LeonP.McLeanMDPhD, MPH

PubMed

• 44 citations
  Adverse events in IBD therapy: the 2018 update.
  Sandra M. Quezada, Leon P McLean, Raymond K. Cross> ;Expert Review of Gastroenterology & Hepatology. 2018 Nov 15
• 6 citations
  Frequency of Surveillance and Impact of Surveillance Colonoscopies in Patients With Ulcerative Colitis Who Developed Colorectal Cancer.
  Elisabeth B. Cole, Yash Shah, Leon P. McLean, Yu-Xiao Yang, Nabeel Khan> ;Clinical Colorectal Cancer. 2018 Jun 1
• 28 citations
  Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines
  Leon P. McLean, Allen Smith, Lumei Cheung, Joseph F. Urban, Rex Sun, Viktoriya Grinchuk, Neemesh Desai, Aiping Zhao, Jean-Pierre Raufman, Terez Shea-Donohue> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2016 Jul 1
• 5 citations
  Pharmacodynamic assessment of vedolizumab for the treatment of ulcerative colitis.
  Leon P. McLean, Raymond K. Cross> ;Expert Opinion on Drug Metabolism & Toxicology. 2016 May 12
• 24 citations
  Integrin antagonists as potential therapeutic options for the treatment of Crohn’s disease
  Leon P. McLean, Raymond K. Cross> ;Expert Opinion on Investigational Drugs. 2016 Feb 22
• 12 citations
  Enteric nematodes and the path to up-regulation of type 2 cytokines IL-4 and IL-13
  Terez Shea-Donohue, Rex Sun, Jennifer A. Bohl, Leon P. McLean, Aiping Zhao> ;Cytokine. 2015 Sep 1
• 17 citations
  Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium.
  Leon P. McLean, Allen Smith, Lumei Cheung, Rex Sun, Viktoriya Grinchuk, Tim Vanuytsel, Neemesh Desai, Joseph F. Urban, Aiping Zhao, Jean-Pierre Raufman, Terez Shea-Don...> ;Inflammatory Bowel Diseases. 2015 Aug 1
• 29 citations
  M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.
  Nathalie H. Urrunaga, Ravirajsinh N. Jadeja, Vikrant Rachakonda, Daniel Ahmad, Leon P. McLean, Kunrong Cheng, Vijay H. Shah, William S. Twaddell, Jean-Pierre Raufman, ...> ;Free Radical Biology & Medicine. 2015 Jan 1
• Right Lower Quadrant Pain in a Patient With Inflammatory Bowel Disease of Undetermined Type
  Leon P. McLean, Jonathan Chun, Raymond K. Cross> ;Clinical Gastroenterology and Hepatology. 2014 Apr 1
• 67 citations
  Adverse events in IBD: to stop or continue immune suppressant and biologic treatment
  Leon P. McLean, Raymond K. Cross> ;Expert Review of Gastroenterology & Hepatology. 2014 Feb 12
• 32 citations
  Role of macrophages in the altered epithelial function during a type 2 immune response induced by enteric nematode infection
  Luigi Notari, Diana C. Riera, Rex Sun, Jennifer A. Bohl, Leon P. McLean, Kathleen B. Madden, Nico van Rooijen, Tim Vanuytsel, Joseph F. Urban, Aiping Zhao, Terez Shea-...> ;Plos One. 2014 Jan 23
• 3 citations
  What is the role of vedolizumab in the era of anti-TNF agents?
  Fong-Kuei F. Cheng, Leon P. McLean, Raymond K. Cross> ;Annals of Translational Medicine. 2014 Jan 1
• 19 citations
  Combined blockade of IL-17A and IL-17F may prevent the development of experimental colitis.
  Leon P. McLean, Raymond K. Cross, Terez Shea-Donohue> ;Immunotherapy. 2013 Sep 2
• 32 citations
  IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent
  Zhonghan Yang, Rex Sun, Viktoriya Grinchuk, Joan Antoni Fernandez Blanco, Luigi Notari, Jennifer A. Bohl, Leon P. McLean, Thirumalai R. Ramalingam, Thomas A. Wynn, Jos...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2013 Feb 15
• 71 citations
  Vedolizumab for the treatment of ulcerative colitis and Crohn's disease.
  Leon P. McLean, Terez Shea-Donohue, Raymond K. Cross> ;Immunotherapy. 2012 Oct 9
• 17 citations
  Diabetic Ketoacidosis Associated with Aripiprazole
  Zaineb Makhzoumi, Leon P. McLean, Jefferson Lee, Ada I Ibe> ;Pharmacotherapy. 2008 Sep 1
• 12 citations
  Hoxa4 expression in developing mouse hair follicles and skin.
  Alan I. Packer, Daniel Jane-wit, Leon P. McLean, Andrei A. Panteleyev, Angela M. Christiano, Debra J. Wolgemuth> ;Mechanisms of Development. 2000 Dec 1
• Join now to see all

Journal Articles

• Adverse Events in IBD: To Stop or Continue Immune Suppressant and Biologic Therapy  
  McLean LP, Cross RK, Expert Rev Gastroenterol Hepatol, 1/1/2014
• Right Lower Quadrant Pain in a Patient with IBD of Undetermined Type  
  McLean LP, Chun JS, Cross RK, Clin Gastroenterol Hepatol, 1/1/2014
• M1 Muscarinic Receptors Modify the Oxidative Stress Response to Acetaminophen-Induced Acute Liver Injury  
  Urrunaga NH, Jadeja RN, Rachakonda V, Ahmad D, McLean LP, Chen K, Shah V, Twaddell WS, Raufman JP, Khurana S, Free Radic Biol Med, 1/1/2014
• Dependence of IL-33-induced Alterations in Intestinal Function and Cytokine Response on MyD88, STAT6, and IL-13 in Mice  
  Yang Z, Sun R, Grinchuk V, Notari L, Stiltz J, McLean LP, Ramalingam TR, Wynn TA, Urban JF, Vogel SM, Shea-Donohue T, Zhao A, Am J Physiol Gastrointest Liver Physiol, 1/1/2013
• Vedolizumab for the Treatment of Ulcerative Colitis and Crohn's Disease  
  McLean LP, Shea-Donohue T, Cross RK, Immunotherapy, 1/1/2012
• Hoxa4 Expression in Developing Mouse Hair Follicles and Skin  
  Packer AI, Jane-Wit D, McLean L, Panteleyev AA, Christiano AM and Wolgemuth DJ, Mech Dev, 1/1/2000
• Join now to see all

Books/Book Chapters

• Gastroenterology Pocket 
  Chapter: Diarrhea and Constipation 
  McLean LP and Greenwald BDEditors: Nichita D and Ghugari R.Borm Bruckmeier Publishing, El Segundo, CA2014
• Gastroenterology Pocket 
  Chapter: Gastrointestinal Bleeding 
  McLean LP and Patil SAEditors: Nichita D and Ghugari R.Borm Bruckmeier Publishing, El Segundo, CA2014

Abstracts/Posters

• Type 3 Muscarinic Receptor Activity Facilitates Clearance of Citrobacter rodentium
  McLean LP, Smith A, Cheung L, Sun R, Grinchuk V, Zhao A, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, Chicago, IL, 1/1/2014
• Type 3 Muscarinic Receptors (M3R) Contribute to Expulsion of Nippostrongylus brasliensis Through Induction of Th2 Cytokines
  McLean LP, Smith A, Cheung L, Desai N, Grinchuk V, Zhao A, Sun R, Raufman JP, Shea-Donohue T, American College of Gastroenterology Annual Scientific Meeting, Am J Gastroenterol, Philadelphia, PA, 1/1/2014
• Type 3 Muscarinic Receptor Deficiency is Associated with Impaired Paracellular Permeability and Activation of Myosin Light Chain (MLC) 2
  McLean LP, Notari L, Sun R, Bohl J, Yan S, Grinchuk V, Zhao A, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, Orlando, FL, 1/1/2013
• Crohn's Disease: An Uncommon Cause of Appendicitis
  McLean LP, Chun J, Cross RK, American College of Gastroenterology Annual Scientific Meeting, Am J Gastroenterol, San Diego, CA, 1/1/2013
• Genetic Ablation of M1 Muscarinic Receptors (M1R) Attenuates Azoxymethane (AOM)-Induced Murine Liver Injury by TRAIL-R2-Mediated Hepatic Stellate Cell (HSC) Apoptosis
  Rachakonda V, Urrunaga NH, Jadeja R, Ahmad D, McLean L, Cheng K, Saxena NK, Raufman J, Khurana S, The 64th Annual Meeting of the American Association for the Study of Liver Diseases, Hepatology, Washington, DC, 1/1/2013
• Mechanisms Underlying Attenuated Acetaminophen (APAP)-Induced Liver Injury in M1R-Deficient (M1R-/-) Mice
  Urrunaga NH, Jadeja R, Rachakonda V, Ahmad D, McLean L, Saxena NK, Cheng K, Raufman J, Khurana S, The 64th Annual Meeting of the American Association for the Study of Liver Diseases, Hepatology, Washington, DC, 1/1/2013
• Type 3 Muscarinic Receptors Modulate Macrophage Phenotype in the Presence of Th1 Cytokines
  McLean L, Grinchuk V, Zhao A, Sun R, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, San Diego, CA, 1/1/2012
• Immune Regulation of the Intestinal Progenitor Cell Microenvironment
  Vanuytsel T, Notari L, Yan S, Zhao A, Bohl J, McLean L, Sun R, Urban J, Smith A, Tack J, Shea-Donohue T, Digestive Disease Week, Gastroenterology, San Diego, CA, 1/1/2012
• Nematode Generated Protease Activation of PAR2 Plays a Key Role in the Th2 Protective Immune Response
  Bohl J, Urban J, Notari L, Sun R, Zhao A, Yan S, Grinchuk V, Vanuytsel T, McLean L, Yang Z, Shea-Donohue T, Digestive Disease Week, Gastroenterology, San Diego, CA, 1/1/2012
• Type 3 Muscarinic Receptors Modulate Macrophage Phenotype in the Presence of Th2 Cytokines
  McLean L, Grinchuk V, Zhao A, Sun R, Raufman JP, Shea-Donohue T, American College of Gastroenterology Annual Scientific Meeting, Am J Gastroenterol, Las Vegas, NV, 1/1/2012
• Genetic Ablation of M1 Subtype Muscarinic Receptor (M1R) Attenuates Azoxymethane (AOM)-Induced Liver Injury by Altering Expression of Fibrogenic Mediators and Inflamma...
  Rachakonda V, Urrunaga N, Ahmad D, Twadell W, Saxena N, Cheng K, McLean L, Raufman JP, Khurana S, The 63rd Annual Meeting of the American Association for the Study of Liver Diseases, Hepatology, Boston, MA, 1/1/2012
• In Mice, Genetic Ablation of M1 Subtype Muscarinic Receptors (Chrm1-/-) Attenuates Acetaminophen (APAP)-Induced Liver Injury
  Urrunaga N, Rachakonda V, Ahmad D, McLean L, Twadell W, Saxena N, Cheng K, Raufman JP, Khurana S, The 63rd Annual Meeting of the American Association for the Study of Liver Diseases, Hepatology, Boston, MA, 1/1/2012
• Type 1 and Type 3 Muscarinic Receptors Modulate Intestinal Barrier Function
  McLean LP, Notari L, Sun R, Stiltz JA, Grinchuk V, Yan S, Zhao A, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, Chicago, IL, 1/1/2011
• Role of Muscarinic 3 Receptors in the Immune, Epithelial, and Smooth Muscle Responses to Enteric Nematode Infection
  McLean LP, Zhao A, Sun R, Stiltz JA, Riera DC, Urban JF, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, San Diego, CA, 1/1/2008
• Muscarinic Type 3 Receptors (M3R) Contribute to Ileal Mucosal Barrier Function
  McLean LP, Sun R, Stiltz J, Zhao A, Raufman JP, Shea-Donohue T, Digestive Disease Week, Gastroenterology, Washington, DC, 1/1/2007
• Compliance with Dyspepsia Guidelines: Experience in a Primary Care General Medicine Setting
  McLean LP and Fairchild DG, American College of Gastroenterology Annual Scientific Meeting and Postgraduate Course, Am J Gastroenterol, Las Vegas, NV, 1/1/2006
• Attitudes of Healthcare Workers Towards Smallpox Vaccination
  McLean LP, Salas FL, Lazar JD, McCarthy TA, Hamer DH, 42nd Annual Meeting of the Infectious Diseases Society of America, Boston, MA, 1/1/2004
• Join now to see all

Lectures

• Type 3 Muscarinic Receptors Contribute to Host Defense within the GI Tract 
  The Johns Hopkins Hospital, Baltimore, MD - 1/1/2014
• The Science of Medical Therapy for Inflammatory Bowel Disease 
  University of Maryland Medical Center, Baltimore, MD - 1/1/2014
• Type 3 Muscarinic Receptor Deficiency is Associated with Impaired Paracellular Permeability and Activation of Myosin Light Chain (MLC) 2 
  Orlando, FL - 1/1/2013
• Type 3 Muscarinic Receptors Modulate Macrophage Phenotype in the Presence of Th1 Cytokines 
  San Diego, CA - 1/1/2012
• The Aberrant Right Subclavian Artery 
  Maryland Chapter of the American College of Physicians, Baltimore, MD - 1/1/2008
• Advanced Lupus Nephritis as an Uncommon Initial Presentation of Systemic Lupus Erythematosus 
  Maryland Chapter of the American College of Physicians, Baltimore, MD - 1/1/2008
• Comparing the Automated and Non-Automated Sign-Out Systems Used by Medicine Interns in Transfers of Patient Care 
  Maryland Chapter of the American College of Physicians, Baltimore, MD - 1/1/2008
• Muscarinic Type 3 Receptors and Ileal Mucosal Barrier Function 
  Maryland Chapter of the American College of Physicians, Baltimore, MD - 1/1/2007
• Join now to see all

Other

• Type 3 Muscarinic Receptors Contribute to Homeostasis and Host Defense within the Gastrointestinal Tract, Doctor of Philosophy Thesis Defense 
  McLean LP
  University of Maryland, Baltimore, Baltimore, MD - 1/1/2014