LawrenceSilvermanMD

PubMed

• 22 citations
  Efficacy and Safety of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Phase 3 Study.
  Cheri L Deal, Joel Steelman, Elpis Vlachopapadopoulou, Renata Stawerska, Lawrence A Silverman, Moshe Phillip, Ho-Seong Kim, CheolWoo Ko, Oleg Malievskiy, Jose F Cara, ...> ;The Journal of Clinical Endocrinology and Metabolism. 2022 Jun 16
• 2 citations
  A review of the genetics and epigenetics of central precocious puberty.
  Joshua Moise-Silverman, Lawrence A Silverman> ;Frontiers in Endocrinology. 2022 Jan 1
• 4 citations
  Gonadotropin-releasing hormone analog therapies for children with central precocious puberty in the United States.
  Jadranka Popovic, Mitchell E Geffner, Alan D Rogol, Lawrence A Silverman, Paul B Kaplowitz, Nelly Mauras, Philip Zeitler, Erica A Eugster, Karen O Klein> ;Frontiers in Pediatrics. 2022 Jan 1
• 1 citations
  Clinical characteristics and treatment patterns with histrelin acetate subcutaneous implants vs. leuprolide injections in children with precocious puberty: a real-worl...
  Lawrence A. Silverman, Xu Han, Huan Huang, Aimee Near, Yiqun Hu> ;Journal of Pediatric Endocrinology & Metabolism. 2021 Jun 21
• 18 citations
  Veganism as a cause of iodine deficient hypothyroidism.
  Olga Yeliosof, Lawrence A. Silverman> ;Journal of Pediatric Endocrinology & Metabolism. 2018 Jan 26
• The Challenges of Applying Massively Parallel Sequencing to Newborn Screening for Cystic Fibrosis.
  Lawrence M. Silverman> ;The Journal of Molecular Diagnostics. 2016 Mar 1
• 36 citations
  Long-Term Continuous Suppression With Once-Yearly Histrelin Subcutaneous Implants for the Treatment of Central Precocious Puberty: A Final Report of a Phase 3 Multicen...
  Lawrence A. Silverman, E. Kirk Neely, Gad B. Kletter, Katherine Lewis, Surya Chitra, Oksana Terleckyj, Erica A. Eugster> ;The Journal of Clinical Endocrinology and Metabolism. 2015 Mar 24
• 5 citations
  A 4-Year, Open-Label, Multicenter, Randomized Trial of Genotropin® Growth Hormone in Patients with Idiopathic Short Stature: Analysis of 4-Year Data Comparing Efficacy...
  Debra Counts, Lawrence A. Silverman, Natasa Rajicic, Mitchell E. Geffner, Ron S. Newfield, Paul S. Thornton, Mauri Carakushansky, Oscar Escobar, Robert Rapaport, Lynne...> ;Hormone Research in Paediatrics. 2015 Jan 1
• 19 citations
  Random unstimulated pediatric luteinizing hormone levels are not reliable in the assessment of pubertal suppression during histrelin implant therapy
  E. Kirk Neely, Lawrence A. Silverman, Mitchell E. Geffner, Theodore M. Danoff, Errol M. Gould, Paul S. Thornton> ;International Journal of Pediatric Endocrinology. 2013 Dec 2
• 28 citations
  Evaluation of high resolution gel β2-transferrin for detection of cerebrospinal fluid leak
  Christopher R. McCudden, Brent A. Senior, Shirley A. Hainsworth, Walter Oliveira, Lawrence M. Silverman, David E. Bruns, Catherine A. Hammett-Stabler> ;Clinical Chemistry and Laboratory Medicine. 2013 Feb 1
• 5 citations
  A four-year, open-label, multi-center, randomized, two-arm study of Genotropin® in patients with idiopathic short stature: comparison of an individualized, target-driv...
  Debra Counts, Lawrence A. Silverman, Mitchell E. Geffner, Natasa Rajicic, Judith Hey-Hadavi, Paul S. Thornton, Michael Wajnrajch> ;Hormone Research in Paediatrics. 2013 Jan 1
• Personalized approach to growth hormone treatment: clinical use of growth prediction models.
  Wit JM, Ranke MB, Albertsson-Wikland K, Carrascosa A, Rosenfeld RG, Van Buuren S, Kristrom B, Schoenau E, Audi L, Hokken-Koelega ACS, Bang P, Jung H, Blum WF, Silverma...> ;Horm Res Paediatr. 2013-01-01
• 40 citations
  Elevated prevalence of 35-44 FMR1 trinucleotide repeats in women with diminished ovarian reserve.
  Lisa M. Pastore, Steven L. Young, Valerie L. Baker, Logan B. Karns, Christopher D. Williams, Lawrence M. Silverman> ;Reproductive Sciences. 2012 May 10
• 17 citations
  Ease of use and preference for a new disposable self-injection pen compared with a reusable pen for administering recombinant human growth hormone: A multicenter, 2-Mo...
  Judith Hey-Hadavi, Andreas M. Pleil, Larry Deeb, John S. Fuqua, Lawrence A. Silverman, Barry Reiner, Ron S. Newfield, Natasa Rajicic, Michael Wajnrajch, Jose Cara> ;Clinical Therapeutics. 2010 Nov 1
• Direct-to-consumer genotyping: are we ready for a brave new world?
  Bender L Silverman LM Dinulos MB Nickel J Grody WW> ;Clin Chem. 2010 Jul
• Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients:...
  Cohen P Germak J Rogol AD Weng W Kappelgaard AM Rosenfeld RG> ;J Clin Endocrinol Metab. 2010 May
• Recombinant insulin-like growth factor (IGF)-I treatment in short children with low IGF-I levels: first-year results from a randomized clinical trial.
  Midyett LK Rogol AD Van Meter QL Frane J Bright GM> ;J Clin Endocrinol Metab. 2010 Feb
• Genetic modifiers of liver disease in cystic fibrosis.
  Bartlett JR Friedman KJ Ling SC Pace RG Bell SC Bourke B Castaldo G Castellani C Cipolli M Colombo C Colombo JL Debray D Fernandez A Lacaille F Macek M Jr Rowland M Sa...> ;JAMA. 2009 Sep 9
• 27 citations
  Results of a Second Year of Therapy with the 12-Month Histrelin Implant for the Treatment of Central Precocious Puberty
  Samar N. Rahhal, William L. Clarke, Gad B. Kletter, Peter A. Lee, E. Kirk Neely, Edward O. Reiter, Paul Saenger, Dorothy I. Shulman, Lawrence A. Silverman, Erica A. Eu...> ;International Journal of Pediatric Endocrinology. 2009 Feb 17
• Detection of immunoglobulin heavy chain gene rearrangements in classic hodgkin lymphoma using commercially available BIOMED-2 primers.
  Chute DJ Cousar JB Mahadevan MS Siegrist KA Silverman LM Stoler MH> ;Diagn Mol Pathol. 2008 Jun
• Consensus characterization of 16 FMR1 reference materials: a consortium study.
  Amos Wilson J Pratt VM Phansalkar A Muralidharan K Highsmith WE Jr Beck JC Bridgeman S Courtney EM Epp L Ferreira-Gonzalez A Hjelm NL Holtegaard LM Jama MA Jakupciak J...> ;J Mol Diagn. 2008 Jan
• 9 citations
  Predictors of first-year growth response to a fixed-dose growth hormone treatment in children born small for gestational age: results of an open-label, multicenter tri...
  Robert Rapaport, Paul Saenger, Michael Wajnrajch, Bruce A. Boston, Mauri Carakushansky, Steven D. Chernausek, Pamela A. Clark, Jay Cohen, Deborah Counts, Patricia A. D...> ;Journal of Pediatric Endocrinology & Metabolism. 2008 Jan 1
• 67 citations
  Efficacy and safety of histrelin subdermal implant in children with central precocious puberty: a multicenter trial.
  Erica A. Eugster, William L. Clarke, Gad B. Kletter, Peter A. Lee, E. Kirk Neely, Edward O. Reiter, Paul Saenger, Dorothy I. Shulman, Lawrence A. Silverman, Lisa Flood...> ;The Journal of Clinical Endocrinology and Metabolism. 2008 Jan 1
• Clinical laboratory reports in molecular pathology.
  Gulley ML Braziel RM Halling KC Hsi ED Kant JA Nikiforova MN Nowak JA Ogino S Oliveira A Polesky HF Silverman L Tubbs RR Van Deerlin VM Vance GH Versalovic J> ;Arch Pathol Lab Med. 2007 Jun
• Molecular diagnostics: a historical perspective.
  Tsongalis GJ Silverman LM> ;Clin Chim Acta. 2006 Jul 23
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Journal Articles

• Veganism as a Cause of Iodine Deficient Hypothyroidism  
  Lawrence Silverman, MD, De Gruyter
• Androgen binding levels in a sexually dimorphic muscle of Xenopus laevis.  
  Segil N, Silverman LA, Kelley DB, Gen Comp Endocrinology 66: 95-101
• Effect of thyrotropin releasing hormone on the carbohydrate structure of secreted mouse thyrotropin.  
  Gesundheit N, Fink D, Silverman LA, Weintraub BD, Biol Chem 262: 5197-5203
• An Insulin-like growth factor-II (IGF-II) analog with highly selective affinity for the IGF-II receptors stimulates differentiation, but not IGF-I receptor down-regula...  
  Rosenthal SM, Hsiao D, Silverman LA, Endocrinology 135:38-44
• Skeletal muscle cell-derived insulin-like growth factor (IGF) binding proteins inhibit IGF-1-induced myogenesis in rat L6E9 cells.  
  Silverman LA, Cheng Z-Q, Hsiao D, Rosenthal SM, Endocrinology, 136:720-726
• Immunoreactive inhibin, MIS and activin as biochemical markers for juvenile granulosa cell tumors.  
  Silverman LA, Gitelman SG, Journal of Pediatrics, 129:918-21
• Growth Assessment and Growth Failure.  
  Kessler DB, Baker SS, Silverman LA, Consensus in Pediatrics
• Long term safety of GnRH agonist therapy in Precocious Puberty: An evaluation of Reproductive Function, Bone Density and Body Composition.  
  Lee PA and Silverman LA, Pediatric Endocrine Reviews 4 (sup 3): 300-305
• Options and Outcomes of CPP Treatment.  
  Silverman, LA, Review of Endocrinology, 2:25-27
• Ease of Use and Preference for a New Disposable Self-Injection Pen Compared With a Reusable Pen for Administering Recombinant Human Growth Hormone: A Multicenter, 2-Mo...  
  Hey-Hadavi J, Pleil A, Deeb LC, Fuqua JS, Silverman LA, Reiner B, Newfield R, Rajicic N, Wajnrajch MP, Cara JF, Clinical Therapeutics 32:1-12
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Books/Book Chapters

• The Insulin-Like Growth Factors and Their Regulatory Proteins. 
  Chapter: Insulin-like growth factors and muscle cell differentiation 
  Rosenthal SM, Hsiao D, Cheng Z-Q, Silverman LAEditors: Baxter, RC, Gluckman, PD, Rosenfeld, RG.Elsevier Science BV, Amsterdam
• Fast Facts in Pediatrics. 
  Chapter: Endocrinology 
  Silverman LAEditors: Feld LG and Meltzer AJ.
• Adrenal causes of electrolyte abnormalities: hyponatremia/hyperkalemia in Fluid and Electrolytes in Pediatrics. 
  Chapter: Adrenal causes of electrolyte abnormalities 
  Silverman LAEditors: Feld LG and Kaskel FJ.Humana Press

Abstracts/Posters

• Androgen binding in the laryngeal muscle of Xenopus laevis: sex differences and hormonal regulation.
  Segil N, Silverman LA, Kelley DB, Rainbow T, Neuroscience Abstract 2:1093
• Carbohydrate structure of thyrotropin secreted by human pituitary adenoma: effect of thyrotropin stimulating hormone.
  Gesundheit N, Silverman LA, Petrick P, Oldfield B, Weintraub BD, Clin Res 2: 643a
• Bone marrow transplantation and total body irradiation: limited adverse effects on endocrine function in children.
  Silverman LA, Cowan MJ, Grumbach MM, Kaplan SL, Bone marrow transplantation and total body irradiation: limited adverse effects on endocrine functio
• Insulin-like growth factor I receptor downregulation induced by IGF-II is mediated principally through the IGF-I receptor in BC3H-1 muscle cells.
  Rosenthal SM, Hsiao D, Silverman LA, Endocrinology 74: 286a
• Growth and acromegaloid features in a hypophysectomized male: the role of prandial hyperinsulinism.
  Silverman LA, Grumbach MM, Conte FA, Ped Res 33: 371a
• Insulin-like growth factor binding proteins inhibit IGF-I induced differentiation in rat L6E9 skeletal muscle cells.
  Silverman LA, Hsiao D, Rosenthal SM, Ped Res 33: 372a
• Inhibin is a biochemical marker for juvenile granulosa cell tumors.
  Silverman LA, Gitelman SE, Woodruff TK, Grumbach MM, Ped Res 35:627a
• The effects of GH therapy on hypertrophic cardiomyopathy.
  Silverman LA, Dhuper S, Singh S, Juan CS, AvRuskin TW, Endocrinology 78:P1-134a
• Evans Syndrome in Turner Syndrome.
  Gates J, Kline R, Silverman LA, Ped Res 49, P2-830
• Effect of GH and GnRHa Therapy on Height, Growth Velocity (GV), Bone Mineral Accrual and Body Composition in Congenital Adrenal Hyperplasia (CAH).
  Gallagher MP, Levine LS, Novogroder M, Rapaport R, Silverman LA, Chin D, Horlick M, Sopher A, Manibo A, McMahon D, Oberfield SE, Endocrinology 85 P1-677
• Growth without growth hormone in a child with optic hypoplasia and diabetes insipidus.
  Silverman LA, Endocrinology 87 P2-59
• Association between central precocious puberty and comorbid medical illness: large-scale retrospective claims analysis of Florida Medicaid-enrolled children. Internati...
  Hankin S, Silverman L, Wang Z, Bronstone A, 10th European Congress
• Association between precocious puberty and psychiatric disorders.
  Hankin C, Silverman L, Bronstone A, Wang S, Annual Meeting of the American Psychiatric Association, Washington
• Year Results of the Histrelin Implant for Treatment of Central Precocious Puberty.
  Rahhal S, Clarke W, Kletter G, Lee P, Neely E, Reiter E, Saenger P, Shulman D, Silverman L, Eugster E, Pediatric Academic Society
• Experience with extended use of the histrelin implant for treatment of central precocious puberty.
  Lewis KA, Clarke WL, Kletter GB, Neely EK, Reiter EO, Shulman D, Silverman LA, Eugster EA, Hormone Research P02-188
• Pituitary Duplication (PD) Associated with Central Precocious Puberty (CPP) in a Boy.
  Buono AC, Silverman LA, Pediatric Academic Society
• Efficacy of the 50 mg Histrelin Implant in Suppressing Puberty in Boys.
  Silverman LA, Chin D, Cerame B, Steelman J, Wilcutts M, Thornton P, Endocr Rev 32: P3-717
• Treatment of Children With Central Precocious Puberty: 3 Years of Continuous Suppression With Histrelin Subdermal Implants.
  Silverman LA, Pediatric Endocrine Nurses Society
• (Unstimulated) Pediatric LH Levels Are Not Reliable in the Assessment of Pubertal Suppression by the Histrelin Subcutaneous Implant.
  Thornton P, Silverman L, Neely E, Geffner M, Potts S, Danoff T, Gould E, Pediatric Academic Society
• A 4-Year, Open-Label, Multi-Center, Randomized, 2-Arm Study of Genotropin® in Idiopathic Short Stature Patients: Comparing an Individualized, Target-Driven Treatment R...
  Counts DR, Geffner ME, Hey-Hadavi JH,. Newfield RS, Silverman LA, Thornton PS, Rajicic N, Wajnrajch MP, Pediatric Academic Society
• Recovery of Normal Hypothalamic-Pituitary-Gonadal Function after Treatment with Subcutaneous Histrelin Implant for Central Precocious Puberty.
  Silverman LA, Kletter GB, Neely EK, Potts S, Gould E, Terleckyj O, Danoff TM, Endocrine Society 2012, Sun-628
• Terleckyj O, Danoff TM, Histrelin Subdermal Implants Provide Continuous Suppression of the Hypothalamic-Pituitary-Gonadal Axis for 4 Years in Children with Central Pre...
  Silverman LA, Kletter GB, Neely EK, Potts S, Gould E, Endocrine Society 2012, Sun-630
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Lectures

• Pediatric ESAP Live 
  ENDO 2019 - New Orleans, LA - 3/24/2019
• Is Growth Hormone Good for the Heart? Is Growth Hormone Safe for the Heart? 
  NCGS Study Coordinators Meeting
• Atlantic Health System. 
  Practical Office Pediatrics, 2000
• Practical Office Pediatrics. 
  Practical Pediatrics Course, Copper Mountain
• Atlantic Health System. 
  Practical Office Pediatrics
• The Metabolic Consequences of SGA. 
  International Symposium: New Horizons in SGA Management, New York
• American Academy of Pediatrics. 
  Practical Pediatrics Course, Hilton Head
• The Cardiac Effects of Growth Hormone. 
  PAS/LWPES Annual Meeting
• Metropolitan. 
  NY/NJ Pediatric Board Review Course, 2006; KIGS National Meeting, 2007
• Negotiating a Clinical Trials Contract: The Physician Perspective. 
  Second Annual Metropolitan NY/NJ Pediatric Board Review Course
• When Puberty Occurs Too Early or Too Late. 
  American Academy of Pediatrics NCE, 2009; KIGS National Meeting, 2011
• Natural History of Pituitary Tumors: Does GH Effect Outcome? Personalized approach to growth hormone treatment. 
  Clinical use of growth prediction models, Nice
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