LawrenceRichardKleinbergMD

Radiation Oncology • Baltimore, MD

Central Nervous System Cancer

Associate Professor of Radiation Oncology and Molecular Radiation Sciences, Associate Professor of Neurological Surgery, Associate Professor of Oncology, Johns Hopkins University School of Medicine

Join to view full profile

Dr. Kleinberg is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Kleinberg's full profile

Already have an account?

Office
401 N. Broadway
Baltimore, MD 21231
Phone+1 410-502-8000

Fax+1 410-502-1419
Is this information wrong?

Education & Training

Memorial Sloan Kettering Cancer CenterResidency, Radiation Oncology, 1990 - 1993
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalInternship, Internal Medicine, 1989 - 1990
Yale School of MedicineClass of 1989

Certifications & Licensure

MD State Medical License 1993 - 2024
DC State Medical License 2019 - 2024
NC State Medical License 2021 - 2022
NY State Medical License 1990 - 1994
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2008-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
America's Top Doctors for Cancer Castle Connolly, 2007-2013
Top Doctors:Baltimore Area Castle Connolly, 2012
Top Doctors:Washington-Baltimore Castle Connolly, 2012
Join now to see all

Clinical Trials

Low Dose Radiation Therapy for Glioblastoma Multiforme Start of enrollment: 2012 Sep 01
Completed
Phase 2
Stereotactic Body Radiation With Nelfinavir for Oligometastases Start of enrollment: 2014 Jan 08
Completed
Phase 2
Radiotherapy for Solid Tumor Spine Metastases Start of enrollment: 2013 May 20
Completed
Phase 2
Hippocampal Prophylactic Cranial Irradiation for Small Cell Lung Cancer Start of enrollment: 2013 Mar 11
Completed
Not Applicable
Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme Start of enrollment: 2014 Jul 08
Recruiting
Phase 2
Spectroscopic MRI-Guided Radiation Therapy Planning in Glioblastoma Start of enrollment: 2017 Sep 20
Active, not recruiting
Phase 2
5 Fraction Stereotactic Radiosurgery With Temozolomide for Glioblastoma Multiforme Start of enrollment: 2017 Oct 18
Completed
Early Phase 1
Pilot Study Using Amide Proton Transfer Magnetic Resonance Imaging Distinguishing Glioma Start of enrollment: 2014 Aug 01
Terminated
Not Applicable
Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma Start of enrollment: 2022 Aug 31
Recruiting
Phase 1
Roles: Principal Investigator, Contact
Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM Start of enrollment: 2020 Dec 08
Active, not recruiting
Not Applicable
Roles: Contact
Join now to see all

Publications & Presentations

PubMed

The Utility of Spectroscopic MRI in Stereotactic Biopsy and Radiotherapy Guidance in Newly Diagnosed Glioblastoma.
Abinand C Rejimon, Karthik K Ramesh, Anuradha G Trivedi, Vicki Huang, Eduard Schreibmann, Hyunsuk Shim, Jeffrey J Olson, Brent D Weinberg, Lawrence R Kleinberg, Hui-Ku...> ;Tomography. 2024 Mar 20
Oncologic and Functional Outcomes After Stereotactic Body Radiation Therapy for High-Grade Malignant Spinal Cord Compression.
Patel, P., McNutt, T., Theodore, N., Lee, S., Lubelski, D., Cao, Y., Chen, X., LeCompte, M., Kleinberg, L., Khan, M., Bydon, A., Kebaish, K., Larry Lo, S., Redmond, K.> ;Advances in Radiation Oncology. 2024 Jan 1
2 citations
Radiation Therapy and Myeloid-Derived Suppressor Cells: Breaking Down Their Cancerous Partnership.
Kyra M Boorsma Bergerud, Matthew Berkseth, Drew M Pardoll, Sudipto Ganguly, Jessica Lawrence, David J Odde, David A Largaespada, Kleinberg, L., Terezakis, S., Sloan, L.> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Nov 30
A multi-site phase I trial of Veliparib with standard radiation and temozolomide in patients with newly diagnosed glioblastoma multiforme (GBM).
Lawrence Kleinberg, Xiaobu Ye, Jeff Supko, Glen H J Stevens, Hui-Kuo Shu, Tom Mikkelsen, Frank Lieberman, Glenn J Lesser, Emerson Lee, Stuart A Grossman> ;Journal of Neuro-Oncology. 2023 Dec 1
2 citations
A Multidimensional Connectomics- and Radiomics-Based Advanced Machine-Learning Framework to Distinguish Radiation Necrosis from True Progression in Brain Metastases.
Yilin Cao, Vishwa S Parekh, Emerson Lee, Xuguang Chen, Kristin J Redmond, Jay J Pillai, Luke Peng, Michael A Jacobs, Lawrence R Kleinberg> ;Cancers. 2023 Aug 15
1 citations
A Fully Automated Post-Surgical Brain Tumor Segmentation Model for Radiation Treatment Planning and Longitudinal Tracking.
Karthik K Ramesh, Karen M Xu, Anuradha G Trivedi, Vicki Huang, Vahid Khalilzad Sharghi, Lawrence R Kleinberg, Eric A Mellon, Hui-Kuo G Shu, Hyunsuk Shim, Brent D Weinberg> ;Cancers. 2023 Aug 3
Spectroscopic MRI-Based Biomarkers Predict Survival for Newly Diagnosed Glioblastoma in a Clinical Trial.
Anuradha G Trivedi, Karthik K Ramesh, Vicki Huang, Eric A Mellon, Peter B Barker, Lawrence R Kleinberg, Brent D Weinberg, Hui-Kuo G Shu, Hyunsuk Shim> ;Cancers. 2023 Jul 7
Applying a Radiation Therapy Volume Analysis Pipeline to Determine the Utility of Spectroscopic MRI-Guided Adaptive Radiation Therapy for Glioblastoma.
Anuradha G Trivedi, Su Hyun Kim, Karthik K Ramesh, Alexander S Giuffrida, Brent D Weinberg, Eric A Mellon, Lawrence R Kleinberg, Peter B Barker, Hui Han, Hui-Kuo G Shu...> ;Tomography. 2023 May 21
2 citations
Recognition and Management of the Long-term Effects of Cranial Radiation.
Sherif G Shaaban, Michael C LeCompte, Lawrence R Kleinberg, Kristin J Redmond, Brandi R Page> ;Current Treatment Options in Oncology. 2023 Jul 1
1 citations
Mutant Isocitrate Dehydrogenase 1 Expression Enhances Response of Gliomas to the Histone Deacetylase Inhibitor Belinostat.
Chi-Ming Chang, Karthik K Ramesh, Vicki Huang, Saumya Gurbani, Lawrence R Kleinberg, Brent D Weinberg, Hyunsuk Shim, Hui-Kuo G Shu> ;Tomography. 2023 May 4
2 citations
Neurosurgical Applications of Magnetic Hyperthermia Therapy.
Daniel Rivera, Alexander J Schupper, Alexandros Bouras, Maria Anastasiadou, Lawrence Kleinberg, Dara L Kraitchman, Anilchandra Attaluri, Robert Ivkov, Constantinos G H...> ;Neurosurgery Clinics of North America. 2023 Apr 1
Response to Letter to the Editor Regarding "Antiresorptive Medications Prior to Stereotactic Body Radiotherapy for Spinal Metastasis are Associated With Reduced Incide...
Palak P Patel, Edward P Esposito, Jiafeng Zhu, Xuguang Chen, Majid Khan, Lawrence Kleinberg, Daniel Lubelski, Nicholas Theodore, Sheng-Fu Larry Lo, Sang H Lee, Khaled ...> ;Global Spine Journal. 2024 Apr 1
1 citations
Epidemiological trends, prognostic factors, and survival outcomes of synchronous brain metastases from 2015 to 2019: a population-based study.
Megan Parker, Kelly Jiang, Jordina Rincon-Torroella, Joshua Materi, Tej D Azad, David O Kamson, Lawrence R Kleinberg, Chetan Bettegowda> ;Neuro-Oncology Advances. 2023 Mar 5
3 citations
Antiresorptive Medications Prior to Stereotactic Body Radiotherapy for Spinal Metastasis are Associated with Reduced Incidence of Vertebral Body Compression Fracture.
Palak P Patel, Edward P Esposito, Jiafeng Zhu, Xuguang Chen, Majid Khan, Lawrence Kleinberg, Daniel Lubelski, Nicholas Theodore, Sheng-Fu Larry Lo, Sang Hun Lee, Khale...> ;Global Spine Journal. 2023 Feb 7
1 citations
A Novel Approach to Determining Tumor Progression Using a Three-Site Pilot Clinical Trial of Spectroscopic MRI-Guided Radiation Dose Escalation in Glioblastoma.
Karthik K Ramesh, Vicki Huang, Jeffrey Rosenthal, Eric A Mellon, Mohammed Goryawala, Peter B Barker, Saumya S Gurbani, Anuradha G Trivedi, Alexander S Giuffrida, Eduar...> ;Tomography. 2023 Feb 6
3 citations
Radiotherapy, lymphopenia and improving the outcome for glioblastoma: a narrative review.
Carmen Kut, Lawrence Kleinberg> ;Chinese Clinical Oncology. 2023 Feb 1
Commentary: Chronic Encapsulated Expanding Hematomas After Stereotactic Radiosurgery for Intracranial Arteriovenous Malformations: An International Multicenter Case Se...
Lawrence Kleinberg> ;Neurosurgery. 2023 Feb 1
3 citations
Validation of a Temperature-Feedback Controlled Automated Magnetic Hyperthermia Therapy Device.
Anirudh Sharma, Avesh Jangam, Julian Low Yung Shen, Aiman Ahmad, Nageshwar Arepally, Benjamin Rodriguez, Joseph Borrello, Alexandros Bouras, Lawrence Kleinberg, Kai Di...> ;Cancers. 2023 Jan 4
Comparison of peripheral leukocyte parameters in patients receiving conventionally and hypofractionated radiotherapy schemes for the treatment of newly diagnosed gliob...
Lindsey Greenlund, Ryan Shanley, Kellen Mulford, Elizabeth C Neil, Jessica Lawrence, Susan Arnold, Michael Olin, G Elizabeth Pluhar, Andrew S Venteicher, Clark C Chen,...> ;Frontiers in Immunology. 2023 Jan 1
From Alpha to Omicron: A Radiation Oncology Network's Biocontainment-Based COVID-19 Experience.
Yilin Cao, Valeria Fabre, Roberta Anderson, Gregory Bova, Annette N Souranis, Valerie Briner, Lawrence R Kleinberg, Sarah Han-Oh, Jean L Wright, Akila N Viswanathan> ;Advances in Radiation Oncology. 2022 Oct 25
4 citations
Tumor Treating Fields (TTFields) therapy vs physicians' choice standard-of-care treatment in patients with recurrent glioblastoma: a post-approval registry study (EF-19).
Jay-Jiguang Zhu, Samuel A Goldlust, Lawrence R Kleinberg, Jérôme Honnorat, Nancy Ann Oberheim Bush, Zvi Ram> ;Discover. Oncology. 2022 Oct 14
7 citations
Deviation from consensus contouring guidelines predicts inferior local control after spine stereotactic body radiotherapy.
Xuguang Chen, Michael C LeCompte, Chengcheng Gui, Ellen Huang, Majid A Khan, Chen Hu, Daniel M Sciubba, Lawrence R Kleinberg, Sheng-Fu Larry Lo, Kristin J Redmond> ;Radiotherapy and Oncology. 2022 Aug 1
6 citations
Final Report on Clinical Outcomes and Tumor Recurrence Patterns of a Pilot Study Assessing Efficacy of Belinostat (PXD-101) with Chemoradiation for Newly Diagnosed Gli...
Karen Xu, Karthik Ramesh, Vicki Huang, Saumya S Gurbani, James Scott Cordova, Eduard Schreibmann, Brent D Weinberg, Soma Sengupta, Alfredo D Voloschin, Matthias Holdho...> ;Tomography. 2022 Mar 3
486 citations
Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Jaffer A Ajani, Thomas A D'Amico, David J Bentrem, Joseph Chao, David Cooke, Carlos Corvera, Prajnan Das, Peter C Enzinger, Thomas Enzler, Paul Fanta, Farhood Farjah, ...> ;Journal of the National Comprehensive Cancer Network. 2022 Feb 1
2 citations
Improving providers' survival estimates and selection of prognosis- and guidelines-appropriate treatment for patients with symptomatic bone metastases: Development of ...
Sara R Alcorn, Christen R Elledge, Anna W LaVigne, Lawrence Kleinberg, Thomas J Smith, Adam S Levin, Jacob Fiksel, Scott Zeger, Todd McNutt, Theodore L DeWeese, Jean L...> ;Journal of Evaluation in Clinical Practice. 2022 Aug 1
Join now to see all

Professional Memberships

American Society of Clinical Oncology - ASCO
Member

Hospital Affiliations

Johns Hopkins HospitalBaltimore, Maryland
Johns Hopkins Bayview Medical CenterBaltimore, Maryland
Sibley Memorial HospitalWashington, District of Columbia

External Links

Johns Hopkins Physicianshttp://www.hopkinsmedicine.org/lawrence-kleinberg