LawrenceWElmerMD

Movement Disorder

Professor of Neurology Director, The Center for Neurological Health Director, Parkinson's Disease and Movement Disorders Program University of Toledo College of Medicine

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Office
3120 Glendale Ave
Toledo, OH 43614
Phone+1 419-383-3760

Fax+1 419-383-3093
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Education & Training

University of Michigan Health SystemResidency, Neurology, 1989 - 1992
University of South DakotaInternship, Internal Medicine, 1988 - 1989
University of Florida College of MedicineClass of 1987

Certifications & Licensure

OH State Medical License 1998 - 2025
MI State Medical License 1989 - 2014
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012

Clinical Trials

Impact of Switching to Continuous Release Dopamine Agonists Start of enrollment: 2007 Jan 01
Completed
Phase 3
A Phase 2 Study to Evaluate the Safety and Efficacy of RM-131 in Patients With Parkinson's Disease & Chronic Constipation Start of enrollment: 2013 Sep 01
Terminated
Phase 2
Fixed-Dose Trial in Early Parkinson's Disease (PD) Start of enrollment: 2019 Dec 13
Active, not recruiting
Phase 3
Roles: Contact
Flexible-Dose, Adjunctive Therapy Trial in Adults With Parkinson's Disease With Motor Fluctuations Start of enrollment: 2020 Oct 27
Completed
Phase 3
Roles: Contact
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Publications & Presentations

PubMed

A Randomized Phase 3 Study Comparing P2B001 to its Components (Low-Dose Extended-Release Rasagiline and Pramipexole) and to Optimized Doses of Marketed Extended-Releas...
C Warren Olanow, Robert A Hauser, Daniel J Burdick, Rohit Dhall, Joy Antonelle de Marcaida, Ramon A Gil, David L Kreitzman, Lawrence W Elmer, Andrew McGarry, Karl Kieb...> ;Movement Disorders. 2024 Feb 1
2 citations
Video Representation of Dopamine-Responsive Multiple System Atrophy Cerebellar Type.
Jonathan P. Doan, Irfan Sheikh, Lawrence Elmer, Mehmood Rashid> ;The American Journal of Case Reports. 2021 Nov 15
9 citations
Prevalence of Dyskinesia and OFF by 30-Minute Intervals Through the Day and Assessment of Daily Episodes of Dyskinesia and OFF: Novel Analyses of Diary Data from Gocov...
Robert A. Hauser, Daniel Kremens, Lawrence Elmer, David L. Kreitzman, Ryan R. Walsh, Reed Johnson, Robert Howard, Jack T. Nguyen, Rajiv Patni> ;Journal of Parkinson's Disease. 2019 Jan 1
5 citations
Author Correction to: Pooled Analyses of Phase III Studies of ADS-5102 (Amantadine) Extended-Release Capsules for Dyskinesia in Parkinson’s Disease
Lawrence Elmer, Jorge L. Juncos, Carlos Singer, Daniel D. Truong, Susan R. Criswell, Sotirios A. Parashos, Larissa Felt, Reed Johnson, Rajiv Patni> ;CNS Drugs. 2018 Apr 10
37 citations
Pooled Analyses of Phase III Studies of ADS-5102 (Amantadine) Extended-Release Capsules for Dyskinesia in Parkinson's Disease
Lawrence Elmer, Jorge L. Juncos, Carlos Singer, Daniel D. Truong, Susan R. Criswell, Sotirios A. Parashos, Larissa Felt, Reed Johnson, Rajiv Patni> ;CNS Drugs. 2018 Apr 1
29 citations
Safety of Converting From Tetrabenazine to Deutetrabenazine for the Treatment of Chorea.
Samuel Frank, David Stamler, Elise Kayson, Daniel O. Claassen, Amy Colcher, Charles S. Davis, Andrew P. Duker, Shirley Eberly, Lawrence Elmer, Erin Furr-Stimming, Mark...> ;JAMA Neurology. 2017 Aug 1
19 citations
A randomized trial of a low-dose Rasagiline and Pramipexole combination (P2B001) in early Parkinson's disease.
C. Warren Olanow, Karl Kieburtz, Mika Leinonen, Lawrence Elmer, Nir Giladi, Robert A. Hauser, Olga S. Klepiskaya, David L. Kreitzman, Mark F. Lew, David S. Russell, Sh...> ;Movement Disorders. 2017 May 1
16 citations
Optimizing extended-release carbidopa/levodopa in Parkinson disease: Consensus on conversion from standard therapy.
Alberto J. Espay, Fernando Pagan, Benjamin L. Walter, John C. Morgan, Lawrence Elmer, Cheryl Waters, Pinky Agarwal, Rohit Dhall, William G. Ondo, Kevin Klos, Dee E. Si...> ;Neurology. Clinical Practice. 2017 Feb 1
3 citations
The Efficacy Profile of Rotigotine During the Waking Hours in Patients With Advanced Parkinson's Disease: A Post Hoc Analysis
Peter A LeWitt, Werner Poewe, Lawrence Elmer, Mahnaz Asgharnejad, Babak Boroojerdi, Frank Grieger, Lars Bauer> ;Clinical Neuropharmacology. 2016 Mar 1
6 citations
Impact of 6-month earlier versus postponed initiation of rotigotine on long-term outcome: post hoc analysis of patients with early Parkinson’s disease with mild sympto...
Lars Timmermann, Mahnaz Asgharnejad, Babak Boroojerdi, Elisabeth Dohin, Franz Woltering, Lawrence Elmer> ;Expert Opinion on Pharmacotherapy. 2015 Jun 25
16 citations
Posterior Reversible Encephalopathy Syndrome Secondary to CSF Leak and Intracranial Hypotension: A Case Report and Literature Review
Tariq Hammad, Alison DeDent, Rami Algahtani, Yaseen Alastal, Lawrence Elmer, Azedine Medhkour, Fadi Safi, Ragheb Assaly> ;Case Reports in Neurological Medicine. 2015 May 27
19 citations
Conversion to IPX066 from Standard Levodopa Formulations in Advanced Parkinson's Disease: Experience in Clinical Trials.
Paul A. Nausieda, Ann Hsu, Lawrence Elmer, Ramon Gil, J Spiegel, Carlos Singer, Sarita Khanna, Robert Rubens, Sherron Kell, Nishit B. Modi, Suneel K. Gupta> ;Journal of Parkinson's Disease. 2015 Jan 1
233 citations
A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit
M. Flint Beal, David Oakes, Ira Shoulson, Claire Henchcliffe, Wendy R. Galpern, Richard H. Haas, Jorge L. Juncos, John G. Nutt, Tiffini Voss, Bernard Ravina, Clifford ...> ;JAMA Neurology. 2014 May 1
30 citations
A randomized study of rotigotine dose response on 'off' time in advanced Parkinson's disease.
Anthony P. Nicholas, Rupam Borgohain, Pedro Chaná, Erwin Surmann, Emily L. Thompson, Lars Bauer, John Whitesides, Lawrence Elmer> ;Journal of Parkinson's Disease. 2014 Jan 1
22 citations
Rasagiline adjunct therapy in patients with Parkinson's disease: post hoc analyses of the PRESTO and LARGO trials.
Lawrence Elmer> ;Parkinsonism & Related Disorders. 2013 Nov 1
34 citations
Long-term safety and tolerability of rotigotine transdermal system in patients with early-stage idiopathic Parkinson’s disease: A prospective, open-label extension study
Lawrence Elmer, Erwin Surmann, Babak Boroojerdi, Joseph Jankovic> ;Parkinsonism & Related Disorders. 2012 Jun 1
194 citations
A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease
Irene H. Richard, Michael P. McDermott, Roger Kurlan, Jeffrey M. Lyness, Peter Como, Nancy Pearson, Stewart A. Factor, Jorge L. Juncos, C. Serrano Ramos, Matthew Brods...> ;Neurology. 2012 Apr 17
64 citations
Pyridostigmine in the treatment of postural orthostatic tachycardia: a single-center experience.
Khalil Kanjwal, Beverly Karabin, Mujeeb Sheikh, Lawrence Elmer, Yousuf Kanjwal, Bilal Saeed, Blair P. Grubb> ;Pacing and Clinical Electrophysiology. 2011 Jun 1
26 citations
Orally disintegrating selegiline in Parkinson patients with dopamine agonist-related adverse effects.
Kelly E. Lyons, Joseph H. Friedman, Neal Hermanowicz, Stuart Isaacson, Robert A. Hauser, B. Hersh, Dee E. Silver, James W. Tetrud, Lawrence Elmer, Sotirios A. Parashos...> ;Clinical Neuropharmacology. 2010 Jan 1
21 citations
Treatment of early Parkinson's disease. Part 1.
Tatyana Simuni, Kelly E. Lyons, Rajesh Pahwa, Robert A. Hauser, Cynthia L. Comella, Lawrence Elmer, Daniel Weintraub> ;European Neurology. 2009 Jan 1
9 citations
Treatment of early Parkinson's disease. Part 2.
Tanya Simuni, Kelly E. Lyons, Rajesh Pahwa, Robert A. Hauser, Cynthia L. Comella, Lawrence Elmer, Daniel Weintraub> ;European Neurology. 2009 Jan 1
27 citations
The increasing role of monoamine oxidase type B inhibitors in Parkinson's disease therapy.
Lawrence Elmer, John M. Bertoni> ;Expert Opinion on Pharmacotherapy. 2008 Oct 20
212 citations
Ropinirole 24-hour prolonged release: Randomized, controlled study in advanced Parkinson disease
Rajesh Pahwa, Mark Stacy, Stewart A. Factor, Kelly E. Lyons, Fabrizio Stocchi, B. Hersh, Lawrence Elmer, Daniel D. Truong, N. L. Earl> ;Neurology. 2007 Apr 3
36 citations
Rasagiline-associated motor improvement in PD occurs without worsening of cognitive and behavioral symptoms.
Lawrence Elmer, S Schwid, Shirley Eberly, Christopher G. Goetz, S Fahn, Karl Kieburtz, D Oakes, K Blindauer, Phyllis Salzman, S Oren, U L Prisco, M Stern, I Shoulson, ...> ;Journal of the Neurological Sciences. 2006 Oct 25
86 citations
Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia.
Nathan Pankratz, Lisa Byder, Cheryl Halter, Alice Rudolph, Clifford W. Shults, P. Michael Conneally, Tatiana Foroud, William C. Nichols, Kelly E. Lyons, Karen Marder, ...> ;Movement Disorders. 2006 Jan 1
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Press Mentions

Novel PD Drug Tops Pramipexole ER with Fewer Side EffectsApril 27th, 2023
Pharma Two B to Present Additional Positive Results from P2B001 Phase 3 Trial at 2023 American Academy of Neurology Annual MeetingApril 23rd, 2023
Toledo Neurologist Offers Life-Changing Care for Parksinson's PatientsApril 13th, 2019
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