Lawrence Richard Kleinberg MD

Radiation Oncology•Baltimore, MD

Central Nervous System Cancer

Associate Professor of Radiation Oncology and Molecular Radiation Sciences, Associate Professor of Neurological Surgery, Associate Professor of Oncology, Johns Hopkins University School of Medicine

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401 North Broadway StreetWeinberg BLDG, Floor-L1 (Lobby Level)Baltimore, MD 21287
Phone+1 410-955-6980
Fax+1 410-502-1419

Education & Training

Memorial Sloan Kettering Cancer CenterResidency, Radiation Oncology, 1990 - 1993
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalInternship, Internal Medicine, 1989 - 1990
Yale School of MedicineClass of 1989

Certifications & Licensure

FL State Medical License 2022 - Present
DC State Medical License 2019 - 2027
MD State Medical License 1993 - 2026
VA State Medical License 2024 - 2026
NC State Medical License 2021 - 2022
PA State Medical License 2020 - 2022
NY State Medical License 1990 - 1994
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2008-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
America's Top Doctors for Cancer Castle Connolly, 2007-2013
Top Doctors:Baltimore Area Castle Connolly, 2012
Top Doctors:Washington-Baltimore Castle Connolly, 2012
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Clinical Trials

Low Dose Radiation Therapy for Glioblastoma Multiforme Start of enrollment: 2012 Sep 01
Completed
Phase 2
Stereotactic Body Radiation With Nelfinavir for Oligometastases Start of enrollment: 2014 Jan 08
Completed
Phase 2
Radiotherapy for Solid Tumor Spine Metastases Start of enrollment: 2013 May 20
Completed
Phase 2
Hippocampal Prophylactic Cranial Irradiation for Small Cell Lung Cancer Start of enrollment: 2013 Mar 11
Completed
Not Applicable
Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme Start of enrollment: 2014 Jul 08
RECRUITING
PHASE2
Spectroscopic MRI-Guided Radiation Therapy Planning in Glioblastoma Start of enrollment: 2017 Sep 20
COMPLETED
PHASE2
5 Fraction Stereotactic Radiosurgery With Temozolomide for Glioblastoma Multiforme Start of enrollment: 2017 Oct 18
Completed
Early Phase 1
Pilot Study Using Amide Proton Transfer Magnetic Resonance Imaging Distinguishing Glioma Start of enrollment: 2014 Aug 01
Terminated
Not Applicable
Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma Start of enrollment: 2022 Aug 31
RECRUITING
PHASE1
Roles: Principal Investigator, Contact
Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM Start of enrollment: 2020 Dec 08
ACTIVE_NOT_RECRUITING
NA
Roles: Contact
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Publications & Presentations

PubMed

Presenting symptoms and outcomes of cervical and thoracic ependymomas compared to conus and filum ependymomas.
Fnu Ruchika, A Karim Ahmed, Abdel-Hameed Al-Mistarehi, Yuanxuan Xia, Joseph Rajasekaran
Journal of Neurosurgery. Spine. 2025-10-24
Low Dose Fractionated Radiation Therapy As a Chemo-Potentiator of Temozolomide for Recurrent Anaplastic Astrocytoma and Glioblastoma: A Single-Arm Phase I/II Trial.
Timothy Lin, Suqi Ke, Chen Hu, Ryan Assadi, James Huang
International Journal of Radiation Oncology, Biology, Physics. 2025-10-23
Stereotactic radiosurgery for patients with extensive brain metastases across the disease course.
Tina Vaziri, I-Chia Liu, Chetan Bettegowda, Victoria Croog, Christopher Jackson
Journal of Neuro-Oncology. 2025-10-16

Press Mentions

On Target with Dr. Akila Viswanathan – ASTRO 2025October 14th, 2025

Professional Memberships

American Society of Clinical Oncology - ASCO
Member

External Links

Johns Hopkins Physicianshttp://www.hopkinsmedicine.org/lawrence-kleinberg