretion in Population Subgroups—Reply  
    Lawrence Appel, MD, JAMA
  • Trends in User Ratings and Reviews of a Popular yet Inaccurate Blood Pressure-Measuring Smartphone App  
    Timothy B Plante, Lawrence J Appel, Seth S Martin, Roger S Blumenthal, Journal of the American Medical Informatics Association
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Books/Book Chapters

  • Hypertension, a Companion to Braunwald's Heart Disease 
    Chapter: Diet and Blood Pressure 
    Appel LJEditors: Black HR and Eliott WJ.Elsevier Saunders, Philadelphia, PA2012
  • Encyclopedia of Human Nutrition 
    Chapter: Hypertension: Dietary Factors 
    Appel LJEditors: Caballero B, Allen L, Prentice A.Elsevier2012
  • Encyclopedia of Human Nutrition 
    Chapter: Potassium 
    Appel LJEditors: Caballero B, Allen L, Prentice A.Elsevier2012
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Lectures

  • Cardiometabolic Health Congress (CMHC 2012) 
    Cardiometabolic Health Congress, Boston, Massachusetts - 10/10/2012
  • OmniHeart: Shifting Carb, Protein, and Fat Balance Lowers Heart Disease Risk 
    American Heart Association, Scientific Sessions 2005, Dallas, Texas, USA
  • OmniHeart: Shifting Carb, Protein, and Fat Balance Lowers Heart Disease Risk 
    Scientific Sessions 2005, Dallas, Texas, USA

Other

  • Utility of blood pressure monitoring outside of the clinic setting. Evidence Report/Technology Assessment No. 63 (prepared by the Johns Hopkins Evidence-based Practice... 
    Appel LJ, Robinson KA, Guallar, E, Erlinger T, Masood SO, Jehn M, Fleisher LA, Bass EB, Agency for Healthcare Research and Quality
    Rockville MD - 1/1/2002
  • Getting to the Heart of Homocysteine 
    Kittner S and Appel LJ., Encyclopedia Britannica, Inc.
    Chicago - 1/1/1997

Authored Content

  • A Clinical Trial of the Effects of Dietary Patterns on Blood PressureApril 1997

Press Mentions

  • Weight Loss May Cut Risk of Heart Disease and Diabetes, Even if You Regain Some Weight
    Weight Loss May Cut Risk of Heart Disease and Diabetes, Even if You Regain Some WeightMarch 29th, 2023
  • Heart Failure: Could a Low Sodium Diet Sometimes Do More Harm Than Good?
    Heart Failure: Could a Low Sodium Diet Sometimes Do More Harm Than Good?March 3rd, 2023
  • Can Sipping More Water Slow Aging and Even Death?
    Can Sipping More Water Slow Aging and Even Death?January 3rd, 2023
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Grant Support

  • Renal Disease Epidemiology Training GrantNational Institute Of Diabetes And Digestive And Kidney Diseases2010–2011
  • Limited Competition: Continuation Of Chronic Renal Insufficiency Cohort (CRC)National Institute Of Diabetes And Digestive And Kidney Diseases2008–2011
  • Integrated Clinical-Behavioral Interventions To Accomplish Weight LossNational Heart, Lung, And Blood Institute2006–2010
  • Chronic Renal Insufficiency Cohort (CRIC) StudyNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2008
  • Weight Loss Maintenance TrialNational Heart, Lung, And Blood Institute2005–2007
  • CRIC StudyNational Center For Research Resources2004–2007
  • Macronutrients And Cardiovascular RiskNational Heart, Lung, And Blood Institute2002–2006
  • Premier Maintenance TrialNational Heart, Lung, And Blood Institute2003–2004
  • African American Study Of Kidney Disease And Hypertension (AASK)National Center For Research Resources2000–2002
  • Premier--Lifestyle Intervene For Blood Pressure ContrlNational Heart, Lung, And Blood Institute1998–2002
  • Dietary Approaches To Stop Hypertension 2 (DASH2)National Center For Research Resources1998–2002
  • African American Study Of Kidney Disease (AASK)National Center For Research Resources1998–2002
  • Dietary Patterns, Sodium Intake And Blood PressureNational Heart, Lung, And Blood Institute1997–2000
  • African American Study Of Kidney Disease And HypertensioNational Institute Of Diabetes And Digestive And Kidney Diseases1996–2000
  • Lifestyle Intervene For Blood Pressure ContrlNational Heart, Lung, And Blood Institute1999
  • Dietary Approaches To Stop Hypertension 2 (Dash 2)National Center For Research Resources1998–1999
  • Vitamins, Teachers, And Longevity Pilot StudyNational Center For Research Resources1997–1999
  • Exercise Lifestyle Interventions In The Elderly--Pilot StudyNational Center For Research Resources1997–1999
  • Effect Of Vitamin E And Vitamin C Supplement On Lipid PeroxidationNational Center For Research Resources1997–1999
  • Dietary Approaches To Stop Hypertension (DASH)National Center For Research Resources1997–1999
  • African American Study Of Kidney Disease &HypertensionNational Institute Of Diabetes And Digestive And Kidney Diseases1997
  • Folic Acid Supplementation Trial (FAST)National Center For Research Resources1997
  • Ambulatory Blood Pressure And Cardiovascular RiskNational Center For Research Resources1997
  • Intermap--The Johns Hopkins Clinical CenterNational Heart, Lung, And Blood Institute1996–1997
  • Dietary Patterns And Blood PressureNational Heart, Lung, And Blood Institute1993–1996
  • Ambulatory Blood Pressure And Cardiovascular RiskNational Heart, Lung, And Blood Institute1992–1996
  • High And Low Potassium Intake In Normotensive Blacks (HALPIN)National Center For Research Resources1993–1994
  • Ambulatory Blood Pressure Monitoring StudyNational Center For Research Resources1993–1994

Professional Memberships

Hospital Affiliations

External Links

Dr. Lawrence Appel, Dr. Lawrence Appel, MD, Dr. L Appel, Dr. Lawrence John Appel