LeiShiMD

PubMed

• 202 citations
  TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion–Positive Intrahepatic Cholangiocarcinoma
  Lipika Goyal, Lei Shi, Leah Y. Liu, Ferran Fece de la Cruz, Jochen K. Lennerz, Srivatsan Raghavan, Ignaty Leschiner, Liudmila Elagina, Giulia Siravegna, Raymond W.S. N...> ;Cancer Discovery. 2019 May 20
• 27 citations
  Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders
  Amy Hauck Newman, Jianjing Cao, Jacqueline D. Keighron, Chloe J. Jordan, Guo-Hua Bi, Ying Liang, Ara M. Abramyan, Alicia J. Avelar, Christopher W. Tschumi, Michael J. ...> ;Neuropsychopharmacology. 2019 Mar 11
• HASH(0x3b84080)
  Guo, G.,Xu, M.,Chang, Y.,Luyten, T.,Seitaj, B.,Liu, W.,Zhu, P.,Bultynck, G.,Shi, L.,Quick, M.,Liu, Q.> ;Structure. 2019 Apr 02
• 36 citations
  Novel and Potent Dopamine D2 Receptor Go-Protein Biased Agonists.
  Alessandro Bonifazi, Hideaki Yano, Adrian M. Guerrero, Vivek Kumar, Alexander F. Hoffman, Carl R. Lupica, Lei Shi, Amy Hauck Newman> ;ACS Pharmacology & Translational Science. 2019 Jan 14
• Synthetic diagnostic for electron cyclotron emission imaging.
  Chen, M.,Zhu, Y.,Luo, C.,Shi, L.,Tobias, B. J.,Luhmann, N. C.> ;Rev Sci Instrum. 2018 Nov 08
• 16 citations
  The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites
  Matthias Quick, Ara M. Abramyan, Pattama Wiriyasermkul, Harel Weinstein, Lei Shi, Jonathan A. Javitch> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug 21
• 55 citations
  Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
  Laura A. Kirkman, Wenhu Zhan, Joseph Visone, Alexis Dziedziech, Pradeep K. Singh, Hao Fan, Xinran Tong, Igor Bruzual, Ryoma Hara, Masanori Kawasaki, Toshihiro Imaeda, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Jul 17
• 46 citations
  Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.
  Hideaki Yano, Alessandro Bonifazi, Min Xu, Daryl A. Guthrie, Stephanie N. Schneck, Ara M. Abramyan, Andrew D. Fant, W. Conrad Hong, Amy Hauck Newman, Lei Shi> ;Neuropharmacology. 2018 May 1
• 24 citations
  The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor.
  Christopher J Draper-Joyce, Mayako Michino, Ravi Kumar Verma, Carmen Klein Herenbrink, Jeremy Shonberg, Anitha Kopinathan, Peter J. Scammells, Ben Capuano, David M. Th...> ;Biochemical Pharmacology. 2018 Feb 1
• 14 citations
  The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions.
  Christopher J Draper-Joyce, Ravi Kumar Verma, Mayako Michino, Jeremy Shonberg, Anitha Kopinathan, Carmen Klein Herenbrink, Peter J. Scammells, Ben Capuano, Ara M. Abra...> ;Scientific Reports. 2018 Jan 19
• 25 citations
  The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.
  Ravi Kumar Verma, Ara M. Abramyan, Mayako Michino, R. Benjamin Free, Jonathan A. Javitch, J. Robert Lane, Lei Shi> ;Plos Computational Biology. 2018 Jan 16
• 13 citations
  Structure–Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopami...
  Mu Fa Zou, Jianjing Cao, Ara M. Abramyan, Theresa A. Kopajtic, Claudio Zanettini, Daryl A. Guthrie, Rana Rais, Barbara S. Slusher, Lei Shi, Claus J. Loland, Amy Hauck ...> ;Journal of Medicinal Chemistry. 2017 Dec 11
• 38 citations
  Identification of a putative binding site critical for general anesthetic activation of TRPA1
  Hoai T. Ton, Thieu X. Phan, Ara M. Abramyan, Lei Shi, Gerard P. Ahern> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Apr 4
• 261 citations
  High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.
  Kathryn G. Roberts, Zhaohui Gu, Debbie Payne-Turner, Kelly McCastlain, Richard C. Harvey, I-Ming Chen, Deqing Pei, Ilaria Iacobucci, Marcus B. Valentine, Stanley Pound...> ;Journal of Clinical Oncology. 2017 Feb 1
• 51 citations
  Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.
  Esilida Sula Karreci, Hao Fan, Mayuko Uehara, Albana B Mihali, Pradeep K. Singh, Ahmed T. Kurdi, Zhabiz Solhjou, Leonardo V. Riella, Irene M. Ghobrial, Teresina Laragi...> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Dec 27
• 18 citations
  Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290.
  George Khelashvili, Solveig G. Schmidt, Lei Shi, Jonathan A. Javitch, Ulrik Gether, Claus J. Loland, Harel Weinstein> ;The Journal of Biological Chemistry. 2016 Sep 16
• 4 citations
  Effects of ezetimibe and anticoagulant combined therapy on progressing stroke: a randomized, placebo-controlled study
  Lan Yang, Pingping Zhao, Jing Zhao, Juan Wang, Lei Shi, Xiaopeng Wang> ;Journal of Neurology. 2016 Sep 15
• 16 citations
  Design and Synthesis of Dimeric Securinine Analogues with Neuritogenic Activities.
  Genyun Tang, Xin Liu, Nan Ma, Xiaojie Huang, Zhen-Long Wu, Wen Zhang, Ying Wang, Bing-Xin Zhao, Zhen-Ya Wang, Fanny Chui Fun Ip, Nancy Y. Ip, Wen-Cai Ye, Lei Shi, Wei-...> ;ACS Chemical Neuroscience. 2016 Aug 11
• 2 citations
  Methods of intra-operative treatment of cranioplasty in patients with abnormal bone window flap pressure after decompressive craniectomy.
  Yi Wan, Xifeng Fei, Lei Shi, Dongyi Jiang, Hanchun Chen, Zhimin Wang, Yanjun Zeng> ;Clinical Neurology and Neurosurgery. 2016 May 1
• 15 citations
  Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain
  Jennifer M. Frost, David A. Degoey, Lei Shi, Rebecca J. Gum, Meagan M. Fricano, Greta L. Lundgaard, Odile F. El-Kouhen, Gin C. Hsieh, Torben R. Neelands, Mark A. Matul...> ;Journal of Medicinal Chemistry. 2016 Apr 5
• 28 citations
  Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity
  Mu Fa Zou, Thomas M. Keck, Vivek Kumar, Prashant Donthamsetti, Mayako Michino, Caitlin Burzynski, Catherine Schweppe, Alessandro Bonifazi, R. Benjamin Free, Aaron Jano...> ;Journal of Medicinal Chemistry. 2016 Apr 1
• 63 citations
  Mit1 Transcription Factor Mediates Methanol Signaling and Regulates the Alcohol Oxidase 1 (AOX1) Promoter in Pichia pastoris
  Xiaolong Wang, Qi Wang, Jinjia Wang, Peng Bai, Lei Shi, Wei Shen, Mian Zhou, Xiangshan Zhou, Yuanxing Zhang, Menghao Cai> ;The Journal of Biological Chemistry. 2016 Mar 18
• 8 citations
  Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury
  Wei Jin, Wei Xu, Jing Chen, Xiaoxiao Zhang, Lei Shi, Chuancheng Ren> ;Journal of Molecular Histology. 2016 Mar 16
• 80 citations
  Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus.
  George Khelashvili, Nathaniel Stanley, Michelle A. Sahai, Jaime Medina, Michael V. LeVine, Lei Shi, Gianni De Fabritiis, Harel Weinstein> ;ACS Chemical Neuroscience. 2015 Nov 18
• 30 citations
  Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter
  Christian B. Billesbølle, Mie Barthold Krüger, Lei Shi, Matthias Quick, Zheng Li, Sebastian Stolzenberg, Julie Kniazeff, Kamil Gotfryd, Jonas S. Mortensen, Jonathan A....> ;The Journal of Biological Chemistry. 2015 Oct 30
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Journal Articles

• Antimalarial Proteasome Inhibitor Reveals Collateral Sensitivity from Intersubunit Interactions and Fitness Cost of Resistance  
  Carl F Nathan, Laura A Kirkman, Lei Shi, Proceedings of the National Academy of Sciences